Abstract:
OBJECTIVE:A circadian rhythm of blood pressure has been demonstrated both in subjects who are physically active during the day and in those confined to bed. The study of the circadian rhythm of arterial flow and peripheral resistance, on the other hand, is limited to pioneer experiments. This paper is aimed at demonstrating that leg peripheral resistance has circadian fluctuations which are modulated by spinal neural traffic. METHODS:Eleven normal (able-bodied) human subjects and 11 patients with spinal transection due to spinal cord injury (SCI) were studied. They were confined to bed for 24 h. Blood pressure and heart rate were monitored every 15 min with an automatic device and leg flow with an automatic strain-gauge plethysmograph synchronised to the pressurometer. Peripheral resistance was calculated at the same intervals. RESULTS:In able-bodied subjects leg resistance was significantly higher during waking hours (when the sympathetic system is more activated) than during sleep, while in subjects with spinal cord injury no difference was detected between day-time and night-time. CONCLUSIONS:The circadian rhythm is controlled by adrenergic fibres transmitted via the spinal cord.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Casiglia E,Pizziol A,Piacentini F,Biasin R,Onesto C,Tikhonoff V,Prati R,Palatini P,Pessina ACdoi
10.1016/s0008-6363(98)00237-5subject
Has Abstractpub_date
1999-01-01 00:00:00pages
312-6issue
1eissn
0008-6363issn
1755-3245pii
S0008636398002375journal_volume
41pub_type
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pub_type: 临床试验,杂志文章
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journal_title:Cardiovascular research
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2011-07-15 00:00:00
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pub_type: 杂志文章
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