Modulation of ERG25 expression by LDL in vascular cells.

abstract：AIMS:Mast cells participate importantly in abdominal aortic aneurysms (AAAs) by releasing inflammatory cytokines to promote vascular cell protease expression and arterial wall remodelling. Mast cells accumulate in AAA lesions during disease progression, but the exact chemokines by which mast cells migrate to the site o...

journal_title：Cardiovascular research

authors： Zhang J,Chen H,Liu L,Sun J,Shi MA,Sukhova GK,Shi GP

更新日期：2012-12-01 00:00:00

abstract：:Congenital coronary artery anomalies are of major significance in clinical cardiology and cardiac surgery due to their association with myocardial ischaemia and sudden death. Such anomalies are detectable by imaging modalities and, according to various definitions, their prevalence ranges from 0.21 to 5.79%. This cons...

journal_title：Cardiovascular research

authors： Pérez-Pomares JM,de la Pompa JL,Franco D,Henderson D,Ho SY,Houyel L,Kelly RG,Sedmera D,Sheppard M,Sperling S,Thiene G,van den Hoff M,Basso C

更新日期：2016-02-01 00:00:00

abstract：AIMS:Acute migraine attack in familial hemiplegic migraine type 2 (FHM2) patients is characterized by sequential hypo- and hyperperfusion. FHM2 is associated with mutations in the Na, K-ATPase α2 isoform. Heterozygous mice bearing one of these mutations (α2+/G301R mice) were shown to have elevated cerebrovascular tone ...

journal_title：Cardiovascular research

authors： Staehr C,Rajanathan R,Postnov DD,Hangaard L,Bouzinova EV,Lykke-Hartmann K,Bach FW,Sandow SL,Aalkjaer C,Matchkov VV

更新日期：2020-10-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to evaluate the thrombolytic efficacy of recombinant double chain tissue plasminogen activator (Duteplase, t-PA) given as a single intravenous bolus versus an infusion in a canine model of coronary arterial occlusion/reperfusion. DESIGN:Coronary arterial thrombi were induced by a copper coi...

journal_title：Cardiovascular research

authors： Longridge DJ,Follenfant MJ,Ford AJ

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVE:The aim of this work was to compare the effects of supplementation of rat chow diet with potassium (K+) and whey mineral concentrate (Whey), a diet rich in milk minerals, on blood pressure and arterial responses in vitro in spontaneously hypertensive rats (SHR). METHODS:Thirty young SHR and twenty Wistar-Kyo...

journal_title：Cardiovascular research

authors： Wu X,Tolvanen JP,Hutri-Kähönen N,Kähönen M,Mäkynen H,Korpela R,Ruskoaho H,Karjala K,Pörsti I

更新日期：1998-11-01 00:00:00

abstract：:Extracellular potassium activity before and after coronary occlusion was measured in the canine heart by means of potassium-selective surface electrodes. In the ischaemic myocardium potassium activity rapidly increased from a preocclusion value of 3.2 +/- 0.3 mmol.litre-1 to 10 +/- 0.6 mmol.litre-1 within the first 5 ...

journal_title：Cardiovascular research

authors： Wiegand V,Güggi M,Meesmann W,Kessler M,Greitschus F

更新日期：1979-05-01 00:00:00

abstract：OBJECTIVE:Effective endogenous fibrinolysis requires rapid release of endothelial tissue plasminogen activator (t-PA). Using the nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA), we examined the contribution of endogenous nitric oxide to substance P-induced t-PA release in vivo in man. METHODS:Blood f...

journal_title：Cardiovascular research

authors： Newby DE,Wright RA,Dawson P,Ludlam CA,Boon NA,Fox KA,Webb DJ

更新日期：1998-05-01 00:00:00

abstract：:This study concerns the longterm effects of both epicardial and endocardial cryosurgery with particular reference to the coronary arteries. Sheep were subjected to epicardial cryosurgery without cardiopulmonary bypass, and to endocardial application with bypass. In both groups the heart was kept beating throughout the...

journal_title：Cardiovascular research

authors： Misaki T,Allwork SP,Bentall HH

更新日期：1983-02-01 00:00:00

abstract：AIMS:The human ether-a-go-go-related gene (hERG) encodes the rapidly activating delayed rectifier potassium channel (IKr). Malfunction of hERG/IKr is the primary cause of acquired long QT syndrome (LQTS), an electrical disorder of the heart that can cause arrhythmias and sudden death. Patients with autoimmune diseases ...

journal_title：Cardiovascular research

authors： Szendrey J,Lamothe SM,Vanner S,Guo J,Yang T,Li W,Davis J,Joneja M,Baranchuk A,Zhang S

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:The aim was to test the hypothesis that A1 receptor mediated cardioprotection by endogenous adenosine is exerted during ischaemia rather than reperfusion. METHODS:Anaesthetised open chest rabbits were subjected to 30 min regional ischaemia and 120 min reperfusion, and randomised to one of six groups: group I...

journal_title：Cardiovascular research

authors： Zhao ZQ,Nakanishi K,McGee DS,Tan P,Vinten-Johansen J

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE AND METHODS:We have previously demonstrated that mechanical loading of cardiac fibroblasts leads to increased synthesis and gene expression of the extracellular matrix protein collagen. We hypothesised that the upregulation of procollagen gene expression in cardiac fibroblasts, in response to cyclic mechanica...

journal_title：Cardiovascular research

authors： Papakrivopoulou J,Lindahl GE,Bishop JE,Laurent GJ

更新日期：2004-03-01 00:00:00

abstract：:The signal transducer and activator of transcription 3 (STAT3) is fundamental for physiological homeostasis and stress-induced remodelling of the heart as deregulated STAT3 circuits are sufficient to induce dilated and peripartum cardiomyopathy and adverse remodelling after myocardial infarction. STAT3 activity depend...

journal_title：Cardiovascular research

authors： Haghikia A,Ricke-Hoch M,Stapel B,Gorst I,Hilfiker-Kleiner D

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:The present study was designed to determine whether tonic nitric oxide (NO)-mediated vasodilator innervation participates in basilar arterial dilatation in the anesthetized Japanese monkey. METHODS:The basilar arterial diameter was angiographically measured, and NG-nitro-L-arginine (L-NNA), a nitric oxide s...

journal_title：Cardiovascular research

authors： Okamura T,Ayajiki K,Toda N

更新日期：1995-11-01 00:00:00

abstract：Aims:To investigate the role of chromobox protein homolog 3 (Cbx3) in vascular smooth muscle cell (VSMC) proliferation, migration, and neointima formation following vascular injury. Methods and results:Overexpression of Cbx3 led to a significant increase in VSMC contractile gene expression and VSMC apoptosis as well a...

journal_title：Cardiovascular research

authors： Zhang C,Chen D,Maguire EM,He S,Chen J,An W,Yang M,Afzal TA,Luong LA,Zhang L,Lei H,Wu Q,Xiao Q

更新日期：2018-03-01 00:00:00

abstract：:An in situ preparation of the rabbit thoracic aorta has been used to study the transport of short-lived radioactive isotopes of oxygen (15O16O), nitrogen (13N14N) and an isotope of xenon (133Xe) from 0.9% NaCl into the artery wall. At a luminal hydrostatic pressure of 2 kPa the uptake of all three isotopes by the inti...

journal_title：Cardiovascular research

authors： Davis J,Klinowski J,Winlove CP

更新日期：1981-08-01 00:00:00

abstract：AIMS:Cardiovascular research requires complex and functionally intact experimental models. Due to major differences in the cellular and subcellular composition of the myocardium between species, the use of human heart tissue is highly desirable. To enhance the experimental use of the human myocardium, we established me...

journal_title：Cardiovascular research

authors： Brandenburger M,Wenzel J,Bogdan R,Richardt D,Nguemo F,Reppel M,Hescheler J,Terlau H,Dendorfer A

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Transient atrial fibrillation is sometimes observed following adenosine administration and adenosine is known to shorten atrial action potential duration and refractory period. This study was designed to characterise the dose-response relationship of adenosine on these variables relative to arrhythmia inducti...

journal_title：Cardiovascular research

authors： Kabell G,Buchanan LV,Gibson JK,Belardinelli L

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:Induction of angiogenesis has been reported subsequent to eNOS overexpression or activation, the latter involving Hsp90 as a chaperone protein. Here, we investigated the potential of regional Hsp90 overexpression to induce therapeutic neovascularization in vivo in a chronic rabbit hindlimb ischemia model. ME...

journal_title：Cardiovascular research

authors： Pfosser A,Thalgott M,Büttner K,Brouet A,Feron O,Boekstegers P,Kupatt C

更新日期：2005-02-15 00:00:00

abstract：OBJECTIVE:Ischemic postconditioning protects the reperfused heart from infarction, and this protection is dependent on the occupancy of adenosine receptors. We further explored the role of adenosine receptors in this salvage. METHODS:In situ rabbit hearts underwent 30 min of regional ischemia and 3 h of reperfusion, a...

journal_title：Cardiovascular research

authors： Philipp S,Yang XM,Cui L,Davis AM,Downey JM,Cohen MV

更新日期：2006-05-01 00:00:00

abstract：:Myocardial lactate content and simultaneous evolution of a lactate arteriovenous gradient associated with incomplete obstruction of the left coronary bed were studied in dog hearts. Samples of blood were taken from a peripheral artery and the coronary sinus; transmural samples of myocardial tissue were obtained from t...

journal_title：Cardiovascular research

authors： Al Makdessi S,Andrieu JL,Chah QT,Tuduri AJ,Faucon G

更新日期：1982-10-01 00:00:00

abstract：OBJECTIVE:The aim was to test for the presence of cAMPi activated and ATPo activated chloride conductances (ICl(cAMP) and ICl(ATP)) in mouse ventricular myocytes. METHODS:Membrane currents were measured in enzymatically dissociated ventricular myocytes using the whole cell configuration of the patch clamp technique. ...

journal_title：Cardiovascular research

authors： Levesque PC,Hume JR

更新日期：1995-03-01 00:00:00

abstract：:The afterload dependency of relaxation rate was reappraised in isolated canine hearts both in isovolumic and isobaric contractions by using the reliable exponential method in which the asymptote LV pressure (P chi) is variable. This method provided a closer correlation (r = 0.999 +/- 0.001) between the measured LV pre...

journal_title：Cardiovascular research

authors： Hori M,Inoue M,Fukunami M,Kitakaze M,Ishida Y,Tsujioka K,Nakajima S,Kitabatake A,Abe H

更新日期：1985-10-01 00:00:00

abstract：AIMS:Macrophage-related oxidative stress plays an important role in the inflammatory process in atherosclerosis. Recently, dextromethorphan (DXM), a common cough-suppressing ingredient with a high safety profile, was found to inhibit the activation of microglia, the resident macrophage in the nervous system. We investi...

journal_title：Cardiovascular research

authors： Liu SL,Li YH,Shi GY,Tang SH,Jiang SJ,Huang CW,Liu PY,Hong JS,Wu HL

更新日期：2009-04-01 00:00:00

abstract：AIMS:The expression of PUMA (p53-up-regulated modulator of apoptosis), an apoptosis-regulating gene, increases during endoplasmic reticulum stress. The mechanisms by which cyclic stretch influences the regulation of PUMA in vascular smooth muscle cells (VSMCs) during apoptosis remain unclear. We hypothesized that cycli...

journal_title：Cardiovascular research

authors： Cheng WP,Wang BW,Chen SC,Chang H,Shyu KG

更新日期：2012-01-01 00:00:00

abstract：:Cholesterol is an essential component of both the peripheral nervous system and central nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes and oligodendrocytes and is almost completely isolated from other pools of cholesterol in the body, but a small fraction can be taken up from t...

journal_title：Cardiovascular research

authors： Vitali C,Wellington CL,Calabresi L

更新日期：2014-08-01 00:00:00

abstract：:Although substantial information has accumulated over the past decade, many gaps remain in our understanding of the regulation of contractility and modulation of inotropic responsiveness in the developing heart. There are several important problems facing investigators in the field of developmental cardiology. Respons...

journal_title：Cardiovascular research

authors： Artman M

更新日期：1992-01-01 00:00:00

abstract：AIM:The interaction between TNF-like weak inducer of apoptosis (TWEAK, Tnfsf12) and the receptor, fibroblast growth factor-inducible 14 (Fn14), regulates vascular damage through different mechanisms, including inflammation. Oxidative stress plays a major role in inflammation and the development of atherosclerosis, but ...

journal_title：Cardiovascular research

authors： Madrigal-Matute J,Fernandez-Laso V,Sastre C,Llamas-Granda P,Egido J,Martin-Ventura JL,Zalba G,Blanco-Colio LM

更新日期：2015-10-01 00:00:00

abstract：:The second messenger cyclic guanosine 3'5' monophosphate (cGMP) and its downstream effector protein kinase G (PKG) have been discovered more than 40 years ago. In vessels, PKG1 induces smooth muscle relaxation in response to nitric oxide signalling and thus lowers systemic and pulmonary blood pressure. In platelets, P...

journal_title：Cardiovascular research

authors： Rainer PP,Kass DA

更新日期：2016-07-15 00:00:00

abstract：:The effect on the microcirculation of long term administration of the alpha 1 blocker prazosin, which increases peripheral blood flow, was studied in skeletal muscles with differing metabolic profiles. Prazosin (50 mg.litre-1), given ad libitum for 5 weeks in the drinking water, resulted in an increase in capillarity ...

journal_title：Cardiovascular research

authors： Dawson JM,Hudlická O

更新日期：1989-11-01 00:00:00

abstract：OBJECTIVE:Infusion of angiotensin II (AngII) during the third and fourth week after balloon injury of the left common carotid artery of the rat induces smooth muscle cell (SMC) DNA synthesis. In this study we wanted to investigate whether alpha 1-adrenoreceptors are involved in AngII-induced SMC DNA synthesis in the ne...

journal_title：Cardiovascular research

authors： van Kleef EM,Smits JF,Schwartz SM,Daemen MJ

更新日期：1996-02-01 00:00:00