Role of phosphatidylinositol 3-kinase activation in the hypertrophic growth of adult ventricular cardiomyocytes.

abstract：Aims:MicroRNAs (miRNAs) have been implicated in the pathogenesis of pulmonary hypertension (PH), a multifactorial and progressive condition associated with an increased afterload of the right ventricle leading to heart failure and death. The main aim of this study was to correlate the levels of miR-424(322) with the se...

journal_title：Cardiovascular research

authors： Baptista R,Marques C,Catarino S,Enguita FJ,Costa MC,Matafome P,Zuzarte M,Castro G,Reis A,Monteiro P,Pêgo M,Pereira P,Girão H

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:The aim was to determine the effect and mechanisms by which myocyte stretch interacts with the prolongation of action potential duration (APD) by the class III antiarrhythmic agent E-4031. METHODS:Action potentials and whole-cell currents were measured in isolated guinea pig ventricular myocytes with a patc...

journal_title：Cardiovascular research

authors： Groh WJ,Gibson KJ,Maylie JG

更新日期：1996-02-01 00:00:00

abstract：:Cardiac hypertrophy was induced in rabbits at atmospheric pressure by exposing them to hypoxia equivalent to an altitude of 6000 m for 280 to 350 h. Intracellular action potentials were recorded from Purkinje cells, and from atrial and papillary muscles, contractions of which were also measured. Hearts from normoxic l...

journal_title：Cardiovascular research

authors： Dukes ID,Vaughan Williams EM

更新日期：1984-10-01 00:00:00

abstract：OBJECTIVE:In pigs, the infarct size (IS) reduction achieved by a strong preconditioning stimulus (IPs) of 10 min ischemia and 15 min reperfusion is greater than that by a weaker preconditioning stimulus (IPw) of 3 min ischemia and 15 min reperfusion. The cardioprotection achieved by IPw is completely abolished by block...

journal_title：Cardiovascular research

authors： Gres P,Schulz R,Jansen J,Umschlag C,Heusch G

更新日期：2002-08-15 00:00:00

abstract：AIMS:Heparanase, which specifically cleaves carbohydrate chains of heparan sulfate, has been implicated in the pathology of diabetes-associated complications. Using high glucose (HG) to replicate hyperglycaemia observed following diabetes, the present study was designed to determine the mechanism by which HG initiates ...

journal_title：Cardiovascular research

authors： Wang F,Wang Y,Kim MS,Puthanveetil P,Ghosh S,Luciani DS,Johnson JD,Abrahani A,Rodrigues B

更新日期：2010-07-01 00:00:00

abstract：AIMS:Neointimal hyperplasia is a common feature of fibro-proliferative vascular disease and characterizes initial stages of atherosclerosis. Neointimal lesions mainly comprise smooth muscle-like cells. The presence of these lesions is related to local differences in shear stress. Neointimal cells may arise through migr...

journal_title：Cardiovascular research

authors： Moonen JR,Lee ES,Schmidt M,Maleszewska M,Koerts JA,Brouwer LA,van Kooten TG,van Luyn MJ,Zeebregts CJ,Krenning G,Harmsen MC

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:To study the effect of cardiac contraction on left coronary artery pressure-flow relations at different vascular volumes and to compare these relations in the beating heart with those in the heart arrested in systole and diastole. METHODS:Maximally vasodilated, Tyrode perfused, rabbit hearts (n = 6) with an ...

journal_title：Cardiovascular research

authors： Sipkema P,Takkenberg JJ,Zeeuwe PE,Westerhof N

更新日期：1998-10-01 00:00:00

abstract：AIMS:Although increased Na(+)/Ca(2+) exchanger 1 (NCX1) expression is observed during heart failure (HF), the pathological role of NCX1 during the progression of HF remains unclear. We examined alterations of NCX1 expression and activity in hearts after transverse aortic constriction (TAC) surgery and explored whether ...

journal_title：Cardiovascular research

authors： Ujihara Y,Iwasaki K,Takatsu S,Hashimoto K,Naruse K,Mohri S,Katanosaka Y

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the effects of aging on left ventricular (LV) geometry, collagen levels, matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) abundance, and myocardial fibroblast function. METHODS:Young (3-month-old; n=28), middle-aged (MA; 15-month-old; n=17), and old (23-month-old; n...

journal_title：Cardiovascular research

authors： Lindsey ML,Goshorn DK,Squires CE,Escobar GP,Hendrick JW,Mingoia JT,Sweterlitsch SE,Spinale FG

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVES:The A10 cell line was derived from the thoracic aorta of embryonic rat and is a commonly used model of vascular smooth muscle cells (VSMC). Despite its wide use this cell line has not been well characterized. This is especially important in light of recent evidence of phenotypically distinct cell populations...

journal_title：Cardiovascular research

authors： Rao RS,Miano JM,Olson EN,Seidel CL

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:We recently showed that mitochondrial coupling factor 6 (CF6) is present as a pressor substance and a prostacyclin inhibitor in systemic circulation. However, the regulation mechanism for circulating CF6 is unknown. We investigated the role of tumor necrosis factor-alpha (TNF-alpha) in the generation and rele...

journal_title：Cardiovascular research

authors： Sasaki S,Osanai T,Tomita H,Matsunaga T,Magota K,Okumura K

更新日期：2004-06-01 00:00:00

abstract：:An in situ preparation of the rabbit thoracic aorta has been used to study the transport of short-lived radioactive isotopes of oxygen (15O16O), nitrogen (13N14N) and an isotope of xenon (133Xe) from 0.9% NaCl into the artery wall. At a luminal hydrostatic pressure of 2 kPa the uptake of all three isotopes by the inti...

journal_title：Cardiovascular research

authors： Davis J,Klinowski J,Winlove CP

更新日期：1981-08-01 00:00:00

abstract：:Effects of sublingual glyceryl trinitrate (GTN) were studied in ten patients without heart failure during diagnostic cardiac catheterisation following angiography. GTN caused substantial reduction in peak left ventricular and aortic pressure (19 mmHg) with lesser reduction in mean aortic pressure (9 mmHg) and no chang...

journal_title：Cardiovascular research

authors： Yaginuma T,Avolio A,O'Rourke M,Nichols W,Morgan JJ,Roy P,Baron D,Branson J,Feneley M

更新日期：1986-02-01 00:00:00

abstract：AIMS:Atherogenesis, evolution of plaque, and outcomes following endovascular intervention depend heavily on the unique vascular architecture of each individual. Patient-specific, multiscale models able to correlate changes in microscopic cellular responses with relevant macroscopic flow, and structural conditions may h...

journal_title：Cardiovascular research

authors： Martorell J,Santomá P,Kolandaivelu K,Kolachalama VB,Melgar-Lesmes P,Molins JJ,Garcia L,Edelman ER,Balcells M

更新日期：2014-07-01 00:00:00

abstract：:In this study we report about the modulation of connexin45 (Cx45) gap junction channel properties by phosphorylation of the connexin molecules through different protein kinases. Phosphorylation of Cx45 was studied in HeLa cells transfected with mouse Cx45 (mCx45). Using Western blotting (WB) and immunocytochemistry, t...

journal_title：Cardiovascular research

authors： van Veen TA,van Rijen HV,Jongsma HJ

更新日期：2000-06-01 00:00:00

abstract：:Acadesine is the prototype of a new class of therapeutic compounds termed adenosine regulating agents. Acadesine is pharmacologically silent in normal circumstances, but its activity becomes operative during situations of net ATP catabolism, when it increases local adenosine levels. Thus acadesine is able to harness t...

journal_title：Cardiovascular research

authors： Mullane K

更新日期：1993-01-01 00:00:00

abstract：:Because of ventricular interdependence, part of the measured left ventricular diastolic pressure can be attributed to the right ventricle. Therefore, we examined the hypothesis that left ventricular diastolic properties are modified by alterations in right ventricular compliance and pressure even without a change in r...

journal_title：Cardiovascular research

authors： Santamore WP,Constantinescu M,Vinten-Johansen J,Johnston WE,Little WC

更新日期：1988-11-01 00:00:00

abstract：AIMS:Sphingosine-1-phosphate (S1P), a key regulator of vascular homeostasis and angiogenesis, promotes endothelial cell migration via stimulation of phosphoinositide 3-kinase (PI3K). The aim of this study was to identify the role of PI3Kbeta and gamma isoforms and their downstream effector pathways in mediating endothe...

journal_title：Cardiovascular research

authors： Heller R,Chang Q,Ehrlich G,Hsieh SN,Schoenwaelder SM,Kuhlencordt PJ,Preissner KT,Hirsch E,Wetzker R

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the ventricular/vascular coupling of the intact right heart under conditions of normal operation and acute pulmonary hypertension. METHODS:Right ventricular contractility was obtained by calculating the end systolic pressure-volume relationship (Ees) and the effective pulmonary art...

journal_title：Cardiovascular research

authors： Fourie PR,Coetzee AR,Bolliger CT

更新日期：1992-09-01 00:00:00

abstract：AIMS:in this study, we attempted to detect a recent myocardial ischaemic event using ultrasound molecular imaging (UMI) with microbubbles (MB) targeted to intercellular adhesion molecule-1 (ICAM-1) in the late phase of reperfusion. METHODS AND RESULTS:we created a myocardial ischaemia-reperfusion model in 60 C57/BL ma...

journal_title：Cardiovascular research

authors： Yan Y,Liao Y,Yang L,Wu J,Du J,Xuan W,Ji L,Huang Q,Liu Y,Bin J

更新日期：2011-01-01 00:00:00

abstract：AIMS:Neovascularization is an important element of long-term functional recovery during chronic ischaemia. We postulated that haeme oxygenase (HO) is required for progenitor cell recruitment, neovascularization, and blood flow recovery after critical hindlimb ischaemia (HLI). METHODS AND RESULTS:The femoral artery was...

journal_title：Cardiovascular research

authors： Tongers J,Knapp JM,Korf M,Kempf T,Limbourg A,Limbourg FP,Li Z,Fraccarollo D,Bauersachs J,Han X,Drexler H,Fiedler B,Wollert KC

更新日期：2008-05-01 00:00:00

abstract：AIMS:Melusin is a muscle-specific chaperone protein whose expression is required for a compensatory hypertrophy response to pressure overload. Here, we evaluated the consequences of melusin overexpression in the setting of myocardial infarction (MI) using a comprehensive multicentre approach. METHODS AND RESULTS:Mice ...

journal_title：Cardiovascular research

authors： Unsöld B,Kaul A,Sbroggiò M,Schubert C,Regitz-Zagrosek V,Brancaccio M,Damilano F,Hirsch E,Van Bilsen M,Munts C,Sipido K,Bito V,Detre E,Wagner NM,Schäfer K,Seidler T,Vogt J,Neef S,Bleckmann A,Maier LS,Balligand JL,

更新日期：2014-01-01 00:00:00

abstract：AIMS:We have previously characterized a cGMP-dependent Ca(2+)-activated Cl(-) current in vascular smooth muscle cells (SMCs) and have shown its dependence on bestrophin-3 expression. We hypothesize that this current is important for synchronization of SMCs in the vascular wall. In the present study, we aimed to test th...

journal_title：Cardiovascular research

authors： Broegger T,Jacobsen JC,Secher Dam V,Boedtkjer DM,Kold-Petersen H,Pedersen FS,Aalkjaer C,Matchkov VV

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:We propose that ischemic preconditioning (IPC) and mitochondrial K(ATP) channel activation protect the myocardium by inhibiting mitochondrial permeability transition pore (MPTP) opening at reperfusion. METHODS:Isolated rat hearts were subjected to 35 min ischemia/120 min reperfusion and assigned to the follo...

journal_title：Cardiovascular research

authors： Hausenloy DJ,Maddock HL,Baxter GF,Yellon DM

更新日期：2002-08-15 00:00:00

abstract：:The effect of acetylcholine on the aconitine induced delayed afterdepolarisation and triggered electrical activities under nominally calcium free conditions were studied in frog atrium and ventricle. The changes in intracellular potassium activity were also examined. The aconitine induced delayed afterdepolarisation a...

journal_title：Cardiovascular research

authors： Sawanobori T,Hirano Y,Hiraoka M

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVES:The state of the vasodilator systems in congestive heart failure is poorly defined. Plasma atrial natriuretic peptide is increased, whereas endothelium derived relaxing factor activity can be decreased. Atrial natriuretic peptide and endothelium derived relaxing factor both cause vascular relaxation by gener...

journal_title：Cardiovascular research

authors： Arnal JF,Hofmann F,Michel JB

更新日期：1993-06-01 00:00:00

abstract：:Computation of indices of regional myocardial contractility such as the shortening, or the work done by or on a segment of myocardium in a single cardial cycle is tedious to perform manually, and complex interfacing and software is needed for digital computation. We describe the principles of an on-line, analogue devi...

journal_title：Cardiovascular research

authors： Lab MJ,Gartside I,Wassermann S

更新日期：1983-12-01 00:00:00

abstract：AIMS:Hypertension is accompanied by structural remodelling of vascular extracellular matrix (ECM). Tissue inhibitor of metalloproteinases (TIMPs) inhibits matrix metalloproteinases (MMPs) that degrade the matrix structural proteins. In response to a hypertensive stimulus, the balance between MMPs and TIMPs is altered. ...

journal_title：Cardiovascular research

authors： Basu R,Lee J,Morton JS,Takawale A,Fan D,Kandalam V,Wang X,Davidge ST,Kassiri Z

更新日期：2013-06-01 00:00:00

abstract：:The effects of L-propionylcarnitine on the recovery of cardiac contractile performance after global ischaemia and reperfusion were studied in isolated perfused rat hearts. The addition of either 5.5 or 11 mmol X litre-1 L-propionylcarnitine significantly improved the recovery of cardiac output, left ventricular pressu...

journal_title：Cardiovascular research

authors： Paulson DJ,Traxler J,Schmidt M,Noonan J,Shug AL

更新日期：1986-07-01 00:00:00

abstract：OBJECTIVE:Decay kinetics of the voltage-gated L-type Ca(2+) current (I(CaL)) control the magnitude of Ca(2+) influx during the cardiac action potential. We investigated the influence of changes in diastolic membrane potential on I(CaL) decay kinetics in cardiac cells. METHODS:Cells were isolated enzymatically from rat...

journal_title：Cardiovascular research

authors： Barrère-Lemaire S,Piot C,Leclercq F,Nargeot J,Richard S

更新日期：2000-08-01 00:00:00