Differences in the mechanism of metabolic regulation of ATP-sensitive K+ channels containing Kir6.1 and Kir6.2 subunits.

abstract：AIMS:Pulmonary arterial endothelial cells (PAECs) express the enzymes needed for generation of l-arginine from intracellular l-citrulline but do not express the enzymes needed for de novo l-citrulline synthesis. Hence, l-citrulline levels in PAECs are dependent on l-citrulline transport. Once generated, l-arginine can ...

journal_title：Cardiovascular research

authors： Fike CD,Sidoryk-Wegrzynowicz M,Aschner M,Summar M,Prince LS,Cunningham G,Kaplowitz M,Zhang Y,Aschner JL

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:The aim was to evaluate in a minipig model of acute myocardial infarction the cardioprotection provided by the beta adrenoceptor blocking and vasodilating activities present in carvedilol; comparison was made to the pure beta adrenoceptor antagonist, propranolol. METHODS:Experiments were performed in 25 Yuca...

journal_title：Cardiovascular research

authors： Bril A,Slivjak M,DiMartino MJ,Feuerstein GZ,Linee P,Poyser RH,Ruffolo RR Jr,Smith EF 3rd

更新日期：1992-05-01 00:00:00

abstract：AIMS:Myocardial function is severely compromised during sepsis. Several underlying mechanisms have been proposed. The innate immune system, i.e. toll-like receptor (TLR) 2 and 4, significantly contributes to cardiac dysfunction. Little is known regarding TLR9 and its pathogenic ligand bacterial DNA in the myocardium. W...

journal_title：Cardiovascular research

authors： Knuefermann P,Schwederski M,Velten M,Krings P,Ehrentraut H,Rüdiger M,Boehm O,Fink K,Dreiner U,Grohé C,Hoeft A,Baumgarten G,Koch A,Zacharowski K,Meyer R

更新日期：2008-04-01 00:00:00

abstract：AIMS:GATA4 is a transcription factor that is up-regulated during cardiac hypertrophy and plays a fundamental role in myocyte growth and survival. In this study, we investigate the transcriptional vs. post-transcriptional mechanisms that are involved in regulating GATA4 in the heart during neonatal and pressure overload...

journal_title：Cardiovascular research

authors： Han M,Yang Z,Sayed D,He M,Gao S,Lin L,Yoon S,Abdellatif M

更新日期：2012-03-15 00:00:00

abstract：:To investigate the effects of sodium-potassium activated adenosine triphosphatase inhibition on central cardiovascular regulation a microinjection of ouabain was given into the hypothalamus of urethane anaesthetised rats. Doses of 0.01-1.0 micrograms per rat injected into the posterior hypothalamus produced a rise in ...

journal_title：Cardiovascular research

authors： Iyoda I,Takahashi H,Lee LC,Okajima H,Inoue A,Sasaki S,Takeda K,Yoshimura M,Ijichi H

更新日期：1986-04-01 00:00:00

abstract：:Ischemia-reperfusion of the heart and other organs results in the accumulation of unesterified arachidonic acid (AA) via the action of membrane-bound phospholipases, primarily phospholipase A2. AA can be metabolized by the classical cyclooxygenase (COX) and lipoxygenase (LOX) pathways to well-characterized metabolites...

journal_title：Cardiovascular research

authors： Gross GJ,Falck JR,Gross ER,Isbell M,Moore J,Nithipatikom K

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:During reperfusion of ischaemic myocardium, Na+/H+ exchange promotes recovery from acidosis resulting in an accumulation of intracellular Na+. This leads to calcium overload via Na+/Ca2+ exchange and might result in cell necrosis contributing to reperfusion injury. METHODS AND RESULTS:We assessed whether HO...

journal_title：Cardiovascular research

authors： Rohmann S,Weygandt H,Minck KO

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVES:Angiotensin converting enzyme (ACE) activity in the plasma does not change significantly with hypertension in two-kidney, one-clip hypertensive (2K-1C) rats. However, heart ACE activity and mRNA increase with hypertension. We measured the ACE activity and mRNA in hypertrophied hearts at different times after...

journal_title：Cardiovascular research

authors： Challah M,Nicoletti A,Arnal JF,Philippe M,Laboulandine I,Allegrini J,Alhenc-Gelas F,Danilov S,Michel JB

更新日期：1995-08-01 00:00:00

abstract：:Ultrasound has become a useful high resolution imaging modality for examining the cardiac microcirculation. With the use of microbubbles as an ultrasound contrast agent, ultrasound can be utilized to image the microcirculation and detect capillary flow abnormalities in acute ischaemia. A wide range of ultrasound frequ...

journal_title：Cardiovascular research

authors： Porter TR

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Matrix metalloproteinase-9 (MMP-9) activity is up regulated in the heart subjected to ischemic insult. Whether increased MMP-9 activity contributes to acute myocardial injury after ischemia-reperfusion remains unknown. To investigate the role of MMP-9 in myocardial infarction, we utilized a MMP-9 knockout mou...

journal_title：Cardiovascular research

authors： Romanic AM,Harrison SM,Bao W,Burns-Kurtis CL,Pickering S,Gu J,Grau E,Mao J,Sathe GM,Ohlstein EH,Yue TL

更新日期：2002-06-01 00:00:00

abstract：:Numerous epidemiological studies documented an inverse relationship between plasma high-density lipoprotein (HDL) cholesterol levels and the extent of atherosclerotic disease. However, clinical interventions targeting HDL cholesterol failed to show clinical benefits with respect to cardiovascular risk reduction, sugge...

journal_title：Cardiovascular research

authors： Potì F,Simoni M,Nofer JR

更新日期：2014-08-01 00:00:00

abstract：:STUDY OBJECTIVE - The aim of the study was to determine the changes in the beta adrenergic system induced by cardiac hypertrophy due to valvular aortic stenosis. DESIGN - Density of beta adrenoceptors, cardiac tissue noradrenalime concentrations, coronary blood flow (using radioactive microspheres), and haemodynamic v...

journal_title：Cardiovascular research

authors： Scholz PM,Upsher ME,Eliades D,Kedem J,Weiss HR

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:Peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily and are key regulators of fatty acid oxidation (FAO) in the heart. Systemic carnitine deficiency (SCD) causes disorders of FAO and induces hypertrophic cardiomy...

journal_title：Cardiovascular research

authors： Asai T,Okumura K,Takahashi R,Matsui H,Numaguchi Y,Murakami H,Murakami R,Murohara T

更新日期：2006-06-01 00:00:00

abstract：AIMS:Coronary arteritis is a life-threatening complication that may arise in the acute stage of Kawasaki disease (KD), the leading cause of systemic vasculitis in childhood. Various microorganisms and molecular pathogens have been reported to cause KD. However, little is known about the key molecules that contribute to...

journal_title：Cardiovascular research

authors： Nakashima Y,Sakai Y,Mizuno Y,Furuno K,Hirono K,Takatsuki S,Suzuki H,Onouchi Y,Kobayashi T,Tanabe K,Hamase K,Miyamoto T,Aoyagi R,Arita M,Yamamura K,Tanaka T,Nishio H,Takada H,Ohga S,Hara T

更新日期：2021-01-01 00:00:00

abstract：AIMS:Hypertension is accompanied by structural remodelling of vascular extracellular matrix (ECM). Tissue inhibitor of metalloproteinases (TIMPs) inhibits matrix metalloproteinases (MMPs) that degrade the matrix structural proteins. In response to a hypertensive stimulus, the balance between MMPs and TIMPs is altered. ...

journal_title：Cardiovascular research

authors： Basu R,Lee J,Morton JS,Takawale A,Fan D,Kandalam V,Wang X,Davidge ST,Kassiri Z

更新日期：2013-06-01 00:00:00

abstract：:Increased Na/Ca exchange (NCX) expression may be part of the genetic reprogramming in cardiac remodeling. In this review we address the following questions: (1) Is increased NCX activity a general feature of cardiac remodeling in hypertrophy and heart failure? (2) How does this contribute to the contractile and electr...

journal_title：Cardiovascular research

authors： Sipido KR,Volders PG,Vos MA,Verdonck F

更新日期：2002-03-01 00:00:00

abstract：AIMS:The regulation of vascular diameter by vasoconstrictors and vasodilators requires that vascular smooth muscle cells (VSMCs) be physically coupled to extracellular matrix (ECM) and neighbouring cells in order for a vessel to mechanically function and transfer force. The hypothesis was tested that integrin-mediated ...

journal_title：Cardiovascular research

authors： Hong Z,Sun Z,Li Z,Mesquitta WT,Trzeciakowski JP,Meininger GA

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:In isolated cardiac preparations of non-failing hearts from different species, including man, there is a positive force-frequency relation which is reversed into a negative relation in preparation from failing hearts. Whether or not such relations between ventricular function and heart rate hold true in the i...

journal_title：Cardiovascular research

authors： Neumann T,Ravens U,Heusch G

更新日期：1998-02-01 00:00:00

abstract：:Attempts were made to demonstrate release of vasoactive substances from the heart during coronary occlusion (for 60 min) and reperfusion (for 60 min), and to clarify the pathophysiological significance of them. Vasoactive substances were detected by superfusion of rabbit aortic and dog coronary arterial strips with gr...

journal_title：Cardiovascular research

authors： Tanabe M,Terashita ZI,Fujiwara S,Shimamoto N,Goto N,Nishikawa K,Hirata M

更新日期：1982-02-01 00:00:00

abstract：OBJECTIVE:To determine the effect of acute left ventricular dilatation on refractoriness in normal hearts. METHODS:During sustained ventricular fibrillation (VF) in isolated perfused hearts, recording of local activation time yields VF intervals which provide an index of local refractoriness. Simultaneous measurement ...

journal_title：Cardiovascular research

authors： Burton FL,Cobbe SM

更新日期：1998-08-01 00:00:00

abstract：:Following a myocardial infarction (MI), the immune system helps to repair ischaemic damage and restore tissue integrity, but excessive inflammation has been implicated in adverse cardiac remodelling and development towards heart failure (HF). Pre-clinical studies suggest that timely resolution of inflammation may help...

journal_title：Cardiovascular research

authors： Panahi M,Papanikolaou A,Torabi A,Zhang JG,Khan H,Vazir A,Hasham MG,Cleland JGF,Rosenthal NA,Harding SE,Sattler S

更新日期：2018-09-01 00:00:00

abstract：AIMS:Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine that contributes to pathogenic cardiac remodelling via mechanisms that involve oxidative stress. However, the direct impact of TGF-beta1 on contractile function of ventricular myocytes is incompletely understood. METHODS AND RESULTS:Reacti...

journal_title：Cardiovascular research

authors： Li S,Li X,Zheng H,Xie B,Bidasee KR,Rozanski GJ

更新日期：2008-01-01 00:00:00

abstract：:Pressure--diameter loops were generated in normal, conscious dogs during left ventricular contraction by means of endocardial ultrasonic gauges and micromanometers. Studies were made in the control state, during volume and pressure loading, and during enhancement of contractility. The diameter at the end of ejection w...

journal_title：Cardiovascular research

authors： Mahler F,Covell JW,Ross J Jr

更新日期：1975-07-01 00:00:00

abstract：AIMS:Baicalin is the major component found in Scutellaria baicalensis root, a widely used herb in traditional Chinese medicine. Although it has been used for thousands of years to treat stroke, the mechanisms of action of S. baicalensis have not been clearly elucidated. In this report, we studied the modulation of angi...

journal_title：Cardiovascular research

authors： Zhang K,Lu J,Mori T,Smith-Powell L,Synold TW,Chen S,Wen W

更新日期：2011-02-01 00:00:00

abstract：:Matrix metalloproteinase (MMP)-2 belongs to a family of zinc-dependent proteases which are best known for their ability to proteolyse extracellular matrix proteins throughout the body, including the cardiovascular system. Increased MMP-2 activity has been demonstrated in myocardial ischaemia and reperfusion injury and...

journal_title：Cardiovascular research

authors： Kandasamy AD,Chow AK,Ali MA,Schulz R

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate whether intrinsic cardiac neurones can be involved in the genesis of ventricular arrhythmias. METHODS:Nicotinic, muscarinic, beta adrenergic, peptidergic, and amino acidergic agonists, as well as purinergic compounds, were individually administered in microliter quantities adjacent...

journal_title：Cardiovascular research

authors： Huang MH,Wolf SG,Armour JA

更新日期：1994-05-01 00:00:00

abstract：:Microvascular barrier dysfunction is implicated in the initiation and progression of inflammation, posttraumatic complications, sepsis, ischaemia-reperfusion injury, atherosclerosis, and diabetes. Under physiological conditions, a precise equilibrium between endothelial cell-cell adhesion and actin-myosin-based centri...

journal_title：Cardiovascular research

authors： Shen Q,Rigor RR,Pivetti CD,Wu MH,Yuan SY

更新日期：2010-07-15 00:00:00

abstract：OBJECTIVES:I(Ks), the slow component of the delayed rectifier potassium current, underlies a strong beta-adrenergic regulation in the heart. Catecholamines, like isoproterenol, induce a strong increase in I(Ks). Recent work has pointed to an opposing biological effect of beta(1)- and beta(3)-adrenoceptors in the heart....

journal_title：Cardiovascular research

authors： Bosch RF,Schneck AC,Kiehn J,Zhang W,Hambrock A,Eigenberger BW,Rüb N,Gogel J,Mewis C,Seipel L,Kühlkamp V

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:Current guidelines are controversial regarding exercise intensity in cardiovascular prevention and rehabilitation. Although high-intensity training induces larger increases in fitness and maximal oxygen uptake (VO(2max)), moderate intensity is often recommended as equally effective. Controlled preclinical stu...

journal_title：Cardiovascular research

authors： Kemi OJ,Haram PM,Loennechen JP,Osnes JB,Skomedal T,Wisløff U,Ellingsen Ø

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:The atrial natriuretic peptide (ANP) family is a complex system consisting of at least three polypeptides and at least three types of receptor. Each peptide interacts with different types of receptor at varying degrees of affinity. To determine if natriuretic peptide levels influence natriuretic peptide rece...

journal_title：Cardiovascular research

authors： Vera N,Tse MY,Watson JD,Sarda S,Steinhelper ME,John SW,Flynn TG,Pang SC

更新日期：2000-06-01 00:00:00