Netrin-1 as a novel therapeutic target in cardiovascular disease: to activate or inhibit?

abstract：:The effects of L-propionylcarnitine on the recovery of cardiac contractile performance after global ischaemia and reperfusion were studied in isolated perfused rat hearts. The addition of either 5.5 or 11 mmol X litre-1 L-propionylcarnitine significantly improved the recovery of cardiac output, left ventricular pressu...

journal_title：Cardiovascular research

authors： Paulson DJ,Traxler J,Schmidt M,Noonan J,Shug AL

更新日期：1986-07-01 00:00:00

abstract：AIMS:Ischaemia-reperfusion provokes barrier failure of the coronary microvasculature, impeding functional recovery of the heart during reperfusion. The aim of the present study was to investigate whether the stimulation of cGMP signalling by activation of soluble guanylyl cyclase (sGC) can reduce reperfusion-induced en...

journal_title：Cardiovascular research

authors： Kasseckert SA,Schäfer C,Kluger A,Gligorievski D,Tillmann J,Schlüter KD,Noll T,Sauer H,Piper HM,Abdallah Y

更新日期：2009-07-15 00:00:00

abstract：OBJECTIVE:Inhibition by endothelin antagonist is a potential therapy in heart failure. However, the effect of endothelin inhibition during the development of heart failure has not been evaluated. The goal of our study was to examine the acute hemodynamic effects of the mixed endothelin receptor antagonist bosentan in t...

journal_title：Cardiovascular research

authors： Choussat R,Hittinger L,Barbe F,Maistre G,Carayon A,Crozatier B,Su J

更新日期：1998-09-01 00:00:00

abstract：AIMS:Current mechanisms driving cardiac pacemaker function have focused on ion channel and gap junction channel function, which are essential for action potential generation and propagation between pacemaker cells. However, pacemaker cells also harbour desmosomes that structurally anchor pacemaker cells to each other i...

journal_title：Cardiovascular research

authors： Mezzano V,Liang Y,Wright AT,Lyon RC,Pfeiffer E,Song MY,Gu Y,Dalton ND,Scheinman M,Peterson KL,Evans SM,Fowler S,Cerrone M,McCulloch AD,Sheikh F

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:Apolipoprotein E-deficient mice (apoE(-/-)) on a regular diet become hypercholesterolemic and develop atherosclerosis, but endothelium-dependent relaxation remains undisturbed for up to 6 months. We investigated whether vasomotor dysfunction develops in aged apoE(-/-), whether the defect was systemic (hyperch...

journal_title：Cardiovascular research

authors： Crauwels HM,Van Hove CE,Holvoet P,Herman AG,Bult H

更新日期：2003-07-01 00:00:00

abstract：AIMS:Chronic pressure or volume overload induce concentric vs. eccentric left ventricular (LV) remodelling, respectively. Previous studies suggest that distinct signalling pathways are involved in these responses. NADPH oxidase-4 (Nox4) is a reactive oxygen species-generating enzyme that can limit detrimental cardiac r...

journal_title：Cardiovascular research

authors： Schnelle M,Sawyer I,Anilkumar N,Mohamed BA,Richards DA,Toischer K,Zhang M,Catibog N,Sawyer G,Mongue-Din H,Schröder K,Hasenfuss G,Shah AM

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:After-depolarization associated arrhythmias are frequently observed in heart failure and associated with spontaneous calcium release from sarcoplasmic reticulum (SR), calcium after-transients. We hypothesize that disturbed SR calcium handling underlies calcium after-transients in heart failure (HF). METHODS:...

journal_title：Cardiovascular research

authors： Baartscheer A,Schumacher CA,Belterman CN,Coronel R,Fiolet JW

更新日期：2003-04-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to evaluate the thrombolytic efficacy of recombinant double chain tissue plasminogen activator (Duteplase, t-PA) given as a single intravenous bolus versus an infusion in a canine model of coronary arterial occlusion/reperfusion. DESIGN:Coronary arterial thrombi were induced by a copper coi...

journal_title：Cardiovascular research

authors： Longridge DJ,Follenfant MJ,Ford AJ

更新日期：1991-03-01 00:00:00

abstract：:A mathematical formulation of the blood flow behaviour through a capillaron model is described. The formulation is applied to the analysis of post-occlusion (reactive) hyperaemia and autoregulation. ...

journal_title：Cardiovascular research

authors： Murao H,Rodbard S

更新日期：1976-01-01 00:00:00

abstract：Aims:Circular RNA (circRNA) is a newly validated class of single-stranded RNA, ubiquitously expressed in mammalian tissues and possessing key functions including acting as microRNA sponges and as transcriptional regulators by binding to RNA-binding proteins. While independent studies confirm the expression of circRNA i...

journal_title：Cardiovascular research

authors： Tan WL,Lim BT,Anene-Nzelu CG,Ackers-Johnson M,Dashi A,See K,Tiang Z,Lee DP,Chua WW,Luu TD,Li PY,Richards AM,Foo RS

更新日期：2017-03-01 00:00:00

abstract：AIMS:Diabetes is a major risk factor for cardiovascular diseases. Circulating endothelial microparticles (EMP) are increased in diabetic patients, but their potential contribution in atherogenesis is unclear. We sought to determine the role of EMP derived under high glucose conditions in the development of atherosclero...

journal_title：Cardiovascular research

authors： Jansen F,Yang X,Franklin BS,Hoelscher M,Schmitz T,Bedorf J,Nickenig G,Werner N

更新日期：2013-04-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to evaluate the protective effect of verapamil during myocardial ischaemia and reperfusion. DESIGN:In vivo phosphorus-31 (31P) magnetic resonance spectroscopy was performed on rats pretreated with verapamil (mg.kg-1 intraperitoneal) and controls during a 45 min left coronary artery occlusio...

journal_title：Cardiovascular research

authors： Wolfe CL,Donnelly TJ,Sievers R,Parmley WW

更新日期：1991-02-01 00:00:00

abstract：:Conventional antithrombotic treatments with antiplatelet, anticoagulant or fibrinolytic drugs are not uniformly successful and are associated with hemorrhagic side effects. Thus, new approaches to the prevention and treatment of arterial thrombosis are desirable. The gene transfer approach is particularly attractive b...

journal_title：Cardiovascular research

authors： Vassalli G,Dichek DA

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:Heme oxygenases (HO) are the rate-limiting enzymes in heme degradation, catalyzing the breakdown of heme to equimolar quantities of biliverdin (BV), carbon monoxide (CO), and ferrous iron. The inducible HO isoform, HO-1, confers protection against ischemia/reperfusion (I/R)-injury in the heart. We hypothesize...

journal_title：Cardiovascular research

authors： Tongers J,Fiedler B,König D,Kempf T,Klein G,Heineke J,Kraft T,Gambaryan S,Lohmann SM,Drexler H,Wollert KC

更新日期：2004-08-15 00:00:00

abstract：:To improve assessment of ventricular function during cardiac catheterisation there should be available a continuous registration of stroke volume and cardiac output in addition to ventricular pressure. To obtain the desired volumetric quantities a catheter has been developed which measures changes in intraventricular ...

journal_title：Cardiovascular research

authors： Baan J,Jong TT,Kerkhof PL,Moene RJ,van Dijk AD,van der Velde ET,Koops J

更新日期：1981-06-01 00:00:00

abstract：OBJECTIVES:Elevated systemic arterial blood pressure is associated with left ventricular hypertrophy and fibrosis. It has been suggested that both circulating and local myocardial renin-angiotensin systems play a role in mediating these responses. Here we describe the natural history of ventricular hypertrophy and fibr...

journal_title：Cardiovascular research

authors： Bishop JE,Kiernan LA,Montgomery HE,Gohlke P,McEwan JR

更新日期：2000-07-01 00:00:00

abstract：AIM:To assess whether endothelin-1 (ET-1) induces the in vivo expression of inflammatory-related proteins, namely cyclooxygenase-2 (COX-2) and tissue factor, in the myocardium and circulating leukocytes of guinea-pigs. The involvement of platelets was also analyzed. METHODS:ET-1 (0.013 microg/min) was infused to male ...

journal_title：Cardiovascular research

authors： Molero L,Farré J,García-Mendez A,Jiménez Mateos-Caceres P,Carrasco Martín C,Millás I,Navarro F,Córdoba M,Casado S,López-Farré A

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:It has been suggested that nitric oxide (NO) is involved in the regulation of myocardial function in a variety of diseases such as dilated cardiomyopathy, myocarditis, heart transplant rejection, and septic shock. However, the underlying mechanism of NO mediated reduction of cardiac contractility has not been...

journal_title：Cardiovascular research

authors： Kelm M,Schäfer S,Dahmann R,Dolu B,Perings S,Decking UK,Schrader J,Strauer BE

更新日期：1997-11-01 00:00:00

abstract：:Surgical preparation of human saphenous vein for coronary artery bypass grafting involving distension and storage in iso-osmotic sodium chloride solution reduced tissue adenosine triphosphate (ATP) (mean(SEM] concentration from 280(20) nmol.g-1 wet wt (n = 25) to 140(30) nmol.g-1 wet wt (n = 12) and the adenosine trip...

journal_title：Cardiovascular research

authors： Angelini GD,Passani SL,Breckenridge IM,Newby AC

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:The functional status of heart failure (HF) is conventionally evaluated by peak exercise oxygen consumption (VO2 max). Dobutamine echocardiography can be used to evaluate myocardial reserve. The aim of this study was to estimate the functional status of chronic HF in patients with dilated cardiomyopathy, by ...

journal_title：Cardiovascular research

authors： Paraskevaidis IA,Tsiapras DP,Adamopoulos S,Kremastinos DT

更新日期：1999-07-01 00:00:00

abstract：AIMS:Regional heterogeneities in contraction contribute to heart failure with reduced ejection fraction (HFrEF). We aimed to determine whether regional changes in myocardial relaxation similarly contribute to diastolic dysfunction in post-infarction HFrEF, and to elucidate the underlying mechanisms. METHODS AND RESULT...

journal_title：Cardiovascular research

authors： Røe ÅT,Ruud M,Espe EK,Manfra O,Longobardi S,Aronsen JM,Nordén ES,Husebye T,Kolstad TRS,Cataliotti A,Christensen G,Sejersted OM,Niederer SA,Andersen GØ,Sjaastad I,Louch WE

更新日期：2019-03-15 00:00:00

abstract：OBJECTIVE:The present study investigated whether activation of phosphatidylinositol 3-kinase (PI3-kinase) is involved in the stimulation of hypertrophic growth of adult ventricular cardiomyocytes under alpha- or beta-adrenoceptor stimulation. METHODS:Adult ventricular rat cardiomyocytes were used either directly after...

journal_title：Cardiovascular research

authors： Schlüter KD,Goldberg Y,Taimor G,Schäfer M,Piper HM

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:The aim was to determine the relationship between the rate of reflow and vulnerability to reperfusion induced arrhythmias. METHODS:Isolated rat hearts, in which left and right coronary arteries were perfused independently, were subjected to transient (10 min) cessation of flow to the left coronary bed. Durin...

journal_title：Cardiovascular research

authors： Ibuki C,Hearse DJ,Avkiran M

更新日期：1992-04-01 00:00:00

abstract：AIMS:Arrhythmias and sudden cardiac death (SCD) occur commonly in patients with heart failure. We found T-box 5 (TBX5) dysregulated in ventricular myocardium from heart failure patients and thus we hypothesized that TBX5 reduction contributes to arrhythmia development in these patients. To understand the underlying mec...

journal_title：Cardiovascular research

authors： Rathjens FS,Blenkle A,Iyer LM,Renger A,Syeda F,Noack C,Jungmann A,Dewenter M,Toischer K,El-Armouche A,Müller OJ,Fabritz L,Zimmermann WH,Zelarayan LC,Zafeiriou MP

更新日期：2020-08-10 00:00:00

abstract：OBJECTIVE:Myocardial adaptation has been reported to result from mild but chronic ischaemia in the hearts of patients with coronary artery disease. The aim of this study was to test the hypothesis that the responses of the chronically hypoxic myocardium to an episode of severe ischaemia, or the effects of acute ischaem...

journal_title：Cardiovascular research

authors： Tajima M,Katayose D,Bessho M,Isoyama S

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:The aim was to study the effect of thyroid hormone on collagen gene expression in the myocardium of the tight skin mouse (TSK), a genetic model of myocardial fibrosis. METHODS:Heterozygous male (TSK/+) (n = 20) and normal (+/+) homozygous mice (n = 20), 1.5-2 months old of the C57 BL/6 strain were studied. V...

journal_title：Cardiovascular research

authors： Yao J,Eghbali M

更新日期：1992-06-01 00:00:00

abstract：:Gender has an important influence on blood pressure, with premenopausal women having a lower arterial blood pressure than age-matched men. Compared with premenopausal women, postmenopausal women have higher blood pressures, suggesting that ovarian hormones may modulate blood pressure. However, whether sex hormones are...

journal_title：Cardiovascular research

authors： Dubey RK,Oparil S,Imthurn B,Jackson EK

更新日期：2002-02-15 00:00:00

abstract：:Labetolol, which blocks both alpha and beta-adrenoceptors, was found to have direct actions on cardiac muscle which could themselves be antiarrhythmic. It depressed the maximum rate of depolarisation, and reduced conduction velocity, in atrial and ventricular muscle and in Purkinje cells, implying restriction of fast ...

journal_title：Cardiovascular research

authors： Vaughn Williams EM,Millar JS,Campbell TJ

更新日期：1982-05-01 00:00:00

abstract：AIMS:Both cyclooxygenase-2 (COX-2) and the transcription factor signal transducer and activator of transcription 3 (Stat3) are involved in adaptive growth and survival of cardiomyocytes. In ventricular cardiomyocytes, prostaglandin E(2) (PGE(2)), a major COX-2 product, leads to adaptive growth via Stat3 activation, but...

journal_title：Cardiovascular research

authors： Frias MA,Somers S,Gerber-Wicht C,Opie LH,Lecour S,Lang U

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:Our aim was to determine in desmin homozygous mutant mice the viscoelastic properties, the mechanical strength and the structure of the carotid artery. METHODS:To assess the viscoelastic properties of large arteries, we have performed an in vivo analysis of the diameter-, and distensibility-pressure curves o...

journal_title：Cardiovascular research

authors： Lacolley P,Challande P,Boumaza S,Cohuet G,Laurent S,Boutouyrie P,Grimaud JA,Paulin D,Lamazière JM,Li Z

更新日期：2001-07-01 00:00:00