Effect of cardiopulmonary bypass on circulating concentrations of leucocyte elastase and free radical activity.

Abstract:

:Circulating concentrations of leucocyte elastase and free radical activity were measured in 11 adults undergoing cardiopulmonary bypass. In all patients the bypass procedure was associated with pronounced changes in plasma elastase concentrations, and peak enzyme concentrations correlated closely with the duration of bypass (r = 0.91, p less than 0.001). Serial measurement of octadeca-9, 11-dienoic acid, a non-peroxide marker of free radical activity, showed significant changes only in the plasma free fatty acid fraction, suggesting a direct relation to the action of heparin rather than to the bypass procedure as such. These studies support the hypothesis that neutrophil activation plays a central role in the organ dysfunction that may complicate cardiopulmonary bypass and suggest that elastase release rather than free radical generation may be the appropriate marker of the event.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Hind CR,Griffin JF,Pack S,Latchman YE,Drake HF,Jones HM,Brostoff J,Dormandy TL,Treasures T

doi

10.1093/cvr/22.1.37

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

37-41

issue

1

eissn

0008-6363

issn

1755-3245

journal_volume

22

pub_type

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