Mechanical stretch induces the apoptosis regulator PUMA in vascular smooth muscle cells.

abstract：OBJECTIVE:Anisotropic conduction characteristics, which may be expressed as the ratio of conduction velocities in the longitudinal (Vlong) and transverse (Vtrans) fibre directions, have been shown to stabilise reentry and favour the induction of sustained, uniform ventricular tachycardia. The aim of this study was to i...

journal_title：Cardiovascular research

authors： Hélie F,Cossette J,Vermeulen M,Cardinal R

更新日期：1995-03-01 00:00:00

abstract：Aims:Metabolic syndrome (MS) is a cluster of cardio-metabolic risk factors associated with atherosclerosis and low-grade inflammation. Using unbiased expression screenings in peripheral blood mononuclear cells, we depict here a novel expression chart of 678 genes and 84 microRNAs (miRNAs) controlling inflammatory, immu...

journal_title：Cardiovascular research

authors： D'Amore S,Härdfeldt J,Cariello M,Graziano G,Copetti M,Di Tullio G,Piglionica M,Scialpi N,Sabbà C,Palasciano G,Vacca M,Moschetta A

更新日期：2018-07-01 00:00:00

abstract：:There is mounting interest in the use of the monophasic action potential for electrophysiological investigation of regional myocardial ischaemia. There is, however, no systematic study of the relation between the changes in monophasic action potential and regional myocardial blood flow. In this study monophasic action...

journal_title：Cardiovascular research

authors： Kingaby RO,Lab MJ,Cole AW,Palmer TN

更新日期：1986-10-01 00:00:00

abstract：OBJECTIVE:The aims of the study were (1) to elucidate the effects of raised oxygen tension on the response of the ductus arteriosus to a range of vasodilators; and (2) to establish the effect, if any, of cyclo-oxygenase inhibition on the interaction between oxygen and prostaglandin (PG)E2. METHODS:Rings of ductus arte...

journal_title：Cardiovascular research

authors： Smith GC,McGrath JC

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVE:Effective endogenous fibrinolysis requires rapid release of endothelial tissue plasminogen activator (t-PA). Using the nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA), we examined the contribution of endogenous nitric oxide to substance P-induced t-PA release in vivo in man. METHODS:Blood f...

journal_title：Cardiovascular research

authors： Newby DE,Wright RA,Dawson P,Ludlam CA,Boon NA,Fox KA,Webb DJ

更新日期：1998-05-01 00:00:00

abstract：Aims:Fibroblast growth factor 1 (FGF1), a heparin/heparan sulfate-binding growth factor, is a potent cardioprotective agent against myocardial infarction (MI). The impact of heparin, the standard of care for MI patients entering the emergency room, on cardioprotective effects of FGF1 is unknown, however. Methods and r...

journal_title：Cardiovascular research

authors： Huang C,Liu Y,Beenken A,Jiang L,Gao X,Huang Z,Hsu A,Gross GJ,Wang YG,Mohammadi M,Schultz JEJ

更新日期：2017-11-01 00:00:00

abstract：AIMS:TRPM2 is a Ca(2+)-permeable cationic channel of the transient receptor potential (TRP) superfamily that is linked to apoptotic signalling. Its involvement in cardiac pathophysiology is unknown. The aim of this study was to determine whether the pro-apoptotic cytokine tumour necrosis factor-α (TNF-α) induces a TRPM...

journal_title：Cardiovascular research

authors： Roberge S,Roussel J,Andersson DC,Meli AC,Vidal B,Blandel F,Lanner JT,Le Guennec JY,Katz A,Westerblad H,Lacampagne A,Fauconnier J

更新日期：2014-07-01 00:00:00

abstract：AIMS:Autonomic dysfunction can promote atrial fibrillation (AF) and results from AF-related remodelling. N-type Ca2+-channels (NTCCs) at sympathetic nerve terminals mediate Ca2+-entry that triggers neurotransmitter release. AF-associated remodelling plays an important role in AF pathophysiology but the effects of NTCC ...

journal_title：Cardiovascular research

authors： Tajiri K,Guichard JB,Qi X,Xiong F,Naud P,Tardif JC,Costa AD,Aonuma K,Nattel S

更新日期：2019-12-01 00:00:00

abstract：:We have studied the responses to a brief interruption of a train of steady state beats, namely: (1) a single prolonged depolarisation within the train; (2) a single short interval within the train; (3) a single long interval within the train. These responses are predicted by a two compartment model of intracellular ca...

journal_title：Cardiovascular research

authors： Noble MI,Arlock P,Gath J,Grainger N,Ravens U,Wohlfart B

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:Decay kinetics of the voltage-gated L-type Ca(2+) current (I(CaL)) control the magnitude of Ca(2+) influx during the cardiac action potential. We investigated the influence of changes in diastolic membrane potential on I(CaL) decay kinetics in cardiac cells. METHODS:Cells were isolated enzymatically from rat...

journal_title：Cardiovascular research

authors： Barrère-Lemaire S,Piot C,Leclercq F,Nargeot J,Richard S

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:Cytokine induction of intercellular adhesion molecule-1 (ICAM-1) on cardiac myocytes may be a critical step in cardiac inflammation associated with acute myocardial infarction and myocarditis. The aim of this study was to investigate the involvement of monocyte chemoattractant protein-1 (MCP-1), a homologue o...

journal_title：Cardiovascular research

authors： Ban K,Ikeda U,Takahashi M,Kanbe T,Kasahara T,Shimada K

更新日期：1994-08-01 00:00:00

abstract：:Atrial fibrillation is the most common cardiac arrhythmia with an overall prevalence of almost 1%. Increasing prevalence and associated risks such as stroke and mortality have increased the need for better and more reliable therapeutic treatment. This has stimulated research to elucidate the pathophysiological mechani...

journal_title：Cardiovascular research

authors： Thijssen VL,Ausma J,Borgers M

更新日期：2001-10-01 00:00:00

abstract：:Methodology has been developed for utilising ultrasonic crystals in closed chest cats to measure alterations in regional left ventricular function. The technique is a modification of one previously utilised to monitor regional left ventricular length and thickness changes in closed chest dogs. The ultrasonic crystals ...

journal_title：Cardiovascular research

authors： Hurlbut TA,Scales F,Buja LM,Willerson JT

更新日期：1978-06-01 00:00:00

abstract：OBJECTIVES:We studied the effects of chronic left coronary artery ligation on cardiac structure and function in the mouse. METHODS:Morphometric studies of the left ventricle were performed in coronary artery-ligated and sham-operated animals at one, two, three and five weeks after surgery. The fraction of DNA-synthesi...

journal_title：Cardiovascular research

authors： Lutgens E,Daemen MJ,de Muinck ED,Debets J,Leenders P,Smits JF

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:The factors involved in restenosis after balloon angioplasty are poorly characterized but the local concentration of the potent mitogens angiotensin II (AII) and thrombin is known to be increased at sites of vascular injury. We investigated the possibility of a synergistic interaction between AII and thrombin...

journal_title：Cardiovascular research

authors： Fisslthaler B,Schini-Kerth VB,Fleming I,Busse R

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:Hemodynamic stresses are considered to be important regulators of gene expression in vascular cells. In this study, we have investigated the role of shear stress on ACE expression in cultured rat vascular cells, and focused on the regulation of ACE expression in smooth muscle cells. METHODS:Rat aortic endoth...

journal_title：Cardiovascular research

authors： Gosgnach W,Challah M,Coulet F,Michel JB,Battle T

更新日期：2000-01-14 00:00:00

abstract：:The velocity of contraction has been reported to be more rapid in left atrium (LA) than left ventricle (LV), but the mechanics of contraction in these two chambers have not been compared under physiological conditions. Accordingly, sonomicrometer crystals and solid state pressure transducers were used to measure LV an...

journal_title：Cardiovascular research

authors： Goldman S,Olajos M,Morkin E

更新日期：1984-10-01 00:00:00

abstract：AIMS:We have previously characterized a cGMP-dependent Ca(2+)-activated Cl(-) current in vascular smooth muscle cells (SMCs) and have shown its dependence on bestrophin-3 expression. We hypothesize that this current is important for synchronization of SMCs in the vascular wall. In the present study, we aimed to test th...

journal_title：Cardiovascular research

authors： Broegger T,Jacobsen JC,Secher Dam V,Boedtkjer DM,Kold-Petersen H,Pedersen FS,Aalkjaer C,Matchkov VV

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:We tested the hypothesis that simultaneous inhibition of the endothelial integrin alpha(v)beta(3) and the platelet glycoprotein IIb/IIIa receptor will substantially reduce infarct size in a model of acute coronary thrombosis and primary angioplasty. METHODS:Dogs were subjected to thrombus formation in the le...

journal_title：Cardiovascular research

authors： Sakuma T,Sari I,Goodman CN,Lindner JR,Klibanov AL,Kaul S

更新日期：2005-06-01 00:00:00

abstract：AIMS:Ischaemic preconditioning (IPC) protects the heart against prolonged lethal ischaemia through a signalling cascade involving Akt, glycogen synthase kinase-3β (GSK-3β), and mitochondrial ATP-sensitive potassium channels (mitoK(ATP)). We previously demonstrated the involvement of the Wnt pathway in IPC in vivo via G...

journal_title：Cardiovascular research

authors： Vigneron F,Dos Santos P,Lemoine S,Bonnet M,Tariosse L,Couffinhal T,Duplaà C,Jaspard-Vinassa B

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Plasma low density lipoproteins (LDL) play a key role in the pathogenesis of atherosclerosis. LDL modify gene expression in vascular cells leading to disturbances in the functional state of the vessel wall. METHODS:Expression levels of C-4 sterol methyl oxidase gene (ERG25), sterol regulatory element bindin...

journal_title：Cardiovascular research

authors： Rodriguez C,Raposo B,Martínez-González J,Llorente-Cortés V,Vilahur G,Badimon L

更新日期：2003-04-01 00:00:00

abstract：AIMS:Herpes virus entry mediator (HVEM) is considered to be a molecular 'switch' for immune responses, and a role in immune modification has been reported. The aim of this study was to assess whether HVEM-mediated immune suppression could protect against experimental autoimmune myocarditis (EAM) induced by myosin. MET...

journal_title：Cardiovascular research

authors： Cai G,Wang H,Qin Q,Zhang J,Zhu Z,Liu M,Shen Q

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:Cholinergic vasodilation has been thought to play little if any role in the regulation of blood pressure in humans. Autonomic denervation potentiates the vasoconstriction evoked by nitric oxide synthase inhibition in humans, but the mechanism is unclear. We hypothesized that this may be related to loss of neu...

journal_title：Cardiovascular research

authors： Lepori M,Sartori C,Duplain H,Nicod P,Scherrer U

更新日期：2001-09-01 00:00:00

abstract：:Myocardial function, flow and O2 consumption were compared in cardiac hypertrophy induced by pressure-loading (P) and by volume overloading (V). Increases in LV-to-body weight ratios in P and V hypertrophied hearts were comparable. Indices of LV function such as cardiac output, stroke volume, stroke work, minute work,...

journal_title：Cardiovascular research

authors： Malik AB,Geha AS

更新日期：1977-07-01 00:00:00

abstract：AIMS:Brugada syndrome (BrS) is an autosomal-inherited cardiac arrhythmia characterized by an ST-segment elevation in the right precordial leads of the electrocardiogram and an increased risk of syncope and sudden death. SCN5A, encoding the cardiac sodium channel Na(v)1.5, is the main gene involved in BrS. Despite the f...

journal_title：Cardiovascular research

authors： Clatot J,Ziyadeh-Isleem A,Maugenre S,Denjoy I,Liu H,Dilanian G,Hatem SN,Deschênes I,Coulombe A,Guicheney P,Neyroud N

更新日期：2012-10-01 00:00:00

abstract：AIMS:Smad7 plays a negative regulatory role in many inflammatory diseases, but its effect on hypertensive disease remains unknown. The present study tested the hypothesis that overexpression of Smad7 may have therapeutic potential for angiotensin II (Ang II)-mediated hypertensive cardiac remodelling. METHODS AND RESUL...

journal_title：Cardiovascular research

authors： Wei LH,Huang XR,Zhang Y,Li YQ,Chen HY,Yan BP,Yu CM,Lan HY

更新日期：2013-09-01 00:00:00

abstract：:Exaggerated cardiovascular responsiveness is common in young men and may cause non-specific symptoms and poor performance. Conventional autonomic function tests are not clinically useful. We have therefore designed a thermal entrainment method to evaluate sympathetic and parasympathetic cardiovascular function in subj...

journal_title：Cardiovascular research

authors： Lindqvist A,Parviainen P,Kolari P,Tuominen J,Välimäki I,Antila K,Laitinen LA

更新日期：1989-03-01 00:00:00

abstract：OBJECTIVE:Induction of angiogenesis has been reported subsequent to eNOS overexpression or activation, the latter involving Hsp90 as a chaperone protein. Here, we investigated the potential of regional Hsp90 overexpression to induce therapeutic neovascularization in vivo in a chronic rabbit hindlimb ischemia model. ME...

journal_title：Cardiovascular research

authors： Pfosser A,Thalgott M,Büttner K,Brouet A,Feron O,Boekstegers P,Kupatt C

更新日期：2005-02-15 00:00:00

abstract：OBJECTIVES:To elucidate the effect of selective endothelin ET(A)- and mixed ET(A/B)-receptor antagonists on endothelial vasomotor dysfunction in rats with heart failure after myocardial infarction (MI). METHODS:Vasoreactivity and superoxide anion formation were determined in aortic rings from Wistar rats 12 weeks afte...

journal_title：Cardiovascular research

authors： Bauersachs J,Fraccarollo D,Galuppo P,Widder J,Ertl G

更新日期：2000-07-01 00:00:00

abstract：AIMS:The cAMP-dependent protein kinase (PKA) mediates β-adrenoceptor (β-AR) regulation of cardiac contraction and gene expression. Whereas PKA activity is well characterized in various subcellular compartments of adult cardiomyocytes, its regulation in the nucleus remains largely unknown. The aim of the present study w...

journal_title：Cardiovascular research

authors： Haj Slimane Z,Bedioune I,Lechêne P,Varin A,Lefebvre F,Mateo P,Domergue-Dupont V,Dewenter M,Richter W,Conti M,El-Armouche A,Zhang J,Fischmeister R,Vandecasteele G

更新日期：2014-04-01 00:00:00