当前位置： SCI文献检索 > CARDIOVASCULAR RESEARCH期刊下所有文献 > Metabolic damage to human saphenous vein during preparation for coronary artery bypass grafting.

Metabolic damage to human saphenous vein during preparation for coronary artery bypass grafting.

Abstract：

:Segments of saphenous vein from patients undergoing coronary artery by-pass graft surgery were frozen in liquid nitrogen immediately on dissection (control), after stripping of the adventitia and side branch ligation (manipulation), after distention with blood (distention), or at completion of the last proximal anastomosis (prepared vein). Vein was stored during the operation in patient's heparinised arterial blood at room temperature. Frozen vein was extracted with perchloric acid. ATP, ADP, and AMP, adenosine, inosine and hypoxanthine concentrations were measured by high pressure liquid chromatography. Prepared vein had ca 50% lower ATP concentrations and ATP/ADP ratio than control vein, higher concentrations of inosine and hypoxanthine and lower concentrations of AMP and adenosine. ATP concentration and ATP/ADP ratio did not correlate with the time elapsed between dissection and freezing of the prepared vein. The characteristic changes seen in prepared vein were not seen when control vein was simply stored in arterial blood at 23 degrees C, in normal saline at 23 degrees C or 4 degrees C, in Krebs-Ringer bicarbonate buffer at 37 degrees C or at St Thomas's Hospital cardioplegic solution at 4 degrees C. Distention with unlimited pressure did not distension at less than 300 mmHg gave rise to the same changes in ATP concentration and ATP/ADP ratio as in the prepared vein. These results show that vein suffered metabolic changes during preparation for bypass grafting and suggest that uncontrolled distention may contribute to these changes. Such biochemical measurements provide a quantitative estimate of tissue damage and allow objective comparison of different preparative techniques.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Angelini GD,Breckenridge IM,Butchart EG,Armistead SH,Middleton KM,Henderson AH,Newby AC

doi

10.1093/cvr/19.6.326

subject

Has Abstract

pub_date

1985-06-01 00:00:00

pages

326-34

issue

6

eissn

0008-6363

issn

1755-3245

journal_volume

19

pub_type

杂志文章

相关文献

CARDIOVASCULAR RESEARCH文献大全
  • Nitrated fatty acids suppress angiotensin II-mediated fibrotic remodelling and atrial fibrillation.

    abstract：AIM:Atrial fibrosis, one of the most striking features in the pathology of atrial fibrillation (AF), is promoted by local and systemic inflammation. Electrophilic fatty acid nitroalkenes, endogenously generated by both metabolic and inflammatory reactions, are anti-inflammatory mediators that in synthetic form may be u...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvv254

    authors： Rudolph TK,Ravekes T,Klinke A,Friedrichs K,Mollenhauer M,Pekarova M,Ambrozova G,Martiskova H,Kaur JJ,Matthes B,Schwoerer A,Woodcock SR,Kubala L,Freeman BA,Baldus S,Rudolph V

    更新日期：2016-01-01 00:00:00

  • PEDF induces p53-mediated apoptosis through PPAR gamma signaling in human umbilical vein endothelial cells.

    abstract：OBJECTIVE:Pigment epithelial-derived factor (PEDF) is a potent anti-angiogenic factor whose effects are partially mediated through the induction of endothelial cell apoptosis. The pathway mediating endothelial cell apoptosis has not been fully established. Here we investigated the participation of peroxisome proliferat...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2007.06.032

    authors： Ho TC,Chen SL,Yang YC,Liao CL,Cheng HC,Tsao YP

    更新日期：2007-11-01 00:00:00

  • Effect of sustained stretch on dispersion of ventricular fibrillation intervals in normal rabbit hearts.

    abstract：OBJECTIVE:To determine the effect of acute left ventricular dilatation on refractoriness in normal hearts. METHODS:During sustained ventricular fibrillation (VF) in isolated perfused hearts, recording of local activation time yields VF intervals which provide an index of local refractoriness. Simultaneous measurement ...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(98)00092-3

    authors： Burton FL,Cobbe SM

    更新日期：1998-08-01 00:00:00

  • Enhanced hindlimb collateralization induced by acidic fibroblast growth factor is dependent upon femoral artery extraction.

    abstract：UNLABELLED:Recent investigations have established the feasibility of using exogenously delivered angiogenic growth factors to increase collateral artery development in animal models of myocardial and hindlimb ischemia. OBJECTIVE:Our aim was to evaluate the ability of a stabilized form of acidic fibroblast growth facto...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(03)00522-4

    authors： Hershey JC,Corcoran HA,Baskin EP,Gilberto DB,Mao X,Thomas KA,Cook JJ

    更新日期：2003-10-01 00:00:00

  • Early atherosclerosis in humans: role of diffuse intimal thickening and extracellular matrix proteoglycans.

    abstract：:This review attempts to define the early events that lead to lesions of human atherosclerosis based on careful morphological studies in human autopsy specimens. In contrast to most small laboratory animals, diffuse intimal thickening (DIT) is present in human arteries before atherosclerosis develops, particularly in t...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1093/cvr/cvn099

    authors： Nakashima Y,Wight TN,Sueishi K

    更新日期：2008-07-01 00:00:00

  • 17β-Estradiol-induced interaction of ERα with NPPA regulates gene expression in cardiomyocytes.

    abstract：AIMS:17β-Oestradiol (E2) and its receptors (ERα and ERβ) are important regulators of physiological and pathological processes in the cardiovascular system. ER act in concert with other regulatory factors mediating oestrogenic effects. However, the underlying mechanisms modulating ER transcriptional activity are not ful...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvs281

    authors： Mahmoodzadeh S,Pham TH,Kuehne A,Fielitz B,Dworatzek E,Kararigas G,Petrov G,Davidson MM,Regitz-Zagrosek V

    更新日期：2012-12-01 00:00:00

  • Comparative DNA methylation and gene expression analysis identifies novel genes for structural congenital heart diseases.

    abstract：AIMS:For the majority of congenital heart diseases (CHDs), the full complexity of the causative molecular network, which is driven by genetic, epigenetic, and environmental factors, is yet to be elucidated. Epigenetic alterations are suggested to play a pivotal role in modulating the phenotypic expression of CHDs and t...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvw195

    authors： Grunert M,Dorn C,Cui H,Dunkel I,Schulz K,Schoenhals S,Sun W,Berger F,Chen W,Sperling SR

    更新日期：2016-10-01 00:00:00

  • Noninvasive determination of the mitral valve area in stenosis: a computational model and correlation with autopsy and open heart measurements.

    abstract：:An analytical formulation has been developed which allows the computation of mitral valve area (A) from the potentially noninvasive paramaeters of hear rate (R), cardiac output (CO) and diastolic filling period (DFP) by the equation A = 21 CO/R x DFP2. The computed areas correlate with autopsy and open heart measureme...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/14.4.223

    authors： Seitz WS,Operschall EJ

    更新日期：1980-04-01 00:00:00

  • Intracoronary administration of saralasin: effects on cardiac arrhythmias induced by ischaemia and reperfusion in the anaesthetised dog.

    abstract：OBJECTIVE:The aim was to study (1) the effects of intracoronary saralasin, an angiotensin II receptor antagonist, on ischaemia induced and reperfusion induced regional cardiac noradrenaline release and ventricular arrhythmias; and (2) the implication of angiotensin II in coronary constriction during myocardial ischaemi...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/26.10.968

    authors： Ribuot C,Yamaguchi N,Godin D,Jetté L,Nadeau R

    更新日期：1992-10-01 00:00:00

  • Changes in left ventricular internal diameter with increasing pericardial pressure.

    abstract：:Changes in left ventricular internal diameter resulting from increasing intrapericardial pressure induced by increasing the pericardial fluid volume were studied in closed chest, anaesthetized dogs. Left ventricular internal diameters were measured by placing an ultrasonic dimension catheter in the left ventricle at t...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/9.6.707

    authors： Pegram BL,Kardon MB,Bishop VS

    更新日期：1975-11-01 00:00:00

  • Matrix metalloproteinase-3 and coronary remodelling: implications for unstable coronary disease.

    abstract：OBJECTIVES:Matrix metalloproteinases (MMPs) are plausible candidates for prediction of unstable coronary syndromes. We hypothesised that the MMP-3 polymorphism (- 1171, 5A/6A) would relate to coronary plaque characteristics and unstable clinical presentation. METHODS AND RESULTS:Forty patients with de novo presentatio...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2007.05.003

    authors： White AJ,Duffy SJ,Walton AS,Ng JF,Rice GE,Mukherjee S,Shaw JA,Jennings GL,Dart AM,Kingwell BA

    更新日期：2007-09-01 00:00:00

  • Adenosine receptor specificity in preconditioning of isolated rabbit cardiomyocytes: evidence of A3 receptor involvement.

    abstract：OBJECTIVE:The aim was to further characterise an experimental model of preconditioning of isolated rabbit cardiomyocytes and to determine the role of adenosine receptor subtypes in initiation of the protective response. METHODS:Isolated myocytes were subjected to 5 min preincubation in the presence or absence of gluco...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/28.7.1049

    authors： Armstrong S,Ganote CE

    更新日期：1994-07-01 00:00:00

  • Experimental evidence for proarrhythmic mechanisms of antiarrhythmic drugs.

    abstract：:The major limitation to antiarrhythmic drug therapy is the risk of arrhythmia promotion, or 'proarrhythmia.' This complication may be lethal, and greatly restricts the value of antiarrhythmic agents, particularly for arrhythmias without an intrinsic mortality risk, such as atrial fibrillation. In order for improved an...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/s0008-6363(97)00293-9

    authors： Nattel S

    更新日期：1998-03-01 00:00:00

  • Controversies on the sensitivity of the diabetic heart to ischemic injury: the sensitivity of the diabetic heart to ischemic injury is decreased.

    abstract：:Controversy exists as to whether the diabetic heart is more or less sensitive to ischemic injury. Although a considerable number of experimental studies have directly determined the effects of ischemia on the diabetic heart, there is still no general agreement as to whether metabolic changes within the myocardium cont...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/s0008-6363(97)00037-0

    authors： Feuvray D,Lopaschuk GD

    更新日期：1997-04-01 00:00:00

  • Cardiac angiotensin converting enzyme overproduction indicates interstitial activation in renovascular hypertension.

    abstract：OBJECTIVES:Angiotensin converting enzyme (ACE) activity in the plasma does not change significantly with hypertension in two-kidney, one-clip hypertensive (2K-1C) rats. However, heart ACE activity and mRNA increase with hypertension. We measured the ACE activity and mRNA in hypertrophied hearts at different times after...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：

    authors： Challah M,Nicoletti A,Arnal JF,Philippe M,Laboulandine I,Allegrini J,Alhenc-Gelas F,Danilov S,Michel JB

    更新日期：1995-08-01 00:00:00

  • Acute effects of doxorubicin on skinned cardiac muscle fibres of guinea pigs.

    abstract：OBJECTIVE:The aim was to examine the effect of doxorubicin on spontaneous cyclic Ca2+ release from the sarcoplasmic reticulum of skinned fibres, as measured by isometric tension development in EGTA free, Ca2+ free solution. METHODS:Experiments were done on fragments of papillary muscles from the right ventricles of gu...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/26.4.371

    authors： Asayama J,Yamahara Y,Tatsumi T,Miyazaki H,Inoue M,Omori I,Inoue D,Nakagawa M

    更新日期：1992-04-01 00:00:00

  • Effect of mechanical boundary conditions on orientation of angiogenic microvessels.

    abstract：AIM:Mechanical forces are important regulators of cell and tissue phenotype. We hypothesized that mechanical loading and boundary conditions would influence neovessel activity during angiogenesis. METHODS AND RESULTS:Using an in vitro model of angiogenesis sprouting and a mechanical loading system, we evaluated the ef...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvn055

    authors： Krishnan L,Underwood CJ,Maas S,Ellis BJ,Kode TC,Hoying JB,Weiss JA

    更新日期：2008-05-01 00:00:00

  • Dominant-negative I(Ks) suppression by KCNQ1-deltaF339 potassium channels linked to Romano-Ward syndrome.

    abstract：OBJECTIVE:Hereditary long QT syndrome (LQTS) is a genetically heterogeneous disease characterized by prolonged QT intervals and an increased risk for ventricular arrhythmias and sudden cardiac death. Mutations in the voltage-gated potassium channel subunit KCNQ1 induce the most common form of LQTS. KCNQ1 is associated ...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/j.cardiores.2005.05.003

    authors： Thomas D,Wimmer AB,Karle CA,Licka M,Alter M,Khalil M,Ulmer HE,Kathöfer S,Kiehn J,Katus HA,Schoels W,Koenen M,Zehelein J

    更新日期：2005-08-15 00:00:00

  • High Sodium Intake, Glomerular Hyperfiltration and Protein Catabolism in Patients with Essential Hypertension.

    abstract：AIMS:A blood pressure-independent metabolic shift toward a catabolic state upon high sodium (Na+) diet, ultimately favouring body fluid preservation, has recently been described in pre-clinical controlled settings. We sought to investigate the real-life impact of high Na+ intake on measures of renal Na+/water handling ...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvaa205

    authors： Rossitto G,Maiolino G,Lerco S,Ceolotto G,Blackburn G,Mary S,Antonelli G,Berton C,Bisogni V,Cesari M,Seccia TM,Lenzini L,Pinato A,Montezano A,Touyz RM,Petrie MC,Daly R,Welsh P,Plebani M,Rossi GP,Delles C

    更新日期：2020-07-16 00:00:00

  • Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.

    abstract：Aims:Sirtuin 3 (Sirt3) is a mitochondrial, nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that reduces oxidative stress by activation of superoxide dismutase 2 (SOD2). Oxidative stress enhances arterial thrombosis. This study investigated the effects of genetic Sirt3 deletion on arterial thrombosis in m...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvy036

    authors： Gaul DS,Weber J,van Tits LJ,Sluka S,Pasterk L,Reiner MF,Calatayud N,Lohmann C,Klingenberg R,Pahla J,Vdovenko D,Tanner FC,Camici GG,Eriksson U,Auwerx J,Mach F,Windecker S,Rodondi N,Lüscher TF,Winnik S,Matter CM

    更新日期：2018-07-01 00:00:00

  • The importance of thrombus organization and stellate cell phenotype in collagen I gene expression in human, coronary atherosclerotic and restenotic lesions.

    abstract：OBJECTIVES:Collagen synthesis is one of the major mechanisms of primary atherosclerotic plaque growth and is likely to be similarly important in restenosis. The patterns of collagen gene expression in human restenosis and associations with thrombosis/hemorrhage have not been described. METHODS:Using human coronary art...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：

    authors： Rekhter MD,O'Brien E,Shah N,Schwartz SM,Simpson JB,Gordon D

    更新日期：1996-09-01 00:00:00

  • Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries.

    abstract：AIMS:We have previously characterized a cGMP-dependent Ca(2+)-activated Cl(-) current in vascular smooth muscle cells (SMCs) and have shown its dependence on bestrophin-3 expression. We hypothesize that this current is important for synchronization of SMCs in the vascular wall. In the present study, we aimed to test th...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvr111

    authors： Broegger T,Jacobsen JC,Secher Dam V,Boedtkjer DM,Kold-Petersen H,Pedersen FS,Aalkjaer C,Matchkov VV

    更新日期：2011-09-01 00:00:00

  • Ca2+/calmodulin-dependent protein kinase: a key component in the contractile recovery from acidosis.

    abstract：:Intracellular acidosis exerts substantial effects on the contractile performance of the heart. Soon after the onset of acidosis, contractility diminishes, largely due to a decrease in myofilament Ca(2+) responsiveness. This decrease in contractility is followed by a progressive recovery that occurs despite the persist...

    journal_title：Cardiovascular research

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardiores.2006.12.002

    authors： Mattiazzi A,Vittone L,Mundiña-Weilenmann C

    更新日期：2007-03-01 00:00:00

  • The effect of therapeutic doses of lidocaine hydrochloride on the effective refractory period of the right ventricle in man.

    abstract：:The effect of lidocaine on the effective refractory period of the right ventricle (EVRP) was measured in 10 patients using the extra stimulus technique of progressive introduction of premature stimuli until a response could not be elicited. In four patients lidocaine produced a significant decrease in the EVRP, in a f...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/9.5.621

    authors： Olsson SB,Harper R,Rydén L,Hilmy WA

    更新日期：1975-09-01 00:00:00

  • Effects of oxidised low density lipoprotein on dendritic cells: a possible immunoregulatory component of the atherogenic micro-environment?

    abstract：OBJECTIVE:The objective of this study was to explore the relationship between low density lipoprotein (LDL) and dendritic cell (DC) activation, based upon the hypothesis that reactive oxygen species (ROS)-mediated modification of proteins that may be present in local DC microenvironments could be important as mediators...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(02)00447-9

    authors： Alderman CJ,Bunyard PR,Chain BM,Foreman JC,Leake DS,Katz DR

    更新日期：2002-09-01 00:00:00

  • Impaired P2X signalling pathways in renal microvascular myocytes in genetic hypertension.

    abstract：AIMS:P2X receptors (P2XRs) mediate sympathetic control and autoregulation of renal circulation triggering preglomerular vasoconstriction, which protects glomeruli from elevated pressures. Although previous studies established a casual link between glomerular susceptibility to hypertensive injury and decreased preglomer...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvu249

    authors： Gordienko D,Povstyan O,Sukhanova K,Raphaël M,Harhun M,Dyskina Y,Lehen'kyi V,Jama A,Lu ZL,Skryma R,Prevarskaya N

    更新日期：2015-02-01 00:00:00

  • GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways.

    abstract：AIMS:Ischaemic preconditioning (IPC) protects the heart against prolonged lethal ischaemia through a signalling cascade involving Akt, glycogen synthase kinase-3β (GSK-3β), and mitochondrial ATP-sensitive potassium channels (mitoK(ATP)). We previously demonstrated the involvement of the Wnt pathway in IPC in vivo via G...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvr002

    authors： Vigneron F,Dos Santos P,Lemoine S,Bonnet M,Tariosse L,Couffinhal T,Duplaà C,Jaspard-Vinassa B

    更新日期：2011-04-01 00:00:00

  • Full-length dhh and N-terminal shh act as competitive antagonists to regulate angiogenesis and vascular permeability.

    abstract：:The therapeutic potential of Hedgehog (Hh) signalling agonists for vascular diseases is of growing interest. However, molecular and cellular mechanisms underlying the role of the Hh signalling in vascular biology remain poorly understood. AIMS:The purpose of the present paper is to clarify some conflicting literature...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1093/cvr/cvaa285

    authors： Hollier PL,Chapouly C,Diop A,Guimbal S,Cornuault L,Gadeau AP,Renault MA

    更新日期：2020-10-16 00:00:00

  • The L-arginine/nitric oxide pathway contributes to the acute release of tissue plasminogen activator in vivo in man.

    abstract：OBJECTIVE:Effective endogenous fibrinolysis requires rapid release of endothelial tissue plasminogen activator (t-PA). Using the nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA), we examined the contribution of endogenous nitric oxide to substance P-induced t-PA release in vivo in man. METHODS:Blood f...

    journal_title：Cardiovascular research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0008-6363(98)00017-0

    authors： Newby DE,Wright RA,Dawson P,Ludlam CA,Boon NA,Fox KA,Webb DJ

    更新日期：1998-05-01 00:00:00

  • Effect of physiological mechanical perturbations on intact human myocardial repolarization.

    abstract：OBJECTIVE:The objective of this study was to investigate the relationship between acute decreases in right ventricular volume during Valsalva strain (with resultant changes in autonomic neural tone) and measures of local endocardial repolarization time independent of heart rate and autonomic neural tone. METHODS:Patie...

    journal_title：Cardiovascular research

    pub_type： 杂志文章

    doi：10.1016/s0008-6363(99)00261-8

    authors： Nanthakumar K,Dorian P,Paquette M,Hutchison S,Andrews J,Newman D

    更新日期：2000-01-14 00:00:00