Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal.

abstract：OBJECTIVES:We measured the uptake of technetium-99m tetrofosmin (99m Tc) and thallium-201 (201 TI) in areas of healed transmural myocardial infarction and in the regions of acute peri-infarction ischemia. METHODS:Anesthetised pigs with a 1-month old transmural infarction elicited by permanent ligature of the left ante...

journal_title：Cardiovascular research

authors： Cinca J,Garcia-Burillo A,Carreño A,Castell J,Warren M,Candell-Riera J,Domingo A,Soler-Soler J

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:Matrix metalloproteinases (MMPs) cause extracellular matrix degradation and may be involved in the rupture of atherosclerotic plaques by degrading fibrous cap, resulting in the intravascular thrombus formation. Here we examined whether local overexpression of MMP-9 alters the characteristics of arteriosclerot...

journal_title：Cardiovascular research

authors： Morishige K,Shimokawa H,Matsumoto Y,Eto Y,Uwatoku T,Abe K,Sueishi K,Takeshita A

更新日期：2003-02-01 00:00:00

abstract：:Mayer waves are oscillations of arterial pressure occurring spontaneously in conscious subjects at a frequency lower than respiration (approximately 0.1 Hz in humans). Mayer waves are tightly coupled with synchronous oscillations of efferent sympathetic nervous activity and are almost invariably enhanced during states...

journal_title：Cardiovascular research

authors： Julien C

更新日期：2006-04-01 00:00:00

abstract：:Circulating concentrations of leucocyte elastase and free radical activity were measured in 11 adults undergoing cardiopulmonary bypass. In all patients the bypass procedure was associated with pronounced changes in plasma elastase concentrations, and peak enzyme concentrations correlated closely with the duration of ...

journal_title：Cardiovascular research

authors： Hind CR,Griffin JF,Pack S,Latchman YE,Drake HF,Jones HM,Brostoff J,Dormandy TL,Treasures T

更新日期：1988-01-01 00:00:00

abstract：:Papillary muscles isolated from the left ventricle of 17-20 day old Syrian hamsters with genetic cardiomyopathy (BIO 14.6 strain) were examined for their mechanophysiological response to the beta adrenoceptor agonist isoprenaline. The indices of isometric twitch for both myopathic and aged matched normal (BIO RB strai...

journal_title：Cardiovascular research

authors： Rossner KL,Coudrai PR

更新日期：1986-08-01 00:00:00

abstract：:Although the existence of t-tubules in mammalian cardiac ventricular myocytes has been recognized for a long time, it now appears that their structure and function are more complex than previously believed. Recent work has provided evidence that many of the key proteins underlying excitation-contraction coupling are l...

journal_title：Cardiovascular research

authors： Orchard C,Brette F

更新日期：2008-01-15 00:00:00

abstract：:Gender has an important influence on blood pressure, with premenopausal women having a lower arterial blood pressure than age-matched men. Compared with premenopausal women, postmenopausal women have higher blood pressures, suggesting that ovarian hormones may modulate blood pressure. However, whether sex hormones are...

journal_title：Cardiovascular research

authors： Dubey RK,Oparil S,Imthurn B,Jackson EK

更新日期：2002-02-15 00:00:00

abstract：OBJECTIVES:Coronary collateral flow often mitigates the effects of coronary artery obstruction and has a significant impact on the prognosis of patients with coronary artery disease. In the presence of variable degrees of coronary collateral flow, digital radiographic assessment of myocardial blood flow has not been qu...

journal_title：Cardiovascular research

authors： Murata K,Bhargava V,Ricou F,Ono S,Kambayashi M,Oh BH,Peterson KL

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:The aims of the study were to determine the effect of chronic pressure overload of the left ventricle on the density and distribution of neuropeptide-Y-like immunoreactive (NPY-LI) nerve fibres in heart and to compare any changes to those observed in adrenergic nerve fibres, identified by dopamine beta-hydrox...

journal_title：Cardiovascular research

authors： Love S,Nyquist-Battie C,DiMaggio DA,Farah JM Jr,Chronwall BM

更新日期：1993-03-01 00:00:00

abstract：AIMS:Crosstalk between cardiomyocytes and fibroblasts in physiological conditions and during disease remains poorly defined. Previous studies have shown that fibroblasts and myocytes interact via paracrine communication, but several experimental confounding factors, including the use of immature myocytes and the induct...

journal_title：Cardiovascular research

authors： Cartledge JE,Kane C,Dias P,Tesfom M,Clarke L,Mckee B,Al Ayoubi S,Chester A,Yacoub MH,Camelliti P,Terracciano CM

更新日期：2015-03-01 00:00:00

abstract：Aims:Fibroblast growth factor 1 (FGF1), a heparin/heparan sulfate-binding growth factor, is a potent cardioprotective agent against myocardial infarction (MI). The impact of heparin, the standard of care for MI patients entering the emergency room, on cardioprotective effects of FGF1 is unknown, however. Methods and r...

journal_title：Cardiovascular research

authors： Huang C,Liu Y,Beenken A,Jiang L,Gao X,Huang Z,Hsu A,Gross GJ,Wang YG,Mohammadi M,Schultz JEJ

更新日期：2017-11-01 00:00:00

abstract：AIMS:Neointimal hyperplasia is a common feature of fibro-proliferative vascular disease and characterizes initial stages of atherosclerosis. Neointimal lesions mainly comprise smooth muscle-like cells. The presence of these lesions is related to local differences in shear stress. Neointimal cells may arise through migr...

journal_title：Cardiovascular research

authors： Moonen JR,Lee ES,Schmidt M,Maleszewska M,Koerts JA,Brouwer LA,van Kooten TG,van Luyn MJ,Zeebregts CJ,Krenning G,Harmsen MC

更新日期：2015-12-01 00:00:00

abstract：:Therapeutic neovascularization for cardiovascular ischemia is a promising avenue in spite of disappointing early clinical trial results. The concept of three different mechanisms of neovascularization has served to define potential therapeutic targets such as vascular remodeling and stem cell recruitment, but it is an...

journal_title：Cardiovascular research

authors： Cao Y,Hong A,Schulten H,Post MJ

更新日期：2005-02-15 00:00:00

abstract：OBJECTIVE:Previous studies showed that treatment of hearts with nisoldipine improves recovery of cardiac function following ischaemia, improves reperfusion, and reduces the constrictor sensitivity to endothelin. The aim of the present study was to assess the reduction in vasodilator responses that occurs following isch...

journal_title：Cardiovascular research

authors： Yaghi MM,Watts JA

更新日期：1993-06-01 00:00:00

abstract：:The kinetics of onset of rate-dependent depression of maximum rate of depolarisation (Vmax) of guinea-pig ventricular action potentials were studied for nine Class I anti-arrhythmic drugs using standard microelectrode techniques. The drugs were found to fall into three well-demarcated subgroups with "fast" (lignocaine...

journal_title：Cardiovascular research

authors： Campbell TJ

更新日期：1983-06-01 00:00:00

abstract：:The efficacy of cardioprotective strategies can be quantified by myocardial salvage as an indicator of therapeutic benefit. Salvage is calculated as the difference between the area at risk (AAR) and the final infarct size (FIS). AAR has been quantified by angiographic assessment followed by quantification of FIS by bi...

journal_title：Cardiovascular research

authors： Bøtker HE,Kaltoft AK,Pedersen SF,Kim WY

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:Infusion of angiotensin II (AngII) during the third and fourth week after balloon injury of the left common carotid artery of the rat induces smooth muscle cell (SMC) DNA synthesis. In this study we wanted to investigate whether alpha 1-adrenoreceptors are involved in AngII-induced SMC DNA synthesis in the ne...

journal_title：Cardiovascular research

authors： van Kleef EM,Smits JF,Schwartz SM,Daemen MJ

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:Anoxia followed by reoxygenation (A/R) increases endothelial cell superoxide (O2-) generation which is implicated in E-selectin overexpression. The mechanisms which govern these processes are not fully understood and therefore the goal of our study was to determine the functional importance of NADPH oxidase i...

journal_title：Cardiovascular research

authors： Rupin A,Paysant J,Sansilvestri-Morel P,Lembrez N,Lacoste JM,Cordi A,Verbeuren TJ

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:The purpose was to investigate the influence of the 38-amino-acid neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP38), on contractile function and coronary vascular tone in neonatal hearts. METHODS:Isolated, paced (150 bpm), isovolumically-beating, piglet hearts (n = 19) underwent retr...

journal_title：Cardiovascular research

authors： Ascuitto RJ,Ross-Ascuitto NT,Waddell AE,Kadowitz PJ

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:Norepinephrine (NE) induced hypertrophy and remodelling of the extracellular matrix (ECM) in the left ventricle (LV) of the rat heart with resulting fibrosis. However, there was no increased collagen deposition in the right ventricle (RV). To test the hypothesis that lack of RV fibrosis is the result of eleva...

journal_title：Cardiovascular research

authors： Briest W,Hölzl A,Rassler B,Deten A,Baba HA,Zimmer HG

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVES:Prior studies have shown that the performance of the left ventricle on any one beat is influenced by the mechanical events of the previous beat, a phenomenon called "previous-beat contraction history". This previous-beat contraction history, which appears to be an interplay between the mechanical events of o...

journal_title：Cardiovascular research

authors： Slinker BK,Tobias AH

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:The aim was to further characterise an experimental model of preconditioning of isolated rabbit cardiomyocytes and to determine the role of adenosine receptor subtypes in initiation of the protective response. METHODS:Isolated myocytes were subjected to 5 min preincubation in the presence or absence of gluco...

journal_title：Cardiovascular research

authors： Armstrong S,Ganote CE

更新日期：1994-07-01 00:00:00

abstract：:Platelet-activating factor might be responsible for the alterations of diastolic function observed in different disease states and these potential effects have not been studied. The effect of incremental concentrations of platelet-activating factor (to a maximum of 200 nM) was therefore examined in isolated perfused r...

journal_title：Cardiovascular research

authors： Muñoz HR,Evans RD,Marsch SC,Foëx P

更新日期：1995-12-01 00:00:00

abstract：AIMS:Regulated cell death is a main contributor of myocardial ischaemia-reperfusion (IR) injury during acute myocardial infarction. In this context, targeting apoptosis could be a potent therapeutical strategy. In a previous study, we showed that DAXX (death-associated protein) was essential for transducing the FAS-dep...

journal_title：Cardiovascular research

authors： Boisguérin P,Covinhes A,Gallot L,Barrère C,Vincent A,Busson M,Piot C,Nargeot J,Lebleu B,Barrère-Lemaire S

更新日期：2020-03-01 00:00:00

abstract：:Protein and lipid oxidation-mainly by mitochondrial reactive oxygen species (mtROS)-was proposed as a crucial determinant of health and lifespan. Angiotensin II (Ang II) enhances ROS production by activating NAD(P)H oxidase and uncoupling endothelial nitric oxide synthase (NOS). Ang II also stimulates mtROS production...

journal_title：Cardiovascular research

authors： de Cavanagh EM,Inserra F,Ferder L

更新日期：2011-01-01 00:00:00

abstract：:Atherosclerosis is characterized by a persistent, low-grade inflammation of the arterial wall. Monocytes and monocyte-derived macrophages play a pivotal role in the various stages of atherosclerosis. In the past few years, metabolic reprogramming has been identified as an important controller of myeloid cell activatio...

journal_title：Cardiovascular research

authors： van Tuijl J,Joosten LAB,Netea MG,Bekkering S,Riksen NP

更新日期：2019-07-01 00:00:00

abstract：AIMS:The expression of PUMA (p53-up-regulated modulator of apoptosis), an apoptosis-regulating gene, increases during endoplasmic reticulum stress. The mechanisms by which cyclic stretch influences the regulation of PUMA in vascular smooth muscle cells (VSMCs) during apoptosis remain unclear. We hypothesized that cycli...

journal_title：Cardiovascular research

authors： Cheng WP,Wang BW,Chen SC,Chang H,Shyu KG

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:To investigate the effect of alpha,beta(1) and beta(2) adrenergic receptor (AR) stimulation on coronary hemodynamics, myocardial oxygen consumption (M(v)O(2)) and metabolic substrate preference in advanced dilated cardiomyopathy (DCM). METHODS:We studied 19 conscious, instrumented dogs with pacing-induced D...

journal_title：Cardiovascular research

authors： Nikolaidis LA,Hentosz T,Doverspike A,Huerbin R,Stolarski C,Shen YT,Shannon RP

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:The mechanism of defibrillation is controversial. Reentry appearing immediately after the shock has been shown to be responsible for defibrillation failure in some studies while other studies have demonstrated that a rapid train of focal activations with the first focus appearing >50 ms after the shock is re...

journal_title：Cardiovascular research

authors： Chattipakorn N,Banville I,Gray RA,Ideker RE

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:To assess the contribution of the Na, K pump current (I(p)) to the action potential duration (APD) and effective refractory period (ERP) in human atrial cells, and to investigate whether I(p) contributes to the changes in APD and ERP associated with chronic atrial fibrillation (AF). METHODS:Action potentials...

journal_title：Cardiovascular research

authors： Workman AJ,Kane KA,Rankin AC

更新日期：2003-09-01 00:00:00