Noninvasive determination of the mitral valve area in stenosis: a computational model and correlation with autopsy and open heart measurements.

abstract：OBJECTIVE:Anisotropic conduction characteristics, which may be expressed as the ratio of conduction velocities in the longitudinal (Vlong) and transverse (Vtrans) fibre directions, have been shown to stabilise reentry and favour the induction of sustained, uniform ventricular tachycardia. The aim of this study was to i...

journal_title：Cardiovascular research

authors： Hélie F,Cossette J,Vermeulen M,Cardinal R

更新日期：1995-03-01 00:00:00

abstract：:Cardiovascular complications in the course of human immunodeficiency virus (HIV) infection are multifactorial and may be caused by the virus itself or by the related opportunistic infections and neoplasms. Highly active antiretroviral therapy (HAART) has prolonged many patients' lives, but many cardiac sequelae of HIV...

journal_title：Cardiovascular research

authors： Barbaro G

更新日期：2003-10-15 00:00:00

abstract：OBJECTIVE:Earlier studies have revealed sarcolemmal (SL) defects in congestive heart failure due to myocardial infarction; however, the mechanisms of SL changes in the failing heart are poorly understood. Since congestive heart failure is associated with various metabolic abnormalities including a deficiency of carniti...

journal_title：Cardiovascular research

authors： Sethi R,Dhalla KS,Ganguly PK,Ferrari R,Dhalla NS

更新日期：1999-06-01 00:00:00

abstract：:The significance of pre-existing coronary collaterals for preservation of the myocardium during coronary occlusion and reperfusion was studied in anaesthetised open-chest dogs. The extent of myocardial ischaemic damage was assessed by the accumulation of calcium in the central zone of the ischaemic area and the size o...

journal_title：Cardiovascular research

authors： Tanabe M,Fujiwara S,Ohta N,Shimamoto N,Hirata M

更新日期：1980-05-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate whether infusion of either atrial natriuretic factor (ANF, 800 ng.h-1.rat-1) or a specific inhibitory of neutral endopeptidase 24.11 (NEI, UK 73,967, 5.4 mg.kg-1.d-1) can influence the reversal of the pulmonary vascular remodelling produced by exposure to hypoxia. METHODS:Male Wist...

journal_title：Cardiovascular research

authors： Zhao L,Hughes JM,Winter RJ

更新日期：1994-04-01 00:00:00

abstract：:The effect of lidocaine on the effective refractory period of the right ventricle (EVRP) was measured in 10 patients using the extra stimulus technique of progressive introduction of premature stimuli until a response could not be elicited. In four patients lidocaine produced a significant decrease in the EVRP, in a f...

journal_title：Cardiovascular research

authors： Olsson SB,Harper R,Rydén L,Hilmy WA

更新日期：1975-09-01 00:00:00

abstract：AIMS:Macrophage-related oxidative stress plays an important role in the inflammatory process in atherosclerosis. Recently, dextromethorphan (DXM), a common cough-suppressing ingredient with a high safety profile, was found to inhibit the activation of microglia, the resident macrophage in the nervous system. We investi...

journal_title：Cardiovascular research

authors： Liu SL,Li YH,Shi GY,Tang SH,Jiang SJ,Huang CW,Liu PY,Hong JS,Wu HL

更新日期：2009-04-01 00:00:00

abstract：AIMS:Ivabradine (Iva) has shown beneficial structural and functional effects in clinical and experimental heart failure (HF), but its action in combination with mechanical unloading (MU), such as during treatment with left ventricular assist devices (LVAD), is unknown. The aim of this study was to investigate the effec...

journal_title：Cardiovascular research

authors： Navaratnarajah M,Ibrahim M,Siedlecka U,van Doorn C,Shah A,Gandhi A,Dias P,Sarathchandra P,Yacoub MH,Terracciano CM

更新日期：2013-02-01 00:00:00

abstract：AIMS:Aortic adaptive immunity plays a role in atherosclerosis; however, the precise mechanisms leading to T-cell activation in the arterial wall remain poorly understood. METHODS AND RESULTS:Here, we have identified naïve T cells in the aorta of wild-type and T-cell receptor transgenic mice and we demonstrate that naï...

journal_title：Cardiovascular research

authors： MacRitchie N,Grassia G,Noonan J,Cole JE,Hughes CE,Schroeder J,Benson RA,Cochain C,Zernecke A,Guzik TJ,Garside P,Monaco C,Maffia P

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:The concept of lethal reperfusion injury in ischemic myocardium has been the subject of controversy. Adenosine administered during reperfusion has been reported to limit lethal reperfusion injury in several studies. On the contrary, it has been reported that cardioprotection may not be achieved with adenosin...

journal_title：Cardiovascular research

authors： Vander Heide RS,Reimer KA

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:Preexposure of macrophages to oxidized low-density lipoprotein (oxLDL) attenuates formation of reactive oxygen species (ROS) upon stimulation with phorbol 12-myristate 13-acetate (PMA) or acute exposure to oxLDL. We examined whether attenuation of the oxidative burst is attributed to down-regulation of protei...

journal_title：Cardiovascular research

authors： Köhl R,Preiss S,von Knethen A,Brüne B

更新日期：2006-08-01 00:00:00

abstract：:The cardiac mechano- and chemoreceptors are broadly distributed in the myocardium and coronary vessels. A portion of these receptors extends over the epicardium and pericardium and therefore can be excited by mechanical or chemical stimuli directly applied to the surface of the heart. Excitation of epicardial receptor...

journal_title：Cardiovascular research

authors： Cinca J,Rodríguez-Sinovas A

更新日期：2000-01-01 00:00:00

abstract：:Cell communication, an essential component of integrated physiological function in multicellular organisms, is mediated largely through informational molecules, such as hormones and neurotransmitters. After binding to specific receptors, these first messengers activate intracellular signaling cascades and, thereby, tr...

journal_title：Cardiovascular research

authors： Goette A,Lendeckel U,Klein HU

更新日期：2002-05-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common tachyarrhythmia in clinical practice. Over decades of research, a vast amount of knowledge has been gathered about the causes and consequences of AF related to cellular electrophysiology and features of the tissue structure that influence the propagation of fibrillation wave...

journal_title：Cardiovascular research

authors： Opacic D,van Bragt KA,Nasrallah HM,Schotten U,Verheule S

更新日期：2016-04-01 00:00:00

abstract：AIMS:Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine that contributes to pathogenic cardiac remodelling via mechanisms that involve oxidative stress. However, the direct impact of TGF-beta1 on contractile function of ventricular myocytes is incompletely understood. METHODS AND RESULTS:Reacti...

journal_title：Cardiovascular research

authors： Li S,Li X,Zheng H,Xie B,Bidasee KR,Rozanski GJ

更新日期：2008-01-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is the most common type of arrhythmia in humans, yet the genetic cause of AF remains elusive. Genome-wide association studies (GWASs) have reported risk variants in four distinct genetic loci, and more recently, a meta-GWAS has further implicated six new loci in AF. However, the functional...

journal_title：Cardiovascular research

authors： Lozano-Velasco E,Hernández-Torres F,Daimi H,Serra SA,Herraiz A,Hove-Madsen L,Aránega A,Franco D

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:L-arginine exerts anti-atherosclerotic effects in hypercholesterolaemic rabbits via modulating endogenous NO production. We investigated whether L-arginine inhibits thromboxane formation in vivo and platelet aggregation ex vivo in this animal model. METHODS:The urinary excretion rates of 2,3-dinor-6-keto-PG...

journal_title：Cardiovascular research

authors： Bode-Böger SM,Böger RH,Kienke S,Böhme M,Phivthong-ngam L,Tsikas D,Frölich JC

更新日期：1998-03-01 00:00:00

abstract：Aims:Endothelial hyperpermeability exacerbates multiple organ damage during inflammation or infection. The endothelial glycocalyx, a protective matrix covering the luminal surface of endothelial cells (ECs), undergoes enzymatic shedding during inflammation, contributing to barrier hyperpermeability. A disintegrin and m...

journal_title：Cardiovascular research

authors： Yang X,Meegan JE,Jannaway M,Coleman DC,Yuan SY

更新日期：2018-11-01 00:00:00

abstract：:Major advances in molecular biology over the past decade have increased our understanding of how genes are expressed and regulated in mammalian cells in vivo. This knowledge has been translated to investigations of the molecular and cellular biology of the cardiovascular system. Gene transfer, the introduction of a re...

journal_title：Cardiovascular research

authors： Nabel EG,Pompili VJ,Plautz GE,Nabel GJ

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVE:Myogenic tone, which has a major role in the regulation of local blood flow, refers to the ability of vascular smooth muscle to adapt its contractility to changes in transmural pressure. Although Rho-kinase is involved in myogenic tone, the pathway involved remains unclear, especially concerning translocation...

journal_title：Cardiovascular research

authors： Dubroca C,Loyer X,Retailleau K,Loirand G,Pacaud P,Feron O,Balligand JL,Lévy BI,Heymes C,Henrion D

更新日期：2007-01-01 00:00:00

abstract：:An in situ preparation of the rabbit thoracic aorta has been used to study the transport of short-lived radioactive isotopes of oxygen (15O16O), nitrogen (13N14N) and an isotope of xenon (133Xe) from 0.9% NaCl into the artery wall. At a luminal hydrostatic pressure of 2 kPa the uptake of all three isotopes by the inti...

journal_title：Cardiovascular research

authors： Davis J,Klinowski J,Winlove CP

更新日期：1981-08-01 00:00:00

abstract：Aims:Sirtuin 3 (Sirt3) is a mitochondrial, nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that reduces oxidative stress by activation of superoxide dismutase 2 (SOD2). Oxidative stress enhances arterial thrombosis. This study investigated the effects of genetic Sirt3 deletion on arterial thrombosis in m...

journal_title：Cardiovascular research

authors： Gaul DS,Weber J,van Tits LJ,Sluka S,Pasterk L,Reiner MF,Calatayud N,Lohmann C,Klingenberg R,Pahla J,Vdovenko D,Tanner FC,Camici GG,Eriksson U,Auwerx J,Mach F,Windecker S,Rodondi N,Lüscher TF,Winnik S,Matter CM

更新日期：2018-07-01 00:00:00

abstract：:A diminished sympathetic activity has been related to training bradycardia seen at rest and during exercise. In order to evaluate if changes in heart adrenergic receptors can be one of the mechanisms by which the sympathetic responsiveness could be decreased by physical training, the number and affinity of beta-adrene...

journal_title：Cardiovascular research

authors： Sylvestre-Gervais L,Nadeau A,Nguyen MH,Tancrède G,Rousseau-Migneron S

更新日期：1982-09-01 00:00:00

abstract：:Cardiovascular diseases are among the main causes of morbidity and mortality in Western countries and considered as a leading public health issue. Therefore, there is a strong need for new disease models to support the development of novel therapeutics approaches. The successive improvement of genome editing tools wit...

journal_title：Cardiovascular research

authors： Vermersch E,Jouve C,Hulot JS

更新日期：2020-04-01 00:00:00

abstract：AIMS:Myocardial function is severely compromised during sepsis. Several underlying mechanisms have been proposed. The innate immune system, i.e. toll-like receptor (TLR) 2 and 4, significantly contributes to cardiac dysfunction. Little is known regarding TLR9 and its pathogenic ligand bacterial DNA in the myocardium. W...

journal_title：Cardiovascular research

authors： Knuefermann P,Schwederski M,Velten M,Krings P,Ehrentraut H,Rüdiger M,Boehm O,Fink K,Dreiner U,Grohé C,Hoeft A,Baumgarten G,Koch A,Zacharowski K,Meyer R

更新日期：2008-04-01 00:00:00

abstract：:STUDY OBJECTIVE - The aim of the study was to determine the changes in the beta adrenergic system induced by cardiac hypertrophy due to valvular aortic stenosis. DESIGN - Density of beta adrenoceptors, cardiac tissue noradrenalime concentrations, coronary blood flow (using radioactive microspheres), and haemodynamic v...

journal_title：Cardiovascular research

authors： Scholz PM,Upsher ME,Eliades D,Kedem J,Weiss HR

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:Angiotensin converting enzyme (ACE) activity in the plasma does not change significantly with hypertension in two-kidney, one-clip hypertensive (2K-1C) rats. However, heart ACE activity and mRNA increase with hypertension. We measured the ACE activity and mRNA in hypertrophied hearts at different times after...

journal_title：Cardiovascular research

authors： Challah M,Nicoletti A,Arnal JF,Philippe M,Laboulandine I,Allegrini J,Alhenc-Gelas F,Danilov S,Michel JB

更新日期：1995-08-01 00:00:00

abstract：AIMS:The cAMP-dependent protein kinase (PKA) mediates β-adrenoceptor (β-AR) regulation of cardiac contraction and gene expression. Whereas PKA activity is well characterized in various subcellular compartments of adult cardiomyocytes, its regulation in the nucleus remains largely unknown. The aim of the present study w...

journal_title：Cardiovascular research

authors： Haj Slimane Z,Bedioune I,Lechêne P,Varin A,Lefebvre F,Mateo P,Domergue-Dupont V,Dewenter M,Richter W,Conti M,El-Armouche A,Zhang J,Fischmeister R,Vandecasteele G

更新日期：2014-04-01 00:00:00

abstract：:We used the phase modulated rotating frame imaging technique to measure transmural distribution of phosphorus metabolites in 10 anaesthetised ventilated pigs using a double surface coil placed on the surface of the left ventricle. Anaesthesia was maintained in five animals with halothane, barbiturate and nitrous oxide...

journal_title：Cardiovascular research

authors： Rajagopalan B,Bristow JD,Radda GK

更新日期：1989-12-01 00:00:00

abstract：AIMS:Baicalin is the major component found in Scutellaria baicalensis root, a widely used herb in traditional Chinese medicine. Although it has been used for thousands of years to treat stroke, the mechanisms of action of S. baicalensis have not been clearly elucidated. In this report, we studied the modulation of angi...

journal_title：Cardiovascular research

authors： Zhang K,Lu J,Mori T,Smith-Powell L,Synold TW,Chen S,Wen W

更新日期：2011-02-01 00:00:00