Induction of the calcineurin variant CnAβ1 after myocardial infarction reduces post-infarction ventricular remodelling by promoting infarct vascularization.

abstract：OBJECTIVE:We tested the hypothesis that simultaneous inhibition of the endothelial integrin alpha(v)beta(3) and the platelet glycoprotein IIb/IIIa receptor will substantially reduce infarct size in a model of acute coronary thrombosis and primary angioplasty. METHODS:Dogs were subjected to thrombus formation in the le...

journal_title：Cardiovascular research

authors： Sakuma T,Sari I,Goodman CN,Lindner JR,Klibanov AL,Kaul S

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:The mechanism of the protective effect of ischaemic preconditioning in the myocardium is not yet known. The aim of this study was to test the hypothesis that endogenous myocardial catecholamines may be mediators of preconditioning. METHODS:To test whether endogenous catecholamines are involved in preconditio...

journal_title：Cardiovascular research

authors： Weselcouch EO,Baird AJ,Sleph PG,Dzwonczyk S,Murray HN,Grover GJ

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:Calcitonin gene related peptide (CGRP) is a potent vasodilator found in sensory nerve endings in coronary arteries. The effect of intravenous CGRP on myocardial ischaemia, cardiovascular haemodynamics, and epicardial coronary artery stenoses was studied in patients with angina to investigate the possible role...

journal_title：Cardiovascular research

authors： Uren NG,Seydoux C,Davies GJ

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVE:Catechol O-methyltransferase (COMT) is believed to exert degradative action at high norepinephrine (NE) levels. Although COMT exists in cardiac tissues, the contribution of cardiac COMT activity to regional NE kinetics, particularly in ischemia-induced NE accumulation, remains unclear. We investigated the rol...

journal_title：Cardiovascular research

authors： Fujii T,Yamazaki T,Akiyama T,Sano S,Mori H

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVES:We performed the following study to define the effects of acute cardiac lymphatic obstruction on left ventricular (LV) systolic and diastolic function. METHODS:Cardiac lymphatic obstruction was created in 8 pentobarbital-anesthetized dogs by identifying (Evans blue) and ligating the right and left epicardia...

journal_title：Cardiovascular research

authors： Ludwig LL,Schertel ER,Pratt JW,McClure DE,Ying AJ,Heck CF,Myerowitz PD

更新日期：1997-01-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis, like the sympathetic nervous system and the renin-angiotensin-aldosterone (RAA) system, sustains life in stressful situations by increasing vascular tone and ensuring fuel availability. It also modulates inflammation and tissue repair processes. Untoward cardiovascular ef...

journal_title：Cardiovascular research

authors： Girod JP,Brotman DJ

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:Anisotropic conduction characteristics, which may be expressed as the ratio of conduction velocities in the longitudinal (Vlong) and transverse (Vtrans) fibre directions, have been shown to stabilise reentry and favour the induction of sustained, uniform ventricular tachycardia. The aim of this study was to i...

journal_title：Cardiovascular research

authors： Hélie F,Cossette J,Vermeulen M,Cardinal R

更新日期：1995-03-01 00:00:00

abstract：AIMS:Current mechanisms driving cardiac pacemaker function have focused on ion channel and gap junction channel function, which are essential for action potential generation and propagation between pacemaker cells. However, pacemaker cells also harbour desmosomes that structurally anchor pacemaker cells to each other i...

journal_title：Cardiovascular research

authors： Mezzano V,Liang Y,Wright AT,Lyon RC,Pfeiffer E,Song MY,Gu Y,Dalton ND,Scheinman M,Peterson KL,Evans SM,Fowler S,Cerrone M,McCulloch AD,Sheikh F

更新日期：2016-08-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is the most common type of arrhythmia in humans, yet the genetic cause of AF remains elusive. Genome-wide association studies (GWASs) have reported risk variants in four distinct genetic loci, and more recently, a meta-GWAS has further implicated six new loci in AF. However, the functional...

journal_title：Cardiovascular research

authors： Lozano-Velasco E,Hernández-Torres F,Daimi H,Serra SA,Herraiz A,Hove-Madsen L,Aránega A,Franco D

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Atrial (ANP) and B-type natriuretics peptides (BNP) via their guanylyl cyclase-A (GC-A) receptor not only regulate arterial blood pressure and volume but also exert local antihypertrophic, antifibrotic and lusitropic effects in the heart. To elucidate whether cardiac hypertrophy/insufficiency and reversal is ...

journal_title：Cardiovascular research

authors： Kuhn M,Voss M,Mitko D,Stypmann J,Schmid C,Kawaguchi N,Grabellus F,Baba HA

更新日期：2004-11-01 00:00:00

abstract：AIMS :Activation of the angiotensin (Ang)-(1-7)/Mas receptor (R) axis protects from sympathetic overactivity. Endocytic trafficking is an essential process that regulates receptor (R) function and its ultimate cellular responses. We investigated whether the blunted responses to Ang-(1-7) in hypertensive rats are associ...

journal_title：Cardiovascular research

authors： Cerniello FM,Silva MG,Carretero OA,Gironacci MM

更新日期：2020-10-01 00:00:00

abstract：Aims:β1-adrenergic receptor autoantibodies (β1-AAs) and β2-adrenergic receptor autoantibodies (β2-AAs) are present in patients with heart failure (HF); however, their interrelationship with cardiac structure and function remains unknown. This study explored the effects of the imbalance between β1-AAs and β2-AAs on card...

journal_title：Cardiovascular research

authors： Cao N,Chen H,Bai Y,Yang X,Xu W,Hao W,Zhou Y,Chai J,Wu Y,Wang Z,Yin X,Wang L,Wang W,Liu H,Fu MLX

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to determine whether exercise training could precondition the myocardium against hydrogen peroxide (H(2)O(2))-induced damage. METHODS:Male Fischer 344 rats ran on a treadmill for 9 weeks (60 min/day, 22 m/min, 6 degrees grade, 5 days/week). Isolated perfused working hearts from ...

journal_title：Cardiovascular research

authors： Taylor RP,Ciccolo JT,Starnes JW

更新日期：2003-06-01 00:00:00

abstract：AIMS:Regulated cell death is a main contributor of myocardial ischaemia-reperfusion (IR) injury during acute myocardial infarction. In this context, targeting apoptosis could be a potent therapeutical strategy. In a previous study, we showed that DAXX (death-associated protein) was essential for transducing the FAS-dep...

journal_title：Cardiovascular research

authors： Boisguérin P,Covinhes A,Gallot L,Barrère C,Vincent A,Busson M,Piot C,Nargeot J,Lebleu B,Barrère-Lemaire S

更新日期：2020-03-01 00:00:00

abstract：AIMS:Our previous studies demonstrated that inflammation contributes to atherosclerosis through disruption of the low density lipoprotein receptor (LDLr) pathway. However, this effect is overridden by rapamycin, which is an inhibitor of mammalian target of rapamycin (mTOR). This study investigated the role of the mTOR ...

journal_title：Cardiovascular research

authors： Ma KL,Liu J,Wang CX,Ni J,Zhang Y,Wu Y,Lv LL,Ruan XZ,Liu BC

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:The aim was to determine if isolated rabbit cardiomyocytes could be preconditioned. METHODS:Cardiomyocytes isolated from rabbit hearts were subjected to 15 min oxygenated preincubation, with and without substrate, prior to concentration into an ischaemic slurry, with or without glucose present. The effects o...

journal_title：Cardiovascular research

authors： Armstrong S,Downey JM,Ganote CE

更新日期：1994-01-01 00:00:00

abstract：AIMS:To define the molecular mechanisms of cardiotoxicity induced by Sunitinib and to identify the role of biological sex in modulating toxicity. METHODS AND RESULTS:Exposure of isolated cardiomyocytes to plasma-relevant concentrations of Sunitinib and other tyrosine kinase inhibitors produces a broad spectrum of abno...

journal_title：Cardiovascular research

authors： Harvey PA,Leinwand LA

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:The aim was to characterise the influence of a decrease in transsarcolemmal calcium influx on the calcium content of the sarcoplasmic reticulum and on the force of postrest contraction, which is largely activated by calcium released from the sarcoplasmic reticulum. METHODS:Isometric force of postrest contrac...

journal_title：Cardiovascular research

authors： Komai H,Rusy BF

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate whether intrinsic cardiac neurones can be involved in the genesis of ventricular arrhythmias. METHODS:Nicotinic, muscarinic, beta adrenergic, peptidergic, and amino acidergic agonists, as well as purinergic compounds, were individually administered in microliter quantities adjacent...

journal_title：Cardiovascular research

authors： Huang MH,Wolf SG,Armour JA

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:To determine the role of calcineurin and Src tyrosine kinase in the regulation of inducible nitric oxide synthase (iNOS) expression and protection in cardiomyocytes. METHODS:iNOS expression was studied in isolated neonatal rat ventricular myocyte cultures in response to bacterial lipopolysaccharide (LPS) or ...

journal_title：Cardiovascular research

authors： Obasanjo-Blackshire K,Mesquita R,Jabr RI,Molkentin JD,Hart SL,Marber MS,Xia Y,Heads RJ

更新日期：2006-09-01 00:00:00

abstract：:The association of nitric oxide (NO) with cardiovascular disease has long been recognized and the extensive research on this topic has revealed both pro- and anti-atherosclerotic effects. While these contradictory findings were initially perplexing recent studies offer molecular mechanisms for the integration of these...

journal_title：Cardiovascular research

authors： Patel RP,Levonen A,Crawford JH,Darley-Usmar VM

更新日期：2000-08-18 00:00:00

abstract：AIMS:Recent publications have shed new light on the role of the adaptive and innate immune system in the pathogenesis of hypertension. However, there are limited data whether receptors of the innate immune system may influence blood pressure. Toll-like receptor 4 (TLR4), a pattern recognition receptor, is a key compone...

journal_title：Cardiovascular research

authors： Sollinger D,Eißler R,Lorenz S,Strand S,Chmielewski S,Aoqui C,Schmaderer C,Bluyssen H,Zicha J,Witzke O,Scherer E,Lutz J,Heemann U,Baumann M

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:The presence is well established in unstable angina of intracoronary thrombosis in a stenosed epicardial coronary artery. The effects of the thrombus formation on the distal microcirculation are however still unclear. METHODS:We adapted the Folts canine model of left circumflex coronary arterial stenosis and...

journal_title：Cardiovascular research

authors： Mansaray M,Belcher PR,Vergroesen I,Wright ZM,Hynd JW,Drake-Holland AJ,Noble MI

更新日期：1999-04-01 00:00:00

abstract：:The distribution of neuropeptide Y (NPY) in the rat cardiovascular system has been examined by radioimmunoassay, chromatographic analysis of tissue extracts, and immunocytochemistry. High concentrations of NPY were identified throughout the heart and within the major blood vessels of the rat in particular in the renal...

journal_title：Cardiovascular research

authors： Allen JM,Polak JM,Rodrigo J,Darcy K,Bloom SR

更新日期：1985-09-01 00:00:00

abstract：:Mayer waves are oscillations of arterial pressure occurring spontaneously in conscious subjects at a frequency lower than respiration (approximately 0.1 Hz in humans). Mayer waves are tightly coupled with synchronous oscillations of efferent sympathetic nervous activity and are almost invariably enhanced during states...

journal_title：Cardiovascular research

authors： Julien C

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVES:Collagen synthesis is one of the major mechanisms of primary atherosclerotic plaque growth and is likely to be similarly important in restenosis. The patterns of collagen gene expression in human restenosis and associations with thrombosis/hemorrhage have not been described. METHODS:Using human coronary art...

journal_title：Cardiovascular research

authors： Rekhter MD,O'Brien E,Shah N,Schwartz SM,Simpson JB,Gordon D

更新日期：1996-09-01 00:00:00

abstract：:It has long been known that gap junctions are required for the propagation of electrical impulse in the heart. A good deal later, the connexins (Cxs), which are probably exclusive components of the junctional channels that constitute the gap junctions, were identified. More recently, the in vivo functions of cardiac C...

journal_title：Cardiovascular research

authors： Gros D,Dupays L,Alcoléa S,Meysen S,Miquerol L,Théveniau-Ruissy M

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:To investigate changes in human atrial single cell functional electrophysiological properties associated with chronic atrial fibrillation (AF), and the contribution to these of accompanying ion current changes. METHODS:The whole cell patch clamp technique was used to record action potentials, the effective r...

journal_title：Cardiovascular research

authors： Workman AJ,Kane KA,Rankin AC

更新日期：2001-11-01 00:00:00

abstract：AIMS:The mesenchymal cushions lining the early embryonic heart undergo complex remodelling to form the membranous ventricular septum as well as the atrioventricular and semilunar valves in later life. Disruption of this process underlies the most common congenital heart defects. Here, we identified a novel role for Sli...

journal_title：Cardiovascular research

authors： Mommersteeg MT,Yeh ML,Parnavelas JG,Andrews WD

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:We studied the effects of chronic left coronary artery ligation on cardiac structure and function in the mouse. METHODS:Morphometric studies of the left ventricle were performed in coronary artery-ligated and sham-operated animals at one, two, three and five weeks after surgery. The fraction of DNA-synthesi...

journal_title：Cardiovascular research

authors： Lutgens E,Daemen MJ,de Muinck ED,Debets J,Leenders P,Smits JF

更新日期：1999-03-01 00:00:00