Effects of adrenaline on a compartment of slowly-exchangeable calcium in the perfused rat heart.

abstract：AIMS:Pulmonary hypertension (PH) is a devastating condition for which no disease-modifying therapies exist. PH is recognized as proliferative disease of the pulmonary artery (PA). In the experimental newborn calf model of hypoxia-induced PH, adventitial fibroblasts in the PA wall exhibit a heightened replication index....

journal_title：Cardiovascular research

authors： Panzhinskiy E,Zawada WM,Stenmark KR,Das M

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:To study the intracellular pathways which mediate the inhibitory actions of adenosine on isoprenaline-stimulated calcium current (ICa) in atrioventricular (AV) nodal myocytes. METHODS:The whole-cell patch-clamp technique was used to record ICa from rabbit AV nodal cells, isolated by enzymatic and mechanical ...

journal_title：Cardiovascular research

authors： Martynyuk AE,Kane KA,Cobbe SM,Rankin AC

更新日期：1997-05-01 00:00:00

abstract：AIMS:Regional heterogeneities in contraction contribute to heart failure with reduced ejection fraction (HFrEF). We aimed to determine whether regional changes in myocardial relaxation similarly contribute to diastolic dysfunction in post-infarction HFrEF, and to elucidate the underlying mechanisms. METHODS AND RESULT...

journal_title：Cardiovascular research

authors： Røe ÅT,Ruud M,Espe EK,Manfra O,Longobardi S,Aronsen JM,Nordén ES,Husebye T,Kolstad TRS,Cataliotti A,Christensen G,Sejersted OM,Niederer SA,Andersen GØ,Sjaastad I,Louch WE

更新日期：2019-03-15 00:00:00

abstract：OBJECTIVE:Decay kinetics of the voltage-gated L-type Ca(2+) current (I(CaL)) control the magnitude of Ca(2+) influx during the cardiac action potential. We investigated the influence of changes in diastolic membrane potential on I(CaL) decay kinetics in cardiac cells. METHODS:Cells were isolated enzymatically from rat...

journal_title：Cardiovascular research

authors： Barrère-Lemaire S,Piot C,Leclercq F,Nargeot J,Richard S

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:Migration and proliferation of arterial smooth muscle cells are critical responses during restenosis after balloon angioplasty. We investigated the changes in the expression of Ca(2+) channels and dystrophin, two determinants of contraction, after balloon injury of rat aortas. METHODS:Proliferation and migra...

journal_title：Cardiovascular research

authors： Quignard JF,Harricane MC,Ménard C,Lory P,Nargeot J,Capron L,Mornet D,Richard S

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:Increased pulse pressure has been observed in aging subjects, but the impact on the structure and reactivity of small arteries has been scarcely evaluated. METHODS:This study presents the modifications of vascular structure and function observed in female rats of 5, 18 and 32 months of age, and their relatio...

journal_title：Cardiovascular research

authors： Moreau P,d'Uscio LV,Lüscher TF

更新日期：1998-01-01 00:00:00

abstract：:Blood flow autoregulation results from the ability of resistance arteries to reduce or increase their diameters in response to changes in intravascular pressure. The mechanism by which arteries maintain a constant blood flow to organs over a range of pressures relies on this myogenic response, which defines the intrin...

journal_title：Cardiovascular research

authors： Kauffenstein G,Laher I,Matrougui K,Guérineau NC,Henrion D

更新日期：2012-07-15 00:00:00

abstract：:Felodipine (4(2,3-dichlorophenyl)-1,4-dihydro-2, 6-dimethyl-3-ethoxycarbonyl-5-methoxycarbonyl pyridine)), a selective vasodilating anti-hypertensive drug, was used in the treatment of spontaneously hypertensive rats (SHRs) and age-matched Wistar-Kyoto rats (WKYs) from age 6 to 14 weeks, ie during the time of high blo...

journal_title：Cardiovascular research

authors： Nyborg NC,Mulvany MJ

更新日期：1985-09-01 00:00:00

abstract：:To determine the effect of an anteroseptal myocardial infarction on right ventricular systolic and diastolic function, we studied 12 pigs before and 1 h after left anterior descending coronary artery occlusion. Total arterial occlusion was achieved by the percutaneous, transcatheter placement of a 1 mm Teflon plug int...

journal_title：Cardiovascular research

authors： Lancaster LD,Kern KB,Morrison DA,Olajos M,Goldman S

更新日期：1989-01-01 00:00:00

abstract：AIMS:Coronary arteritis is a life-threatening complication that may arise in the acute stage of Kawasaki disease (KD), the leading cause of systemic vasculitis in childhood. Various microorganisms and molecular pathogens have been reported to cause KD. However, little is known about the key molecules that contribute to...

journal_title：Cardiovascular research

authors： Nakashima Y,Sakai Y,Mizuno Y,Furuno K,Hirono K,Takatsuki S,Suzuki H,Onouchi Y,Kobayashi T,Tanabe K,Hamase K,Miyamoto T,Aoyagi R,Arita M,Yamamura K,Tanaka T,Nishio H,Takada H,Ohga S,Hara T

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Matrix metalloproteinase-9 (MMP-9) activity is up regulated in the heart subjected to ischemic insult. Whether increased MMP-9 activity contributes to acute myocardial injury after ischemia-reperfusion remains unknown. To investigate the role of MMP-9 in myocardial infarction, we utilized a MMP-9 knockout mou...

journal_title：Cardiovascular research

authors： Romanic AM,Harrison SM,Bao W,Burns-Kurtis CL,Pickering S,Gu J,Grau E,Mao J,Sathe GM,Ohlstein EH,Yue TL

更新日期：2002-06-01 00:00:00

abstract：:The development of the heart is a complex process during which different cell types progressively contribute to shape a four-chambered pumping organ. Over the last decades, our understanding of the specification and transcriptional regulation of cardiac development has been greatly augmented as has our understanding o...

journal_title：Cardiovascular research

authors： Franco D,Chinchilla A,Daimi H,Dominguez JN,Aránega A

更新日期：2011-07-15 00:00:00

abstract：AIMS:Recent publications have shed new light on the role of the adaptive and innate immune system in the pathogenesis of hypertension. However, there are limited data whether receptors of the innate immune system may influence blood pressure. Toll-like receptor 4 (TLR4), a pattern recognition receptor, is a key compone...

journal_title：Cardiovascular research

authors： Sollinger D,Eißler R,Lorenz S,Strand S,Chmielewski S,Aoqui C,Schmaderer C,Bluyssen H,Zicha J,Witzke O,Scherer E,Lutz J,Heemann U,Baumann M

更新日期：2014-03-01 00:00:00

abstract：:We studied the effects of intracoronary vasopressin on the relationship between pressure and flow in the coronary circulation of anaesthetised swine. In addition to measurements at control levels, diastolic pressure-flow relationships were constructed from steady-state points below a coronary pressure of 50 mmHg, wher...

journal_title：Cardiovascular research

authors： Pantely GA,Ladley HD,Anselone CG,Bristow JD

更新日期：1985-07-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of the ATP-sensitive potassium (KATP) channel inhibitor sodium 5-hydroxydecanoate (5-HD) on the reduction in myocardial infarct size afforded by ischaemic preconditioning in the sodium pentobarbitone rabbit. METHODS:New Zealand white rabbits were anaesthetised with sodium pentobarbi...

journal_title：Cardiovascular research

authors： Hide EJ,Thiemermann C

更新日期：1996-06-01 00:00:00

abstract：:End-diastolic current thresholds have been measured in 12 open-chested dogs with epicardial disc electrodes ranging in radius from 0.01 to 9.0 mm. The current threshold for cathodal 1 ms impulses proved to be independent of electrode size for radii smaller than 0.2 mm and proportional to the radius to the power 1.5 fo...

journal_title：Cardiovascular research

authors： Lindemans FW,Denier Van der Gon JJ

更新日期：1978-08-01 00:00:00

abstract：:To evaluate the effect of beta blockade on energy metabolism in ischaemic myocardium metoprolol tartrate in doses of 0.2 or 0.5 mg.kg-1 or saline was injected into 24 anaesthetised dogs 20 min after coronary ligation. Regional myocardial blood flow was measured by the hydrogen gas clearance method, and the heart rate ...

journal_title：Cardiovascular research

authors： Nanki M,Itoh K,Matsubara T,Nishimura K,Kambe T,Sugiyama S,Ozawa T,Sakamoto N

更新日期：1987-09-01 00:00:00

abstract：AIMS:Chronic heart failure is a complex clinical syndrome with impaired myocardial contractility. In failing cardiomyocytes, decreased signalling efficiency between the L-type Ca(2+) channels (LCCs) in the plasma membrane (including transverse tubules, TTs) and the ryanodine receptors (RyRs) in the sarcoplasmic reticul...

journal_title：Cardiovascular research

authors： Zhang HB,Li RC,Xu M,Xu SM,Lai YS,Wu HD,Xie XJ,Gao W,Ye H,Zhang YY,Meng X,Wang SQ

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:During reperfusion of ischaemic myocardium, Na+/H+ exchange promotes recovery from acidosis resulting in an accumulation of intracellular Na+. This leads to calcium overload via Na+/Ca2+ exchange and might result in cell necrosis contributing to reperfusion injury. METHODS AND RESULTS:We assessed whether HO...

journal_title：Cardiovascular research

authors： Rohmann S,Weygandt H,Minck KO

更新日期：1995-12-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to evaluate the thrombolytic efficacy of recombinant double chain tissue plasminogen activator (Duteplase, t-PA) given as a single intravenous bolus versus an infusion in a canine model of coronary arterial occlusion/reperfusion. DESIGN:Coronary arterial thrombi were induced by a copper coi...

journal_title：Cardiovascular research

authors： Longridge DJ,Follenfant MJ,Ford AJ

更新日期：1991-03-01 00:00:00

abstract：:To provide further evidence that the veratrum alkaloids' mechanical, positive inotropic effect and not their chemical depolarising action predominates in initiating the left ventricular mechanoreceptor (including the Bezold) reflex the effect of intracoronary KCl, a chemical depolarising agent like the veratrum alkalo...

journal_title：Cardiovascular research

authors： Estrin JA,Wahler GM,Booth AM,Swayze CR,Fox IJ

更新日期：1984-08-01 00:00:00

abstract：:Ischemic preconditioning is a powerful biologic phenomenon that activates innate cell survival programs to protect the heart from ischemic injury. The preponderance of research into classical ischemic preconditioning has focused on signaling pathways orchestrating cardioprotection. Conceptually classified into trigger...

journal_title：Cardiovascular research

authors： Minners J,McLeod CJ,Sack MN

更新日期：2003-07-01 00:00:00

abstract：:The effect of adding fibrinolytic to penicillin therapy in experimentally induced streptococcal bacterial endocarditis has been studied in the rabbit. In 9 day old infected lesions, the vegetations could be substantially reduced in size after a 3 day course of intravenous streptokinase. Quantitative microbiological te...

journal_title：Cardiovascular research

authors： Johnson CE,Dewar HA,Aherne WA

更新日期：1980-08-01 00:00:00

abstract：:Oxygen-derived free radicals are thought to contribute to the initiation and progression of cardiovascular disease via several different mechanisms, such as consumption of nitric oxide, oxidation of proteins and lipids, and activation of redox-sensitive signalling cascades. Vascular NADPH oxidases are important source...

journal_title：Cardiovascular research

authors： Brandes RP,Kreuzer J

更新日期：2005-01-01 00:00:00

abstract：:CaMKII is a serine-threonine protein kinase that is abundant in myocardium. Emergent evidence suggests that CaMKII may play an important role in promoting atrial fibrillation (AF) by targeting a diverse array of proteins involved in membrane excitability, cell survival, calcium homeostasis, matrix remodelling, inflamm...

journal_title：Cardiovascular research

authors： Mesubi OO,Anderson ME

更新日期：2016-04-01 00:00:00

abstract：:Cardiomyocytes are long-lived post-mitotic cells with limited regenerative capacity. Proper cardiomyocyte function depends critically on the maintenance of a healthy homeostasis of protein expression, folding, assembly, trafficking, function, and degradation, together commonly referred to as proteostasis. Impairment o...

journal_title：Cardiovascular research

authors： Zhang D,Hu X,Henning RH,Brundel BJ

更新日期：2016-04-01 00:00:00

abstract：:This review attempts to define the early events that lead to lesions of human atherosclerosis based on careful morphological studies in human autopsy specimens. In contrast to most small laboratory animals, diffuse intimal thickening (DIT) is present in human arteries before atherosclerosis develops, particularly in t...

journal_title：Cardiovascular research

authors： Nakashima Y,Wight TN,Sueishi K

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:To determine whether the cytokine cardiotrophin-1 (CT-1) can protect the adult heart against ischaemia/reperfusion when added either prior to ischaemia or at reperfusion. BACKGROUND:CT-1 has previously been shown to protect cultured embryonic or neonatal cardiocytes from cell death. To assess the therapeuti...

journal_title：Cardiovascular research

authors： Liao Z,Brar BK,Cai Q,Stephanou A,O'Leary RM,Pennica D,Yellon DM,Latchman DS

更新日期：2002-03-01 00:00:00

abstract：:The influence of experimental diabetes on the endothelium mediated relaxation and contractile responses of canine isolated coronary arteries was studied in arteries removed from alloxan treated diabetic (280 mmol.kg-1) and control mongrel dogs. Strips with and without endothelium were suspended in Krebs bicarbonate so...

journal_title：Cardiovascular research

authors： Gebremedhin D,Koltai MZ,Pogátsa G,Magyar K,Hadházy P

更新日期：1988-08-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to evaluate the influence that centrally administered angiotensin-II has on the intrarenal renin-angiotensin system and renal sympathetic nerve activity. DESIGN:Renal responses to centrally administered angiotensin-II (10 micrograms) or saralasin (50 micrograms) were measured in anaesthetis...

journal_title：Cardiovascular research

authors： Weekley LB

更新日期：1991-05-01 00:00:00