Activin-like kinase receptor 1 (ALK1) in atherosclerotic lesions and vascular mesenchymal cells.

abstract：AIMS:Diabetes impinges upon mechanisms of cardiovascular repair. However, the biochemical adaptation of cardiac stem cells to sustained hyperglycaemia remains largely unknown. Here, we investigate the molecular targets of high glucose-induced damage in cardiac progenitor cells (CPCs) from murine and human hearts and at...

journal_title：Cardiovascular research

authors： Katare R,Oikawa A,Cesselli D,Beltrami AP,Avolio E,Muthukrishnan D,Munasinghe PE,Angelini G,Emanueli C,Madeddu P

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to assess whether the plasma levels of soluble adhesion molecules including E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are elevated in patients with variant angina and whether they are released in the coronary circulation...

journal_title：Cardiovascular research

authors： Miwa K,Igawa A,Inoue H

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:In heart failure (HF), the generation of reactive oxygen species (ROS) is enhanced. It was shown that failing cardiac myocytes are more susceptible to ROS-induced damage, possibly due to increased expression of the sarcolemmal Na-Ca exchanger (NCX). METHODS:We investigated the consequences of increased expre...

journal_title：Cardiovascular research

authors： Wagner S,Seidler T,Picht E,Maier LS,Kazanski V,Teucher N,Schillinger W,Pieske B,Isenberg G,Hasenfuss G,Kögler H

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:The aim was to compare differences in peak twitch force occurring despite similar degrees of right ventricular hypertrophy in ferrets with pulmonary artery banding at either weanling or juvenile age. METHODS:After inducing pressure overload hypertrophy by banding the pulmonary artery of weanling and juvenile...

journal_title：Cardiovascular research

authors： Gwathmey JK,Liao R,Ingwall JS

更新日期：1995-04-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to determine if prostaglandin like activity might be involved in changes due to exercise training in the coronary flow responses to hypoxia. DESIGN:The coronary flow response to hypoxia was measured under constant perfusion pressure in isolated perfused hearts from 12 endurance exercise tra...

journal_title：Cardiovascular research

authors： Baur TS,Brodowicz GR,Lamb DR

更新日期：1990-09-01 00:00:00

abstract：AIMS:Tungstate reduces blood pressure in experimental animal models of both hypertension and metabolic syndrome, although the underlying mechanisms are not fully understood. Given that the large-conductance voltage- and Ca(2+)-dependent K(+) (BK) channel is a key element in the control of arterial tone, our aim was to ...

journal_title：Cardiovascular research

authors： Fernández-Mariño AI,Porras-González C,González-Rodríguez P,Selent J,Pastor M,Ureña J,Castellano A,Valverde MA,Fernández-Fernández JM

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:Both superoxide dismutase (SOD) and nitric oxide synthase (NOS) have been implicated in delayed preconditioning (DP) to ischemia/reperfusion (I/R) in the heart. We used isolated cardiac myocytes to test the hypothesis that SOD and NOS may interact in the development of DP. METHODS:Mouse neonatal cardiac myoc...

journal_title：Cardiovascular research

authors： Rui T,Cepinskas G,Feng Q,Kvietys PR

更新日期：2003-10-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to record diastolic transmitral pressure gradients at high sensitivity to quantitate the effect on transmitral pressure gradients of changing the heart rate. DESIGN:Diastolic left atrial and left ventricular pressures were recorded at high sensitivity (40 mm Hg = 10 mm recorded deflection) ...

journal_title：Cardiovascular research

authors： Carmeliet P,Aubert A,Van de Werf F,De Geest H

更新日期：1990-07-01 00:00:00

abstract：:Microvascular barrier dysfunction is implicated in the initiation and progression of inflammation, posttraumatic complications, sepsis, ischaemia-reperfusion injury, atherosclerosis, and diabetes. Under physiological conditions, a precise equilibrium between endothelial cell-cell adhesion and actin-myosin-based centri...

journal_title：Cardiovascular research

authors： Shen Q,Rigor RR,Pivetti CD,Wu MH,Yuan SY

更新日期：2010-07-15 00:00:00

abstract：OBJECTIVES:The contribution of vascular changes to the development of heart failure is largely unknown. In the present study, we evaluated endothelial and vascular contractile function in the rat hindlimb vascular bed after myocardial infarction (MI), including the modulatory role of basal nitric oxide (NO) production ...

journal_title：Cardiovascular research

authors： Ceiler DL,Nelissen-Vrancken M,De Mey JG,Smits JF

更新日期：1999-08-15 00:00:00

abstract：AIMS:Angiotensin II is a potential contributor to the development of abdominal aortic aneurysm (AAA). In aortic vascular smooth muscle cells, exposure to angiotensin II induces mitochondrial fission via dynamin-related protein 1 (Drp1). However, pathophysiological relevance of mitochondrial morphology in angiotensin II...

journal_title：Cardiovascular research

authors： Cooper HA,Cicalese S,Preston KJ,Kawai T,Okuno K,Choi ET,Kasahara S,Uchida HA,Otaka N,Scalia R,Rizzo V,Eguchi S

更新日期：2020-05-08 00:00:00

abstract：AIMS:A robust inflammatory response to tissue injury is a necessary part of the repair process but the deposition of scar tissue is a direct downstream consequence of this response in many tissues including the heart. Adult zebrafish not only possess the capacity to regenerate lost cardiomyocytes but also to remodel an...

journal_title：Cardiovascular research

authors： Bevan L,Lim ZW,Venkatesh B,Riley PR,Martin P,Richardson RJ

更新日期：2020-06-01 00:00:00

abstract：:Systemic haemodynamics and regional myocardial blood flow responses to hypertonic mannitol were studied in 10 conscious and 23 anaesthetized dogs. Mannitol infusion significantly increased regional myocardial blood flow in the conscious, intact dogs. Mannitol increased total coronary flow 20% in anasethetized animals ...

journal_title：Cardiovascular research

authors： Hutton I,Marynick SP,Fixler DE,Templeton GH,Willerson JT

更新日期：1975-01-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is a major risk factor for cardio-embolic stroke. Anticoagulant drugs are effective in preventing AF-related stroke. However, the high frequency of anticoagulant-associated major bleeding is a major concern. This study sought to identify new targets to develop safer antithrombotic therapie...

journal_title：Cardiovascular research

authors： Allende M,Molina E,Guruceaga E,Tamayo I,González-Porras JR,Gonzalez-López TJ,Toledo E,Rabal O,Ugarte A,Roldán V,Rivera J,Oyarzabal J,Montes R,Hermida J

更新日期：2016-06-01 00:00:00

abstract：AIMS:in this study, we attempted to detect a recent myocardial ischaemic event using ultrasound molecular imaging (UMI) with microbubbles (MB) targeted to intercellular adhesion molecule-1 (ICAM-1) in the late phase of reperfusion. METHODS AND RESULTS:we created a myocardial ischaemia-reperfusion model in 60 C57/BL ma...

journal_title：Cardiovascular research

authors： Yan Y,Liao Y,Yang L,Wu J,Du J,Xuan W,Ji L,Huang Q,Liu Y,Bin J

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:To investigate the effect of alpha,beta(1) and beta(2) adrenergic receptor (AR) stimulation on coronary hemodynamics, myocardial oxygen consumption (M(v)O(2)) and metabolic substrate preference in advanced dilated cardiomyopathy (DCM). METHODS:We studied 19 conscious, instrumented dogs with pacing-induced D...

journal_title：Cardiovascular research

authors： Nikolaidis LA,Hentosz T,Doverspike A,Huerbin R,Stolarski C,Shen YT,Shannon RP

更新日期：2002-02-01 00:00:00

abstract：:Functional studies in extrarenal non-epithelial cells such as smooth muscle cells and easily accessible human lymphocytes have demonstrated that aldosterone not only produces classical genomic effects, but also rapid non-genomic effects on transmembrane electrolyte movements. These involve the activation of the Na+/H+...

journal_title：Cardiovascular research

authors： Wehling M

更新日期：1995-02-01 00:00:00

abstract：:The effect of catheterisation on the rabbit aortic wall is investigated employing a technique identical to that used for continuous monitoring of blood pressure in humans. The catheters were introduced into the aorta through the right femoral artery of the rabbit using the Seldinger technique, except that the catheter...

journal_title：Cardiovascular research

authors： Madsen JK,Garbarsch C,Nielsen PE

更新日期：1979-09-01 00:00:00

abstract：:Segments of saphenous vein from patients undergoing coronary artery by-pass graft surgery were frozen in liquid nitrogen immediately on dissection (control), after stripping of the adventitia and side branch ligation (manipulation), after distention with blood (distention), or at completion of the last proximal anasto...

journal_title：Cardiovascular research

authors： Angelini GD,Breckenridge IM,Butchart EG,Armistead SH,Middleton KM,Henderson AH,Newby AC

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVE:The development of collateral microvessels following therapeutic angiogenesis with vascular endothelial growth factor (VEGF) was investigated using a new system of microangiography that employs monochromatic synchrotron radiation (SR) and a high definition video system to visualize arteries with a spatial res...

journal_title：Cardiovascular research

authors： Takeshita S,Isshiki T,Mori H,Tanaka E,Tanaka A,Umetani K,Eto K,Miyazawa Y,Ochiai M,Sato T

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To characterise the effect of coronary intra-arterial thrombosis upon the downstream vascular bed. BACKGROUND:The vascular response downstream from a coronary intra-arterial thrombus has not previously been characterised. We postulated that downstream vasoconstriction might result from the presence of endoth...

journal_title：Cardiovascular research

authors： Belcher PR,Vergroesen I,Drake-Holland AJ,Noble MI

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:Ischemic postconditioning protects the reperfused heart from infarction, and this protection is dependent on the occupancy of adenosine receptors. We further explored the role of adenosine receptors in this salvage. METHODS:In situ rabbit hearts underwent 30 min of regional ischemia and 3 h of reperfusion, a...

journal_title：Cardiovascular research

authors： Philipp S,Yang XM,Cui L,Davis AM,Downey JM,Cohen MV

更新日期：2006-05-01 00:00:00

abstract：:Arteriogenesis, the process of collateral artery growth as an adaptation to major arterial occlusion, can be life- and tissue saving and may alter the natural course of the consequences and organ manifestations of arterial disease. This is achieved by an active growth process that is coupled to complete arterial remod...

journal_title：Cardiovascular research

authors： Schaper W,Buschmann I

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:The aim was to determine if isolated rabbit cardiomyocytes could be preconditioned. METHODS:Cardiomyocytes isolated from rabbit hearts were subjected to 15 min oxygenated preincubation, with and without substrate, prior to concentration into an ischaemic slurry, with or without glucose present. The effects o...

journal_title：Cardiovascular research

authors： Armstrong S,Downey JM,Ganote CE

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVES:Age-related medial calcification (elastocalcinosis) of large arteries is accelerated in diabetes and appears mainly in distal arteries. The aim was to devise a rat model of elastocalcinosis in association with diabetes to examine the hypothesis that diabetes accelerates vascular calcification experimentally....

journal_title：Cardiovascular research

authors： Bouvet C,Peeters W,Moreau S,DeBlois D,Moreau P

更新日期：2007-02-01 00:00:00

abstract：:The development of the heart is a complex process during which different cell types progressively contribute to shape a four-chambered pumping organ. Over the last decades, our understanding of the specification and transcriptional regulation of cardiac development has been greatly augmented as has our understanding o...

journal_title：Cardiovascular research

authors： Franco D,Chinchilla A,Daimi H,Dominguez JN,Aránega A

更新日期：2011-07-15 00:00:00

abstract：:The most critical determinant of prognosis in patients with acute myocardial infarction (MI) is infarct magnitude, which can be established within several hours of an attack. The importance of the subsequent healing process is not negligible, however. In fact, much experimental and clinical evidence suggests that late...

journal_title：Cardiovascular research

authors： Takemura G,Nakagawa M,Kanamori H,Minatoguchi S,Fujiwara H

更新日期：2009-07-15 00:00:00

abstract：:Injudicious selection of a saphenous vein graft can adversely affect the the late postoperative patency of the proximal coronary artery which it bypasses. The purpose of this investigation was to deduce an upper bound for graft diameter, at small angle of distal anastomosis, below which the stenosed artery will remain...

journal_title：Cardiovascular research

authors： Moskowitz SE,Lewis BS,Milo S,Amar R

更新日期：1979-07-01 00:00:00

abstract：Aims:Sirtuin 3 (Sirt3) is a mitochondrial, nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that reduces oxidative stress by activation of superoxide dismutase 2 (SOD2). Oxidative stress enhances arterial thrombosis. This study investigated the effects of genetic Sirt3 deletion on arterial thrombosis in m...

journal_title：Cardiovascular research

authors： Gaul DS,Weber J,van Tits LJ,Sluka S,Pasterk L,Reiner MF,Calatayud N,Lohmann C,Klingenberg R,Pahla J,Vdovenko D,Tanner FC,Camici GG,Eriksson U,Auwerx J,Mach F,Windecker S,Rodondi N,Lüscher TF,Winnik S,Matter CM

更新日期：2018-07-01 00:00:00

abstract：AIMS :Activation of the angiotensin (Ang)-(1-7)/Mas receptor (R) axis protects from sympathetic overactivity. Endocytic trafficking is an essential process that regulates receptor (R) function and its ultimate cellular responses. We investigated whether the blunted responses to Ang-(1-7) in hypertensive rats are associ...

journal_title：Cardiovascular research

authors： Cerniello FM,Silva MG,Carretero OA,Gironacci MM

更新日期：2020-10-01 00:00:00