Mas receptor is translocated to the nucleus upon agonist stimulation in brainstem neurons from spontaneously hypertensive rats but not normotensive rats.

abstract：AIMS:Germ-line mutations in genes encoding components of the RAS/mitogen-activated protein kinase (MAPK) pathway cause developmental disorders called RASopathies. Hypertrophic cardiomyopathy (HCM) is the most common myocardial pathology and a leading cause of death in RASopathy patients. KRAS mutations are found in Noo...

journal_title：Cardiovascular research

authors： Dalin MG,Zou Z,Scharin-Täng M,Safari R,Karlsson C,Bergo MO

更新日期：2014-02-01 00:00:00

abstract：:The mechanical, haemodynamic, and energetic functions of isolated perfused working hearts from chronic alcoholic and control rats were studied. Male Long-Evans rats were fed a nutritionally-complete liquid diet containing 38% of daily calories as ethanol (isocaloric replacement with dextrin-maltose for controls) for 3...

journal_title：Cardiovascular research

authors： Segel LD,Rendig SV,Mason DT

更新日期：1979-03-01 00:00:00

abstract：AIMS:Alteration of connexin43 (Cx43)-mediated intercellular communication is known to promote susceptibility to ventricular tachyarrhythmias. However, the precise mechanism of the altered Cx43 responsible for arrhythmogenesis remains unclear. We sought to understand changes in impulse propagation of ventricular myocyte...

journal_title：Cardiovascular research

authors： Nakagami T,Tanaka H,Dai P,Lin SF,Tanabe T,Mani H,Fujiwara K,Matsubara H,Takamatsu T

更新日期：2008-07-01 00:00:00

abstract：AIMS:In cardiomyocytes, protein kinase D1 (PKD1) plays a central role in the response to stress signals. From a yeast two-hybrid assay, we have identified Enigma Homolog 1 (ENH1) as a new binding partner of PKD1. Since in neurons, ENH1, associated with protein kinase Cepsilon, was shown to modulate the activity of N-ty...

journal_title：Cardiovascular research

authors： Maturana AD,Wälchli S,Iwata M,Ryser S,Van Lint J,Hoshijima M,Schlegel W,Ikeda Y,Tanizawa K,Kuroda S

更新日期：2008-06-01 00:00:00

abstract：:Sudden cardiac death, which is mainly associated with the presence of life-threatening ventricular arrhythmias, is a common 'killer' among patients with coronary artery disease. Moreover, atrial fibrillation is the most common arrhythmia encountered in the clinical practice. The beneficial effect of statins on cardiov...

journal_title：Cardiovascular research

authors： Kostapanos MS,Liberopoulos EN,Goudevenos JA,Mikhailidis DP,Elisaf MS

更新日期：2007-07-01 00:00:00

abstract：AIMS:Melusin is a muscle-specific chaperone protein whose expression is required for a compensatory hypertrophy response to pressure overload. Here, we evaluated the consequences of melusin overexpression in the setting of myocardial infarction (MI) using a comprehensive multicentre approach. METHODS AND RESULTS:Mice ...

journal_title：Cardiovascular research

authors： Unsöld B,Kaul A,Sbroggiò M,Schubert C,Regitz-Zagrosek V,Brancaccio M,Damilano F,Hirsch E,Van Bilsen M,Munts C,Sipido K,Bito V,Detre E,Wagner NM,Schäfer K,Seidler T,Vogt J,Neef S,Bleckmann A,Maier LS,Balligand JL,

更新日期：2014-01-01 00:00:00

abstract：:Since the establishment of the inflammatory basis of atherosclerosis, several pro- or anti-inflammatory agents have been examined as potential mediators of the biochemical pathways of lesion formation. Interleukin (IL)-8 was first characterized in 1987. Since then, knowledge regarding its role in leucocyte trafficking...

journal_title：Cardiovascular research

authors： Apostolakis S,Vogiatzi K,Amanatidou V,Spandidos DA

更新日期：2009-12-01 00:00:00

abstract：AIMS:Ischaemia-reperfusion provokes barrier failure of the coronary microvasculature, impeding functional recovery of the heart during reperfusion. The aim of the present study was to investigate whether the stimulation of cGMP signalling by activation of soluble guanylyl cyclase (sGC) can reduce reperfusion-induced en...

journal_title：Cardiovascular research

authors： Kasseckert SA,Schäfer C,Kluger A,Gligorievski D,Tillmann J,Schlüter KD,Noll T,Sauer H,Piper HM,Abdallah Y

更新日期：2009-07-15 00:00:00

abstract：:Primary cardiomyopathy is an important cause of mortality in children and adults. Apart from inherited disorders of myocardial contractile and structural proteins, several defects of energy metabolism may cause cardiomyopathy. Most of the energy required for myocardial contraction is derived from aerobic metabolism. F...

journal_title：Cardiovascular research

authors： Antozzi C,Zeviani M

更新日期：1997-08-01 00:00:00

abstract：Aims:To investigate the role of chromobox protein homolog 3 (Cbx3) in vascular smooth muscle cell (VSMC) proliferation, migration, and neointima formation following vascular injury. Methods and results:Overexpression of Cbx3 led to a significant increase in VSMC contractile gene expression and VSMC apoptosis as well a...

journal_title：Cardiovascular research

authors： Zhang C,Chen D,Maguire EM,He S,Chen J,An W,Yang M,Afzal TA,Luong LA,Zhang L,Lei H,Wu Q,Xiao Q

更新日期：2018-03-01 00:00:00

abstract：AIMS:Acute migraine attack in familial hemiplegic migraine type 2 (FHM2) patients is characterized by sequential hypo- and hyperperfusion. FHM2 is associated with mutations in the Na, K-ATPase α2 isoform. Heterozygous mice bearing one of these mutations (α2+/G301R mice) were shown to have elevated cerebrovascular tone ...

journal_title：Cardiovascular research

authors： Staehr C,Rajanathan R,Postnov DD,Hangaard L,Bouzinova EV,Lykke-Hartmann K,Bach FW,Sandow SL,Aalkjaer C,Matchkov VV

更新日期：2020-10-01 00:00:00

abstract：:Supravalvar aortic banding was performed in 6 to 12 week puppies. Sixteen animals were studied 7.3 (3.5 to 10) months later, closed-chested under morphine-chloralose, catheters being positioned in the great vessels and heart, including the left atrium for microsphere injection. Compared with 11 controls, eight dogs de...

journal_title：Cardiovascular research

authors： Einzig S,Leonard JJ,Tripp MR,Lucas RV,Swayze CR,Fox IJ

更新日期：1981-12-01 00:00:00

abstract：:The effects of adrenaline on kinetically-distinct compartments of exchangeable calcium in the spontaneously-beating perfused rat heart were investigated under steady-state conditions using a 45Ca2+ outflow technique together with a nonlinear least-squares curve fitting procedure and 51Cr-EDTA to monitor the loss of fr...

journal_title：Cardiovascular research

authors： Lamont SV,Barritt GJ

更新日期：1983-02-01 00:00:00

abstract：:Congestive heart failure may be deemed the epidemic of cardiology in the 21st century in the industrialized part of the world. Although new therapies improving morbidity and mortality from chronic heart failure have emerged it is likely that there is a growing role for digoxin. Thus, digoxin treatment is known to cont...

journal_title：Cardiovascular research

authors： Kjeldsen K,Nørgaard A,Gheorghiade M

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:The aim was to study L type calcium current alterations in relation to the action potential lengthening induced by hypertrophy in isolated cardiomyocytes from the right ventricle of ferret. METHODS:Chronic pulmonary artery constriction was established in adult male ferrets under anaesthesia. Sham operated an...

journal_title：Cardiovascular research

authors： Bouron A,Potreau D,Raymond G

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVE:Evidence suggests important relationships among chronic inflammatory processes, endothelial dysfunction, hypertension and target organ damage. The present study examined the effects of chronic treatment with an anti-inflammatory p38 mitogen-activated protein kinase (MAPK) inhibitor (SB-239063AN) in the N(omeg...

journal_title：Cardiovascular research

authors： Olzinski AR,McCafferty TA,Zhao SQ,Behm DJ,Eybye ME,Maniscalco K,Bentley R,Frazier KS,Milliner CM,Mirabile RC,Coatney RW,Willette RN

更新日期：2005-04-01 00:00:00

abstract：Aims:Heart failure (HF) produces left atrial (LA)-selective fibrosis and promotes atrial fibrillation. HF also causes adrenergic activation, which contributes to remodelling via a variety of signalling molecules, including the exchange protein activated by cAMP (Epac). Here, we evaluate the effects of Epac1-signalling ...

journal_title：Cardiovascular research

authors： Surinkaew S,Aflaki M,Takawale A,Chen Y,Qi XY,Gillis MA,Shi YF,Tardif JC,Chattipakorn N,Nattel S

更新日期：2019-01-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to investigate observed differences in beta adrenergic and apparent non-beta-adrenergic binding of (-)[125I]-iodocyanopindolol (125I-ICYP). DESIGN:Binding parameters for several beta adrenergic agonists and antagonists were examined in radioligand binding assay, using 125I-ICYP as radioliga...

journal_title：Cardiovascular research

authors： Bjørnerheim R,Golf S,Hansson V

更新日期：1991-09-01 00:00:00

abstract：AIMS:Hyperhomocysteinaemia is an independent risk factor for atherosclerotic vascular disease and is associated with vascular endothelial dysfunction. Homocysteine modulates cellular methylation reactions. P66shc is a protein that promotes oxidative stress whose expression is governed by promoter methylation. We asked ...

journal_title：Cardiovascular research

authors： Kim CS,Kim YR,Naqvi A,Kumar S,Hoffman TA,Jung SB,Kumar A,Jeon BH,McNamara DM,Irani K

更新日期：2011-12-01 00:00:00

abstract：AIMS:Vascular remodelling and aortic aneurysm formation are induced mainly by inflammatory responses in the adventitia and media. However, relatively little is known about the mechanistic significance of endothelium in the pathogenesis of these vascular disorders. The transcription factor nuclear factor-kappa B (NF-κB)...

journal_title：Cardiovascular research

authors： Saito T,Hasegawa Y,Ishigaki Y,Yamada T,Gao J,Imai J,Uno K,Kaneko K,Ogihara T,Shimosawa T,Asano T,Fujita T,Oka Y,Katagiri H

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Effective endogenous fibrinolysis requires rapid release of endothelial tissue plasminogen activator (t-PA). Using the nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA), we examined the contribution of endogenous nitric oxide to substance P-induced t-PA release in vivo in man. METHODS:Blood f...

journal_title：Cardiovascular research

authors： Newby DE,Wright RA,Dawson P,Ludlam CA,Boon NA,Fox KA,Webb DJ

更新日期：1998-05-01 00:00:00

abstract：:Experimental studies have provided evidence that the autonomic nervous activity is modulated by oestrogen. Such modulation at central and peripheral levels tends to suppress sympathetic but elevate parasympathetic tone to the cardiovascular system. Thus, available data support the view that cardiovascular protection b...

journal_title：Cardiovascular research

authors： Du XJ,Riemersma RA,Dart AM

更新日期：1995-08-01 00:00:00

abstract：:Controversy exists as to whether the diabetic heart is more or less sensitive to ischemic injury. Although a considerable number of experimental studies have directly determined the effects of ischemia on the diabetic heart, there is still no general agreement as to whether metabolic changes within the myocardium cont...

journal_title：Cardiovascular research

authors： Feuvray D,Lopaschuk GD

更新日期：1997-04-01 00:00:00

abstract：AIMS:Brugada syndrome (BrS) is an autosomal-inherited cardiac arrhythmia characterized by an ST-segment elevation in the right precordial leads of the electrocardiogram and an increased risk of syncope and sudden death. SCN5A, encoding the cardiac sodium channel Na(v)1.5, is the main gene involved in BrS. Despite the f...

journal_title：Cardiovascular research

authors： Clatot J,Ziyadeh-Isleem A,Maugenre S,Denjoy I,Liu H,Dilanian G,Hatem SN,Deschênes I,Coulombe A,Guicheney P,Neyroud N

更新日期：2012-10-01 00:00:00

abstract：:Cardiomyocytes are long-lived post-mitotic cells with limited regenerative capacity. Proper cardiomyocyte function depends critically on the maintenance of a healthy homeostasis of protein expression, folding, assembly, trafficking, function, and degradation, together commonly referred to as proteostasis. Impairment o...

journal_title：Cardiovascular research

authors： Zhang D,Hu X,Henning RH,Brundel BJ

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:Atrial remodeling contributes to the maintenance of atrial fibrillation (AF) in several cardiac disorders. There is evidence that angiotensin-converting enzyme (ACE) inhibitors reduce the prevalence of AF in patients with congestive heart failure (CHF). There have been no studies performed to assess the effec...

journal_title：Cardiovascular research

authors： Shi Y,Li D,Tardif JC,Nattel S

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:The present study investigated whether activation of phosphatidylinositol 3-kinase (PI3-kinase) is involved in the stimulation of hypertrophic growth of adult ventricular cardiomyocytes under alpha- or beta-adrenoceptor stimulation. METHODS:Adult ventricular rat cardiomyocytes were used either directly after...

journal_title：Cardiovascular research

authors： Schlüter KD,Goldberg Y,Taimor G,Schäfer M,Piper HM

更新日期：1998-10-01 00:00:00

abstract：:We have used a miniature cadmium telluride detector in the assessment of muscle blood flow during dynamic exercise in man following local injection of 133Xenon. The results obtained were compared with those using a conventional sodium iodide detector. There was no significant difference between the results obtained wi...

journal_title：Cardiovascular research

authors： Smith RS,Bojsen J,Warren DJ

更新日期：1981-12-01 00:00:00

abstract：OBJECTIVES:5-Hydroxytryptamine (5-HT) has a wide range of vascular effects mediated via specific receptors and it has been suggested to be a mediator in ischemic heart disease. The aim of the present study was to localise the 5-HT receptors within the vessel wall. METHODS:Epicardial coronary arteries obtained from pat...

journal_title：Cardiovascular research

authors： Dahm PL,Bodelsson M,Törnebrandt K,Muddle JR,Sykes RM,Yacoub M,Dashwood MR

更新日期：1996-05-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to evaluate the protective effect of verapamil during myocardial ischaemia and reperfusion. DESIGN:In vivo phosphorus-31 (31P) magnetic resonance spectroscopy was performed on rats pretreated with verapamil (mg.kg-1 intraperitoneal) and controls during a 45 min left coronary artery occlusio...

journal_title：Cardiovascular research

authors： Wolfe CL,Donnelly TJ,Sievers R,Parmley WW

更新日期：1991-02-01 00:00:00