Effect of cardiopulmonary bypass on circulating concentrations of leucocyte elastase and free radical activity.


:Circulating concentrations of leucocyte elastase and free radical activity were measured in 11 adults undergoing cardiopulmonary bypass. In all patients the bypass procedure was associated with pronounced changes in plasma elastase concentrations, and peak enzyme concentrations correlated closely with the duration of bypass (r = 0.91, p less than 0.001). Serial measurement of octadeca-9, 11-dienoic acid, a non-peroxide marker of free radical activity, showed significant changes only in the plasma free fatty acid fraction, suggesting a direct relation to the action of heparin rather than to the bypass procedure as such. These studies support the hypothesis that neutrophil activation plays a central role in the organ dysfunction that may complicate cardiopulmonary bypass and suggest that elastase release rather than free radical generation may be the appropriate marker of the event.


Cardiovasc Res


Cardiovascular research


Hind CR,Griffin JF,Pack S,Latchman YE,Drake HF,Jones HM,Brostoff J,Dormandy TL,Treasures T




Has Abstract


1988-01-01 00:00:00












  • Catecholamine stimulation is associated with impaired myocardial O(2) utilization in heart failure.

    abstract:OBJECTIVES:To investigate the effect of alpha,beta(1) and beta(2) adrenergic receptor (AR) stimulation on coronary hemodynamics, myocardial oxygen consumption (M(v)O(2)) and metabolic substrate preference in advanced dilated cardiomyopathy (DCM). METHODS:We studied 19 conscious, instrumented dogs with pacing-induced D...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Nikolaidis LA,Hentosz T,Doverspike A,Huerbin R,Stolarski C,Shen YT,Shannon RP

    更新日期:2002-02-01 00:00:00

  • A spectrum of functional effects for disease causing mutations in the Jervell and Lange-Nielsen syndrome.

    abstract:OBJECTIVE:Jervell and Lange-Nielsen syndrome (JLNS) is a recessively inherited long QT syndrome (LQTS) characterised by profound sensorineural deafness and predisposition to syncope and sudden cardiac death. Mutation analysis has established the presence of mutations in affected individuals in the genes KCNQ1 and KCNE1...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Huang L,Bitner-Glindzicz M,Tranebjaerg L,Tinker A

    更新日期:2001-09-01 00:00:00

  • Specific non-beta-adrenergic binding sites for 125I-iodocyanopindolol in myocardial membrane preparations: a comparative study between human, rat, and porcine hearts.

    abstract:STUDY OBJECTIVE:The aim was to investigate observed differences in beta adrenergic and apparent non-beta-adrenergic binding of (-)[125I]-iodocyanopindolol (125I-ICYP). DESIGN:Binding parameters for several beta adrenergic agonists and antagonists were examined in radioligand binding assay, using 125I-ICYP as radioliga...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Bjørnerheim R,Golf S,Hansson V

    更新日期:1991-09-01 00:00:00

  • Pathways of matrix metalloproteinase induction in heart failure: bioactive molecules and transcriptional regulation.

    abstract::The structural basis for the development of congestive heart failure (CHF) is a maladaptive myocardial remodeling process which occurs secondarily to post-myocardial infarction (MI), hypertensive hypertrophy, or cardiomyopathy. Both cellular and extracellular factors are involved in the remodeling process and it is th...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审


    authors: Deschamps AM,Spinale FG

    更新日期:2006-02-15 00:00:00

  • Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload.

    abstract:OBJECTIVE:We have previously demonstrated that nuclear factor kappa B (NFkappaB) activation is needed for the development of cardiac hypertrophy in vivo. NFkappaB is a downstream transcription factor in the Toll-like receptor (TLR)-mediated signaling pathway; therefore, we investigated a role of TLR4 in cardiac hypertr...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Ha T,Li Y,Hua F,Ma J,Gao X,Kelley J,Zhao A,Haddad GE,Williams DL,William Browder I,Kao RL,Li C

    更新日期:2005-11-01 00:00:00

  • Reversible activation of nuclear factor-kappaB in human end-stage heart failure after left ventricular mechanical support.

    abstract:OBJECTIVE:Left ventricular assist devices (LVAD) have been used to 'bridge' patients with end-stage heart failure to transplantation. Although several reports have suggested that the native ventricular function recovers after long-term LVAD support, a process called 'reverse remodeling', the underlying biological mecha...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Grabellus F,Levkau B,Sokoll A,Welp H,Schmid C,Deng MC,Takeda A,Breithardt G,Baba HA

    更新日期:2002-01-01 00:00:00

  • Comparison of twitch force and calcium handling in papillary muscles from right ventricular pressure overload hypertrophy in weanling and juvenile ferrets.

    abstract:OBJECTIVE:The aim was to compare differences in peak twitch force occurring despite similar degrees of right ventricular hypertrophy in ferrets with pulmonary artery banding at either weanling or juvenile age. METHODS:After inducing pressure overload hypertrophy by banding the pulmonary artery of weanling and juvenile...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Gwathmey JK,Liao R,Ingwall JS

    更新日期:1995-04-01 00:00:00

  • Preischaemic as well as postischaemic application of a Na+/H+ exchange inhibitor reduces infarct size in pigs.

    abstract:BACKGROUND:During reperfusion of ischaemic myocardium, Na+/H+ exchange promotes recovery from acidosis resulting in an accumulation of intracellular Na+. This leads to calcium overload via Na+/Ca2+ exchange and might result in cell necrosis contributing to reperfusion injury. METHODS AND RESULTS:We assessed whether HO...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Rohmann S,Weygandt H,Minck KO

    更新日期:1995-12-01 00:00:00

  • Cardiac angiotensin converting enzyme overproduction indicates interstitial activation in renovascular hypertension.

    abstract:OBJECTIVES:Angiotensin converting enzyme (ACE) activity in the plasma does not change significantly with hypertension in two-kidney, one-clip hypertensive (2K-1C) rats. However, heart ACE activity and mRNA increase with hypertension. We measured the ACE activity and mRNA in hypertrophied hearts at different times after...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Challah M,Nicoletti A,Arnal JF,Philippe M,Laboulandine I,Allegrini J,Alhenc-Gelas F,Danilov S,Michel JB

    更新日期:1995-08-01 00:00:00

  • Adenosine inhibits norepinephrine release in the postischemic rat heart: the mechanism of neuronal stunning.

    abstract:OBJECTIVE:Numerous studies support the concept of impaired postischemic sympathetic neurotransmission in the heart. We hypothesized that postischemic neuronal dysfunction (neuronal stunning) is caused by a transient suppression of exocytotic norepinephrine (NE) release from sympathetic nerve terminals. Furthermore, we ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Burgdorf C,Richardt D,Kurz T,Seyfarth M,Jain D,Katus HA,Richardt G

    更新日期:2001-03-01 00:00:00

  • NO contributes to EDHF-like responses in rat small arteries: a role for NO stores.

    abstract:OBJECTIVES:Responses to EDHF are usually characterised in the presence of nitric oxide synthase (NOS) and cyclooxygenase (COX) inhibitors. The contribution of NO to endothelium-dependent relaxation in the presence of NOS inhibitors was assessed using NO scavengers with the objective of testing (i) whether any residual ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Chauhan S,Rahman A,Nilsson H,Clapp L,MacAllister R,Ahluwalia A

    更新日期:2003-01-01 00:00:00

  • Sphingosine kinase regulation and cardioprotection.

    abstract::Activation of sphingosine kinase/sphingosine-1-phosphate (SK/S1P)-mediated signalling has been recognized as critical for cardioprotection in response to acute ischaemia/reperfusion injury. Incubation of S1P with cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischaemia or ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审


    authors: Karliner JS

    更新日期:2009-05-01 00:00:00

  • Mechanisms of the pro- and anti-oxidant actions of nitric oxide in atherosclerosis.

    abstract::The association of nitric oxide (NO) with cardiovascular disease has long been recognized and the extensive research on this topic has revealed both pro- and anti-atherosclerotic effects. While these contradictory findings were initially perplexing recent studies offer molecular mechanisms for the integration of these...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审


    authors: Patel RP,Levonen A,Crawford JH,Darley-Usmar VM

    更新日期:2000-08-18 00:00:00

  • Matrix metalloproteinase-3 and coronary remodelling: implications for unstable coronary disease.

    abstract:OBJECTIVES:Matrix metalloproteinases (MMPs) are plausible candidates for prediction of unstable coronary syndromes. We hypothesised that the MMP-3 polymorphism (- 1171, 5A/6A) would relate to coronary plaque characteristics and unstable clinical presentation. METHODS AND RESULTS:Forty patients with de novo presentatio...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: White AJ,Duffy SJ,Walton AS,Ng JF,Rice GE,Mukherjee S,Shaw JA,Jennings GL,Dart AM,Kingwell BA

    更新日期:2007-09-01 00:00:00

  • Spontaneous diastolic contractions and phosphorylation of the cardiac ryanodine receptor at serine-2808 in congestive heart failure in rat.

    abstract:OBJECTIVE:The role of phosphorylation of the ryanodine receptor at serine-2808 (RyRS2808) in congestive heart failure (CHF) is controversial, and effects of RyRS2808 phosphorylation on contraction are unclear. It has been reported that diastolic sarcomere length (SL) fluctuations accompany propagating contractile waves...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Obayashi M,Xiao B,Stuyvers BD,Davidoff AW,Mei J,Chen SR,ter Keurs HE

    更新日期:2006-01-01 00:00:00

  • The role of taurine in the pathogenesis of the cardiomyopathy of insulin-dependent diabetes mellitus.

    abstract::The cellular and molecular physiology and pathology of insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM) are mostly studied and understood through the use of animal models. Fundamental differences between the IDDM and NIDDM animal models may help to explain the etiology beh...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审


    authors: Militante JD,Lombardini JB,Schaffer SW

    更新日期:2000-06-01 00:00:00

  • Immunometabolism orchestrates training of innate immunity in atherosclerosis.

    abstract::Atherosclerosis is characterized by a persistent, low-grade inflammation of the arterial wall. Monocytes and monocyte-derived macrophages play a pivotal role in the various stages of atherosclerosis. In the past few years, metabolic reprogramming has been identified as an important controller of myeloid cell activatio...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审


    authors: van Tuijl J,Joosten LAB,Netea MG,Bekkering S,Riksen NP

    更新日期:2019-07-01 00:00:00

  • Anatomical arrangement of muscle tissue in the anterior mitral leaflet in man.

    abstract::Muscle tissue in atrioventricular (A-V) cardiac valve leaflets was studied in 35 human hearts and was found to be more prominent in the anterior leaflet of the mitral (MAL) than in the other valve leaflets. From serial sectioning and wax model reconstruction, the anatomic arrangement of the muscle in the MAL indicates...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Boucek RJ,Boucková B,Levy S

    更新日期:1978-11-01 00:00:00

  • beta3-Adrenergic regulation of an ion channel in the heart-inhibition of the slow delayed rectifier potassium current I(Ks) in guinea pig ventricular myocytes.

    abstract:OBJECTIVES:I(Ks), the slow component of the delayed rectifier potassium current, underlies a strong beta-adrenergic regulation in the heart. Catecholamines, like isoproterenol, induce a strong increase in I(Ks). Recent work has pointed to an opposing biological effect of beta(1)- and beta(3)-adrenoceptors in the heart....

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Bosch RF,Schneck AC,Kiehn J,Zhang W,Hambrock A,Eigenberger BW,Rüb N,Gogel J,Mewis C,Seipel L,Kühlkamp V

    更新日期:2002-12-01 00:00:00

  • Effects of chronic treatment with adrenaline or propranolol on platelet function and c-AMP levels in the rat.

    abstract::Most of our knowledge about the modulation of platelet function by catecholamines is based on observations of acute in vitro actions. Little is known about the effects of chronically elevated or reduced adrenergic stimulation of the platelets. We therefore treated rats for 8 weeks with either adrenaline or the beta-bl...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Terres W,Becker BF,Schrödl W,Gerlach E

    更新日期:1989-02-01 00:00:00

  • Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha} pathway.

    abstract:AIMS:Baicalin is the major component found in Scutellaria baicalensis root, a widely used herb in traditional Chinese medicine. Although it has been used for thousands of years to treat stroke, the mechanisms of action of S. baicalensis have not been clearly elucidated. In this report, we studied the modulation of angi...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Zhang K,Lu J,Mori T,Smith-Powell L,Synold TW,Chen S,Wen W

    更新日期:2011-02-01 00:00:00

  • Alterations in c-fos expression, cell proliferation and apoptosis in pressure distended human saphenous vein.

    abstract:OBJECTIVES:Saphenous vein graft failures, resulting from thrombosis and the abnormal proliferation, migration and apoptosis of vascular smooth muscle cells (VSMC) are major limitations of coronary artery bypass surgery. We investigated whether surgical trauma of human saphenous vein induces the early response gene c-fo...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Galea J,Armstrong J,Francis SE,Cooper G,Crossman DC,Holt CM

    更新日期:1999-11-01 00:00:00

  • Accumulation of technetium-99m pyrophosphate in experimental infarctions in the rat.

    abstract::Cardiac accumulation patterns of pyrophosphate labelled with techetium-99m (TcPyP) in rats one hour to 7 days after coronary artery ligation were studied by light microscopy, myocardial scintigraphy, imaging the isolated heart and by direct measurement of tissue activity. Results suggest that myocardial cells taking u...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Lessem J,Polimeni PI,Page E,Resnekov L,Harper PV,Stark V

    更新日期:1980-06-01 00:00:00

  • Wall stress induced arrhythmia is enhanced by low potassium and early left ventricular hypertrophy in the working rat heart.

    abstract:OBJECTIVE:The aim was to investigate the effect of lowering external potassium on the sensitivity of the normal and hypertrophied rat heart to arrhythmias induced by increases in ventricular wall stress. METHODS:The isolated working heart model was used to compare hypertrophied hearts from the spontaneously hypertensi...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Evans SJ,Levi AJ,Jones JV

    更新日期:1995-04-01 00:00:00

  • Apoptotic versus autophagic cell death in heart failure.

    abstract:OBJECTIVE:Progressive loss of cardiomyocytes is one of the most important pathogenic characteristics of heart failure. Apoptosis may be an important mode of cell death in heart failure but it must be demonstrated by multiple criteria and not just TUNEL staining alone. Previously, we and others have demonstrated that be...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Knaapen MW,Davies MJ,De Bie M,Haven AJ,Martinet W,Kockx MM

    更新日期:2001-08-01 00:00:00

  • Genome-wide association studies of cardiac electrical phenotypes.

    abstract::The genetic basis of cardiac electrical phenotypes has in the last 25 years been the subject of intense investigation. While in the first years, such efforts were dominated by the study of familial arrhythmia syndromes, in recent years, large consortia of investigators have successfully pursued genome-wide association...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Glinge C,Lahrouchi N,Jabbari R,Tfelt-Hansen J,Bezzina CR

    更新日期:2020-07-15 00:00:00

  • The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation.

    abstract:OBJECTIVE:To investigate changes in human atrial single cell functional electrophysiological properties associated with chronic atrial fibrillation (AF), and the contribution to these of accompanying ion current changes. METHODS:The whole cell patch clamp technique was used to record action potentials, the effective r...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Workman AJ,Kane KA,Rankin AC

    更新日期:2001-11-01 00:00:00

  • Tumor necrosis factor alpha as an endogenous stimulator for circulating coupling factor 6.

    abstract:OBJECTIVE:We recently showed that mitochondrial coupling factor 6 (CF6) is present as a pressor substance and a prostacyclin inhibitor in systemic circulation. However, the regulation mechanism for circulating CF6 is unknown. We investigated the role of tumor necrosis factor-alpha (TNF-alpha) in the generation and rele...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Sasaki S,Osanai T,Tomita H,Matsunaga T,Magota K,Okumura K

    更新日期:2004-06-01 00:00:00

  • Hydroxylation of D-phenylalanine as a novel approach to detect hydroxyl radicals: application to cardiac pathophysiology.

    abstract:OBJECTIVE:Research in the pathophysiology of ischemia/reperfusion or redox signaling is hindered by lack of simple methodology to measure short-lived oxygen radicals. In the presence of hydroxyl radical ((*)OH), d-phenylalanine (d-Phe) yields para-, meta- and ortho-tyrosine. We have previously demonstrated that d-Phe c...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Biondi R,Ambrosio G,Liebgott T,Cardounel AJ,Bettini M,Tritto I,Zweier JL

    更新日期:2006-07-15 00:00:00

  • Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1.

    abstract:AIMS:Animal studies show that transforming growth factor-β1 (TGF-β1) is an important mediator of atrial fibrosis and atrial fibrillation (AF). This study investigated the role of TGF-β1 in human AF and the mechanism of atrial-selective fibrosis. METHODS AND RESULTS:Atrial specimens from 17 open heart surgery patients ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Rahmutula D,Marcus GM,Wilson EE,Ding CH,Xiao Y,Paquet AC,Barbeau R,Barczak AJ,Erle DJ,Olgin JE

    更新日期:2013-09-01 00:00:00