Mechanosensitive nonselective cation channel facilitation by endothelin-1 is regulated by protein kinase C in arterial myocytes.

abstract：AIMS:Neointimal hyperplasia is a common feature of fibro-proliferative vascular disease and characterizes initial stages of atherosclerosis. Neointimal lesions mainly comprise smooth muscle-like cells. The presence of these lesions is related to local differences in shear stress. Neointimal cells may arise through migr...

journal_title：Cardiovascular research

authors： Moonen JR,Lee ES,Schmidt M,Maleszewska M,Koerts JA,Brouwer LA,van Kooten TG,van Luyn MJ,Zeebregts CJ,Krenning G,Harmsen MC

更新日期：2015-12-01 00:00:00

abstract：:Sinoatrial conduction times, estimated by premature atrial stimulation, were compared with direct measurement of the sinoatrial conduction time in 15 isolated rabbit sinus node preparations before and after intrasinusal pacemaker shifts induced by cooling. Transmembrane potentials and surface electrograms were recorde...

journal_title：Cardiovascular research

authors： Le Heuzey JY,Guize L,Valty J,Moutet JP,Kouz S,Lavergne T,Boutjdir M,Peronneau P

更新日期：1986-02-01 00:00:00

abstract：:A recently developed highly sensitive radioimmunoassay method for detecting plasma kinin was used to re-evaluate the results of previous studies, in which plasma kinin had been measured with a bioassay method. To clarify the mechanism of plasma kinin release in global myocardial ischaemia the left main coronary artery...

journal_title：Cardiovascular research

authors： Matsuki T,Shoji T,Yoshida S,Kudoh Y,Motoe M,Inoue M,Nakata T,Hosoda S,Shimamoto K,Yellon D

更新日期：1987-06-01 00:00:00

abstract：OBJECTIVE:Despite the frequent use of anti-arrhythmic drugs in the general population, the electrophysiologic effects of these agents have not been elucidated in congestive heart failure (CHF). METHODS:To examine the impact of left ventricular dysfunction on actions of type III anti-arrhythmic drugs, we evaluated the ...

journal_title：Cardiovascular research

authors： Chugh SS,Johnson SB,Packer DL

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:Current guidelines are controversial regarding exercise intensity in cardiovascular prevention and rehabilitation. Although high-intensity training induces larger increases in fitness and maximal oxygen uptake (VO(2max)), moderate intensity is often recommended as equally effective. Controlled preclinical stu...

journal_title：Cardiovascular research

authors： Kemi OJ,Haram PM,Loennechen JP,Osnes JB,Skomedal T,Wisløff U,Ellingsen Ø

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:While natriuretic peptides can inhibit growth of vascular muscle cells (VSMC), controversy exists as to whether this effect is mediated via the guanylate cyclase-coupled receptors, NPR-A and NPR-B, or the clearance receptor, NPR-C. The original aim of this study was to examine the mechanism by which the NPR-C...

journal_title：Cardiovascular research

authors： Hutchinson HG,Trindade PT,Cunanan DB,Wu CF,Pratt RE

更新日期：1997-07-01 00:00:00

abstract：:The development of the heart is a complex process during which different cell types progressively contribute to shape a four-chambered pumping organ. Over the last decades, our understanding of the specification and transcriptional regulation of cardiac development has been greatly augmented as has our understanding o...

journal_title：Cardiovascular research

authors： Franco D,Chinchilla A,Daimi H,Dominguez JN,Aránega A

更新日期：2011-07-15 00:00:00

abstract：AIMS:Baicalin is the major component found in Scutellaria baicalensis root, a widely used herb in traditional Chinese medicine. Although it has been used for thousands of years to treat stroke, the mechanisms of action of S. baicalensis have not been clearly elucidated. In this report, we studied the modulation of angi...

journal_title：Cardiovascular research

authors： Zhang K,Lu J,Mori T,Smith-Powell L,Synold TW,Chen S,Wen W

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the ventricular/vascular coupling of the intact right heart under conditions of normal operation and acute pulmonary hypertension. METHODS:Right ventricular contractility was obtained by calculating the end systolic pressure-volume relationship (Ees) and the effective pulmonary art...

journal_title：Cardiovascular research

authors： Fourie PR,Coetzee AR,Bolliger CT

更新日期：1992-09-01 00:00:00

abstract：:The effect of circulation time on plasma high density lipoprotein cholesterol concentrations was investigated in 20 male Wistar rats injected with alcohol, stressed with lighting, or fed a high fat diet. Circulation time was measured during anaesthesia with a computerised dichromatic earpiece densitometer. Indocyanine...

journal_title：Cardiovascular research

authors： Ishizuka T

更新日期：1988-05-01 00:00:00

abstract：:The importance of the vascular adventitia is increasingly being recognized not only in vascular disease but also in normal maintenance and homeostasis of vessels. Activation of the adventitia and its resident fibrocytic cells in response to injury, stretch, cytokines, and hormones has been shown to stimulate different...

journal_title：Cardiovascular research

authors： Haurani MJ,Pagano PJ

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:To determine the effect of Na(+)-H+ exchange blockade on ischemic rigor contracture and reperfusion-induced hypercontracture. METHODS:Thirty-six pigs were submitted to 55 min of coronary occlusion and 5 h reperfusion. Myocardial segment length analysis with ultrasonic microcrystals was used to detect ischemi...

journal_title：Cardiovascular research

authors： Garcia-Dorado D,González MA,Barrabés JA,Ruiz-Meana M,Solares J,Lidon RM,Blanco J,Puigfel Y,Piper HM,Soler-Soler J

更新日期：1997-07-01 00:00:00

abstract：:Muscle tissue in atrioventricular (A-V) cardiac valve leaflets was studied in 35 human hearts and was found to be more prominent in the anterior leaflet of the mitral (MAL) than in the other valve leaflets. From serial sectioning and wax model reconstruction, the anatomic arrangement of the muscle in the MAL indicates...

journal_title：Cardiovascular research

authors： Boucek RJ,Boucková B,Levy S

更新日期：1978-11-01 00:00:00

abstract：:The effects of L-propionylcarnitine on the recovery of cardiac contractile performance after global ischaemia and reperfusion were studied in isolated perfused rat hearts. The addition of either 5.5 or 11 mmol X litre-1 L-propionylcarnitine significantly improved the recovery of cardiac output, left ventricular pressu...

journal_title：Cardiovascular research

authors： Paulson DJ,Traxler J,Schmidt M,Noonan J,Shug AL

更新日期：1986-07-01 00:00:00

abstract：AIMS:Cardiac β-adrenergic receptors (β-AR) are key regulators of cardiac haemodynamics and size. The scaffolding protein A-kinase anchoring protein 79/150 (AKAP5) is a key regulator of myocardial signalling by β-ARs. We examined the function of AKAP5 in regulating cardiac haemodynamics and size, and the role of β-ARs a...

journal_title：Cardiovascular research

authors： Li X,Matta SM,Sullivan RD,Bahouth SW

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:Decay kinetics of the voltage-gated L-type Ca(2+) current (I(CaL)) control the magnitude of Ca(2+) influx during the cardiac action potential. We investigated the influence of changes in diastolic membrane potential on I(CaL) decay kinetics in cardiac cells. METHODS:Cells were isolated enzymatically from rat...

journal_title：Cardiovascular research

authors： Barrère-Lemaire S,Piot C,Leclercq F,Nargeot J,Richard S

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:We investigated the influence of experimental hyperlipidemia on the formation of cardiac NO, superoxide, and peroxynitrite (ONOO(-)) in rat hearts. METHODS:Wistar rats were fed 2% cholesterol-enriched diet or normal diet for 8 weeks. Separate groups of normal and hyperlipidemic rats were injected twice intra...

journal_title：Cardiovascular research

authors： Onody A,Csonka C,Giricz Z,Ferdinandy P

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:Mechanoelectric Feedback, a mechanical intervention inducing an electrical change, is gaining credence as a cause of cardiac arrhythmia in the clinical situation. However, the precise mechanism is unknown. To elucidate this we investigated mechanical and chemical modulation of stretch-induced premature ventri...

journal_title：Cardiovascular research

authors： Dick DJ,Lab MJ

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the influence of coronary occlusion on myocardial interstitial noradrenaline levels in the ischaemic and non-ischaemic regions, using the dialysis technique. METHODS:In nine anaesthetised cats, regional ischaemia was produced by occlusion of the left anterior descending coronary ar...

journal_title：Cardiovascular research

authors： Akiyama T,Yamazaki T,Ninomiya I

更新日期：1993-05-01 00:00:00

abstract：AIMS:Germ-line mutations in genes encoding components of the RAS/mitogen-activated protein kinase (MAPK) pathway cause developmental disorders called RASopathies. Hypertrophic cardiomyopathy (HCM) is the most common myocardial pathology and a leading cause of death in RASopathy patients. KRAS mutations are found in Noo...

journal_title：Cardiovascular research

authors： Dalin MG,Zou Z,Scharin-Täng M,Safari R,Karlsson C,Bergo MO

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Impairment of endothelium-dependent relaxation is related to dyslipidemia and may be an early marker for atherosclerosis in angiographically smooth arteries. The aim of the present study was to relate preoperative serum lipids to endothelium-dependent relaxation in internal mammary arteries of patients underg...

journal_title：Cardiovascular research

authors： Voors AA,Oosterga M,Buikema H,May JF,Grandjean JG,van Buiten A,van Gilst WH

更新日期：1997-06-01 00:00:00

abstract：:A new type of pneumonia caused by a novel coronavirus SARS-CoV-2 outbreaks recently in China and spreads into many other countries. This disease, named as COVID-19, is similar to patients infected by SARS-CoV and MERS-CoV, and nearly 20% of patients developed severe condition. Cardiac injury is a prevalent complicatio...

journal_title：Cardiovascular research

authors： Chen L,Li X,Chen M,Feng Y,Xiong C

更新日期：2020-05-01 00:00:00

abstract：:The rate of QT adaptation to abrupt changes in pacing rate was studied in seven patients with newly diagnosed complete heart block with a ventricular escape rate of less than 40 beats.min-1. Their median age was 70 (range 36-84) years, and none was taking any cardioactive medication known to affect the QT interval. Fr...

journal_title：Cardiovascular research

authors： Lau CP,Freedman AR,Fleming S,Malik M,Camm AJ,Ward DE

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:The mechanism of defibrillation is controversial. Reentry appearing immediately after the shock has been shown to be responsible for defibrillation failure in some studies while other studies have demonstrated that a rapid train of focal activations with the first focus appearing >50 ms after the shock is re...

journal_title：Cardiovascular research

authors： Chattipakorn N,Banville I,Gray RA,Ideker RE

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:We investigated the efficacy of nicaraven in reducing myocardial as well as coronary endothelial preservation-reperfusion (P/R) injury. METHODS:In experiment I, isolated rat hearts were mounted on a Langendorff (L) apparatus to estimate the baseline cardiac function. Group 1, 8- and 12-h storage in histidine...

journal_title：Cardiovascular research

authors： Alam MS,Ku K,Hashimoto M,Nosaka S,Saitoh Y,Yamauchi M,Masumura S,Nakayama K,Tamura K

更新日期：1997-03-01 00:00:00

abstract：:Experimental studies have provided evidence that the autonomic nervous activity is modulated by oestrogen. Such modulation at central and peripheral levels tends to suppress sympathetic but elevate parasympathetic tone to the cardiovascular system. Thus, available data support the view that cardiovascular protection b...

journal_title：Cardiovascular research

authors： Du XJ,Riemersma RA,Dart AM

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVE:Inhibition by endothelin antagonist is a potential therapy in heart failure. However, the effect of endothelin inhibition during the development of heart failure has not been evaluated. The goal of our study was to examine the acute hemodynamic effects of the mixed endothelin receptor antagonist bosentan in t...

journal_title：Cardiovascular research

authors： Choussat R,Hittinger L,Barbe F,Maistre G,Carayon A,Crozatier B,Su J

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:Air bubbles entering the coronary artery may have harmful effects on cardiac function. From the physical point of view it is the relatively high surface tension of the blood-air interface which causes bubbles to trap in small vessels. The aim of the present study was to reduce depression of myocardial functio...

journal_title：Cardiovascular research

authors： van Blankenstein JH,Slager CJ,Soei LK,Boersma H,Stijnen T,Schuurbiers JC,Krams R,Lachmann B,Verdouw PD

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVES:Age-related medial calcification (elastocalcinosis) of large arteries is accelerated in diabetes and appears mainly in distal arteries. The aim was to devise a rat model of elastocalcinosis in association with diabetes to examine the hypothesis that diabetes accelerates vascular calcification experimentally....

journal_title：Cardiovascular research

authors： Bouvet C,Peeters W,Moreau S,DeBlois D,Moreau P

更新日期：2007-02-01 00:00:00

abstract：:One of the obstacles to a better understanding of the pathogenesis of human cardiomyopathies has been poor availability of heart-tissue samples at early stages of disease development. This has possibly changed by the advent of patient-derived induced pluripotent stem cell (hiPSC) from which cardiomyocytes can be deriv...

journal_title：Cardiovascular research

authors： Eschenhagen T,Mummery C,Knollmann BC

更新日期：2015-04-01 00:00:00