Hysteresis of the ventricular paced QT interval in response to abrupt changes in pacing rate.

abstract：OBJECTIVES:While it is probable that the cerebrovascular spasm which occurs after subarachnoid haemorrhage results from the action of haemoglobin, the mechanism of that process remains unclear. These studies were thus designed to test the hypothesis that the action of oxyhaemoglobin results from the iron-catalyzed form...

journal_title：Cardiovascular research

authors： Vollrath B,Chan P,Findlay M,Cook D

更新日期：1995-10-01 00:00:00

abstract：AIMS:Pulmonary hypertension (PH) is a devastating condition for which no disease-modifying therapies exist. PH is recognized as proliferative disease of the pulmonary artery (PA). In the experimental newborn calf model of hypoxia-induced PH, adventitial fibroblasts in the PA wall exhibit a heightened replication index....

journal_title：Cardiovascular research

authors： Panzhinskiy E,Zawada WM,Stenmark KR,Das M

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:To study the effect of cardiac contraction on left coronary artery pressure-flow relations at different vascular volumes and to compare these relations in the beating heart with those in the heart arrested in systole and diastole. METHODS:Maximally vasodilated, Tyrode perfused, rabbit hearts (n = 6) with an ...

journal_title：Cardiovascular research

authors： Sipkema P,Takkenberg JJ,Zeeuwe PE,Westerhof N

更新日期：1998-10-01 00:00:00

abstract：AIMS:The aim of this study was to explore meprinα-mediated transactivation of the epidermal growth factor receptor (EGFR) and reactive oxygen species (ROS) production in macrophages. METHODS AND RESULTS:Accelerated atherosclerotic lesions were established by administration of a high-fat diet in apolipoprotein E-defici...

journal_title：Cardiovascular research

authors： Gao P,Wang XM,Qian DH,Qin ZX,Jin J,Xu Q,Yuan QY,Li XJ,Si LY

更新日期：2013-03-01 00:00:00

abstract：:Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in multiple human tissues and regulate different cellular functions...

journal_title：Cardiovascular research

authors： Perrucci GL,Gowran A,Zanobini M,Capogrossi MC,Pompilio G,Nigro P

更新日期：2015-06-01 00:00:00

abstract：:In this review, we summarize current knowledge on the genetics of coronary artery disease, based on 10 years of genome-wide association studies. The discoveries began with individual studies using 200K single nucleotide polymorphism arrays and progressed to large-scale collaborative efforts, involving more than a 100 ...

journal_title：Cardiovascular research

authors： Erdmann J,Kessler T,Munoz Venegas L,Schunkert H

更新日期：2018-07-15 00:00:00

abstract：OBJECTIVE:Ghrelin, the endogenous ligand of growth hormone secretagogue receptor (GHS-R), acts on the pituitary and the hypothalamus to stimulate the release of growth hormone (GH) and promotes appetite and adiposity. It has also been reported to increase myocardial contractility, induce vasodilation, and protect again...

journal_title：Cardiovascular research

authors： Iglesias MJ,Piñeiro R,Blanco M,Gallego R,Diéguez C,Gualillo O,González-Juanatey JR,Lago F

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:Although aldosterone has been implicated in the pathogenesis of cardiac hypertrophy and heart failure, its cellular mechanism of action on cardiomyocyte function is not yet completely elucidated. This study was designed to investigate the effect of aldosterone on calcium channel expression and cardiomyocyte c...

journal_title：Cardiovascular research

authors： Lalevée N,Rebsamen MC,Barrère-Lemaire S,Perrier E,Nargeot J,Bénitah JP,Rossier MF

更新日期：2005-08-01 00:00:00

abstract：:The effects of adrenaline on kinetically-distinct compartments of exchangeable calcium in the spontaneously-beating perfused rat heart were investigated under steady-state conditions using a 45Ca2+ outflow technique together with a nonlinear least-squares curve fitting procedure and 51Cr-EDTA to monitor the loss of fr...

journal_title：Cardiovascular research

authors： Lamont SV,Barritt GJ

更新日期：1983-02-01 00:00:00

abstract：OBJECTIVE:We investigated the efficacy of nicaraven in reducing myocardial as well as coronary endothelial preservation-reperfusion (P/R) injury. METHODS:In experiment I, isolated rat hearts were mounted on a Langendorff (L) apparatus to estimate the baseline cardiac function. Group 1, 8- and 12-h storage in histidine...

journal_title：Cardiovascular research

authors： Alam MS,Ku K,Hashimoto M,Nosaka S,Saitoh Y,Yamauchi M,Masumura S,Nakayama K,Tamura K

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:The aim was to test the hypothesis that in normal humans angiotensin II would stimulate local release of noradrenaline under basal conditions or during a sympathetic stimulus provided by lower body negative pressure (LBNP). METHODS:Nine healthy volunteers received intra-arterial infusions of angiotensin II, ...

journal_title：Cardiovascular research

authors： Goldsmith SR,Rector TS,Bank AJ,Garr M,Kubo SH

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:Impairment of endothelium-dependent relaxation is related to dyslipidemia and may be an early marker for atherosclerosis in angiographically smooth arteries. The aim of the present study was to relate preoperative serum lipids to endothelium-dependent relaxation in internal mammary arteries of patients underg...

journal_title：Cardiovascular research

authors： Voors AA,Oosterga M,Buikema H,May JF,Grandjean JG,van Buiten A,van Gilst WH

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:Temporal effects of prolonged hypoxaemia and reoxygenation, on the systemic pulmonary and mesenteric circulations in newborn piglets, were investigated. METHODS:Two groups [control (n = 5), hypoxaemic (n = 7)] of 1-3 day old anaesthetised piglets were instrumented with ultrasound flow probes placed to measur...

journal_title：Cardiovascular research

authors： Cheung PY,Barrington KJ,Bigam DL

更新日期：1998-08-01 00:00:00

abstract：:There is mounting interest in the use of the monophasic action potential for electrophysiological investigation of regional myocardial ischaemia. There is, however, no systematic study of the relation between the changes in monophasic action potential and regional myocardial blood flow. In this study monophasic action...

journal_title：Cardiovascular research

authors： Kingaby RO,Lab MJ,Cole AW,Palmer TN

更新日期：1986-10-01 00:00:00

abstract：OBJECTIVE:Anisotropic conduction characteristics, which may be expressed as the ratio of conduction velocities in the longitudinal (Vlong) and transverse (Vtrans) fibre directions, have been shown to stabilise reentry and favour the induction of sustained, uniform ventricular tachycardia. The aim of this study was to i...

journal_title：Cardiovascular research

authors： Hélie F,Cossette J,Vermeulen M,Cardinal R

更新日期：1995-03-01 00:00:00

abstract：AIMS:Both mitochondria and nitric oxide (NO*) contribute to cardioprotection by ischaemic preconditioning (IPC). IPC causes mild uncoupling of mitochondria via uncoupling proteins (UCPs) and the adenine nucleotide translocase (ANT), and mild uncoupling per se is cardioprotective. Although electrophilic lipids are known...

journal_title：Cardiovascular research

authors： Nadtochiy SM,Baker PR,Freeman BA,Brookes PS

更新日期：2009-05-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is a major risk factor for cardio-embolic stroke. Anticoagulant drugs are effective in preventing AF-related stroke. However, the high frequency of anticoagulant-associated major bleeding is a major concern. This study sought to identify new targets to develop safer antithrombotic therapie...

journal_title：Cardiovascular research

authors： Allende M,Molina E,Guruceaga E,Tamayo I,González-Porras JR,Gonzalez-López TJ,Toledo E,Rabal O,Ugarte A,Roldán V,Rivera J,Oyarzabal J,Montes R,Hermida J

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:Epidemiological evidence in humans suggests that intrauterine growth retardation is associated with an increased risk of hypertension and coronary heart disease in later life. To begin to understand the mechanisms involved, we developed and exploited a rat model of intrauterine growth retardation to assess p...

journal_title：Cardiovascular research

authors： Hu XW,Levy A,Hart EJ,Nolan LA,Dalton GR,Levi AJ

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:The aim was to correlate the relative abilities of amiodarone, lignocaine, and penticainide in suppressing ventricular tachyarrhythmias in response to coronary artery occlusion with their relative abilities to prolong ventricular functional refractory periods and to reduce intraventricular conduction velociti...

journal_title：Cardiovascular research

authors： Li JY,Northover BJ

更新日期：1992-11-01 00:00:00

abstract：:The afterload dependency of relaxation rate was reappraised in isolated canine hearts both in isovolumic and isobaric contractions by using the reliable exponential method in which the asymptote LV pressure (P chi) is variable. This method provided a closer correlation (r = 0.999 +/- 0.001) between the measured LV pre...

journal_title：Cardiovascular research

authors： Hori M,Inoue M,Fukunami M,Kitakaze M,Ishida Y,Tsujioka K,Nakajima S,Kitabatake A,Abe H

更新日期：1985-10-01 00:00:00

abstract：:Congenital coronary artery anomalies are of major significance in clinical cardiology and cardiac surgery due to their association with myocardial ischaemia and sudden death. Such anomalies are detectable by imaging modalities and, according to various definitions, their prevalence ranges from 0.21 to 5.79%. This cons...

journal_title：Cardiovascular research

authors： Pérez-Pomares JM,de la Pompa JL,Franco D,Henderson D,Ho SY,Houyel L,Kelly RG,Sedmera D,Sheppard M,Sperling S,Thiene G,van den Hoff M,Basso C

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:This study aimed to examine the effects of adenovirus-mediated expression of p35, a baculovirus gene, on apoptosis induced by hypoxia/reoxygenation (H/R) in cardiomyocytes. METHODS:Neonatal rat cardiomyocytes were infected with recombinant adenoviral vectors expressing p35 (Ad2/CMVp35) or no transgene (Ad2/C...

journal_title：Cardiovascular research

authors： Date T,Belanger AJ,Mochizuki S,Sullivan JA,Liu LX,Scaria A,Cheng SH,Gregory RJ,Jiang C

更新日期：2002-08-01 00:00:00

abstract：AIMS:Although the use of drug-eluting stents (DESs) has been shown to limit neointima hyperplasia, currently available DESs may adversely affect re-endothelialization. To evaluate whether a novel gene silencer pyrrole-imidazole (PI) polyamide targeting transforming growth factor (TGF)-beta1 is a candidate agent for the...

journal_title：Cardiovascular research

authors： Yao EH,Fukuda N,Ueno T,Matsuda H,Nagase H,Matsumoto Y,Sugiyama H,Matsumoto K

更新日期：2009-03-01 00:00:00

abstract：AIMS:Cardiovascular research requires complex and functionally intact experimental models. Due to major differences in the cellular and subcellular composition of the myocardium between species, the use of human heart tissue is highly desirable. To enhance the experimental use of the human myocardium, we established me...

journal_title：Cardiovascular research

authors： Brandenburger M,Wenzel J,Bogdan R,Richardt D,Nguemo F,Reppel M,Hescheler J,Terlau H,Dendorfer A

更新日期：2012-01-01 00:00:00

abstract：:Functional studies in extrarenal non-epithelial cells such as smooth muscle cells and easily accessible human lymphocytes have demonstrated that aldosterone not only produces classical genomic effects, but also rapid non-genomic effects on transmembrane electrolyte movements. These involve the activation of the Na+/H+...

journal_title：Cardiovascular research

authors： Wehling M

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:Washed platelets have been shown to protect isolated buffer perfused rat hearts from injury and dysfunction following ischaemia-reperfusion. This study was designed to investigate whether platelet glutathione redox cycle contributes to the protective effect of platelets. METHODS:Isolated rat hearts were perf...

journal_title：Cardiovascular research

authors： Yang BC,Mehta A,Mehta JL

更新日期：1994-10-01 00:00:00

abstract：:The cardiac SR Ca(2+)-ATPase (SERCA2a) regulates intracellular Ca(2+)-handling and thus, plays a crucial role in initiating cardiac contraction and relaxation. SERCA2a may be modulated through its accessory phosphoprotein phospholamban or by direct phosphorylation through Ca(2+)/calmodulin dependent protein kinase II ...

journal_title：Cardiovascular research

authors： Frank KF,Bölck B,Erdmann E,Schwinger RH

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Air bubbles entering the coronary artery may have harmful effects on cardiac function. From the physical point of view it is the relatively high surface tension of the blood-air interface which causes bubbles to trap in small vessels. The aim of the present study was to reduce depression of myocardial functio...

journal_title：Cardiovascular research

authors： van Blankenstein JH,Slager CJ,Soei LK,Boersma H,Stijnen T,Schuurbiers JC,Krams R,Lachmann B,Verdouw PD

更新日期：1997-06-01 00:00:00

abstract：:Myocardial lactate content and simultaneous evolution of a lactate arteriovenous gradient associated with incomplete obstruction of the left coronary bed were studied in dog hearts. Samples of blood were taken from a peripheral artery and the coronary sinus; transmural samples of myocardial tissue were obtained from t...

journal_title：Cardiovascular research

authors： Al Makdessi S,Andrieu JL,Chah QT,Tuduri AJ,Faucon G

更新日期：1982-10-01 00:00:00

abstract：:Mechanical stress signals transmitted through the heart walls during hemodynamic loading are sensed by the myocytes, which respond with changes in contractile performance and gene expression. External forces play an important role in physiological heart development and hypertrophy, but disruption of the well-balanced ...

journal_title：Cardiovascular research

authors： Linke WA

更新日期：2008-03-01 00:00:00