Abstract:
:Intracellular acidosis exerts substantial effects on the contractile performance of the heart. Soon after the onset of acidosis, contractility diminishes, largely due to a decrease in myofilament Ca(2+) responsiveness. This decrease in contractility is followed by a progressive recovery that occurs despite the persistent acidosis. This recovery is the result of different mechanisms that converge to increase diastolic Ca(2+) levels and Ca(2+) transient amplitude. Recent experimental evidence indicates that activation of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is an essential step in the sequence of events that increases the Ca(2+) transient amplitude and produces contractile recovery. CaMKII may act as an amplifier, providing compensatory pathways to offset the inhibitory effects of acidosis on many of the Ca(2+) handling proteins. CaMKII-induced phosphorylation of the SERCA2a regulatory protein phospholamban (PLN) has the potential to promote an increase in sarcoplasmic reticulum (SR) Ca(2+) uptake and SR Ca(2+) load, and is a likely candidate to mediate the mechanical recovery from acidosis. In addition, CaMKII-dependent phosphorylation of proteins other than PLN may also contribute to this recovery.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Mattiazzi A,Vittone L,Mundiña-Weilenmann Cdoi
10.1016/j.cardiores.2006.12.002subject
Has Abstractpub_date
2007-03-01 00:00:00pages
648-56issue
4eissn
0008-6363issn
1755-3245pii
S0008-6363(06)00565-7journal_volume
73pub_type
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journal_title:Cardiovascular research
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更新日期:2003-04-01 00:00:00
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更新日期:1990-01-01 00:00:00
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更新日期:1976-09-01 00:00:00
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更新日期:2003-07-01 00:00:00
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更新日期:2010-04-01 00:00:00
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更新日期:2000-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章,评审
doi:10.1093/cvr/26.1.3
更新日期:1992-01-01 00:00:00
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更新日期:2002-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.cardiores.2006.12.022
更新日期:2007-04-01 00:00:00
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更新日期:2005-03-01 00:00:00
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更新日期:1998-09-01 00:00:00
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更新日期:2008-04-01 00:00:00
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journal_title:Cardiovascular research
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更新日期:1984-07-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-05-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
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更新日期:2008-05-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/j.cardiores.2004.01.024
更新日期:2004-06-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章,多中心研究
doi:10.1093/cvr/cvx187
更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0008-6363(00)00320-5
更新日期:2001-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-02-01 00:00:00