Abstract：
:The efficacy of cardioprotective strategies can be quantified by myocardial salvage as an indicator of therapeutic benefit. Salvage is calculated as the difference between the area at risk (AAR) and the final infarct size (FIS). AAR has been quantified by angiographic assessment followed by quantification of FIS by biochemical ischaemic markers or imaging modalities such as cardiovascular magnetic resonance (CMR). Angiographical methods may overestimate AAR and since methodological differences may exist between different modalities, the use of different modalities for estimating AAR and FIS may not be recommended. (99m)Technetium (Tc)-Sestamibi single-photon emission tomography (SPECT) allows quantification of AAR and FIS by tracer injection prior to revascularization and after 1 month, respectively. SPECT provides the most validated measure of myocardial salvage and has been utilized in multiple randomized clinical trials. However, SPECT is logistically challenging, expensive, and includes radiation exposure. More recently, a large number of studies have suggested that CMR can determine salvage in a single examination by combining measures of myocardial oedema in the AAR exposed to ischaemia reperfusion with FIS quantification by late gadolinium enhancement. The T1- and T2-weighted CMR approaches for quantification of AAR utilize non-contrast, early and late gadolinium enhancement techniques. The technical progress, high spatial resolution and the potential for retrospective quantification of the AAR makes CMR the most appropriate technique for assessment of myocardial salvage. However, the optimum CMR technique for assessment of myocardial AAR remains to be defined. Consequently, we recommend a comprehensive CMR protocol to ensure reliable assessment of myocardial salvage.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Bøtker HE,Kaltoft AK,Pedersen SF,Kim WYdoi
10.1093/cvr/cvs081subject
Has Abstractpub_date
2012-05-01 00:00:00pages
266-75issue
2eissn
0008-6363issn
1755-3245pii
cvs081journal_volume
94pub_type
杂志文章,评审abstract：:Myocardial capillary permeability was determined in 20 dogs by applying a new method which resembles the tissue-uptake technique. The method consisted of a bolus injection of 51Cr-EDTA into the left atrium, determination of the average arterial tracer concentration and subsequent assay of myocardial tissue activity 10...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/18.5.277
更新日期：1984-05-01 00:00:00
abstract：OBJECTIVES:It has been shown that circulating human non-adherent CD34+ cells coexpressing vascular endothelial growth factor (VEGF)-R2 and AC133 have the capacity to differentiate into adherent mature endothelial cells. However, prior studies have demonstrated that a much bigger subset of primary adherent mononuclear c...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(00)00270-4
更新日期：2001-02-16 00:00:00
abstract：:18 patients without valvular pathology, coronary artery disease, or idiopathic hypertrophic subaortic stenosis were haemodynamically and angiographically investigated in order to analyse the effects of a ventricular extrasystolic beat upon the post-extrasystolic left ventricular peak pressure. In eight normal patients...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/13.6.338
更新日期：1979-06-01 00:00:00
abstract：AIMS:The regulation of vascular diameter by vasoconstrictors and vasodilators requires that vascular smooth muscle cells (VSMCs) be physically coupled to extracellular matrix (ECM) and neighbouring cells in order for a vessel to mechanically function and transfer force. The hypothesis was tested that integrin-mediated ...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvs239
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of the ATP-sensitive potassium (KATP) channel inhibitor sodium 5-hydroxydecanoate (5-HD) on the reduction in myocardial infarct size afforded by ischaemic preconditioning in the sodium pentobarbitone rabbit. METHODS:New Zealand white rabbits were anaesthetised with sodium pentobarbi...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：:By measuring the coronary sinus blood flow using the thermodilution technique the influence of "thermodilution catheter" withdrawal from the great cardiac vein to the ostium of the coronary sinus was investigated in 41 patients. In addition, the influence of normal and forced respiration on coronary sinus blood flow w...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/19.1.27
更新日期：1985-01-01 00:00:00
abstract：:Arteriogenesis, the process of collateral artery growth as an adaptation to major arterial occlusion, can be life- and tissue saving and may alter the natural course of the consequences and organ manifestations of arterial disease. This is achieved by an active growth process that is coupled to complete arterial remod...
journal_title：Cardiovascular research
pub_type： 杂志文章,评审
doi：10.1016/s0008-6363(99)00191-1
更新日期：1999-09-01 00:00:00
abstract：OBJECTIVE:The heart contains proteins of the annexin family, a unique group of calcium binding proteins. This study was aimed at identifying the major cardiac annexins and determining their distribution in the rat heart. METHODS:Annexins were isolated by affinity chromatography and purified by ion exchange high pressu...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/27.7.1359
更新日期：1993-07-01 00:00:00
abstract：OBJECTIVE:The adhesive interaction of monocytes and endothelial cells has been implicated as a regulatory signal in the cell activation that is involved in the pathogenesis of atherosclerosis. We investigated the effect of monocyte-endothelial cell interaction on the expression of adhesion molecules, intercellular adhe...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/0008-6363(96)00085-5
更新日期：1996-08-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to determine whether chronic beta-adrenergic receptor (beta-AR) stimulation induces proliferation of human cardiac fibroblasts and to investigate the mechanism(s) involved. METHODS AND RESULTS:In vitro cultures of human cardiac fibroblasts were established from biopsies of right atr...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(02)00729-0
更新日期：2003-03-01 00:00:00
abstract：OBJECTIVES:Cardiovascular disease is rare in premenopausal women, but increases after the menopause when hormone replacement therapy reduces coronary events. Vascular smooth muscle cell (SMC) proliferation and migration occur in atherosclerosis, restenosis and venous graft disease. We studied the effects of 17 beta-est...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：
更新日期：1996-11-01 00:00:00
abstract：OBJECTIVE:There is accumulating evidence that oestrogen replacement therapy protects against the development of coronary atherosclerosis and myocardial infarction in postmenopausal women. The mechanism of this protective effect is uncertain. The aim of this study was to measure the effects of 17 beta-oestradiol on huma...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/27.11.1939
更新日期：1993-11-01 00:00:00
abstract：OBJECTIVE:In heart failure (HF), the generation of reactive oxygen species (ROS) is enhanced. It was shown that failing cardiac myocytes are more susceptible to ROS-induced damage, possibly due to increased expression of the sarcolemmal Na-Ca exchanger (NCX). METHODS:We investigated the consequences of increased expre...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2003.08.006
更新日期：2003-11-01 00:00:00
abstract：OBJECTIVE:Intercellular adhesion molecule (ICAM)-1 is an immunoglobulin-like cell adhesion molecule expressed by several cell types, including proliferating vascular smooth muscle cells (VSMC). Cross-linking ICAM-1 on the surface of different cell types has previously been shown to cause an increase in cellular activat...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(01)00207-3
更新日期：2001-06-01 00:00:00
abstract：AIMS:Percutaneous implantation has already been used clinically and is a great option for treating young patients. The use of autologous tissue-engineered valved stents might solve the problem of degeneration and limited durability of biological heart valves. METHODS AND RESULTS:Porcine pulmonary heart valves and smal...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvq212
更新日期：2010-12-01 00:00:00
abstract：:End tidal PCO2 (PETCO2) has been found to be a good prognostic indicator of successful resuscitation from cardiac arrest. To explore the value of this measurement further, we carried out a series of experiments during cardiac arrest and closed chest resuscitation in 14 mechanically ventilated Sprague-Dawley rats. Vent...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/23.4.364
更新日期：1989-04-01 00:00:00
abstract：BACKGROUND:Nitric oxide (NO) attenuates neutrophil (PMN)-mediated damage, partly by inhibiting superoxide anion (O2-) generation and adherence to the coronary artery endothelium. L-Arginine is the endogenous substrate for production of NO via the NO synthase pathway. This study tested the hypothesis that the endogenous...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：STUDY OBJECTIVE:Afterload reduction is known to reduce regurgitant flow in patients with aortic regurgitation. Both arterial compliance and total peripheral resistance are determinants of afterload. The aim of this study was to evaluate the influence of arterial compliance and total peripheral resistance on the regurgi...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/25.10.869
更新日期：1991-10-01 00:00:00
abstract：OBJECTIVE:Resveratrol, a natural phytoalexin compound, is present in grapes and wine, and it can produce vasorelaxation. However, little is known of its mechanisms of action on ionic currents in endothelial cells. METHODS:The effect of resveratrol on Ca(2+)-activated K+ currents in an endothelial cell line (HUV-EC-C) ...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(99)00397-1
更新日期：2000-03-01 00:00:00
abstract：OBJECTIVES:Angiotensin converting enzyme (ACE) activity in the plasma does not change significantly with hypertension in two-kidney, one-clip hypertensive (2K-1C) rats. However, heart ACE activity and mRNA increase with hypertension. We measured the ACE activity and mRNA in hypertrophied hearts at different times after...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：
更新日期：1995-08-01 00:00:00
abstract：OBJECTIVE:The aim was to investigate the influence of coronary occlusion on myocardial interstitial noradrenaline levels in the ischaemic and non-ischaemic regions, using the dialysis technique. METHODS:In nine anaesthetised cats, regional ischaemia was produced by occlusion of the left anterior descending coronary ar...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/27.5.817
更新日期：1993-05-01 00:00:00
abstract：OBJECTIVE:Air bubbles entering the coronary artery may have harmful effects on cardiac function. From the physical point of view it is the relatively high surface tension of the blood-air interface which causes bubbles to trap in small vessels. The aim of the present study was to reduce depression of myocardial functio...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/s0008-6363(97)00063-1
更新日期：1997-06-01 00:00:00
abstract：OBJECTIVE:The aim was to evaluate the hypothesis that the oxygen demand of stimulated myocardium is downregulated and ischaemia avoided when oxygen supply is limited. METHODS:Isoprenaline stimulation during reduced coronary perfusion pressure or moderate coronary hypoxaemia was studied in relation to myocardial oxygen...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/27.8.1542
更新日期：1993-08-01 00:00:00
abstract：OBJECTIVES:M cells have been described in many mammalian species. They are thought to be relevant for the genesis of long QT intervals, afterdepolarizations and for dispersion in action potential duration and in repolarization time. Their role in the human heart is subject to debate. METHODS:We simulated action potent...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2004.02.016
更新日期：2004-05-01 00:00:00
abstract：:Effects of sublingual glyceryl trinitrate (GTN) were studied in ten patients without heart failure during diagnostic cardiac catheterisation following angiography. GTN caused substantial reduction in peak left ventricular and aortic pressure (19 mmHg) with lesser reduction in mean aortic pressure (9 mmHg) and no chang...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/20.2.153
更新日期：1986-02-01 00:00:00
abstract：AIMS:Vascular calcification often occurs with advancing age, atherosclerosis, and metabolic disorders such as diabetes mellitus and end-stage renal disease. Vascular calcification is associated with cardiovascular events and increased mortality. Nitric oxide (NO) is crucial for maintaining vascular function, but little...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvm049
更新日期：2008-01-01 00:00:00
abstract：AIMS:The discovery of a specific prorenin receptor (PRR) suggests a biological function of prorenin that is independent of angiotensin I production. In the present study, we investigated the role of PRR on smooth muscle cell (SMC) migration. METHODS AND RESULTS:PRR was expressed in human mammary arteries and in cultur...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvs204
更新日期：2012-08-01 00:00:00
abstract：AIMS:Antihypertensive drugs are included in the medical therapy of vascular Ehlers-Danlos syndrome (vEDS). The β-blocker celiprolol has been suggested to prevent arterial damage in vEDS, but the underlying mechanism remains unclear. It is also unknown whether the widely used angiotensin II receptor type 1 antagonist lo...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvz095
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:In menopause, aging and decreased estrogen levels are risk factors contributing to impaired vascular function. Previously, in a young ovariectomized rat model, we demonstrated an increase in prostaglandin H synthase (PGHS)-dependent vasoconstriction that could be prevented by estrogen replacement. Subsequentl...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1016/j.cardiores.2003.11.009
更新日期：2004-02-01 00:00:00
abstract：AIMS:Cytotoxic T lymphocyte antigen 4 (CTLA4) exerts inhibitory effects on T-cell activation by competition with CD28. In this study, we investigated the effect of CTLA4-IgG on homocysteine (Hcy)-induced T-cell activation and potential signal pathways involved in atherosclerotic formation. METHODS AND RESULTS:The CD28...
journal_title：Cardiovascular research
pub_type： 杂志文章
doi：10.1093/cvr/cvs330
更新日期：2013-02-01 00:00:00
