Strategies to achieve coronary arterial plaque stabilization.

Abstract:

:Acute coronary syndromes result from fissure, erosion or rupture of a vulnerable atherosclerotic plaque. The characteristics of a vulnerable plaque include a large lipid pool, an abundance of inflammatory cells and mediators, a reduced smooth muscle cell and collagen content and a thin overlying fibrous cap. Potential therapeutic strategies at achieving plaque stabilization have targeted these features. Lipid lowering agents, beta-adrenergic blockers, angiotensin converting enzyme inhibitors and antioxidants have been shown to reduce the incidence of acute coronary syndromes, presumably through plaque stabilization. Matrix metalloproteinase inhibitors as well as macrolide antibiotics and gene therapy approaches show promise in achieving plaque stabilization. The evidence supporting plaque stabilization by these agents and the mechanisms by which these agents stabilize plaques are discussed in detail in this review.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Rabbani R,Topol EJ

doi

10.1016/s0008-6363(98)00279-x

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

402-17

issue

2

eissn

0008-6363

issn

1755-3245

pii

S0008-6363(98)00279-X

journal_volume

41

pub_type

杂志文章,评审
  • Endogenous catecholamines are not necessary for ischaemic preconditioning in the isolated perfused rat heart.

    abstract:OBJECTIVE:The mechanism of the protective effect of ischaemic preconditioning in the myocardium is not yet known. The aim of this study was to test the hypothesis that endogenous myocardial catecholamines may be mediators of preconditioning. METHODS:To test whether endogenous catecholamines are involved in preconditio...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:

    authors: Weselcouch EO,Baird AJ,Sleph PG,Dzwonczyk S,Murray HN,Grover GJ

    更新日期:1995-01-01 00:00:00

  • Forearm arterial compliance: a new measure of arterial compliance?

    abstract::This study has investigated the origin of the pulsatile expansion of the forearm recorded by the amplification of the pulsatile signal derived from a mercury in rubber plethysmograph. Venous occlusion to pressures of 40 mmHg had no effect on the amplitude of the volume pulse, suggesting that the volume pulse originate...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/18.11.651

    authors: Fitchett DH

    更新日期:1984-11-01 00:00:00

  • Biochemical changes associated with development and reversal of cardiac hypertrophy in spontaneously hypertensive rats.

    abstract::This study is the first report describing the sequence of biochemical alterations of myocardium during the progression of naturally occurring hypertrophy in spontaneously hypertensive rats (SHRs) and then with its reversal by alpha-methyldopa therapy. Changes in DNA, RNA, hydroxyproline, as well as incorporation of 14...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/10.2.254

    authors: Sen S,Tarazi RC,Bumpus FM

    更新日期:1976-03-01 00:00:00

  • Myocardial oedema: a preventable cause of reperfusion injury?

    abstract::Myocardial ischaemia increases cellular and extracellular osmolarity, alters membrane permeability to ions and causes moderate cell swelling and interstitial oedema. Ischaemia also reduces the mechanical resistance of the sarcolemma of myocytes, probably as a result of proteolytic digestion of the connections between ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1093/cvr/27.9.1555

    authors: Garcia-Dorado D,Oliveras J

    更新日期:1993-09-01 00:00:00

  • Mitochondrial K(ATP) channels: role in cardioprotection.

    abstract::The role of the mitochondrial ATP-sensitive potassium channel (mK(ATP)) in ischemic preconditioning and cardioprotection is reviewed. A great deal of accumulated evidence implicatese opening of this channel as an important step in the anti-infarct effect of ischemic preconditioning. Recent studies, however, reveal tha...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1016/s0008-6363(02)00439-x

    authors: Oldenburg O,Cohen MV,Yellon DM,Downey JM

    更新日期:2002-08-15 00:00:00

  • The circadian pacemaker generates similar circadian rhythms in the fractal structure of heart rate in humans and rats.

    abstract:AIMS:Adverse cardiovascular events in humans occur with a day/night pattern, presumably related to a daily pattern of behaviours or endogenous circadian rhythms in cardiovascular variables. Healthy humans possess a scale-invariant/fractal structure in heartbeat fluctuations that exhibits an endogenous circadian rhythm ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvn150

    authors: Hu K,Scheer FA,Buijs RM,Shea SA

    更新日期:2008-10-01 00:00:00

  • Matricellular proteins in the heart: possible role during stress and remodeling.

    abstract::Matricellular proteins are extracellular matrix proteins that modulate cell-matrix interactions and cell function, and do not seem to have a direct structural role. The family includes tenascin-C (TN-C), tenascin-X (TN-X), osteonectin, osteopontin, thrombospondin-1 (TSP1) and thrombospondin-2 (TSP2). Expression of mat...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1016/j.cardiores.2004.06.006

    authors: Schellings MW,Pinto YM,Heymans S

    更新日期:2004-10-01 00:00:00

  • The angiotensin II type 2 receptor activates flow-mediated outward remodelling through T cells-dependent interleukin-17 production.

    abstract:AIMS:The angiotensin II type 1 receptor (AT1R) through the activation of immune cells plays a key role in arterial inward remodelling and reduced blood flow in cardiovascular disorders. On the other side, flow (shear stress)-mediated outward remodelling (FMR), involved in collateral arteries growth in ischaemic disease...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvw172

    authors: Caillon A,Grenier C,Grimaud L,Vessieres E,Guihot AL,Blanchard S,Lelievre E,Chabbert M,Foucher ED,Jeannin P,Beauvillain C,Abraham P,Loufrani L,Delneste Y,Henrion D

    更新日期:2016-10-01 00:00:00

  • Those who faced turbulence and launched the era of flow dynamic concepts for cardiac investigation.

    abstract::This paper puts emphasis on pioneers who developed cardiac flow dynamics concepts during the second half of the 20th century at a period where pressure measurements were the rule. Thinking flow instead of pressure dynamics corresponded to in-depth conceptual changes: whereas blood pressure generally has a single posit...

    journal_title:Cardiovascular research

    pub_type: 社论,历史文章

    doi:10.1016/s0008-6363(01)00307-8

    authors: Veyrat C

    更新日期:2001-08-01 00:00:00

  • Endothelium independent relaxation of human coronary arteries by 17 beta-oestradiol in vitro.

    abstract:OBJECTIVE:There is accumulating evidence that oestrogen replacement therapy protects against the development of coronary atherosclerosis and myocardial infarction in postmenopausal women. The mechanism of this protective effect is uncertain. The aim of this study was to measure the effects of 17 beta-oestradiol on huma...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/27.11.1939

    authors: Mügge A,Riedel M,Barton M,Kuhn M,Lichtlen PR

    更新日期:1993-11-01 00:00:00

  • Spontaneous diastolic contractions and phosphorylation of the cardiac ryanodine receptor at serine-2808 in congestive heart failure in rat.

    abstract:OBJECTIVE:The role of phosphorylation of the ryanodine receptor at serine-2808 (RyRS2808) in congestive heart failure (CHF) is controversial, and effects of RyRS2808 phosphorylation on contraction are unclear. It has been reported that diastolic sarcomere length (SL) fluctuations accompany propagating contractile waves...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/j.cardiores.2005.07.010

    authors: Obayashi M,Xiao B,Stuyvers BD,Davidoff AW,Mei J,Chen SR,ter Keurs HE

    更新日期:2006-01-01 00:00:00

  • Reactive and reparative fibrillar collagen remodelling in the hypertrophied rat left ventricle: two experimental models of myocardial fibrosis.

    abstract:STUDY OBJECTIVE:The aim was to compare the temporal sequence and structural relationship between perivascular and interstitial fibrosis and microscopic scarring seen in the left ventricle in response to either a transient or sustained stimulus to fibrosis. DESIGN:In 72 male Wistar rats (250-350 g) the transient stimul...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/24.9.741

    authors: Silver MA,Pick R,Brilla CG,Jalil JE,Janicki JS,Weber KT

    更新日期:1990-09-01 00:00:00

  • Dominant-negative effect of SCN5A N-terminal mutations through the interaction of Na(v)1.5 α-subunits.

    abstract:AIMS:Brugada syndrome (BrS) is an autosomal-inherited cardiac arrhythmia characterized by an ST-segment elevation in the right precordial leads of the electrocardiogram and an increased risk of syncope and sudden death. SCN5A, encoding the cardiac sodium channel Na(v)1.5, is the main gene involved in BrS. Despite the f...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvs211

    authors: Clatot J,Ziyadeh-Isleem A,Maugenre S,Denjoy I,Liu H,Dilanian G,Hatem SN,Deschênes I,Coulombe A,Guicheney P,Neyroud N

    更新日期:2012-10-01 00:00:00

  • Noninvasive determination of the mitral valve area in stenosis: a computational model and correlation with autopsy and open heart measurements.

    abstract::An analytical formulation has been developed which allows the computation of mitral valve area (A) from the potentially noninvasive paramaeters of hear rate (R), cardiac output (CO) and diastolic filling period (DFP) by the equation A = 21 CO/R x DFP2. The computed areas correlate with autopsy and open heart measureme...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/14.4.223

    authors: Seitz WS,Operschall EJ

    更新日期:1980-04-01 00:00:00

  • Physiological and pathophysiological roles of eicosanoids in the microcirculation.

    abstract::Eicosanoids are important mediators of both physiological and pathophysiological responses of the microcirculation. These biologically active lipid mediators can be produced locally by the cellular elements within the microvasculature (endothelium, pericytes, smooth muscle cells) as well as interstitial cells (e.g. fi...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:

    authors: Gerritsen ME

    更新日期:1996-10-01 00:00:00

  • Significance of matrix metalloproteinases in norepinephrine-induced remodelling of rat hearts.

    abstract:OBJECTIVE:Norepinephrine (NE) induced hypertrophy and remodelling of the extracellular matrix (ECM) in the left ventricle (LV) of the rat heart with resulting fibrosis. However, there was no increased collagen deposition in the right ventricle (RV). To test the hypothesis that lack of RV fibrosis is the result of eleva...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/s0008-6363(02)00700-9

    authors: Briest W,Hölzl A,Rassler B,Deten A,Baba HA,Zimmer HG

    更新日期:2003-02-01 00:00:00

  • Taurine depresses INa and depolarises the membrane but does not affect membrane surface charges in perfused rabbit hearts.

    abstract:STUDY OBJECTIVE:The aim was to determine whether taurine influences the membrane surface charges in cardiac muscle. DESIGN:Screening of the negative charges at the outside surface of the membrane results in a shift of the steady state inactivation of the sodium system towards less negative potentials. This feature was...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/24.11.918

    authors: Dumaine R,Schanne OF,Ruiz-Petrich E

    更新日期:1990-11-01 00:00:00

  • Evidence for the stimulatory effect of resveratrol on Ca(2+)-activated K+ current in vascular endothelial cells.

    abstract:OBJECTIVE:Resveratrol, a natural phytoalexin compound, is present in grapes and wine, and it can produce vasorelaxation. However, little is known of its mechanisms of action on ionic currents in endothelial cells. METHODS:The effect of resveratrol on Ca(2+)-activated K+ currents in an endothelial cell line (HUV-EC-C) ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/s0008-6363(99)00397-1

    authors: Li HF,Chen SA,Wu SN

    更新日期:2000-03-01 00:00:00

  • Evidence for P(2)-purinoceptors contribution in H(2)O(2)-induced contraction of rat aorta in the absence of endothelium.

    abstract:OBJECTIVE:H(2)O(2) can contract many arteries, however the underlying mechanisms are not fully understood. This study aims to test whether H(2)O(2)-induced vasoconstriction could be functionally attributed to the activation of P(2)-purinoceptors in rat aorta and to explore its possible signaling mechanisms. METHODS:Is...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/s0008-6363(00)00123-1

    authors: Shen JZ,Zheng XF,Kwan CY

    更新日期:2000-08-18 00:00:00

  • Role of microRNAs in the reperfused myocardium towards post-infarct remodelling.

    abstract::Myocardial ischaemia/reperfusion (I/R)-induced remodelling generally includes cell death (necrosis and apoptosis), myocyte hypertrophy, angiogenesis, cardiac fibrosis, and myocardial dysfunction. It is becoming increasingly clear that microRNAs (miRNAs or miRs), a group of highly conserved small (∼18-24 nucleotide) no...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1093/cvr/cvr291

    authors: Zhu H,Fan GC

    更新日期:2012-05-01 00:00:00

  • Pericytes influence endothelial cell growth characteristics: role of plasminogen activator inhibitor type 1 (PAI-1).

    abstract:OBJECTIVE:Pericytes, located in close proximity to the underlying endothelium, form an integral component of the microvasculature. These cells are intimately involved in angiogenesis, which is of fundamental importance in many physiological and pathological processes. We evaluated the influence of pericyte-conditioned ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/j.cardiores.2005.08.003

    authors: McIlroy M,O'Rourke M,McKeown SR,Hirst DG,Robson T

    更新日期:2006-01-01 00:00:00

  • NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse.

    abstract:AIMS:Extracellular nucleotides are vasoactive molecules. The concentrations of these molecules are regulated by ectonucleotidases. In this study, we investigated the role of the blood vessel ectonucleotidase NTPDase1, in the vasoconstrictor effect of nucleotides using Entpd1(-/-) mice. METHODS AND RESULTS:Immunofluore...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvp265

    authors: Kauffenstein G,Drouin A,Thorin-Trescases N,Bachelard H,Robaye B,D'Orléans-Juste P,Marceau F,Thorin E,Sévigny J

    更新日期:2010-01-01 00:00:00

  • The angiotensin-converting enzyme inhibitor, fosinopril, and the angiotensin II receptor antagonist, losartan, inhibit LDL oxidation and attenuate atherosclerosis independent of lowering blood pressure in apolipoprotein E deficient mice.

    abstract:OBJECTIVE:To investigate the possible mechanisms of the antiatherosclerotic effects of the angiotensin-converting enzyme (ACE) inhibitor, fosinopril, in apolipoprotein (apo) E deficient mice. METHODS:Apo E deficient (E0) mice at the age of 8 weeks received either placebo or a high dose (25 mg/kg/d) of fosinopril suppl...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/s0008-6363(99)00239-4

    authors: Hayek T,Attias J,Coleman R,Brodsky S,Smith J,Breslow JL,Keidar S

    更新日期:1999-12-01 00:00:00

  • Differences in bleeding time, aspirin sensitivity and adrenaline between acute myocardial infarction and unstable angina.

    abstract::STUDY OBJECTIVE - The objective was to measure platelet function in vivo (as cutaneous bleeding time), the role of catecholamines, and the effect of inhibiting thromboxane synthesis on bleeding time, in patients with myocardial infarction, unstable angina, and non-cardiac chest pain. DESIGN - Haemotological variables ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/24.1.19

    authors: Kristensen SD,Bath PM,Martin JF

    更新日期:1990-01-01 00:00:00

  • Alterations in c-fos expression, cell proliferation and apoptosis in pressure distended human saphenous vein.

    abstract:OBJECTIVES:Saphenous vein graft failures, resulting from thrombosis and the abnormal proliferation, migration and apoptosis of vascular smooth muscle cells (VSMC) are major limitations of coronary artery bypass surgery. We investigated whether surgical trauma of human saphenous vein induces the early response gene c-fo...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/s0008-6363(99)00220-5

    authors: Galea J,Armstrong J,Francis SE,Cooper G,Crossman DC,Holt CM

    更新日期:1999-11-01 00:00:00

  • Adenovirus-mediated expression of p35 prevents hypoxia/reoxygenation injury by reducing reactive oxygen species and caspase activity.

    abstract:OBJECTIVE:This study aimed to examine the effects of adenovirus-mediated expression of p35, a baculovirus gene, on apoptosis induced by hypoxia/reoxygenation (H/R) in cardiomyocytes. METHODS:Neonatal rat cardiomyocytes were infected with recombinant adenoviral vectors expressing p35 (Ad2/CMVp35) or no transgene (Ad2/C...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/s0008-6363(02)00412-1

    authors: Date T,Belanger AJ,Mochizuki S,Sullivan JA,Liu LX,Scaria A,Cheng SH,Gregory RJ,Jiang C

    更新日期:2002-08-01 00:00:00

  • Mechanical properties and structure of carotid arteries in mice lacking desmin.

    abstract:OBJECTIVE:Our aim was to determine in desmin homozygous mutant mice the viscoelastic properties, the mechanical strength and the structure of the carotid artery. METHODS:To assess the viscoelastic properties of large arteries, we have performed an in vivo analysis of the diameter-, and distensibility-pressure curves o...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/s0008-6363(01)00278-4

    authors: Lacolley P,Challande P,Boumaza S,Cohuet G,Laurent S,Boutouyrie P,Grimaud JA,Paulin D,Lamazière JM,Li Z

    更新日期:2001-07-01 00:00:00

  • Current thresholds and liminal size in excitation of heart muscle.

    abstract::End-diastolic current thresholds have been measured in 12 open-chested dogs with epicardial disc electrodes ranging in radius from 0.01 to 9.0 mm. The current threshold for cathodal 1 ms impulses proved to be independent of electrode size for radii smaller than 0.2 mm and proportional to the radius to the power 1.5 fo...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/12.8.477

    authors: Lindemans FW,Denier Van der Gon JJ

    更新日期:1978-08-01 00:00:00

  • Chronic ET(A) receptor blockade prevents endothelial dysfunction of small arteries in apolipoprotein E-deficient mice.

    abstract:OBJECTIVE:This study investigated whether endothelial dysfunction occurs in mesenteric arteries of apoE-deficient mice and determined the role of endothelin (ET)-1, which is increased in human atherosclerosis, using an orally active endothelin ET(A) receptor antagonist. METHODS:ApoE-deficient and C57BL/6J control mice...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/s0008-6363(01)00469-2

    authors: d'Uscio LV,Barton M,Shaw S,Lüscher TF

    更新日期:2002-02-01 00:00:00

  • Noninvasively and invasively measured pulsatile haemodynamics with graded arterial stenosis.

    abstract::Pulsatile haemodynamics associated with graded degrees of experimentally produced stenosis were studied in the canine femoral artery. Invasively determined pulsatile blood flow and noninvasively determined blood velocity with Doppler ultrasound were measured an average of 1.3 and 2.3 cm proximal to the stenosis, respe...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/13.1.45

    authors: Farrar DJ,Green HD,Peterson DW

    更新日期:1979-01-01 00:00:00