Nitrated fatty acids suppress angiotensin II-mediated fibrotic remodelling and atrial fibrillation.

abstract：:Exogenous angiotensin II causes noradrenaline supersensitivity in rat mesenteric vasculature preparations. The noradrenaline supersensitivity of tissues from renal/salt hypertensive rats, with low plasma renin activity, is not caused by endogenous angiotensin II since it was unaffected by Sar1 Ileu8 angiotensin II. Di...

journal_title：Cardiovascular research

authors： Collis MG,Alps BJ

更新日期：1976-03-01 00:00:00

abstract：OBJECTIVES:Action potential prolongation related to the alteration of several membrane currents is constantly reported in heart failure (HF) but reports about its role in arrhythmogenesis are sparse. Our aim was to determine, by analogy with long QT syndromes, whether prolonged repolarization is associated with increas...

journal_title：Cardiovascular research

authors： Lacroix D,Gluais P,Marquié C,D'Hoinne C,Adamantidis M,Bastide M

更新日期：2002-04-01 00:00:00

abstract：AIMS:Therapeutic use of sulfhydrylated inhibitor S-zofenopril has raised different hypotheses regarding the role played by its thiol group in the beneficial clinical effects exerted compared with other angiotensin-converting enzyme (ACE) inhibitors. Here, we investigated hydrogen sulfide (H2S) pathway as accountable fo...

journal_title：Cardiovascular research

authors： Bucci M,Vellecco V,Cantalupo A,Brancaleone V,Zhou Z,Evangelista S,Calderone V,Papapetropoulos A,Cirino G

更新日期：2014-04-01 00:00:00

abstract：AIMS:Adequate microcirculatory perfusion, and not just opening of occluded arteries, is critical to salvage heart tissue following myocardial infarction. However, the degree of microvascular perfusion taking place is not known, limited primarily by an inability to directly image coronary microcirculation in a beating h...

journal_title：Cardiovascular research

authors： Kavanagh DPJ,Lokman AB,Neag G,Colley A,Kalia N

更新日期：2019-11-01 00:00:00

abstract：:Ischemia-reperfusion of the heart and other organs results in the accumulation of unesterified arachidonic acid (AA) via the action of membrane-bound phospholipases, primarily phospholipase A2. AA can be metabolized by the classical cyclooxygenase (COX) and lipoxygenase (LOX) pathways to well-characterized metabolites...

journal_title：Cardiovascular research

authors： Gross GJ,Falck JR,Gross ER,Isbell M,Moore J,Nithipatikom K

更新日期：2005-10-01 00:00:00

abstract：:The most critical determinant of prognosis in patients with acute myocardial infarction (MI) is infarct magnitude, which can be established within several hours of an attack. The importance of the subsequent healing process is not negligible, however. In fact, much experimental and clinical evidence suggests that late...

journal_title：Cardiovascular research

authors： Takemura G,Nakagawa M,Kanamori H,Minatoguchi S,Fujiwara H

更新日期：2009-07-15 00:00:00

abstract：:The effect of lidocaine on the effective refractory period of the right ventricle (EVRP) was measured in 10 patients using the extra stimulus technique of progressive introduction of premature stimuli until a response could not be elicited. In four patients lidocaine produced a significant decrease in the EVRP, in a f...

journal_title：Cardiovascular research

authors： Olsson SB,Harper R,Rydén L,Hilmy WA

更新日期：1975-09-01 00:00:00

abstract：OBJECTIVE:Rapid ventricular pacing reliably induces severe congestive heart failure in dogs, with an associated attenuation of baroreflex sensitivity. Unique to this model is the capacity for rapid recovery of haemodynamics and plasma noradrenaline following the cessation of pacing; however, whether baroreflex sensitiv...

journal_title：Cardiovascular research

authors： Grima EA,Moe GW,Howard RJ,Armstrong PW

更新日期：1994-03-01 00:00:00

abstract：:In the superior vena cava of anaesthetised open chest dogs the axial pressure gradient was measured simultaneously with the blood flow velocity under different preload conditions. Both pressure gradient and velocity curves showed distinct systolic and diastolic waves. Peak pressure gradient ranged between 26 and 93 Pa...

journal_title：Cardiovascular research

authors： Minten J,Van de Werf F,Eaubert A,De Geest H

更新日期：1986-12-01 00:00:00

abstract：:Currently, a high carbohydrate/low fat diet is recommended for patients with hypertension; however, the potentially important role that the composition of dietary fat and carbohydrate plays in hypertension and the development of pathological left ventricular hypertrophy (LVH) has not been well characterized. Recent st...

journal_title：Cardiovascular research

authors： Sharma N,Okere IC,Duda MK,Chess DJ,O'Shea KM,Stanley WC

更新日期：2007-01-15 00:00:00

abstract：:We studied the effects of intravenously administered autonomic agents, the calcium channel blocker diltiazem, and Class I and III anti-arrhythmic agents on a re-entry model for atrial tachycardia in seven conscious dogs. The model was created by a Y-shaped incision in the intercaval region and front free wall of the r...

journal_title：Cardiovascular research

authors： Wu KM,Hunter T,Proakis A

更新日期：1989-05-01 00:00:00

abstract：:Acadesine is the prototype of a new class of therapeutic compounds termed adenosine regulating agents. Acadesine is pharmacologically silent in normal circumstances, but its activity becomes operative during situations of net ATP catabolism, when it increases local adenosine levels. Thus acadesine is able to harness t...

journal_title：Cardiovascular research

authors： Mullane K

更新日期：1993-01-01 00:00:00

abstract：AIMS:Despite the observation that ErbB2 regulates sensitivity of the heart to doxorubicin or ErbB2-targeted cancer therapies, mechanisms that regulate ErbB2 expression and activity have not been studied. Since isoproterenol up-regulates ErbB2 in kidney and salivary glands and β2AR and ErbB2 complex in brain and heart, ...

journal_title：Cardiovascular research

authors： Sysa-Shah P,Tocchetti CG,Gupta M,Rainer PP,Shen X,Kang BH,Belmonte F,Li J,Xu Y,Guo X,Bedja D,Gao WD,Paolocci N,Rath R,Sawyer DB,Naga Prasad SV,Gabrielson K

更新日期：2016-03-01 00:00:00

abstract：AIMS:Our objective was to explore the functional interdependence of protein kinase A (PKA) phosphorylation with binding of modulatory FK506 binding proteins (FKBP12/12.6) to the ryanodine receptor (RyR). RyR type 1 or type 2 was prepared from rabbit skeletal muscle or pig cardiac muscle, respectively. In heart failure,...

journal_title：Cardiovascular research

authors： Blayney LM,Jones JL,Griffiths J,Lai FA

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Preexposure of macrophages to oxidized low-density lipoprotein (oxLDL) attenuates formation of reactive oxygen species (ROS) upon stimulation with phorbol 12-myristate 13-acetate (PMA) or acute exposure to oxLDL. We examined whether attenuation of the oxidative burst is attributed to down-regulation of protei...

journal_title：Cardiovascular research

authors： Köhl R,Preiss S,von Knethen A,Brüne B

更新日期：2006-08-01 00:00:00

abstract：AIMS:To compare the prevalence of electrocardiogram (ECG)-documented atrial fibrillation (or flutter) (AF) across eight regions of the world, and to examine anti-thrombotic use and clinical outcomes. METHODS AND RESULTS:Baseline ECGs were collected in 153,152 middle-aged participants (ages 35 to 70 years) to document ...

journal_title：Cardiovascular research

authors： Joseph PG,Healey JS,Raina P,Connolly SJ,Ibrahim Q,Gupta R,Avezum A,Dans AL,Lopez-Jaramillo P,Yeates K,Teo K,Douma R,Bohonar A,Chifamba J,Lanas F,Dagenais GR,Lear SA,Kumar R,Kengne AP,Keskinler M,Mohan V,Mony P,

更新日期：2020-08-10 00:00:00

abstract：OBJECTIVE:The objective of this study was to investigate the relationship between acute decreases in right ventricular volume during Valsalva strain (with resultant changes in autonomic neural tone) and measures of local endocardial repolarization time independent of heart rate and autonomic neural tone. METHODS:Patie...

journal_title：Cardiovascular research

authors： Nanthakumar K,Dorian P,Paquette M,Hutchison S,Andrews J,Newman D

更新日期：2000-01-14 00:00:00

abstract：AIMS:Placental growth factor (PlGF), a homologue of vascular endothelial growth factor, is a pleiotropic cytokine with a pro-inflammatory activity. Previous gene-inactivation studies revealed that the loss of PlGF delays atherosclerotic lesion development and inhibits macrophage infiltration, but the activity of an ant...

journal_title：Cardiovascular research

authors： Roncal C,Buysschaert I,Gerdes N,Georgiadou M,Ovchinnikova O,Fischer C,Stassen JM,Moons L,Collen D,De Bock K,Hansson GK,Carmeliet P

更新日期：2010-04-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to evaluate the influence that centrally administered angiotensin-II has on the intrarenal renin-angiotensin system and renal sympathetic nerve activity. DESIGN:Renal responses to centrally administered angiotensin-II (10 micrograms) or saralasin (50 micrograms) were measured in anaesthetis...

journal_title：Cardiovascular research

authors： Weekley LB

更新日期：1991-05-01 00:00:00

abstract：AIMS:The aim of this study was to explore meprinα-mediated transactivation of the epidermal growth factor receptor (EGFR) and reactive oxygen species (ROS) production in macrophages. METHODS AND RESULTS:Accelerated atherosclerotic lesions were established by administration of a high-fat diet in apolipoprotein E-defici...

journal_title：Cardiovascular research

authors： Gao P,Wang XM,Qian DH,Qin ZX,Jin J,Xu Q,Yuan QY,Li XJ,Si LY

更新日期：2013-03-01 00:00:00

abstract：:Segments of saphenous vein from patients undergoing coronary artery by-pass graft surgery were frozen in liquid nitrogen immediately on dissection (control), after stripping of the adventitia and side branch ligation (manipulation), after distention with blood (distention), or at completion of the last proximal anasto...

journal_title：Cardiovascular research

authors： Angelini GD,Breckenridge IM,Butchart EG,Armistead SH,Middleton KM,Henderson AH,Newby AC

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVE:The aim was to establish whether the duration of coronary ischaemia and coronary ischaemia with reperfusion selectively reduced the magnitude of relaxation mediated by endothelium dependent relaxing factor (EDRF) in response to thrombin, compared with relaxation produced by acetylcholine and calcimycin. METH...

journal_title：Cardiovascular research

authors： Winn MJ,Ku DD

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVE:The K(+) channel encoded by the human ether-a-go-go-related gene (HERG) is crucial for repolarization in the human heart. In order to investigate the impact of HERG current (I(Kr)) on the incidence of cardiac arrhythmias, we generated a transgenic mouse expressing HERG specifically in the heart. METHODS AND ...

journal_title：Cardiovascular research

authors： Royer A,Demolombe S,El Harchi A,Le Quang K,Piron J,Toumaniantz G,Mazurais D,Bellocq C,Lande G,Terrenoire C,Motoike HK,Chevallier JC,Loussouarn G,Clancy CE,Escande D,Charpentier F

更新日期：2005-01-01 00:00:00

abstract：AIMS:Anthracycline-induced cardiotoxicity (AIC) is a serious adverse effect among cancer patients. A central mechanism of AIC is irreversible mitochondrial damage. Despite major efforts, there are currently no effective therapies able to prevent AIC. METHODS AND RESULTS:Forty Large-White pigs were included. In Study 1...

journal_title：Cardiovascular research

authors： Galán-Arriola C,Villena-Gutiérrez R,Higuero-Verdejo MI,Díaz-Rengifo IA,Pizarro G,López GJ,de Molina-Iracheta A,Pérez-Martínez C,García RD,González-Calle D,Lobo M,Sánchez PL,Oliver E,Córdoba R,Fuster V,Sánchez-González J,I

更新日期：2020-06-29 00:00:00

abstract：OBJECTIVE AND METHODS:In this study, we investigated whether Ca(2+) transients are altered in Purkinje cell aggregates dispersed from the subendocardium overlying the infarcted zone of the left ventricle (IZPCs) 48 h after coronary artery occlusion. To do so, we combined epifluorescent imaging with microelectrode recor...

journal_title：Cardiovascular research

authors： Boyden PA,Barbhaiya C,Lee T,ter Keurs HE

更新日期：2003-03-01 00:00:00

abstract：STUDY OBJECTIVE:Compensatory mechanisms of the left ventricle for volume overloading caused by acute aortic regurgitation and associated changes in physiological properties of the aorta were studied in rabbits. DESIGN:Aortic regurgitation was produced by aortic valve perforation, and haemodynamic measurements were per...

journal_title：Cardiovascular research

authors： Wainai Y

更新日期：1991-06-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to study the interactions between pulmonary capillary wedge pressure (an estimate of left atrial pressure), left atrial dimension, and atrial natriuretic factor during evolving heart failure. DESIGN:Sequential simultaneous measurements of haemodynamic variables, left atrial dimension, and p...

journal_title：Cardiovascular research

authors： Moe GW,Angus C,Howard RJ,De Bold AJ,Armstrong PW

更新日期：1990-07-01 00:00:00

abstract：:Ventricular function curves relating stroke work and left ventricular end-diastolic pressure were generated in awake dogs during increases in preload produced by infusion of fluid and during increases in afterload produced by administration of phenylephrine. The ventricular function curves produced by preloading were ...

journal_title：Cardiovascular research

authors： Rosenfeldt FL,Cobb FR,Bache RJ,Sabiston DC Jr

更新日期：1979-07-01 00:00:00

abstract：AIMS:Intracellular Ca(2+) ([Ca(2+)](i)) regulation in endothelial cells depends on transient receptor potential channels (TRPs), and the role of canonical TRPs (TRPCs) during hypoxia-reoxygenation (H-R) is unclear. We hypothesized that TRPC3 contributes to endothelial nitric oxide (NO) release and that H-R may reduce T...

journal_title：Cardiovascular research

authors： Huang JH,He GW,Xue HM,Yao XQ,Liu XC,Underwood MJ,Yang Q

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:The aim was to further characterise an experimental model of preconditioning of isolated rabbit cardiomyocytes and to determine the role of adenosine receptor subtypes in initiation of the protective response. METHODS:Isolated myocytes were subjected to 5 min preincubation in the presence or absence of gluco...

journal_title：Cardiovascular research

authors： Armstrong S,Ganote CE

更新日期：1994-07-01 00:00:00