Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes.

abstract：AIMS:Disturbed blood flow at arterial branches and curvatures modulates endothelial function and predisposes the region to endothelial inflammation and subsequent development of atherosclerotic lesions. Activation of the endothelial Toll-like receptors (TLRs), in particular TLR4, contributes to vascular inflammation. T...

journal_title：Cardiovascular research

authors： Qu D,Wang L,Huo M,Song W,Lau CW,Xu J,Xu A,Yao X,Chiu JJ,Tian XY,Huang Y

更新日期：2020-01-01 00:00:00

abstract：:Sudden hypothermia utilising liquid nitrogen has been used for immediate inhibition of metabolic reactions and preservation of labile compounds in heart muscle. It has been suggested that this rapid transfer of tissue into liquid nitrogen, within 1 to 2 s, is essential for accurate assessment of internal milieu condit...

journal_title：Cardiovascular research

authors： Allison TB,Ramey CA,Holsinger JW Jr

更新日期：1978-03-01 00:00:00

abstract：Aims:Circular RNA (circRNA) is a newly validated class of single-stranded RNA, ubiquitously expressed in mammalian tissues and possessing key functions including acting as microRNA sponges and as transcriptional regulators by binding to RNA-binding proteins. While independent studies confirm the expression of circRNA i...

journal_title：Cardiovascular research

authors： Tan WL,Lim BT,Anene-Nzelu CG,Ackers-Johnson M,Dashi A,See K,Tiang Z,Lee DP,Chua WW,Luu TD,Li PY,Richards AM,Foo RS

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:The restitution mechanism has been the focus of attention as the possible mechanism behind ventricular fibrillation (VF). However, its contribution in chronic ischemic heart has not been established. METHODS:We investigated chronic ischemic dogs with occlusion of left anterior descending artery. Sixty unipol...

journal_title：Cardiovascular research

authors： Yuuki K,Hosoya Y,Kubota I,Yamaki M

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:Resveratrol, a natural phytoalexin compound, is present in grapes and wine, and it can produce vasorelaxation. However, little is known of its mechanisms of action on ionic currents in endothelial cells. METHODS:The effect of resveratrol on Ca(2+)-activated K+ currents in an endothelial cell line (HUV-EC-C) ...

journal_title：Cardiovascular research

authors： Li HF,Chen SA,Wu SN

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVES:The state of the vasodilator systems in congestive heart failure is poorly defined. Plasma atrial natriuretic peptide is increased, whereas endothelium derived relaxing factor activity can be decreased. Atrial natriuretic peptide and endothelium derived relaxing factor both cause vascular relaxation by gener...

journal_title：Cardiovascular research

authors： Arnal JF,Hofmann F,Michel JB

更新日期：1993-06-01 00:00:00

abstract：:The interest in mouse electrophysiology is expanding fast, despite the marked differences between mouse and man. Different methods have become available to analyse the electrical activity in the mouse heart in vivo. The mouse genome can be altered with relative ease, which allows the molecular dissection of the variou...

journal_title：Cardiovascular research

authors： Wehrens XH,Kirchhoff S,Doevendans PA

更新日期：2000-01-01 00:00:00

abstract：AIMS:Human influenza A virus (hIAV) infection is associated with important cardiovascular complications, although cardiac infection pathophysiology is poorly understood. We aimed to study the ability of hIAV of different pathogenicity to infect the mouse heart, and establish the relationship between the infective capac...

journal_title：Cardiovascular research

authors： Filgueiras-Rama D,Vasilijevic J,Jalife J,Noujaim SF,Alfonso JM,Nicolas-Avila JA,Gutierrez C,Zamarreño N,Hidalgo A,Bernabé A,Cop CP,Ponce-Balbuena D,Guerrero-Serna G,Calle D,Desco M,Ruiz-Cabello J,Nieto A,Falcon A

更新日期：2020-04-28 00:00:00

abstract：STUDY OBJECTIVE:The aim was to quantify the changes in placental blood flow and combined ventricular output with gestational age in normal human fetuses to determine the percentage of total cardiac output that placental blood flow represented, and whether this changed with age. DESIGN:Two dimensional echocardiographic...

journal_title：Cardiovascular research

authors： Sutton MG,Plappert T,Doubilet P

更新日期：1991-07-01 00:00:00

abstract：OBJECTIVE:Experimental and clinical studies have shown that administration of insulin during reperfusion is cardioprotective, but the underlying mechanisms are still unknown. In this study, we investigated in isolated rat cardiomyocytes subjected to hypoxia and reoxygenation whether administration of insulin during reo...

journal_title：Cardiovascular research

authors： Abdallah Y,Gkatzoflia A,Gligorievski D,Kasseckert S,Euler G,Schlüter KD,Schäfer M,Piper HM,Schäfer C

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:R 75,231, a potent and specific nucleoside transport inhibitor, largely prevents cardiac damage and death in catecholamine challenged rabbits. The major biochemical effect of nucleoside transport inhibition in ischaemic and reperfused myocardium is a prolonged accumulation of adenosine. The cardioprotection b...

journal_title：Cardiovascular research

authors： Van Belle H,Ver Donck K,Verheyen W

更新日期：1993-01-01 00:00:00

abstract：AIMS:Ischaemia-reperfusion provokes barrier failure of the coronary microvasculature, impeding functional recovery of the heart during reperfusion. The aim of the present study was to investigate whether the stimulation of cGMP signalling by activation of soluble guanylyl cyclase (sGC) can reduce reperfusion-induced en...

journal_title：Cardiovascular research

authors： Kasseckert SA,Schäfer C,Kluger A,Gligorievski D,Tillmann J,Schlüter KD,Noll T,Sauer H,Piper HM,Abdallah Y

更新日期：2009-07-15 00:00:00

abstract：:The rate of QT adaptation to abrupt changes in pacing rate was studied in seven patients with newly diagnosed complete heart block with a ventricular escape rate of less than 40 beats.min-1. Their median age was 70 (range 36-84) years, and none was taking any cardioactive medication known to affect the QT interval. Fr...

journal_title：Cardiovascular research

authors： Lau CP,Freedman AR,Fleming S,Malik M,Camm AJ,Ward DE

更新日期：1988-01-01 00:00:00

abstract：:Ventricular function curves relating stroke work and left ventricular end-diastolic pressure were generated in awake dogs during increases in preload produced by infusion of fluid and during increases in afterload produced by administration of phenylephrine. The ventricular function curves produced by preloading were ...

journal_title：Cardiovascular research

authors： Rosenfeldt FL,Cobb FR,Bache RJ,Sabiston DC Jr

更新日期：1979-07-01 00:00:00

abstract：:Impairment of contractile function and extent of release of several intracellular marker enzymes and DNA were studied in isolated perfused rat hearts after low-flow (0.16 ml . min-1) ischaemia followed by 2 h of reperfusion and after anoxia followed by 2 h of reoxygenation. After varying periods of ischaemia or anoxia...

journal_title：Cardiovascular research

authors： van der Laarse A,Altona JC,Zoet AC,Oemrawsingh P,van Dijkman PR

更新日期：1984-12-01 00:00:00

abstract：AIMS:The goal of this study was to determine whether the A1 adenosine receptor (AR) plays a role in atherosclerosis development and to explore its potential mechanisms. METHODS AND RESULTS:Double knockout (DKO) mice, deficient in the genes encoding A1 AR and apolipoprotein E (apoE), demonstrated reduced atheroscleroti...

journal_title：Cardiovascular research

authors： Teng B,Smith JD,Rosenfeld ME,Robinet P,Davis ME,Morrison RR,Mustafa SJ

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:Activin-like kinase receptor 1 (ALK1) is a transforming growth factor (TGF)-beta type I receptor expressed in vascular mesenchyme, yet its function in vascular mesenchymal cells (VMC) is unclear. We examined ALK1 expression in human coronary atherosclerotic lesions and bovine and human VMC undergoing cellular...

journal_title：Cardiovascular research

authors： Yao Y,Zebboudj AF,Torres A,Shao E,Boström K

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVES:Gap junctions have been demonstrated ultrastructurally in cardiac regions where connexin40 (Cx40) and connexin43 (Cx43) protein could not be detected immunohistochemically. We investigated therefore the distribution of their mRNAs with more sensitive techniques. METHODS:In situ hybridizations with Cx40 and ...

journal_title：Cardiovascular research

authors： Van Kempen MJ,Vermeulen JL,Moorman AF,Gros D,Paul DL,Lamers WH

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVES:The present study was designed to determine whether tonic nitric oxide (NO)-mediated vasodilator innervation participates in basilar arterial dilatation in the anesthetized Japanese monkey. METHODS:The basilar arterial diameter was angiographically measured, and NG-nitro-L-arginine (L-NNA), a nitric oxide s...

journal_title：Cardiovascular research

authors： Okamura T,Ayajiki K,Toda N

更新日期：1995-11-01 00:00:00

abstract：AIMS:Heart failure is associated with deficient endothelial nitric oxide (NO) production as well as increased oxidative stress and accelerated NO degradation. The aim of this study was to evaluate platelet NO biosynthesis and superoxide anion (O(2)(-)) production in patients with heart failure. METHODS AND RESULTS:In ...

journal_title：Cardiovascular research

authors： Shah A,Passacquale G,Gkaliagkousi E,Ritter J,Ferro A

更新日期：2011-09-01 00:00:00

abstract：AIMS:Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is caused by mutations in the cardiac ryanodine receptor (RyR2) that lead to disrupted Ca(2+) handling in cardiomyocytes and ventricular tachycardia. The aim of this study was to test whether exercise training could reduce the propensity for arrh...

journal_title：Cardiovascular research

authors： Manotheepan R,Danielsen TK,Sadredini M,Anderson ME,Carlson CR,Lehnart SE,Sjaastad I,Stokke MK

更新日期：2016-08-01 00:00:00

abstract：:Microelectrode recordings of skin nerve sympathetic activity were made in the median nerve supplying the right hand of nine patients with Raynaud's phenomenon and 10 control subjects. With subjects warmed up (finger temperature 33 to 34 degrees C) different manoeuvres were used to evoke strong, single sympathetic burs...

journal_title：Cardiovascular research

authors： Fagius J,Blumberg H

更新日期：1985-05-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the effects of a calcium antagonist (diltiazem) and a catecholamine (noradrenaline) on extracellular potassium accumulation during global ischaemia. METHODS:Extracellular potassium concentration ([K+]e) was measured during 30 min global ischaemia in the isolated rat heart using a v...

journal_title：Cardiovascular research

authors： Mitani A,Kinoshita K,Fukamachi K,Sakamoto M,Kurisu K,Fukumura F,Tsuruhara Y,Nakashima A,Tokunaga K

更新日期：1992-11-01 00:00:00

abstract：:Although fully explored in larger animals, the role of injection site and sample microsphere content on variability of coronary blood flow (CBF) measurement using the microsphere technique remains controversial in rats despite the fact that this species is extensively used in cardiovascular research. We therefore inve...

journal_title：Cardiovascular research

authors： Wicker PA,Healy BP

更新日期：1989-05-01 00:00:00

abstract：AIMS:Statins have beneficial vascular effects beyond their cholesterol-lowering action. Since macrophages play a central role in atherogenesis, we characterized the effects of simvastatin on gene expression profile of human peripheral blood monocyte (HPBM)-macrophages. METHODS AND RESULTS:Gene expression profile was s...

journal_title：Cardiovascular research

authors： Tuomisto TT,Lumivuori H,Kansanen E,Häkkinen SK,Turunen MP,van Thienen JV,Horrevoets AJ,Levonen AL,Ylä-Herttuala S

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:Effective endogenous fibrinolysis requires rapid release of endothelial tissue plasminogen activator (t-PA). Using the nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA), we examined the contribution of endogenous nitric oxide to substance P-induced t-PA release in vivo in man. METHODS:Blood f...

journal_title：Cardiovascular research

authors： Newby DE,Wright RA,Dawson P,Ludlam CA,Boon NA,Fox KA,Webb DJ

更新日期：1998-05-01 00:00:00

abstract：:Isolated, buffer perfused guinea pig hearts were used to study the effects of sotalol on arrhythmias and electrophysiology during 30 min of myocardial ischaemia, induced by reducing coronary flow to 10% of control, and subsequent reperfusion. Action potentials were recorded using the floating microelectrode technique ...

journal_title：Cardiovascular research

authors： Culling W,Penny WJ,Sheridan DJ

更新日期：1984-07-01 00:00:00

abstract：:Since data on velocity fields in the ascending aorta downstream of normal aortic valves in pigs have not yet been obtained velocity profiles were visualised using a hot film anemometer needle probe before and after total cardiopulmonary bypass and cold cardioplegic arrest. Furthermore, measurements were made during in...

journal_title：Cardiovascular research

authors： Hasenkam JM,Ostergaard JH,Pedersen EM,Paulsen PK,Nygaard H,Schurizek BA,Johannsen G

更新日期：1988-07-01 00:00:00

abstract：:The role of mediators of inflammation in the pathogenesis and evolution of myocardial infarction has attracted increased interest as interventions which inhibit the inflammatory response after coronary artery occlusion have been shown to decrease infarct size. The distribution of fibrinogen and albumin in ischaemia my...

journal_title：Cardiovascular research

authors： Fishbein MC,Kulber D,Stancl M,Edwalds G

更新日期：1986-01-01 00:00:00

abstract：:Data from experiments in isolated cardiac muscle preparations indicate that adenosine in high concentration (10(-3) mol X litre-1) exerts a negative inotropic effect on the myocardium under basal conditions. The following study was performed to test the hypothesis that adenosine exerts a similar negative inotropic eff...

journal_title：Cardiovascular research

authors： Gewirtz H,Salvo A,Sun Y,Most AS

更新日期：1984-04-01 00:00:00