Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis.

abstract：AIMS:Anthracycline-induced cardiotoxicity (AIC) is a serious adverse effect among cancer patients. A central mechanism of AIC is irreversible mitochondrial damage. Despite major efforts, there are currently no effective therapies able to prevent AIC. METHODS AND RESULTS:Forty Large-White pigs were included. In Study 1...

journal_title：Cardiovascular research

authors： Galán-Arriola C,Villena-Gutiérrez R,Higuero-Verdejo MI,Díaz-Rengifo IA,Pizarro G,López GJ,de Molina-Iracheta A,Pérez-Martínez C,García RD,González-Calle D,Lobo M,Sánchez PL,Oliver E,Córdoba R,Fuster V,Sánchez-González J,I

更新日期：2020-06-29 00:00:00

abstract：OBJECTIVE:The mechanism of the protective effect of ischaemic preconditioning in the myocardium is not yet known. The aim of this study was to test the hypothesis that endogenous myocardial catecholamines may be mediators of preconditioning. METHODS:To test whether endogenous catecholamines are involved in preconditio...

journal_title：Cardiovascular research

authors： Weselcouch EO,Baird AJ,Sleph PG,Dzwonczyk S,Murray HN,Grover GJ

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:Pigment epithelial-derived factor (PEDF) is a potent anti-angiogenic factor whose effects are partially mediated through the induction of endothelial cell apoptosis. The pathway mediating endothelial cell apoptosis has not been fully established. Here we investigated the participation of peroxisome proliferat...

journal_title：Cardiovascular research

authors： Ho TC,Chen SL,Yang YC,Liao CL,Cheng HC,Tsao YP

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:The aim of the presented method was the characterization of different complex heart rate dynamics in conscious rabbits as well as during general anaesthesia and vagal blockade. This was done by non-linear prediction of original measured and special surrogate data in the phase space. METHOD:The development of...

journal_title：Cardiovascular research

authors： Hoyer D,Schmidt K,Zwiener U,Bauer R

更新日期：1996-03-01 00:00:00

abstract：AIMS:To describe the overall role of reduced sarcoplasmic reticulum Ca(2+) ATPase (SERCA2) for Ca(2+) wave development. METHODS AND RESULTS:SERCA2 knockout [Serca2(flox/flox) Tg(alphaMHC-MerCreMer); KO] mice allowing inducible cardiomyocyte-specific disruption of the Serca2 gene in adult mice were compared with Serca(...

journal_title：Cardiovascular research

authors： Stokke MK,Hougen K,Sjaastad I,Louch WE,Briston SJ,Enger UH,Andersson KB,Christensen G,Eisner DA,Sejersted OM,Trafford AW

更新日期：2010-04-01 00:00:00

abstract：:The potent anaphylatoxin C3a was measured in the peripheral blood of eleven patients receiving radiocontrast agents whilst undergoing coronary angiography. In seven patients C3a levels were raised during this procedure and in three of these the anaphylatoxin was increased between four and tenfold. In four patients C3a...

journal_title：Cardiovascular research

authors： Westaby S,Dawson P,Turner MW,Pridie RB

更新日期：1985-02-01 00:00:00

abstract：:Physical training has been advocated to minimize the problems associated with coronary heart disease; however, the responsible mechanisms are obscure. Rats trained to run on a treadmill were subjected to acute conditions of hypoxia and myocardial ischaemia. Trained rats were better able to maintain a higher level of c...

journal_title：Cardiovascular research

authors： Carey RA,Tipton CM,Lund DR

更新日期：1976-05-01 00:00:00

abstract：STUDY OBJECTIVE:The objectives were (a) to describe the effects of vasoactive drugs in normal rats upon cardiovascular function assessed by computing aortic haemodynamic power and input impedance, each separated into their component parts, and (b) to study the relationship between left ventricular pulsatile power outpu...

journal_title：Cardiovascular research

authors： Wright G

更新日期：1991-11-01 00:00:00

abstract：AIMS:We analysed the possible protective role of human endothelial (EPCs) and smooth muscle (SPCs) progenitor cells on atherosclerosis development in apoE(-/-)RAG2(-/-) mice. We determined plasma levels of SPCs in coronary patients. METHODS AND RESULTS:ApoE(-/-)RAG2(-/-) mice received four intravenous injections of sa...

journal_title：Cardiovascular research

authors： Zoll J,Fontaine V,Gourdy P,Barateau V,Vilar J,Leroyer A,Lopes-Kam I,Mallat Z,Arnal JF,Henry P,Tobelem G,Tedgui A

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:Intercellular adhesion molecule (ICAM)-1 is an immunoglobulin-like cell adhesion molecule expressed by several cell types, including proliferating vascular smooth muscle cells (VSMC). Cross-linking ICAM-1 on the surface of different cell types has previously been shown to cause an increase in cellular activat...

journal_title：Cardiovascular research

authors： Lawson C,Ainsworth ME,McCormack AM,Yacoub M,Rose ML

更新日期：2001-06-01 00:00:00

abstract：:This review focuses on the genomic response following a preconditioning stimulus. Initial studies demonstrated that classical ischemic preconditioning mediated by cyclic episodes of short durations of reversible ischemia and reperfusion could result in the reprogramming of gene expression. Some of these genes are tran...

journal_title：Cardiovascular research

authors： Das DK,Maulik N

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVES:We performed the following study to define the effects of acute cardiac lymphatic obstruction on left ventricular (LV) systolic and diastolic function. METHODS:Cardiac lymphatic obstruction was created in 8 pentobarbital-anesthetized dogs by identifying (Evans blue) and ligating the right and left epicardia...

journal_title：Cardiovascular research

authors： Ludwig LL,Schertel ER,Pratt JW,McClure DE,Ying AJ,Heck CF,Myerowitz PD

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:Although aldosterone has been implicated in the pathogenesis of cardiac hypertrophy and heart failure, its cellular mechanism of action on cardiomyocyte function is not yet completely elucidated. This study was designed to investigate the effect of aldosterone on calcium channel expression and cardiomyocyte c...

journal_title：Cardiovascular research

authors： Lalevée N,Rebsamen MC,Barrère-Lemaire S,Perrier E,Nargeot J,Bénitah JP,Rossier MF

更新日期：2005-08-01 00:00:00

abstract：STUDY OBJECTIVE:Compensatory mechanisms of the left ventricle for volume overloading caused by acute aortic regurgitation and associated changes in physiological properties of the aorta were studied in rabbits. DESIGN:Aortic regurgitation was produced by aortic valve perforation, and haemodynamic measurements were per...

journal_title：Cardiovascular research

authors： Wainai Y

更新日期：1991-06-01 00:00:00

abstract：AIMS:It is well established that leukotrienes (LTs), products of the 5-lipoxygenase (5-LO) pathway, participate in inflammatory tissue reactions and immune responses. In the present study, the impact of the 5-LO pathway on vasculogenesis of mouse embryonic stem (ES) cells was investigated. METHODS AND RESULTS:Immunohi...

journal_title：Cardiovascular research

authors： Finkensieper A,Kieser S,Bekhite MM,Richter M,Mueller JP,Graebner R,Figulla HR,Sauer H,Wartenberg M

更新日期：2010-04-01 00:00:00

abstract：:The progress made in our understanding of the pathophysiology and treatment of congestive heart failure (CHF) would not have been possible without a number of animal models of heart failure and hypertrophy, each one having unique advantages as well as disadvantages. The species and interventions used to create CHF dep...

journal_title：Cardiovascular research

authors： Hasenfuss G

更新日期：1998-07-01 00:00:00

abstract：:Increased Na/Ca exchange (NCX) expression may be part of the genetic reprogramming in cardiac remodeling. In this review we address the following questions: (1) Is increased NCX activity a general feature of cardiac remodeling in hypertrophy and heart failure? (2) How does this contribute to the contractile and electr...

journal_title：Cardiovascular research

authors： Sipido KR,Volders PG,Vos MA,Verdonck F

更新日期：2002-03-01 00:00:00

abstract：AIM:Mechanical forces are important regulators of cell and tissue phenotype. We hypothesized that mechanical loading and boundary conditions would influence neovessel activity during angiogenesis. METHODS AND RESULTS:Using an in vitro model of angiogenesis sprouting and a mechanical loading system, we evaluated the ef...

journal_title：Cardiovascular research

authors： Krishnan L,Underwood CJ,Maas S,Ellis BJ,Kode TC,Hoying JB,Weiss JA

更新日期：2008-05-01 00:00:00

abstract：AIMS:For the majority of congenital heart diseases (CHDs), the full complexity of the causative molecular network, which is driven by genetic, epigenetic, and environmental factors, is yet to be elucidated. Epigenetic alterations are suggested to play a pivotal role in modulating the phenotypic expression of CHDs and t...

journal_title：Cardiovascular research

authors： Grunert M,Dorn C,Cui H,Dunkel I,Schulz K,Schoenhals S,Sun W,Berger F,Chen W,Sperling SR

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:Diastolic dysfunction that determines symptoms and prognosis in patients with systolic dysfunction causes heart failure even in the absence of systolic dysfunction. Our recent studies have suggested that myocardial stiffening is likely to play a crucial role in triggering deleterious cardiac disorder. This s...

journal_title：Cardiovascular research

authors： Yamamoto K,Masuyama T,Sakata Y,Nishikawa N,Mano T,Yoshida J,Miwa T,Sugawara M,Yamaguchi Y,Ookawara T,Suzuki K,Hori M

更新日期：2002-07-01 00:00:00

abstract：AIMS:Ischaemic preconditioning (IPC) protects the heart against prolonged lethal ischaemia through a signalling cascade involving Akt, glycogen synthase kinase-3β (GSK-3β), and mitochondrial ATP-sensitive potassium channels (mitoK(ATP)). We previously demonstrated the involvement of the Wnt pathway in IPC in vivo via G...

journal_title：Cardiovascular research

authors： Vigneron F,Dos Santos P,Lemoine S,Bonnet M,Tariosse L,Couffinhal T,Duplaà C,Jaspard-Vinassa B

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Plasma low density lipoproteins (LDL) play a key role in the pathogenesis of atherosclerosis. LDL modify gene expression in vascular cells leading to disturbances in the functional state of the vessel wall. METHODS:Expression levels of C-4 sterol methyl oxidase gene (ERG25), sterol regulatory element bindin...

journal_title：Cardiovascular research

authors： Rodriguez C,Raposo B,Martínez-González J,Llorente-Cortés V,Vilahur G,Badimon L

更新日期：2003-04-01 00:00:00

abstract：:Acute occlusions of the proximal left circumflex coronary arteriovenous pedicle were performed in open chest anaesthetised dogs. Twenty eight dogs were randomly allocated to receive acebutolol (3 mg X kg-1 twice daily) or placebo given blindly by mouth for five days; a control group of 14 dogs without any pretreatment...

journal_title：Cardiovascular research

authors： Puddu PE,Jouve R,Langlet F,Guillen JC,Fornaris M,Torresani J,Reale A

更新日期：1986-10-01 00:00:00

abstract：OBJECTIVES:We studied the effects of chronic left coronary artery ligation on cardiac structure and function in the mouse. METHODS:Morphometric studies of the left ventricle were performed in coronary artery-ligated and sham-operated animals at one, two, three and five weeks after surgery. The fraction of DNA-synthesi...

journal_title：Cardiovascular research

authors： Lutgens E,Daemen MJ,de Muinck ED,Debets J,Leenders P,Smits JF

更新日期：1999-03-01 00:00:00

abstract：:To investigate cardiovascular changes in experimental acromegaly, a growth hormone-secreting tumour (MtT-W-15) was implanted in adult female rats. Somatic and tumour growth occurred steadily during the 8 week study period, as did an increase in serum growth hormone titre. Weight of left ventricle and right ventricle i...

journal_title：Cardiovascular research

authors： Penney DG,Dunbar JC Jr,Baylerian MS

更新日期：1985-05-01 00:00:00

abstract：:Congestive heart failure may be deemed the epidemic of cardiology in the 21st century in the industrialized part of the world. Although new therapies improving morbidity and mortality from chronic heart failure have emerged it is likely that there is a growing role for digoxin. Thus, digoxin treatment is known to cont...

journal_title：Cardiovascular research

authors： Kjeldsen K,Nørgaard A,Gheorghiade M

更新日期：2002-09-01 00:00:00

abstract：:We have used a miniature cadmium telluride detector in the assessment of muscle blood flow during dynamic exercise in man following local injection of 133Xenon. The results obtained were compared with those using a conventional sodium iodide detector. There was no significant difference between the results obtained wi...

journal_title：Cardiovascular research

authors： Smith RS,Bojsen J,Warren DJ

更新日期：1981-12-01 00:00:00

abstract：OBJECTIVE:To investigate changes in human atrial single cell functional electrophysiological properties associated with chronic atrial fibrillation (AF), and the contribution to these of accompanying ion current changes. METHODS:The whole cell patch clamp technique was used to record action potentials, the effective r...

journal_title：Cardiovascular research

authors： Workman AJ,Kane KA,Rankin AC

更新日期：2001-11-01 00:00:00

abstract：:Twenty patients who had suffered myocardial infarction within the previous 3 to 13 days performed face immersion with breath-holding. The maximum reduction in heart rate was 17 +/- 9 beats-min--1 (mean +/- SD). When compared with 24 patients without evidence ischaemic heart disease, they behaved more like younger pati...

journal_title：Cardiovascular research

authors： Gooden BA,Holdstock G,Hampton JR

更新日期：1978-04-01 00:00:00

abstract：:The function of the right ventricle (RV) determines the prognosis of patients with pulmonary hypertension. While much progress has been made in the treatment of pulmonary hypertension, therapies for the RV are less well established. In this review of treatment strategies for the RV, first we focus on ways to reduce wa...

journal_title：Cardiovascular research

authors： Westerhof BE,Saouti N,van der Laarse WJ,Westerhof N,Vonk Noordegraaf A

更新日期：2017-10-01 00:00:00