Transport of radioactive oxygen, nitrogen and xenon into the rabbit thoracic aorta in situ.

abstract：:This study is the first report describing the sequence of biochemical alterations of myocardium during the progression of naturally occurring hypertrophy in spontaneously hypertensive rats (SHRs) and then with its reversal by alpha-methyldopa therapy. Changes in DNA, RNA, hydroxyproline, as well as incorporation of 14...

journal_title：Cardiovascular research

authors： Sen S,Tarazi RC,Bumpus FM

更新日期：1976-03-01 00:00:00

abstract：:To investigate cardiovascular changes in experimental acromegaly, a growth hormone-secreting tumour (MtT-W-15) was implanted in adult female rats. Somatic and tumour growth occurred steadily during the 8 week study period, as did an increase in serum growth hormone titre. Weight of left ventricle and right ventricle i...

journal_title：Cardiovascular research

authors： Penney DG,Dunbar JC Jr,Baylerian MS

更新日期：1985-05-01 00:00:00

abstract：OBJECTIVE:Transient atrial fibrillation is sometimes observed following adenosine administration and adenosine is known to shorten atrial action potential duration and refractory period. This study was designed to characterise the dose-response relationship of adenosine on these variables relative to arrhythmia inducti...

journal_title：Cardiovascular research

authors： Kabell G,Buchanan LV,Gibson JK,Belardinelli L

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:The aim was to test the hypothesis that A1 receptor mediated cardioprotection by endogenous adenosine is exerted during ischaemia rather than reperfusion. METHODS:Anaesthetised open chest rabbits were subjected to 30 min regional ischaemia and 120 min reperfusion, and randomised to one of six groups: group I...

journal_title：Cardiovascular research

authors： Zhao ZQ,Nakanishi K,McGee DS,Tan P,Vinten-Johansen J

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:After-depolarization associated arrhythmias are frequently observed in heart failure and associated with spontaneous calcium release from sarcoplasmic reticulum (SR), calcium after-transients. We hypothesize that disturbed SR calcium handling underlies calcium after-transients in heart failure (HF). METHODS:...

journal_title：Cardiovascular research

authors： Baartscheer A,Schumacher CA,Belterman CN,Coronel R,Fiolet JW

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the ventricular/vascular coupling of the intact right heart under conditions of normal operation and acute pulmonary hypertension. METHODS:Right ventricular contractility was obtained by calculating the end systolic pressure-volume relationship (Ees) and the effective pulmonary art...

journal_title：Cardiovascular research

authors： Fourie PR,Coetzee AR,Bolliger CT

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to explore the relationship between low density lipoprotein (LDL) and dendritic cell (DC) activation, based upon the hypothesis that reactive oxygen species (ROS)-mediated modification of proteins that may be present in local DC microenvironments could be important as mediators...

journal_title：Cardiovascular research

authors： Alderman CJ,Bunyard PR,Chain BM,Foreman JC,Leake DS,Katz DR

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:The aim was to characterise the influence of a decrease in transsarcolemmal calcium influx on the calcium content of the sarcoplasmic reticulum and on the force of postrest contraction, which is largely activated by calcium released from the sarcoplasmic reticulum. METHODS:Isometric force of postrest contrac...

journal_title：Cardiovascular research

authors： Komai H,Rusy BF

更新日期：1993-05-01 00:00:00

abstract：AIMS:Hyperhomocysteinaemia is an independent risk factor for atherosclerotic vascular disease and is associated with vascular endothelial dysfunction. Homocysteine modulates cellular methylation reactions. P66shc is a protein that promotes oxidative stress whose expression is governed by promoter methylation. We asked ...

journal_title：Cardiovascular research

authors： Kim CS,Kim YR,Naqvi A,Kumar S,Hoffman TA,Jung SB,Kumar A,Jeon BH,McNamara DM,Irani K

更新日期：2011-12-01 00:00:00

abstract：AIMS:Ventricular remodelling following myocardial infarction progressively leads to loss of contractile capacity and heart failure. Although calcineurin promotes maladaptive cardiac hypertrophy, we recently showed that the calcineurin splicing variant, CnAβ1, has beneficial effects on the infarcted heart. However, whet...

journal_title：Cardiovascular research

authors： López-Olañeta MM,Villalba M,Gómez-Salinero JM,Jiménez-Borreguero LJ,Breckenridge R,Ortiz-Sánchez P,García-Pavía P,Ibáñez B,Lara-Pezzi E

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to investigate the idea that altered fibroblast contractile activity is involved in the pathogenesis of hypertensive heart disease (HHD). METHODS:Cell area and contraction are quantified using the traction force microscopy technique for cardiac fibroblasts isolated from both normoten...

journal_title：Cardiovascular research

authors： Marganski WA,De Biase VM,Burgess ML,Dembo M

更新日期：2003-12-01 00:00:00

abstract：:The effect of axial rotation on flow through and pressure gradient across saphenous vein segments was studied using 15 cadaver long saphenous veins. A significant reduction in flow occurred at a mean rotation of 25 degrees/cm and a significant increase in head loss across the segments occurred at a mean rotation of 23...

journal_title：Cardiovascular research

authors： Gordon A,Williams J,Buxton B

更新日期：1975-07-01 00:00:00

abstract：:Microelectrode recordings of skin nerve sympathetic activity were made in the median nerve supplying the right hand of nine patients with Raynaud's phenomenon and 10 control subjects. With subjects warmed up (finger temperature 33 to 34 degrees C) different manoeuvres were used to evoke strong, single sympathetic burs...

journal_title：Cardiovascular research

authors： Fagius J,Blumberg H

更新日期：1985-05-01 00:00:00

abstract：Aims:Chronic heart failure is becoming increasingly prevalent and is still associated with a high mortality rate. Myocardial hypertrophy and fibrosis drive cardiac remodelling and heart failure, but they are not sufficiently inhibited by current treatment strategies. Furthermore, despite increasing knowledge on cardiom...

journal_title：Cardiovascular research

authors： Grund A,Szaroszyk M,Döppner JK,Malek Mohammadi M,Kattih B,Korf-Klingebiel M,Gigina A,Scherr M,Kensah G,Jara-Avaca M,Gruh I,Martin U,Wollert KC,Gohla A,Katus HA,Müller OJ,Bauersachs J,Heineke J

更新日期：2019-01-01 00:00:00

abstract：AIMS:Adverse cardiovascular events in humans occur with a day/night pattern, presumably related to a daily pattern of behaviours or endogenous circadian rhythms in cardiovascular variables. Healthy humans possess a scale-invariant/fractal structure in heartbeat fluctuations that exhibits an endogenous circadian rhythm ...

journal_title：Cardiovascular research

authors： Hu K,Scheer FA,Buijs RM,Shea SA

更新日期：2008-10-01 00:00:00

abstract：AIMS:Our recent work demonstrated that common cardiovascular progenitor cells are characterized and induced by the expression of the transcription factor mesoderm posterior1 (MesP1) in vertebrate embryos and murine embryonic stem cells. As the proliferative potential of stem cell-derived cardiomyocytes is limited, it i...

journal_title：Cardiovascular research

authors： David R,Jarsch VB,Schwarz F,Nathan P,Gegg M,Lickert H,Franz WM

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Inhibitors of poly (ADP-ribose) synthetase (PARS) activity reduce the infarct size caused by regional myocardial ischaemia and reperfusion in the rabbit and rat in vivo. The mechanism of action of these inhibitors is unclear. Here we investigate the effects of the PARS inhibitor 3-aminobenzamide (3-AB) on inf...

journal_title：Cardiovascular research

authors： Bowes J,McDonald MC,Piper J,Thiemermann C

更新日期：1999-01-01 00:00:00

abstract：Aims:Heart failure (HF) produces left atrial (LA)-selective fibrosis and promotes atrial fibrillation. HF also causes adrenergic activation, which contributes to remodelling via a variety of signalling molecules, including the exchange protein activated by cAMP (Epac). Here, we evaluate the effects of Epac1-signalling ...

journal_title：Cardiovascular research

authors： Surinkaew S,Aflaki M,Takawale A,Chen Y,Qi XY,Gillis MA,Shi YF,Tardif JC,Chattipakorn N,Nattel S

更新日期：2019-01-01 00:00:00

abstract：:Muscle tissue in atrioventricular (A-V) cardiac valve leaflets was studied in 35 human hearts and was found to be more prominent in the anterior leaflet of the mitral (MAL) than in the other valve leaflets. From serial sectioning and wax model reconstruction, the anatomic arrangement of the muscle in the MAL indicates...

journal_title：Cardiovascular research

authors： Boucek RJ,Boucková B,Levy S

更新日期：1978-11-01 00:00:00

abstract：:Ischemic preconditioning is a well-established phenomenon first described in experimental preparations in which brief episodes of ischemia/reperfusion applied prior to a longer coronary artery occlusion reduce myocardial infarct size. There are ample correlates of ischemic preconditioning in the clinical realm. Precon...

journal_title：Cardiovascular research

authors： Kloner RA,Rezkalla SH

更新日期：2006-05-01 00:00:00

abstract：AIMS:Caveolae are membrane microdomains where important signalling pathways are assembled and molecular effects transduced. In this study, we hypothesized that shear stress-mediated vasodilation (SSD) of mouse small coronary arteries (MCA) is caveolae-dependent. METHODS AND RESULTS:MCA (80-150 μm) isolated from wild-t...

journal_title：Cardiovascular research

authors： Chai Q,Wang XL,Zeldin DC,Lee HC

更新日期：2013-10-01 00:00:00

abstract：:STUDY OBJECTIVE - The aim of the study was to reassess the role of reactive oxygen species in causing reperfusion arrhythmias, which they might do either by directly generating free oxygen radicals or by using scavengers of free oxygen radicals. DESIGN - Ventricular arrhythmias were studied in isolated rat hearts (n =...

journal_title：Cardiovascular research

authors： Coetzee WA,Owen P,Dennis SC,Saman S,Opie LH

更新日期：1990-02-01 00:00:00

abstract：AIMS:Exercise capacity is reduced in heart failure (HF) patients, due mostly to skeletal muscle abnormalities including impaired energy metabolism, mitochondrial dysfunction, fibre type transition, and atrophy. Glucagon-like peptide-1 (GLP-1) has been shown to improve exercise capacity in HF patients. We investigated t...

journal_title：Cardiovascular research

authors： Takada S,Masaki Y,Kinugawa S,Matsumoto J,Furihata T,Mizushima W,Kadoguchi T,Fukushima A,Homma T,Takahashi M,Harashima S,Matsushima S,Yokota T,Tanaka S,Okita K,Tsutsui H

更新日期：2016-09-01 00:00:00

abstract：AIMS:Following a large myocardial infarction (MI), remaining viable muscle often undergoes pathological remodelling and progresses towards chronic heart failure. Mitochondria may also be affected by this process and, due to their functional importance, likely contribute to the progression of the disease. Aerobic interv...

journal_title：Cardiovascular research

authors： Kraljevic J,Marinovic J,Pravdic D,Zubin P,Dujic Z,Wisloff U,Ljubkovic M

更新日期：2013-07-01 00:00:00

abstract：:Although fully explored in larger animals, the role of injection site and sample microsphere content on variability of coronary blood flow (CBF) measurement using the microsphere technique remains controversial in rats despite the fact that this species is extensively used in cardiovascular research. We therefore inve...

journal_title：Cardiovascular research

authors： Wicker PA,Healy BP

更新日期：1989-05-01 00:00:00

abstract：:Injudicious selection of a saphenous vein graft can adversely affect the the late postoperative patency of the proximal coronary artery which it bypasses. The purpose of this investigation was to deduce an upper bound for graft diameter, at small angle of distal anastomosis, below which the stenosed artery will remain...

journal_title：Cardiovascular research

authors： Moskowitz SE,Lewis BS,Milo S,Amar R

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND:The atrial natriuretic peptide (ANP) family is a complex system consisting of at least three polypeptides and at least three types of receptor. Each peptide interacts with different types of receptor at varying degrees of affinity. To determine if natriuretic peptide levels influence natriuretic peptide rece...

journal_title：Cardiovascular research

authors： Vera N,Tse MY,Watson JD,Sarda S,Steinhelper ME,John SW,Flynn TG,Pang SC

更新日期：2000-06-01 00:00:00

abstract：:A mathematical formulation of the blood flow behaviour through a capillaron model is described. The formulation is applied to the analysis of post-occlusion (reactive) hyperaemia and autoregulation. ...

journal_title：Cardiovascular research

authors： Murao H,Rodbard S

更新日期：1976-01-01 00:00:00

abstract：AIMS:Brugada syndrome (BrS) is an autosomal-inherited cardiac arrhythmia characterized by an ST-segment elevation in the right precordial leads of the electrocardiogram and an increased risk of syncope and sudden death. SCN5A, encoding the cardiac sodium channel Na(v)1.5, is the main gene involved in BrS. Despite the f...

journal_title：Cardiovascular research

authors： Clatot J,Ziyadeh-Isleem A,Maugenre S,Denjoy I,Liu H,Dilanian G,Hatem SN,Deschênes I,Coulombe A,Guicheney P,Neyroud N

更新日期：2012-10-01 00:00:00

abstract：UNLABELLED:This study hypothesized that female patients with chronic heart failure (CHF), similarly as previously reported for male patients, have a decreased proportion of type I (slow twitch) muscle fibers combined with fiber atrophy, and respond to exercise training with an increased muscular fiber area and performa...

journal_title：Cardiovascular research

authors： Tyni-Lenné R,Jansson E,Sylvén C

更新日期：1999-04-01 00:00:00