Mechanisms of excitation-contraction coupling studied using the principle of transient perturbation.

abstract：AIMS:Dilated cardiomyopathy (DCM) is characterized by ventricular dilation associated with systolic dysfunction, which could be caused by mutations in lamina/C gene (LMNA). LMNA-linked DCM is severe in males in both human patients and a knock-in mouse model carrying a homozygous p.H222P mutation (LmnaH222P/H222P). The ...

journal_title：Cardiovascular research

authors： Arimura T,Onoue K,Takahashi-Tanaka Y,Ishikawa T,Kuwahara M,Setou M,Shigenobu S,Yamaguchi K,Bertrand AT,Machida N,Takayama K,Fukusato M,Tanaka R,Somekawa S,Nakano T,Yamane Y,Kuba K,Imai Y,Saito Y,Bonne G,Kimura A

更新日期：2013-08-01 00:00:00

abstract：:Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in multiple human tissues and regulate different cellular functions...

journal_title：Cardiovascular research

authors： Perrucci GL,Gowran A,Zanobini M,Capogrossi MC,Pompilio G,Nigro P

更新日期：2015-06-01 00:00:00

abstract：AIMS:AMP-activated protein kinase (AMPK) is thought to be a central player in regulating myocardial metabolism and its activation has been shown to inhibit cardiac hypertrophy. Recently, mice with muscle-specific deletion of AMPK β1/β2 subunits (AMPKβ1β2-deficient mice, β1β2M-KO) have been generated and possess <10% of...

journal_title：Cardiovascular research

authors： Sung MM,Zordoky BN,Bujak AL,Lally JS,Fung D,Young ME,Horman S,Miller EJ,Light PE,Kemp BE,Steinberg GR,Dyck JR

更新日期：2015-07-15 00:00:00

abstract：:A pulsed, range gated, directional, ultrasonic, Doppler blood velocity meter was used to record signals from the pulmonary artery in 52 normal subjects ranging in age from less than 1 week to over 30 years. Signals were obtained from an unfocused transducer in the second or third left intercostal space using a 2.25 MH...

journal_title：Cardiovascular research

authors： Targett RC,Heldt GP,McIlroy MB

更新日期：1986-11-01 00:00:00

abstract：OBJECTIVE:Effective endogenous fibrinolysis requires rapid release of endothelial tissue plasminogen activator (t-PA). Using the nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA), we examined the contribution of endogenous nitric oxide to substance P-induced t-PA release in vivo in man. METHODS:Blood f...

journal_title：Cardiovascular research

authors： Newby DE,Wright RA,Dawson P,Ludlam CA,Boon NA,Fox KA,Webb DJ

更新日期：1998-05-01 00:00:00

abstract：AIMS:Cardiac hypertrophy is a risk factor independent of blood pressure; however, the mechanisms that distinguish pathological remodelling due to local cues from pressure overload are unresolved. This study was aimed at discovering a novel gene expression mechanism in heart failure. METHODS AND RESULTS:In angiotensin ...

journal_title：Cardiovascular research

authors： Yue H,Li W,Desnoyer R,Karnik SS

更新日期：2010-01-01 00:00:00

abstract：:The response of a simple systolic time interval, the interval between the Q wave and the onset of the aortic blood pressure pulse (the QA interval), to changes in cardiac contractility, cardiac loading, and heart rate was evaluated in anaesthetised open chest dogs. The QA interval was found to be sensitive to increase...

journal_title：Cardiovascular research

authors： Cambridge D,Whiting MV

更新日期：1986-06-01 00:00:00

abstract：:Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. The pleiotropic cytokine interferon-gamma (IFN-gamma) is a key pro-inflammatory mediator that is expressed at high levels in atherosclerotic lesions. IFN-gamma regulates the...

journal_title：Cardiovascular research

authors： Harvey EJ,Ramji DP

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:The aim was to determine if isolated rabbit cardiomyocytes could be preconditioned. METHODS:Cardiomyocytes isolated from rabbit hearts were subjected to 15 min oxygenated preincubation, with and without substrate, prior to concentration into an ischaemic slurry, with or without glucose present. The effects o...

journal_title：Cardiovascular research

authors： Armstrong S,Downey JM,Ganote CE

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVES:M cells have been described in many mammalian species. They are thought to be relevant for the genesis of long QT intervals, afterdepolarizations and for dispersion in action potential duration and in repolarization time. Their role in the human heart is subject to debate. METHODS:We simulated action potent...

journal_title：Cardiovascular research

authors： Conrath CE,Wilders R,Coronel R,de Bakker JM,Taggart P,de Groot JR,Opthof T

更新日期：2004-05-01 00:00:00

abstract：AIMS:Levels of circulating CD14(high)CD16(+) monocytes increase in atherosclerotic patients and are predictive of future cardiovascular events. Platelet activation has been identified as a crucial determinant in the acquisition of a CD16(+) phenotype by classical CD14(high)CD16(-) cells. We tested the hypothesis that a...

journal_title：Cardiovascular research

authors： Layne K,Di Giosia P,Ferro A,Passacquale G

更新日期：2016-07-01 00:00:00

abstract：:Coronary artery disease (CAD) remains one of the most important causes of morbidity and mortality worldwide, and the availability of percutaneous or surgical revascularization procedures significantly improves survival. However, both strategies are daunted by complications which limit long-term effectiveness. In-stent...

journal_title：Cardiovascular research

authors： Spadaccio C,Antoniades C,Nenna A,Chung C,Will R,Chello M,Gaudino MFL

更新日期：2020-03-01 00:00:00

abstract：:The potent anaphylatoxin C3a was measured in the peripheral blood of eleven patients receiving radiocontrast agents whilst undergoing coronary angiography. In seven patients C3a levels were raised during this procedure and in three of these the anaphylatoxin was increased between four and tenfold. In four patients C3a...

journal_title：Cardiovascular research

authors： Westaby S,Dawson P,Turner MW,Pridie RB

更新日期：1985-02-01 00:00:00

abstract：AIMS:Following a large myocardial infarction (MI), remaining viable muscle often undergoes pathological remodelling and progresses towards chronic heart failure. Mitochondria may also be affected by this process and, due to their functional importance, likely contribute to the progression of the disease. Aerobic interv...

journal_title：Cardiovascular research

authors： Kraljevic J,Marinovic J,Pravdic D,Zubin P,Dujic Z,Wisloff U,Ljubkovic M

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether chronic beta-adrenergic receptor (beta-AR) stimulation induces proliferation of human cardiac fibroblasts and to investigate the mechanism(s) involved. METHODS AND RESULTS:In vitro cultures of human cardiac fibroblasts were established from biopsies of right atr...

journal_title：Cardiovascular research

authors： Turner NA,Porter KE,Smith WH,White HL,Ball SG,Balmforth AJ

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:The heart contains proteins of the annexin family, a unique group of calcium binding proteins. This study was aimed at identifying the major cardiac annexins and determining their distribution in the rat heart. METHODS:Annexins were isolated by affinity chromatography and purified by ion exchange high pressu...

journal_title：Cardiovascular research

authors： Doubell AF,Lazure C,Charbonneau C,Thibault G

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:During reperfusion of ischaemic myocardium, Na+/H+ exchange promotes recovery from acidosis resulting in an accumulation of intracellular Na+. This leads to calcium overload via Na+/Ca2+ exchange and might result in cell necrosis contributing to reperfusion injury. METHODS AND RESULTS:We assessed whether HO...

journal_title：Cardiovascular research

authors： Rohmann S,Weygandt H,Minck KO

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVES:Injury stimulates smooth muscle cell (SMC) migration and proliferation by mechanisms that are incompletely understood. Surgical preparative injury is an important determinant of neointimal thickening in human saphenous vein bypass grafts. We investigate here whether basement-membrane-degrading metalloprotein...

journal_title：Cardiovascular research

authors： George SJ,Zaltsman AB,Newby AC

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:The acute administration of growth hormone (GH) or insulin-like growth factor-1 (IGF-1) improves cardiac performance, possibly contributing to the beneficial effects of GH therapy on heart failure (HF). GH can induce the production of IGF-1 and thus the actions of GH may be mediated through its IGF-1 inductio...

journal_title：Cardiovascular research

authors： Kinugawa S,Tsutsui H,Ide T,Nakamura R,Arimura K,Egashira K,Takeshita A

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:The aims of the study were to determine the effect of chronic pressure overload of the left ventricle on the density and distribution of neuropeptide-Y-like immunoreactive (NPY-LI) nerve fibres in heart and to compare any changes to those observed in adrenergic nerve fibres, identified by dopamine beta-hydrox...

journal_title：Cardiovascular research

authors： Love S,Nyquist-Battie C,DiMaggio DA,Farah JM Jr,Chronwall BM

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:The aim was to characterise the influence of a decrease in transsarcolemmal calcium influx on the calcium content of the sarcoplasmic reticulum and on the force of postrest contraction, which is largely activated by calcium released from the sarcoplasmic reticulum. METHODS:Isometric force of postrest contrac...

journal_title：Cardiovascular research

authors： Komai H,Rusy BF

更新日期：1993-05-01 00:00:00

abstract：:Although the existence of t-tubules in mammalian cardiac ventricular myocytes has been recognized for a long time, it now appears that their structure and function are more complex than previously believed. Recent work has provided evidence that many of the key proteins underlying excitation-contraction coupling are l...

journal_title：Cardiovascular research

authors： Orchard C,Brette F

更新日期：2008-01-15 00:00:00

abstract：OBJECTIVE:Persistent supraventricular tachycardia leads to the development of a dilated cardiomyopathy with impairment of excitation-contraction (EC) coupling. Since the initial trigger for EC coupling in ventricular muscle is the influx of Ca(2+) through L-type Ca(2+) channels (I(Ca)) in the transverse tubules (T-tubu...

journal_title：Cardiovascular research

authors： He J,Conklin MW,Foell JD,Wolff MR,Haworth RA,Coronado R,Kamp TJ

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:Experimental and clinical studies have shown that administration of insulin during reperfusion is cardioprotective, but the underlying mechanisms are still unknown. In this study, we investigated in isolated rat cardiomyocytes subjected to hypoxia and reoxygenation whether administration of insulin during reo...

journal_title：Cardiovascular research

authors： Abdallah Y,Gkatzoflia A,Gligorievski D,Kasseckert S,Euler G,Schlüter KD,Schäfer M,Piper HM,Schäfer C

更新日期：2006-05-01 00:00:00

abstract：:The effects of increasing oxygen tension from fetal to neonatal levels and of incubation in the cyclo-oxygenase inhibitor, indomethacin, on the response of isolated rings of neonatal rabbit ductus arteriosus and aorta to noradrenaline were studied in vitro. Increasing oxygen tension did not affect the sensitivity, as ...

journal_title：Cardiovascular research

authors： Smith GC,McGrath JC

更新日期：1988-12-01 00:00:00

abstract：OBJECTIVES:Thrombin induces endothelial barrier failure by activating the contractile machinery of endothelial cells. Contractile activation is due to an increase in myosin light chain (MLC) phosphorylation. Here, it was investigated whether stimulation of endothelial cells with ATP can interrupt this thrombin-induced ...

journal_title：Cardiovascular research

authors： Gündüz D,Hirche F,Härtel FV,Rodewald CW,Schäfer M,Pfitzer G,Piper HM,Noll T

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:Previous investigations have shown the effectiveness of sustained intra- or extravascular administration of vascular endothelial growth factor (VEGF) in chronic myocardial ischemia in improvement of left ventricular function. The present investigations were undertaken in order to evaluate efficacy of a single...

journal_title：Cardiovascular research

authors： Lopez JJ,Laham RJ,Stamler A,Pearlman JD,Bunting S,Kaplan A,Carrozza JP,Sellke FW,Simons M

更新日期：1998-11-01 00:00:00

abstract：AIMS:Statins have beneficial vascular effects beyond their cholesterol-lowering action. Since macrophages play a central role in atherogenesis, we characterized the effects of simvastatin on gene expression profile of human peripheral blood monocyte (HPBM)-macrophages. METHODS AND RESULTS:Gene expression profile was s...

journal_title：Cardiovascular research

authors： Tuomisto TT,Lumivuori H,Kansanen E,Häkkinen SK,Turunen MP,van Thienen JV,Horrevoets AJ,Levonen AL,Ylä-Herttuala S

更新日期：2008-04-01 00:00:00

abstract：:A recently developed highly sensitive radioimmunoassay method for detecting plasma kinin was used to re-evaluate the results of previous studies, in which plasma kinin had been measured with a bioassay method. To clarify the mechanism of plasma kinin release in global myocardial ischaemia the left main coronary artery...

journal_title：Cardiovascular research

authors： Matsuki T,Shoji T,Yoshida S,Kudoh Y,Motoe M,Inoue M,Nakata T,Hosoda S,Shimamoto K,Yellon D

更新日期：1987-06-01 00:00:00

abstract：:Blood flow autoregulation results from the ability of resistance arteries to reduce or increase their diameters in response to changes in intravascular pressure. The mechanism by which arteries maintain a constant blood flow to organs over a range of pressures relies on this myogenic response, which defines the intrin...

journal_title：Cardiovascular research

authors： Kauffenstein G,Laher I,Matrougui K,Guérineau NC,Henrion D

更新日期：2012-07-15 00:00:00