Abstract:
STUDY OBJECTIVE:The aim was to study the interactions between pulmonary capillary wedge pressure (an estimate of left atrial pressure), left atrial dimension, and atrial natriuretic factor during evolving heart failure. DESIGN:Sequential simultaneous measurements of haemodynamic variables, left atrial dimension, and plasma atrial natriuretic factor concentrations were obtained during evolving experimental pacing induced heart failure. EXPERIMENTAL MATERIAL:Eight male mongrel dogs were paced (250 beats.min-1) to severe heart failure over 4.9(SD 1.8) weeks. MEASUREMENTS AND RESULTS:The development of heart failure was characterised by a progressive increase in pulmonary capillary wedge pressure and left atrial cross sectional area, from 5.6(1.3) mm Hg and 7.9(1.2) cm2 respectively at control, to 25.3(4.9) mm Hg and 14.2(2.5) cm2 respectively (both p less than 0.01) at severe heart failure. In contrast to the progressive increase in pulmonary capillary wedge pressure and left atrial area, plasma atrial natriuretic factor concentration increased from 98(51) ng.litre-1 at control to a peak of 422(110) ng.litre-1 (p less than 0.01) at 1 week, then plateaued and reached 354(108) ng.litre-1 at severe heart failure (p less than 0.05 v control). Plasma atrial natriuretic factor correlated with pulmonary capillary wedge pressure and left atrial area at 1 week (r = 0.73, r = 0.71 respectively, both p less than 0.01), but not at the time of severe heart failure. CONCLUSION:The divergent time course of the changes in plasma atrial natriuretic factor concentration, pulmonary capillary wedge pressure, and left atrial dimension suggests that in this model, the release of atrial natriuretic factor becomes attenuated as severe heart failure develops.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Moe GW,Angus C,Howard RJ,De Bold AJ,Armstrong PWdoi
10.1093/cvr/24.7.570subject
Has Abstractpub_date
1990-07-01 00:00:00pages
570-7issue
7eissn
0008-6363issn
1755-3245journal_volume
24pub_type
杂志文章abstract::Although the existence of t-tubules in mammalian cardiac ventricular myocytes has been recognized for a long time, it now appears that their structure and function are more complex than previously believed. Recent work has provided evidence that many of the key proteins underlying excitation-contraction coupling are l...
journal_title:Cardiovascular research
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2002-08-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/cvw250
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journal_title:Cardiovascular research
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journal_title:Cardiovascular research
pub_type: 评论,杂志文章,评审
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更新日期:2000-01-01 00:00:00
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doi:10.1016/j.cardiores.2004.12.004
更新日期:2005-03-01 00:00:00
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0008-6363(99)00149-2
更新日期:1999-08-15 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(02)00335-8
更新日期:2002-06-01 00:00:00
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doi:10.1093/cvr/21.2.107
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doi:10.1016/s0008-6363(99)00058-9
更新日期:1999-07-01 00:00:00
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更新日期:2000-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-02-01 00:00:00
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更新日期:2008-05-01 00:00:00
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更新日期:2009-09-01 00:00:00
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更新日期:2016-07-01 00:00:00
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更新日期:2001-08-15 00:00:00