Voltage- and time-dependent depression of maximum rate of depolarisation of guinea-pig ventricular action potentials by two new antiarrhythmic drugs, flecainide and lorcainide.

abstract：:Sudden hypothermia utilising liquid nitrogen has been used for immediate inhibition of metabolic reactions and preservation of labile compounds in heart muscle. It has been suggested that this rapid transfer of tissue into liquid nitrogen, within 1 to 2 s, is essential for accurate assessment of internal milieu condit...

journal_title：Cardiovascular research

authors： Allison TB,Ramey CA,Holsinger JW Jr

更新日期：1978-03-01 00:00:00

abstract：AIMS:Alteration of connexin43 (Cx43)-mediated intercellular communication is known to promote susceptibility to ventricular tachyarrhythmias. However, the precise mechanism of the altered Cx43 responsible for arrhythmogenesis remains unclear. We sought to understand changes in impulse propagation of ventricular myocyte...

journal_title：Cardiovascular research

authors： Nakagami T,Tanaka H,Dai P,Lin SF,Tanabe T,Mani H,Fujiwara K,Matsubara H,Takamatsu T

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:Matrix metalloproteinases (MMPs) are plausible candidates for prediction of unstable coronary syndromes. We hypothesised that the MMP-3 polymorphism (- 1171, 5A/6A) would relate to coronary plaque characteristics and unstable clinical presentation. METHODS AND RESULTS:Forty patients with de novo presentatio...

journal_title：Cardiovascular research

authors： White AJ,Duffy SJ,Walton AS,Ng JF,Rice GE,Mukherjee S,Shaw JA,Jennings GL,Dart AM,Kingwell BA

更新日期：2007-09-01 00:00:00

abstract：:Acadesine is the prototype of a new class of therapeutic compounds termed adenosine regulating agents. Acadesine is pharmacologically silent in normal circumstances, but its activity becomes operative during situations of net ATP catabolism, when it increases local adenosine levels. Thus acadesine is able to harness t...

journal_title：Cardiovascular research

authors： Mullane K

更新日期：1993-01-01 00:00:00

abstract：:Genetic and environmental factors influence the development of coronary artery disease (CAD). Genetic analyses of families and the population continue to yield important fundamental insights for CAD. For the past four decades, CAD human genetic research focused largely on the study of germline genetic variation in CAD...

journal_title：Cardiovascular research

authors： Patel AP,Natarajan P

更新日期：2019-04-15 00:00:00

abstract：:Arterial blood pressures were measured simultaneously in the thoracic and abdominal aortas in the same conscious rats. Intravenous administration of sodium nitroprusside caused a greater fall in systolic blood pressure in the abdominal aorta than in the thoracic aorta, whereas intravenous administration of methoxamine...

journal_title：Cardiovascular research

authors： Gardiner SM,Bennett T

更新日期：1986-05-01 00:00:00

abstract：:Vascular smooth muscle cells (vSMCs) play a crucial role in both the pathogenesis of Aneurysms and Dissections of the ascending thoracic aorta (TAAD) in humans and in the associated adaptive compensatory responses, since thrombosis and inflammatory processes are absent in the majority of cases. Aneurysms and dissectio...

journal_title：Cardiovascular research

authors： Michel JB,Jondeau G,Milewicz DM

更新日期：2018-03-15 00:00:00

abstract：AIMS:Ischaemic preconditioning (IPC) protects the heart against prolonged lethal ischaemia through a signalling cascade involving Akt, glycogen synthase kinase-3β (GSK-3β), and mitochondrial ATP-sensitive potassium channels (mitoK(ATP)). We previously demonstrated the involvement of the Wnt pathway in IPC in vivo via G...

journal_title：Cardiovascular research

authors： Vigneron F,Dos Santos P,Lemoine S,Bonnet M,Tariosse L,Couffinhal T,Duplaà C,Jaspard-Vinassa B

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:In several cell types, proteasome inhibitors like carbobenzoxyl-leucinyl-leucinyl-leucinal (MG132) induce the 72 kDa heat shock protein (Hsp72) and exert cell protective effects. However, data in cardiomyocytes are currently lacking. METHODS AND RESULTS:We investigated the effects of MG132 in cultured neonat...

journal_title：Cardiovascular research

authors： Lüss H,Schmitz W,Neumann J

更新日期：2002-04-01 00:00:00

abstract：AIMS:Moderate wine consumption is associated with a significant reduction of cardiovascular mortality. The molecular basis of this phenomenon remains unknown. Platelet-derived growth factor (PDGF) is an important contributor to atherogenesis. We investigated the effects of selected red and white wines on PDGF receptor ...

journal_title：Cardiovascular research

authors： Sparwel J,Vantler M,Caglayan E,Kappert K,Fries JW,Dietrich H,Böhm M,Erdmann E,Rosenkranz S

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Determine if ischemic tolerance is reduced in the setting of experimental heart failure (HF). METHODS:Dogs were paced for 3 weeks at 240 BPM to induce heart failure which was confirmed with hemodynamic and echocardiographic measurements. The pacemaker was turned off 30 min prior to the ischemia study. Normal...

journal_title：Cardiovascular research

authors： Hoskins DE,Ignasiak DP,Saganek LJ,Gallagher KP,Peterson JT

更新日期：1996-08-01 00:00:00

abstract：AIMS:Macrophage-related oxidative stress plays an important role in the inflammatory process in atherosclerosis. Recently, dextromethorphan (DXM), a common cough-suppressing ingredient with a high safety profile, was found to inhibit the activation of microglia, the resident macrophage in the nervous system. We investi...

journal_title：Cardiovascular research

authors： Liu SL,Li YH,Shi GY,Tang SH,Jiang SJ,Huang CW,Liu PY,Hong JS,Wu HL

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:Inhibition by endothelin antagonist is a potential therapy in heart failure. However, the effect of endothelin inhibition during the development of heart failure has not been evaluated. The goal of our study was to examine the acute hemodynamic effects of the mixed endothelin receptor antagonist bosentan in t...

journal_title：Cardiovascular research

authors： Choussat R,Hittinger L,Barbe F,Maistre G,Carayon A,Crozatier B,Su J

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:Important physiological and pathophysiological conditions are associated with changes in secretion and synthesis of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP). The aim of this study was to examine the effects of mechanical stretch and endothelin-1 on ANF and BNP secretion and gene exp...

journal_title：Cardiovascular research

authors： Bruneau BG,de Bold AJ

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:To investigate the physiological role of cAMP-dependent protein kinase A (PKA)-mediated, cardiac myosin binding protein C (MyBP-C) phosphorylation. METHODS:A cardiac MyBP-C cDNA lacking nine amino acids, which contained a phosphorylation site, was made, and subsequently used to generate multiple lines of tra...

journal_title：Cardiovascular research

authors： Yang Q,Hewett TE,Klevitsky R,Sanbe A,Wang X,Robbins J

更新日期：2001-07-01 00:00:00

abstract：STUDY OBJECTIVE:The objectives were (a) to describe the effects of vasoactive drugs in normal rats upon cardiovascular function assessed by computing aortic haemodynamic power and input impedance, each separated into their component parts, and (b) to study the relationship between left ventricular pulsatile power outpu...

journal_title：Cardiovascular research

authors： Wright G

更新日期：1991-11-01 00:00:00

abstract：:Mechanical stress signals transmitted through the heart walls during hemodynamic loading are sensed by the myocytes, which respond with changes in contractile performance and gene expression. External forces play an important role in physiological heart development and hypertrophy, but disruption of the well-balanced ...

journal_title：Cardiovascular research

authors： Linke WA

更新日期：2008-03-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is a progressive cardiac arrhythmia that increases the risk of hospitalization and adverse cardiovascular events. There is a clear demand for more inclusive and large-scale approaches to understand the molecular drivers responsible for AF, as well as the fundamental mechanisms governing th...

journal_title：Cardiovascular research

authors： Alvarez-Franco A,Rouco R,Ramirez RJ,Guerrero-Serna G,Tiana M,Cogliati S,Kaur K,Saeed M,Magni R,Enriquez JA,Sanchez-Cabo F,Jalife J,Manzanares M

更新日期：2020-10-29 00:00:00

abstract：AIMS:Vascular remodelling and aortic aneurysm formation are induced mainly by inflammatory responses in the adventitia and media. However, relatively little is known about the mechanistic significance of endothelium in the pathogenesis of these vascular disorders. The transcription factor nuclear factor-kappa B (NF-κB)...

journal_title：Cardiovascular research

authors： Saito T,Hasegawa Y,Ishigaki Y,Yamada T,Gao J,Imai J,Uno K,Kaneko K,Ogihara T,Shimosawa T,Asano T,Fujita T,Oka Y,Katagiri H

更新日期：2013-01-01 00:00:00

abstract：:Atherosclerosis is considered a to be multifactorial disease driven by inflammatory reactions. The process of inflammation also contributes to the pathogenesis of acute atherothrombotic events. C-reactive protein (CRP) is an acute phase protein and its concentration in serum reflects the inflammatory condition of the ...

journal_title：Cardiovascular research

authors： Paffen E,DeMaat MP

更新日期：2006-07-01 00:00:00

abstract：:The 'master regulatory factors' that position at the top of the genetic hierarchy of lineage determination have been a focus of intense interest, and have been investigated in various systems. Etv2/Etsrp71/ER71 is such a factor that is both necessary and sufficient for the development of haematopoietic and endothelial...

journal_title：Cardiovascular research

authors： Koyano-Nakagawa N,Garry DJ

更新日期：2017-09-01 00:00:00

abstract：AIMS:Angiotensin II is a potential contributor to the development of abdominal aortic aneurysm (AAA). In aortic vascular smooth muscle cells, exposure to angiotensin II induces mitochondrial fission via dynamin-related protein 1 (Drp1). However, pathophysiological relevance of mitochondrial morphology in angiotensin II...

journal_title：Cardiovascular research

authors： Cooper HA,Cicalese S,Preston KJ,Kawai T,Okuno K,Choi ET,Kasahara S,Uchida HA,Otaka N,Scalia R,Rizzo V,Eguchi S

更新日期：2020-05-08 00:00:00

abstract：:The static elastic properties of the aorta ad systolic blood pressure in the caudal artery have been measured in 55 spontaneously hypertensive rats of the AS strain. Animals were divided into five groups and treated from the age of 4 to 12 weeks as follows: (1) 0.25 mm silver clip positioned around the right renal art...

journal_title：Cardiovascular research

authors： Berry CL,Greenwald SE,Menahem N

更新日期：1981-07-01 00:00:00

abstract：:Pulsatile haemodynamics associated with graded degrees of experimentally produced stenosis were studied in the canine femoral artery. Invasively determined pulsatile blood flow and noninvasively determined blood velocity with Doppler ultrasound were measured an average of 1.3 and 2.3 cm proximal to the stenosis, respe...

journal_title：Cardiovascular research

authors： Farrar DJ,Green HD,Peterson DW

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVE:Vascular smooth muscle cell (VSMC) de-differentiation is a prerequisite for migration from the tunica media to the intima after vascular injury. Integrin cell adhesion molecules participate in VSMC phenotype modulation. Alpha 8 beta 1 integrin is a differentiation marker of VSMCs and its knockdown heightens m...

journal_title：Cardiovascular research

authors： Zargham R,Thibault G

更新日期：2006-07-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to determine if prostaglandin like activity might be involved in changes due to exercise training in the coronary flow responses to hypoxia. DESIGN:The coronary flow response to hypoxia was measured under constant perfusion pressure in isolated perfused hearts from 12 endurance exercise tra...

journal_title：Cardiovascular research

authors： Baur TS,Brodowicz GR,Lamb DR

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:R 75,231, a potent and specific nucleoside transport inhibitor, largely prevents cardiac damage and death in catecholamine challenged rabbits. The major biochemical effect of nucleoside transport inhibition in ischaemic and reperfused myocardium is a prolonged accumulation of adenosine. The cardioprotection b...

journal_title：Cardiovascular research

authors： Van Belle H,Ver Donck K,Verheyen W

更新日期：1993-01-01 00:00:00

abstract：AIMS:Treatment with the anticancer drug taxol (TXL), which polymerizes the cytoskeleton protein tubulin, may evoke cardiac arrhythmias based on reduced human cardiac sodium channel (Na(v)1.5) function. Therefore, we investigated whether enhanced tubulin polymerization by TXL affects Na(v)1.5 function and expression and...

journal_title：Cardiovascular research

authors： Casini S,Tan HL,Demirayak I,Remme CA,Amin AS,Scicluna BP,Chatyan H,Ruijter JM,Bezzina CR,van Ginneken AC,Veldkamp MW

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:Washed platelets have been shown to protect isolated buffer perfused rat hearts from injury and dysfunction following ischaemia-reperfusion. This study was designed to investigate whether platelet glutathione redox cycle contributes to the protective effect of platelets. METHODS:Isolated rat hearts were perf...

journal_title：Cardiovascular research

authors： Yang BC,Mehta A,Mehta JL

更新日期：1994-10-01 00:00:00

abstract：:In the superior vena cava of anaesthetised open chest dogs the axial pressure gradient was measured simultaneously with the blood flow velocity under different preload conditions. Both pressure gradient and velocity curves showed distinct systolic and diastolic waves. Peak pressure gradient ranged between 26 and 93 Pa...

journal_title：Cardiovascular research

authors： Minten J,Van de Werf F,Eaubert A,De Geest H

更新日期：1986-12-01 00:00:00