Angiography and complement activation. Evidence for generation of C3a anaphylatoxin by intravascular contrast agents.

abstract：BACKGROUND:We, and others, have previously reported a strong correlation between increased inter-ventricular dispersion of repolarization and the occurrence of fatal arrhythmia in animal models of CHF. The existence of this and other such distinct electrophysiologic phenotypes in right (RV) vs. left ventricles (LV) cou...

journal_title：Cardiovascular research

authors： Chugh SS,Whitesel S,Turner M,Roberts CT Jr,Nagalla SR

更新日期：2003-02-01 00:00:00

abstract：Aims:Fibroblast growth factor 1 (FGF1), a heparin/heparan sulfate-binding growth factor, is a potent cardioprotective agent against myocardial infarction (MI). The impact of heparin, the standard of care for MI patients entering the emergency room, on cardioprotective effects of FGF1 is unknown, however. Methods and r...

journal_title：Cardiovascular research

authors： Huang C,Liu Y,Beenken A,Jiang L,Gao X,Huang Z,Hsu A,Gross GJ,Wang YG,Mohammadi M,Schultz JEJ

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:Transient atrial fibrillation is sometimes observed following adenosine administration and adenosine is known to shorten atrial action potential duration and refractory period. This study was designed to characterise the dose-response relationship of adenosine on these variables relative to arrhythmia inducti...

journal_title：Cardiovascular research

authors： Kabell G,Buchanan LV,Gibson JK,Belardinelli L

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Plasma low density lipoproteins (LDL) play a key role in the pathogenesis of atherosclerosis. LDL modify gene expression in vascular cells leading to disturbances in the functional state of the vessel wall. METHODS:Expression levels of C-4 sterol methyl oxidase gene (ERG25), sterol regulatory element bindin...

journal_title：Cardiovascular research

authors： Rodriguez C,Raposo B,Martínez-González J,Llorente-Cortés V,Vilahur G,Badimon L

更新日期：2003-04-01 00:00:00

abstract：:Diabetes is one of the most prevalent chronic conditions that has a high association with death from cardiovascular disease(s). An impaired cardiac function independent of vascular disease suggests the existence of a primary myocardial defect in diabetes mellitus. We and others have documented that myocardial performa...

journal_title：Cardiovascular research

authors： Malhotra A,Sanghi V

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVES:I(Ks), the slow component of the delayed rectifier potassium current, underlies a strong beta-adrenergic regulation in the heart. Catecholamines, like isoproterenol, induce a strong increase in I(Ks). Recent work has pointed to an opposing biological effect of beta(1)- and beta(3)-adrenoceptors in the heart....

journal_title：Cardiovascular research

authors： Bosch RF,Schneck AC,Kiehn J,Zhang W,Hambrock A,Eigenberger BW,Rüb N,Gogel J,Mewis C,Seipel L,Kühlkamp V

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:The aims of the study were (1) to elucidate the effects of raised oxygen tension on the response of the ductus arteriosus to a range of vasodilators; and (2) to establish the effect, if any, of cyclo-oxygenase inhibition on the interaction between oxygen and prostaglandin (PG)E2. METHODS:Rings of ductus arte...

journal_title：Cardiovascular research

authors： Smith GC,McGrath JC

更新日期：1993-12-01 00:00:00

abstract：:There is evidence that catecholamines may promote the development of cardiac hypertrophy in hypertension. To test the hypothesis that adrenaline directly determines left ventricular mass, normotensive Wistar rats were made adrenaline-deficient by adrenalectomy and hypertensive by administration of glucocorticoid. Bloo...

journal_title：Cardiovascular research

authors： Burris JF,Waeber B,Brunner HR

更新日期：1985-12-01 00:00:00

abstract：:Zero drift may be a cause of imprecision when micromanometer tipped catheters are used for intravascular pressure measurement over long periods of time. Drift of only a few mm Hg may represent a significant error when accurate recording of low vascular pressures is required. To overcome this problem a micromanometer t...

journal_title：Cardiovascular research

authors： Gibbs JS,Cunningham D,Sparrow J,Poole-Wilson PA,Fox KM

更新日期：1989-02-01 00:00:00

abstract：OBJECTIVE:In diabetes mellitus several cardiac electrophysiological parameters are known to be affected. In rodent experimental diabetes models changes in these parameters were reported, but no such data are available in other mammalian species including the dog. The present study was designed to analyse the effects of...

journal_title：Cardiovascular research

authors： Lengyel C,Virág L,Bíró T,Jost N,Magyar J,Biliczki P,Kocsis E,Skoumal R,Nánási PP,Tóth M,Kecskeméti V,Papp JG,Varró A

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:Acute ischemia comes with two phases of life-threatening arrhythmias, early (within 10 minutes, 1A) and late (after about 15 minutes, 1B). The mechanism of the latter is unknown and in this paper, we test the hypothesis that a phase of intermediate coupling between surviving epicardium and inexcitable midmyoc...

journal_title：Cardiovascular research

authors： de Groot JR,Wilms-Schopman FJ,Opthof T,Remme CA,Coronel R

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:The aim was to study the effect of thyroid hormone on collagen gene expression in the myocardium of the tight skin mouse (TSK), a genetic model of myocardial fibrosis. METHODS:Heterozygous male (TSK/+) (n = 20) and normal (+/+) homozygous mice (n = 20), 1.5-2 months old of the C57 BL/6 strain were studied. V...

journal_title：Cardiovascular research

authors： Yao J,Eghbali M

更新日期：1992-06-01 00:00:00

abstract：STUDY OBJECTIVE:The aim of the study was to test an intermittent ECG synchronised suction device which was added to a coronary vein retroinfusion system (selective suction and retroinfusion = SSR) in order to transport oxygenated fluid more efficiently into ischaemic myocardium. DESIGN:The suction period preceding the...

journal_title：Cardiovascular research

authors： Boekstegers P,Diebold J,Weiss C

更新日期：1990-06-01 00:00:00

abstract：AIMS:Peripheral chemoreflex sensitivity is potentiated in both clinical and experimental chronic heart failure (CHF). NADPH oxidase-derived superoxide mediates angiotensin II (Ang II)-enhanced carotid body (CB) chemoreceptor sensitivity in CHF rabbits, and tempol, the superoxide dismutase (SOD) mimetic, inhibits this A...

journal_title：Cardiovascular research

authors： Ding Y,Li YL,Zimmerman MC,Davisson RL,Schultz HD

更新日期：2009-03-01 00:00:00

abstract：AIMS:Regional heterogeneities in contraction contribute to heart failure with reduced ejection fraction (HFrEF). We aimed to determine whether regional changes in myocardial relaxation similarly contribute to diastolic dysfunction in post-infarction HFrEF, and to elucidate the underlying mechanisms. METHODS AND RESULT...

journal_title：Cardiovascular research

authors： Røe ÅT,Ruud M,Espe EK,Manfra O,Longobardi S,Aronsen JM,Nordén ES,Husebye T,Kolstad TRS,Cataliotti A,Christensen G,Sejersted OM,Niederer SA,Andersen GØ,Sjaastad I,Louch WE

更新日期：2019-03-15 00:00:00

abstract：:Chemokines, originally discovered as mediators of directional migration of immune cells to sites of inflammation and injury, have a function beyond their role in leukocyte chemotaxis. Indeed, they participate in organ development, angiogenesis, tumourigenesis and, more importantly, in the immune response. The chemokin...

journal_title：Cardiovascular research

authors： Balestrieri ML,Balestrieri A,Mancini FP,Napoli C

更新日期：2008-05-01 00:00:00

abstract：:The cardiac mechano- and chemoreceptors are broadly distributed in the myocardium and coronary vessels. A portion of these receptors extends over the epicardium and pericardium and therefore can be excited by mechanical or chemical stimuli directly applied to the surface of the heart. Excitation of epicardial receptor...

journal_title：Cardiovascular research

authors： Cinca J,Rodríguez-Sinovas A

更新日期：2000-01-01 00:00:00

abstract：AIMS:Free fatty acids induce apoptosis in cardiomyocytes, which is implicated in lipotoxic cardiomyopathy. However, the underlying mechanisms remain not fully understood. MicroRNAs (miRNAs) are non-coding small RNAs that control gene expression at the post-transcriptional level. Dysregulated miRNAs have been shown to b...

journal_title：Cardiovascular research

authors： Zhu H,Yang Y,Wang Y,Li J,Schiller PW,Peng T

更新日期：2011-10-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to study the interactions between pulmonary capillary wedge pressure (an estimate of left atrial pressure), left atrial dimension, and atrial natriuretic factor during evolving heart failure. DESIGN:Sequential simultaneous measurements of haemodynamic variables, left atrial dimension, and p...

journal_title：Cardiovascular research

authors： Moe GW,Angus C,Howard RJ,De Bold AJ,Armstrong PW

更新日期：1990-07-01 00:00:00

abstract：AIMS:Pulmonary arterial endothelial cells (PAECs) express the enzymes needed for generation of l-arginine from intracellular l-citrulline but do not express the enzymes needed for de novo l-citrulline synthesis. Hence, l-citrulline levels in PAECs are dependent on l-citrulline transport. Once generated, l-arginine can ...

journal_title：Cardiovascular research

authors： Fike CD,Sidoryk-Wegrzynowicz M,Aschner M,Summar M,Prince LS,Cunningham G,Kaplowitz M,Zhang Y,Aschner JL

更新日期：2012-08-01 00:00:00

abstract：AIMS:Proliferation of mammalian cardiomyocytes stops during the first weeks after birth, preventing the heart from regenerating after injury. Recently, several studies have indicated that induction of cardiomyocyte proliferation can be utilized to regenerate the mammalian heart. Thus, it is important to identify novel ...

journal_title：Cardiovascular research

authors： Novoyatleva T,Diehl F,van Amerongen MJ,Patra C,Ferrazzi F,Bellazzi R,Engel FB

更新日期：2010-03-01 00:00:00

abstract：:A recently developed highly sensitive radioimmunoassay method for detecting plasma kinin was used to re-evaluate the results of previous studies, in which plasma kinin had been measured with a bioassay method. To clarify the mechanism of plasma kinin release in global myocardial ischaemia the left main coronary artery...

journal_title：Cardiovascular research

authors： Matsuki T,Shoji T,Yoshida S,Kudoh Y,Motoe M,Inoue M,Nakata T,Hosoda S,Shimamoto K,Yellon D

更新日期：1987-06-01 00:00:00

abstract：AIMS:Atherosclerotic vascular disease has an inflammatory pathogenesis. Heme from intraplaque hemorrhage may drive a protective and pro-resolving macrophage M2-like phenotype, Mhem, via AMPK and ATF1. The anti-diabetic drug metformin may also activate AMPK-dependent signalling. HYPOTHESIS:Metformin systematically indu...

journal_title：Cardiovascular research

authors： Seneviratne A,Cave L,Hyde G,Moestrup SK,Carling D,Mason JC,Haskard DO,Boyle JJ

更新日期：2020-07-15 00:00:00

abstract：:Vascular smooth muscle cells (vSMCs) play a crucial role in both the pathogenesis of Aneurysms and Dissections of the ascending thoracic aorta (TAAD) in humans and in the associated adaptive compensatory responses, since thrombosis and inflammatory processes are absent in the majority of cases. Aneurysms and dissectio...

journal_title：Cardiovascular research

authors： Michel JB,Jondeau G,Milewicz DM

更新日期：2018-03-15 00:00:00

abstract：AIM:Mechanical forces are important regulators of cell and tissue phenotype. We hypothesized that mechanical loading and boundary conditions would influence neovessel activity during angiogenesis. METHODS AND RESULTS:Using an in vitro model of angiogenesis sprouting and a mechanical loading system, we evaluated the ef...

journal_title：Cardiovascular research

authors： Krishnan L,Underwood CJ,Maas S,Ellis BJ,Kode TC,Hoying JB,Weiss JA

更新日期：2008-05-01 00:00:00

abstract：:Cell communication, an essential component of integrated physiological function in multicellular organisms, is mediated largely through informational molecules, such as hormones and neurotransmitters. After binding to specific receptors, these first messengers activate intracellular signaling cascades and, thereby, tr...

journal_title：Cardiovascular research

authors： Goette A,Lendeckel U,Klein HU

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVES:Gap junctions have been demonstrated ultrastructurally in cardiac regions where connexin40 (Cx40) and connexin43 (Cx43) protein could not be detected immunohistochemically. We investigated therefore the distribution of their mRNAs with more sensitive techniques. METHODS:In situ hybridizations with Cx40 and ...

journal_title：Cardiovascular research

authors： Van Kempen MJ,Vermeulen JL,Moorman AF,Gros D,Paul DL,Lamers WH

更新日期：1996-11-01 00:00:00

abstract：:An isolated working rat heart preparation was used to characterise the temperature-dependency of the anti-ischaemic properties of nifedipine. In this study hearts were subjected to pre-ischaemic infusion with the St Thomas' cardioplegic solution with or without added nifedipine (0.075 mumol X litre-1). Hearts were the...

journal_title：Cardiovascular research

authors： Fukunami M,Hearse DJ

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVES:We performed the following study to define the effects of acute cardiac lymphatic obstruction on left ventricular (LV) systolic and diastolic function. METHODS:Cardiac lymphatic obstruction was created in 8 pentobarbital-anesthetized dogs by identifying (Evans blue) and ligating the right and left epicardia...

journal_title：Cardiovascular research

authors： Ludwig LL,Schertel ER,Pratt JW,McClure DE,Ying AJ,Heck CF,Myerowitz PD

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To investigate the possible mechanisms of the antiatherosclerotic effects of the angiotensin-converting enzyme (ACE) inhibitor, fosinopril, in apolipoprotein (apo) E deficient mice. METHODS:Apo E deficient (E0) mice at the age of 8 weeks received either placebo or a high dose (25 mg/kg/d) of fosinopril suppl...

journal_title：Cardiovascular research

authors： Hayek T,Attias J,Coleman R,Brodsky S,Smith J,Breslow JL,Keidar S

更新日期：1999-12-01 00:00:00