Current thresholds and liminal size in excitation of heart muscle.

abstract：OBJECTIVE:A circadian rhythm of blood pressure has been demonstrated both in subjects who are physically active during the day and in those confined to bed. The study of the circadian rhythm of arterial flow and peripheral resistance, on the other hand, is limited to pioneer experiments. This paper is aimed at demonstr...

journal_title：Cardiovascular research

authors： Casiglia E,Pizziol A,Piacentini F,Biasin R,Onesto C,Tikhonoff V,Prati R,Palatini P,Pessina AC

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate whether infusion of either atrial natriuretic factor (ANF, 800 ng.h-1.rat-1) or a specific inhibitory of neutral endopeptidase 24.11 (NEI, UK 73,967, 5.4 mg.kg-1.d-1) can influence the reversal of the pulmonary vascular remodelling produced by exposure to hypoxia. METHODS:Male Wist...

journal_title：Cardiovascular research

authors： Zhao L,Hughes JM,Winter RJ

更新日期：1994-04-01 00:00:00

abstract：AIMS:Atherosclerotic vascular disease has an inflammatory pathogenesis. Heme from intraplaque hemorrhage may drive a protective and pro-resolving macrophage M2-like phenotype, Mhem, via AMPK and ATF1. The anti-diabetic drug metformin may also activate AMPK-dependent signalling. HYPOTHESIS:Metformin systematically indu...

journal_title：Cardiovascular research

authors： Seneviratne A,Cave L,Hyde G,Moestrup SK,Carling D,Mason JC,Haskard DO,Boyle JJ

更新日期：2020-07-15 00:00:00

abstract：AIMS:For the majority of congenital heart diseases (CHDs), the full complexity of the causative molecular network, which is driven by genetic, epigenetic, and environmental factors, is yet to be elucidated. Epigenetic alterations are suggested to play a pivotal role in modulating the phenotypic expression of CHDs and t...

journal_title：Cardiovascular research

authors： Grunert M,Dorn C,Cui H,Dunkel I,Schulz K,Schoenhals S,Sun W,Berger F,Chen W,Sperling SR

更新日期：2016-10-01 00:00:00

abstract：:The contractile response to beta-adrenoceptor stimulation has been found to be reduced in single myocytes from failing human ventricle. A portion of that reduction was statistically related to the age of the patient. We have developed a method for obtaining viable contracting myocytes from small biopsies of human vent...

journal_title：Cardiovascular research

authors： Davies CH,Ferrara N,Harding SE

更新日期：1996-01-01 00:00:00

abstract：:To investigate the effects of sodium-potassium activated adenosine triphosphatase inhibition on central cardiovascular regulation a microinjection of ouabain was given into the hypothalamus of urethane anaesthetised rats. Doses of 0.01-1.0 micrograms per rat injected into the posterior hypothalamus produced a rise in ...

journal_title：Cardiovascular research

authors： Iyoda I,Takahashi H,Lee LC,Okajima H,Inoue A,Sasaki S,Takeda K,Yoshimura M,Ijichi H

更新日期：1986-04-01 00:00:00

abstract：AIMS:Diabetes impinges upon mechanisms of cardiovascular repair. However, the biochemical adaptation of cardiac stem cells to sustained hyperglycaemia remains largely unknown. Here, we investigate the molecular targets of high glucose-induced damage in cardiac progenitor cells (CPCs) from murine and human hearts and at...

journal_title：Cardiovascular research

authors： Katare R,Oikawa A,Cesselli D,Beltrami AP,Avolio E,Muthukrishnan D,Munasinghe PE,Angelini G,Emanueli C,Madeddu P

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:After-depolarization associated arrhythmias are frequently observed in heart failure and associated with spontaneous calcium release from sarcoplasmic reticulum (SR), calcium after-transients. We hypothesize that disturbed SR calcium handling underlies calcium after-transients in heart failure (HF). METHODS:...

journal_title：Cardiovascular research

authors： Baartscheer A,Schumacher CA,Belterman CN,Coronel R,Fiolet JW

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:We propose that ischemic preconditioning (IPC) and mitochondrial K(ATP) channel activation protect the myocardium by inhibiting mitochondrial permeability transition pore (MPTP) opening at reperfusion. METHODS:Isolated rat hearts were subjected to 35 min ischemia/120 min reperfusion and assigned to the follo...

journal_title：Cardiovascular research

authors： Hausenloy DJ,Maddock HL,Baxter GF,Yellon DM

更新日期：2002-08-15 00:00:00

abstract：OBJECTIVE:We have attempted to demonstrate the induction of inducible nitric oxide synthase in human vascular tissue and define the capacity of different cytokines to induce this enzyme. METHODS:Segments of human arteries were stimulated with lipopolysaccharide (10 micrograms/ml), interleukin-1 beta (5 U/ml), tumor ne...

journal_title：Cardiovascular research

authors： Chester AH,Borland JA,Buttery LD,Mitchell JA,Cunningham DA,Hafizi S,Hoare GS,Springall DR,Polak JM,Yacoub MH

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:Important physiological and pathophysiological conditions are associated with changes in secretion and synthesis of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP). The aim of this study was to examine the effects of mechanical stretch and endothelin-1 on ANF and BNP secretion and gene exp...

journal_title：Cardiovascular research

authors： Bruneau BG,de Bold AJ

更新日期：1994-10-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to compare the temporal sequence and structural relationship between perivascular and interstitial fibrosis and microscopic scarring seen in the left ventricle in response to either a transient or sustained stimulus to fibrosis. DESIGN:In 72 male Wistar rats (250-350 g) the transient stimul...

journal_title：Cardiovascular research

authors： Silver MA,Pick R,Brilla CG,Jalil JE,Janicki JS,Weber KT

更新日期：1990-09-01 00:00:00

abstract：:The static elastic properties of the aorta ad systolic blood pressure in the caudal artery have been measured in 55 spontaneously hypertensive rats of the AS strain. Animals were divided into five groups and treated from the age of 4 to 12 weeks as follows: (1) 0.25 mm silver clip positioned around the right renal art...

journal_title：Cardiovascular research

authors： Berry CL,Greenwald SE,Menahem N

更新日期：1981-07-01 00:00:00

abstract：AIMS:A problem in generating artificial tissues is supplying nutrients to cells within 3D constructs. The use of a decellularized biological vascularized matrix with preserved pedicles (BioVaM), as a scaffold, appears to aid the generation of perfusable tissue constructs in vitro. To prevent vessel occlusion upon impla...

journal_title：Cardiovascular research

authors： Bär A,Dorfman SE,Fischer P,Hilfiker-Kleiner D,Cebotari S,Tudorache I,Suprunov M,Haverich A,Hilfiker A

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether chronic beta-adrenergic receptor (beta-AR) stimulation induces proliferation of human cardiac fibroblasts and to investigate the mechanism(s) involved. METHODS AND RESULTS:In vitro cultures of human cardiac fibroblasts were established from biopsies of right atr...

journal_title：Cardiovascular research

authors： Turner NA,Porter KE,Smith WH,White HL,Ball SG,Balmforth AJ

更新日期：2003-03-01 00:00:00

abstract：AIMS:Thromboxane A2 (TXA2) induces platelet adhesion through thromboxane prostanoid (TP) receptor. Platelets contain many pro-angiogenic factors and are recruited to the site of vascular injury. However, the cellular and molecular mechanisms of platelet-dependent angiogenesis, especially the involvement of TP signallin...

journal_title：Cardiovascular research

authors： Amano H,Ito Y,Eshima K,Kato S,Ogawa F,Hosono K,Oba K,Tamaki H,Sakagami H,Shibuya M,Narumiya S,Majima M

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:The mechanism of spontaneous myogenic tone was investigated in isolated arteriolar segments. METHODS:Arterioles were isolated from rat cremaster muscle. Segments were endothelium-denuded and mounted in a pressure myograph at 75 mmHg. Under this condition, segments spontaneously constricted from a passive dia...

journal_title：Cardiovascular research

authors： Bakker EN,Kerkhof CJ,Sipkema P

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:The aim was to study the contractility of the conduit coronary artery to vasoactive agents in developing and established volume overload cardiac hypertrophy and to compare it with structural alterations in the artery. METHODS:Aortic valve insufficiency in rabbits was used to produce a volume overloaded heart...

journal_title：Cardiovascular research

authors： Gerová M,Holécyová A,Kristek F,Fízel' A,Fízel'ová A

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:Angiotensin II (ANG II) has recently been reported to increase inotropy in adult rabbit myocytes by a mechanism of alkalinization and consequent increased myofilament sensitivity to calcium. Accordingly, we tested the hypothesis that ANG II would have a greater inotropic effect during ischemic conditions than...

journal_title：Cardiovascular research

authors： Libonati JR,Eberli FR,Sesselberg HW,Apstein CS

更新日期：1997-01-01 00:00:00

abstract：AIMS:Notch signalling is essential for blood vessel formation. During angiogenesis, the Notch ligand DLL4 on the leading tip cell activates Notch receptors on the adjacent stalk cells. DLL4-Notch signalling is impaired by the Notch ligand JAG1 in endothelial cells. The Delta/Serrate/Lag2 (DSL) domain of the Notch ligan...

journal_title：Cardiovascular research

authors： Klose R,Berger C,Moll I,Adam MG,Schwarz F,Mohr K,Augustin HG,Fischer A

更新日期：2015-07-01 00:00:00

abstract：AIMS:Despite the observation that ErbB2 regulates sensitivity of the heart to doxorubicin or ErbB2-targeted cancer therapies, mechanisms that regulate ErbB2 expression and activity have not been studied. Since isoproterenol up-regulates ErbB2 in kidney and salivary glands and β2AR and ErbB2 complex in brain and heart, ...

journal_title：Cardiovascular research

authors： Sysa-Shah P,Tocchetti CG,Gupta M,Rainer PP,Shen X,Kang BH,Belmonte F,Li J,Xu Y,Guo X,Bedja D,Gao WD,Paolocci N,Rath R,Sawyer DB,Naga Prasad SV,Gabrielson K

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands have been shown to ameliorate a variety of inflammatory conditions. The present study tested the hypothesis that PPAR-gamma ligands reduce experimental autoimmune myocarditis (EAM) associated with inhibition of the expansion and activation...

journal_title：Cardiovascular research

authors： Yuan Z,Liu Y,Liu Y,Zhang J,Kishimoto C,Wang Y,Ma A,Liu Z

更新日期：2003-09-01 00:00:00

abstract：Aims:Fibroblast growth factor 1 (FGF1), a heparin/heparan sulfate-binding growth factor, is a potent cardioprotective agent against myocardial infarction (MI). The impact of heparin, the standard of care for MI patients entering the emergency room, on cardioprotective effects of FGF1 is unknown, however. Methods and r...

journal_title：Cardiovascular research

authors： Huang C,Liu Y,Beenken A,Jiang L,Gao X,Huang Z,Hsu A,Gross GJ,Wang YG,Mohammadi M,Schultz JEJ

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the possible role of prostacyclin (PGI2) in the pathogenesis of hypertension in spontaneously hypertensive rats (SHR). METHODS:Measurement of mRNA and protein levels of PGH synthase (PGHS)-1, PGI2 synthase and the PGI2 receptor, in the thoracic aorta was performed in SHR...

journal_title：Cardiovascular research

authors： Numaguchi Y,Harada M,Osanai H,Hayashi K,Toki Y,Okumura K,Ito T,Hayakawa T

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:Mechanoelectric Feedback, a mechanical intervention inducing an electrical change, is gaining credence as a cause of cardiac arrhythmia in the clinical situation. However, the precise mechanism is unknown. To elucidate this we investigated mechanical and chemical modulation of stretch-induced premature ventri...

journal_title：Cardiovascular research

authors： Dick DJ,Lab MJ

更新日期：1998-04-01 00:00:00

abstract：:In isolated electrically stimulated guinea pig papillary muscles tiapamil exerts a negative inotropic action that corresponds to its presumptive inhibitory effects on the slow-channel-mediated transmembrane Ca2+ influx. However, contractile depression is always accompanied by marked alterations of the normal Na+-carri...

journal_title：Cardiovascular research

authors： Späh F

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:The pulmonary circulation may contribute to elevated plasma levels of endothelin-1 (ET-1) in congestive heart failure (CHF). The aims of the present study were to determine the mechanisms of increased secretion of ET-1 from the pulmonary circulation in CHF. METHODS:Juvenile pigs were subjected to sham operat...

journal_title：Cardiovascular research

authors： von Lueder TG,Kjekshus H,Edvardsen T,ØIe E,Urheim S,Vinge LE,Ahmed MS,Smiseth OA,Attramadal H

更新日期：2004-07-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is the most common cardiac arrhythmia, and early-onset lone AF has been linked to mutations in genes encoding ion channels. Mutations in the pore forming subunit KV4.3 leading to an increase in the transient outward potassium current (Ito) have previously been associated with the Brugada S...

journal_title：Cardiovascular research

authors： Olesen MS,Refsgaard L,Holst AG,Larsen AP,Grubb S,Haunsø S,Svendsen JH,Olesen SP,Schmitt N,Calloe K

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:Myogenic tone, which has a major role in the regulation of local blood flow, refers to the ability of vascular smooth muscle to adapt its contractility to changes in transmural pressure. Although Rho-kinase is involved in myogenic tone, the pathway involved remains unclear, especially concerning translocation...

journal_title：Cardiovascular research

authors： Dubroca C,Loyer X,Retailleau K,Loirand G,Pacaud P,Feron O,Balligand JL,Lévy BI,Heymes C,Henrion D

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The atrial natriuretic peptide (ANP) family is a complex system consisting of at least three polypeptides and at least three types of receptor. Each peptide interacts with different types of receptor at varying degrees of affinity. To determine if natriuretic peptide levels influence natriuretic peptide rece...

journal_title：Cardiovascular research

authors： Vera N,Tse MY,Watson JD,Sarda S,Steinhelper ME,John SW,Flynn TG,Pang SC

更新日期：2000-06-01 00:00:00