Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells.

abstract：OBJECTIVES:The concept of lethal reperfusion injury in ischemic myocardium has been the subject of controversy. Adenosine administered during reperfusion has been reported to limit lethal reperfusion injury in several studies. On the contrary, it has been reported that cardioprotection may not be achieved with adenosin...

journal_title：Cardiovascular research

authors： Vander Heide RS,Reimer KA

更新日期：1996-05-01 00:00:00

abstract：:Changes in left ventricular internal diameter resulting from increasing intrapericardial pressure induced by increasing the pericardial fluid volume were studied in closed chest, anaesthetized dogs. Left ventricular internal diameters were measured by placing an ultrasonic dimension catheter in the left ventricle at t...

journal_title：Cardiovascular research

authors： Pegram BL,Kardon MB,Bishop VS

更新日期：1975-11-01 00:00:00

abstract：:The effect of acetylcholine on the aconitine induced delayed afterdepolarisation and triggered electrical activities under nominally calcium free conditions were studied in frog atrium and ventricle. The changes in intracellular potassium activity were also examined. The aconitine induced delayed afterdepolarisation a...

journal_title：Cardiovascular research

authors： Sawanobori T,Hirano Y,Hiraoka M

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVE:A circadian rhythm of blood pressure has been demonstrated both in subjects who are physically active during the day and in those confined to bed. The study of the circadian rhythm of arterial flow and peripheral resistance, on the other hand, is limited to pioneer experiments. This paper is aimed at demonstr...

journal_title：Cardiovascular research

authors： Casiglia E,Pizziol A,Piacentini F,Biasin R,Onesto C,Tikhonoff V,Prati R,Palatini P,Pessina AC

更新日期：1999-01-01 00:00:00

abstract：AIMS:Bone marrow (BM) progenitor cells may contribute to vascular remodelling. The present study aimed to investigate the contribution of BM-derived CXCR4(+) (a CXC chemokine receptor) and PDGFRbeta(+) (platelet-derived growth factor receptor beta) progenitor cells in hypoxia-induced muscularization of alveolar arterio...

journal_title：Cardiovascular research

authors： Jie W,Wang X,Huang L,Guo J,Kuang D,Zhu P,Li M,Zhao X,Duan Y,Wang G,Ao Q

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:This study aimed to examine the effects of adenovirus-mediated expression of p35, a baculovirus gene, on apoptosis induced by hypoxia/reoxygenation (H/R) in cardiomyocytes. METHODS:Neonatal rat cardiomyocytes were infected with recombinant adenoviral vectors expressing p35 (Ad2/CMVp35) or no transgene (Ad2/C...

journal_title：Cardiovascular research

authors： Date T,Belanger AJ,Mochizuki S,Sullivan JA,Liu LX,Scaria A,Cheng SH,Gregory RJ,Jiang C

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:To characterise the effect of coronary intra-arterial thrombosis upon the downstream vascular bed. BACKGROUND:The vascular response downstream from a coronary intra-arterial thrombus has not previously been characterised. We postulated that downstream vasoconstriction might result from the presence of endoth...

journal_title：Cardiovascular research

authors： Belcher PR,Vergroesen I,Drake-Holland AJ,Noble MI

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:The aim was to determine if isolated rabbit cardiomyocytes could be preconditioned. METHODS:Cardiomyocytes isolated from rabbit hearts were subjected to 15 min oxygenated preincubation, with and without substrate, prior to concentration into an ischaemic slurry, with or without glucose present. The effects o...

journal_title：Cardiovascular research

authors： Armstrong S,Downey JM,Ganote CE

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:We have previously shown that cardiac-directed expression of adenylycyclase type VI (AC(VI)) increases heart function in transgenic mice, and improves heart function and survival in murine cardiomyopathy. However, a potential problem of crossbreeding paradigms that use lines with two constitutively active tra...

journal_title：Cardiovascular research

authors： Gao MH,Bayat H,Roth DM,Yao Zhou J,Drumm J,Burhan J,Hammond HK

更新日期：2002-11-01 00:00:00

abstract：:We studied the effects of intravenously administered autonomic agents, the calcium channel blocker diltiazem, and Class I and III anti-arrhythmic agents on a re-entry model for atrial tachycardia in seven conscious dogs. The model was created by a Y-shaped incision in the intercaval region and front free wall of the r...

journal_title：Cardiovascular research

authors： Wu KM,Hunter T,Proakis A

更新日期：1989-05-01 00:00:00

abstract：AIMS:Mobilization of stem cells/progenitors is regulated by the interaction between stromal cell-derived factor-1 (SDF-1) and its ligand, CXC chemokine receptor 4 (CXCR4). Statins have been suggested to ameliorate pulmonary arterial hypertension (PAH); however, the mechanisms involved, especially their effects on proge...

journal_title：Cardiovascular research

authors： Satoh K,Fukumoto Y,Nakano M,Sugimura K,Nawata J,Demachi J,Karibe A,Kagaya Y,Ishii N,Sugamura K,Shimokawa H

更新日期：2009-01-01 00:00:00

abstract：AIMS:Cardiac hypertrophy is characterized by a shift in metabolic substrate utilization, but the molecular events underlying the metabolic remodelling remain poorly understood. We explored metabolic remodelling and mitochondrial dysfunction in cardiac hypertrophy and investigated the cardioprotective effects of choline...

journal_title：Cardiovascular research

authors： Xu M,Xue RQ,Lu Y,Yong SY,Wu Q,Cui YL,Zuo XT,Yu XJ,Zhao M,Zang WJ

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Myocardial cellular electrophysiology and intracellular Ca2+ regulation are altered in heart failure. The extent of these changes may vary within the layers of the ventricular wall. To examine this, cell size, action potential and intracellular Ca2+ transient characteristics (Fura-2) were measured in single c...

journal_title：Cardiovascular research

authors： McIntosh MA,Cobbe SM,Smith GL

更新日期：2000-01-14 00:00:00

abstract：OBJECTIVE:The mechanosensitive nonselective cation channel (NSC(MS)) and endothelin-1 (ET-1) play critical roles in the regulation of vascular tone. This study was undertaken to investigate the effect of ET-1 on NSC(MS) and on the myogenic response of arteries. METHODS:Cell-attached patch-clamp techniques were applied...

journal_title：Cardiovascular research

authors： Lee HA,Baek EB,Park KS,Jung HJ,Kim JI,Kim SJ,Earm YE

更新日期：2007-11-01 00:00:00

abstract：:Although researchers in radiation and cancer biology have known about the existence of free radicals and their potential role in pathobiology for several decades, cardiac biologists only began to take notice of these noxious species in the 1970s. Exponential growth of free radical research occurred after the discovery...

journal_title：Cardiovascular research

authors： Singal PK,Khaper N,Palace V,Kumar D

更新日期：1998-12-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to evaluate the thrombolytic efficacy of recombinant double chain tissue plasminogen activator (Duteplase, t-PA) given as a single intravenous bolus versus an infusion in a canine model of coronary arterial occlusion/reperfusion. DESIGN:Coronary arterial thrombi were induced by a copper coi...

journal_title：Cardiovascular research

authors： Longridge DJ,Follenfant MJ,Ford AJ

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVE:The mechanism of the protective effect of ischaemic preconditioning in the myocardium is not yet known. The aim of this study was to test the hypothesis that endogenous myocardial catecholamines may be mediators of preconditioning. METHODS:To test whether endogenous catecholamines are involved in preconditio...

journal_title：Cardiovascular research

authors： Weselcouch EO,Baird AJ,Sleph PG,Dzwonczyk S,Murray HN,Grover GJ

更新日期：1995-01-01 00:00:00

abstract：:The effects of adrenaline on kinetically-distinct compartments of exchangeable calcium in the spontaneously-beating perfused rat heart were investigated under steady-state conditions using a 45Ca2+ outflow technique together with a nonlinear least-squares curve fitting procedure and 51Cr-EDTA to monitor the loss of fr...

journal_title：Cardiovascular research

authors： Lamont SV,Barritt GJ

更新日期：1983-02-01 00:00:00

abstract：OBJECTIVE:Infusion of angiotensin II (AngII) during the third and fourth week after balloon injury of the left common carotid artery of the rat induces smooth muscle cell (SMC) DNA synthesis. In this study we wanted to investigate whether alpha 1-adrenoreceptors are involved in AngII-induced SMC DNA synthesis in the ne...

journal_title：Cardiovascular research

authors： van Kleef EM,Smits JF,Schwartz SM,Daemen MJ

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:Peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily and are key regulators of fatty acid oxidation (FAO) in the heart. Systemic carnitine deficiency (SCD) causes disorders of FAO and induces hypertrophic cardiomy...

journal_title：Cardiovascular research

authors： Asai T,Okumura K,Takahashi R,Matsui H,Numaguchi Y,Murakami H,Murakami R,Murohara T

更新日期：2006-06-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to determine if the adaptational process of the cardiac calcium channel to pressure overload observed in rat heart also occurs in species characterised by a higher sensitivity to external calcium than in the rat. This adaptation occurs via a maintained density of dihydropyridine receptors an...

journal_title：Cardiovascular research

authors： Primot I,Mayoux E,Oliviero P,Charlemagne D

更新日期：1991-10-01 00:00:00

abstract：AIMS:It is well established that dysfunction of voltage-dependent ion channels results in arrhythmias and conduction disturbances in the foetal and adult heart. However, the involvement of voltage-insensitive cationic TRPC (transient receptor potential canonical) channels remains unclear. We assessed the hypothesis tha...

journal_title：Cardiovascular research

authors： Sabourin J,Robin E,Raddatz E

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:The restitution mechanism has been the focus of attention as the possible mechanism behind ventricular fibrillation (VF). However, its contribution in chronic ischemic heart has not been established. METHODS:We investigated chronic ischemic dogs with occlusion of left anterior descending artery. Sixty unipol...

journal_title：Cardiovascular research

authors： Yuuki K,Hosoya Y,Kubota I,Yamaki M

更新日期：2004-09-01 00:00:00

abstract：AIMS:Neovascularization is an important element of long-term functional recovery during chronic ischaemia. We postulated that haeme oxygenase (HO) is required for progenitor cell recruitment, neovascularization, and blood flow recovery after critical hindlimb ischaemia (HLI). METHODS AND RESULTS:The femoral artery was...

journal_title：Cardiovascular research

authors： Tongers J,Knapp JM,Korf M,Kempf T,Limbourg A,Limbourg FP,Li Z,Fraccarollo D,Bauersachs J,Han X,Drexler H,Fiedler B,Wollert KC

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVES:To investigate the effect of alpha,beta(1) and beta(2) adrenergic receptor (AR) stimulation on coronary hemodynamics, myocardial oxygen consumption (M(v)O(2)) and metabolic substrate preference in advanced dilated cardiomyopathy (DCM). METHODS:We studied 19 conscious, instrumented dogs with pacing-induced D...

journal_title：Cardiovascular research

authors： Nikolaidis LA,Hentosz T,Doverspike A,Huerbin R,Stolarski C,Shen YT,Shannon RP

更新日期：2002-02-01 00:00:00

abstract：:Conventional antithrombotic treatments with antiplatelet, anticoagulant or fibrinolytic drugs are not uniformly successful and are associated with hemorrhagic side effects. Thus, new approaches to the prevention and treatment of arterial thrombosis are desirable. The gene transfer approach is particularly attractive b...

journal_title：Cardiovascular research

authors： Vassalli G,Dichek DA

更新日期：1997-09-01 00:00:00

abstract：STUDY OBJECTIVE:It has been suggested that oxygenation of the isolated, crystalloid perfused, Langendorff rabbit heart is inadequate and that consequent hypoxia limits mechanical performance. The isolated working rabbit heart, which has a higher oxygen requirement than the Langendorff preparation, was used to investiga...

journal_title：Cardiovascular research

authors： Murashita T,Kempsford RD,Hearse DJ

更新日期：1991-03-01 00:00:00

abstract：AIMS:For the majority of congenital heart diseases (CHDs), the full complexity of the causative molecular network, which is driven by genetic, epigenetic, and environmental factors, is yet to be elucidated. Epigenetic alterations are suggested to play a pivotal role in modulating the phenotypic expression of CHDs and t...

journal_title：Cardiovascular research

authors： Grunert M,Dorn C,Cui H,Dunkel I,Schulz K,Schoenhals S,Sun W,Berger F,Chen W,Sperling SR

更新日期：2016-10-01 00:00:00

abstract：AIMS:Dilated cardiomyopathy (DCM) is characterized by ventricular dilation associated with systolic dysfunction, which could be caused by mutations in lamina/C gene (LMNA). LMNA-linked DCM is severe in males in both human patients and a knock-in mouse model carrying a homozygous p.H222P mutation (LmnaH222P/H222P). The ...

journal_title：Cardiovascular research

authors： Arimura T,Onoue K,Takahashi-Tanaka Y,Ishikawa T,Kuwahara M,Setou M,Shigenobu S,Yamaguchi K,Bertrand AT,Machida N,Takayama K,Fukusato M,Tanaka R,Somekawa S,Nakano T,Yamane Y,Kuba K,Imai Y,Saito Y,Bonne G,Kimura A

更新日期：2013-08-01 00:00:00

abstract：:The effects of both gradual and abrupt coronary occlusion on regional wall function (sonomicrometry) and left ventricular relaxation were studied in the intact dog heart. The ischaemic dysfunction observed in the two interventions as assessed by pressure-length loops showed considerably different patterns. The regiona...

journal_title：Cardiovascular research

authors： Doyle RL,Foëx P,Ryder WA,Jones LA

更新日期：1987-07-01 00:00:00