Effect of sustained stretch on dispersion of ventricular fibrillation intervals in normal rabbit hearts.

abstract：OBJECTIVE:In heart failure (HF), the generation of reactive oxygen species (ROS) is enhanced. It was shown that failing cardiac myocytes are more susceptible to ROS-induced damage, possibly due to increased expression of the sarcolemmal Na-Ca exchanger (NCX). METHODS:We investigated the consequences of increased expre...

journal_title：Cardiovascular research

authors： Wagner S,Seidler T,Picht E,Maier LS,Kazanski V,Teucher N,Schillinger W,Pieske B,Isenberg G,Hasenfuss G,Kögler H

更新日期：2003-11-01 00:00:00

abstract：:Exogenous angiotensin II causes noradrenaline supersensitivity in rat mesenteric vasculature preparations. The noradrenaline supersensitivity of tissues from renal/salt hypertensive rats, with low plasma renin activity, is not caused by endogenous angiotensin II since it was unaffected by Sar1 Ileu8 angiotensin II. Di...

journal_title：Cardiovascular research

authors： Collis MG,Alps BJ

更新日期：1976-03-01 00:00:00

abstract：:Cardiac accumulation patterns of pyrophosphate labelled with techetium-99m (TcPyP) in rats one hour to 7 days after coronary artery ligation were studied by light microscopy, myocardial scintigraphy, imaging the isolated heart and by direct measurement of tissue activity. Results suggest that myocardial cells taking u...

journal_title：Cardiovascular research

authors： Lessem J,Polimeni PI,Page E,Resnekov L,Harper PV,Stark V

更新日期：1980-06-01 00:00:00

abstract：OBJECTIVE:In several cell types, proteasome inhibitors like carbobenzoxyl-leucinyl-leucinyl-leucinal (MG132) induce the 72 kDa heat shock protein (Hsp72) and exert cell protective effects. However, data in cardiomyocytes are currently lacking. METHODS AND RESULTS:We investigated the effects of MG132 in cultured neonat...

journal_title：Cardiovascular research

authors： Lüss H,Schmitz W,Neumann J

更新日期：2002-04-01 00:00:00

abstract：:The second messenger cyclic guanosine 3'5' monophosphate (cGMP) and its downstream effector protein kinase G (PKG) have been discovered more than 40 years ago. In vessels, PKG1 induces smooth muscle relaxation in response to nitric oxide signalling and thus lowers systemic and pulmonary blood pressure. In platelets, P...

journal_title：Cardiovascular research

authors： Rainer PP,Kass DA

更新日期：2016-07-15 00:00:00

abstract：:The effects of adrenaline on kinetically-distinct compartments of exchangeable calcium in the spontaneously-beating perfused rat heart were investigated under steady-state conditions using a 45Ca2+ outflow technique together with a nonlinear least-squares curve fitting procedure and 51Cr-EDTA to monitor the loss of fr...

journal_title：Cardiovascular research

authors： Lamont SV,Barritt GJ

更新日期：1983-02-01 00:00:00

abstract：:It has long been known that gap junctions are required for the propagation of electrical impulse in the heart. A good deal later, the connexins (Cxs), which are probably exclusive components of the junctional channels that constitute the gap junctions, were identified. More recently, the in vivo functions of cardiac C...

journal_title：Cardiovascular research

authors： Gros D,Dupays L,Alcoléa S,Meysen S,Miquerol L,Théveniau-Ruissy M

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:The adhesive interaction of monocytes and endothelial cells has been implicated as a regulatory signal in the cell activation that is involved in the pathogenesis of atherosclerosis. We investigated the effect of monocyte-endothelial cell interaction on the expression of adhesion molecules, intercellular adhe...

journal_title：Cardiovascular research

authors： Takahashi M,Ikeda U,Masuyama J,Kitagawa S,Kasahara T,Shimpo M,Kano S,Shimada K

更新日期：1996-08-01 00:00:00

abstract：STUDY OBJECTIVE:Afterload reduction is known to reduce regurgitant flow in patients with aortic regurgitation. Both arterial compliance and total peripheral resistance are determinants of afterload. The aim of this study was to evaluate the influence of arterial compliance and total peripheral resistance on the regurgi...

journal_title：Cardiovascular research

authors： Slørdahl SA,Piene H

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVE:Some neuropeptides have direct cardiac effects and also modulate the cardiac effects of catecholamines. Vasopressin is an abundantly available neuropeptide having well known interactions with catecholamines in vascular smooth muscle. The aim of this study was to determine the direct and modulatory effects of ...

journal_title：Cardiovascular research

authors： Sun LS,Sawyer WH,Steinberg SF,Rosen MR

更新日期：1993-09-01 00:00:00

abstract：:Since the discovery of atrial natriuretic peptide (ANP) more than 20 years ago, numerous studies have focused on the mechanisms regulating ANP secretion. From a physiological standpoint, the most important factor governing ANP secretion is mechanical stretching of the atria, which normally occurs when extracellular fl...

journal_title：Cardiovascular research

authors： Dietz JR

更新日期：2005-10-01 00:00:00

abstract：:There is mounting interest in the use of the monophasic action potential for electrophysiological investigation of regional myocardial ischaemia. There is, however, no systematic study of the relation between the changes in monophasic action potential and regional myocardial blood flow. In this study monophasic action...

journal_title：Cardiovascular research

authors： Kingaby RO,Lab MJ,Cole AW,Palmer TN

更新日期：1986-10-01 00:00:00

abstract：AIMS:A cytosolic calcium (Ca(2+)(i)) increase is an important activation signal for the endothelium. We investigated whether interendothelial spreading of the Ca(2+) signal via gap junctions (GJs) plays a role for the overall Ca(2+)(i) increase in response to vasoactive agonists. METHODS AND RESULTS:In human umbilical...

journal_title：Cardiovascular research

authors： Kameritsch P,Pogoda K,Ritter A,Münzing S,Pohl U

更新日期：2012-03-01 00:00:00

abstract：AIMS:Cathepsin-L (CTSL) is a member of the lysozomal cysteine protease family, which participates in remodelling of various tissues. Herein, we sought to examine the potential regulation of CTSL in cardiac remodelling post-infarction. METHODS AND RESULTS:Experimental myocardial infarction (MI) was created in CTSL-defi...

journal_title：Cardiovascular research

authors： Sun M,Chen M,Liu Y,Fukuoka M,Zhou K,Li G,Dawood F,Gramolini A,Liu PP

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVES:The concept of lethal reperfusion injury in ischemic myocardium has been the subject of controversy. Adenosine administered during reperfusion has been reported to limit lethal reperfusion injury in several studies. On the contrary, it has been reported that cardioprotection may not be achieved with adenosin...

journal_title：Cardiovascular research

authors： Vander Heide RS,Reimer KA

更新日期：1996-05-01 00:00:00

abstract：:Controversy exists as to whether the diabetic heart is more or less sensitive to ischemic injury. Although a considerable number of experimental studies have directly determined the effects of ischemia on the diabetic heart, there is still no general agreement as to whether metabolic changes within the myocardium cont...

journal_title：Cardiovascular research

authors： Feuvray D,Lopaschuk GD

更新日期：1997-04-01 00:00:00

abstract：AIM:Mechanical forces are important regulators of cell and tissue phenotype. We hypothesized that mechanical loading and boundary conditions would influence neovessel activity during angiogenesis. METHODS AND RESULTS:Using an in vitro model of angiogenesis sprouting and a mechanical loading system, we evaluated the ef...

journal_title：Cardiovascular research

authors： Krishnan L,Underwood CJ,Maas S,Ellis BJ,Kode TC,Hoying JB,Weiss JA

更新日期：2008-05-01 00:00:00

abstract：:Diabetes is one of the most prevalent chronic conditions that has a high association with death from cardiovascular disease(s). An impaired cardiac function independent of vascular disease suggests the existence of a primary myocardial defect in diabetes mellitus. We and others have documented that myocardial performa...

journal_title：Cardiovascular research

authors： Malhotra A,Sanghi V

更新日期：1997-04-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to evaluate the protective effect of verapamil during myocardial ischaemia and reperfusion. DESIGN:In vivo phosphorus-31 (31P) magnetic resonance spectroscopy was performed on rats pretreated with verapamil (mg.kg-1 intraperitoneal) and controls during a 45 min left coronary artery occlusio...

journal_title：Cardiovascular research

authors： Wolfe CL,Donnelly TJ,Sievers R,Parmley WW

更新日期：1991-02-01 00:00:00

abstract：AIMS:Cardiac hypertrophy is a risk factor independent of blood pressure; however, the mechanisms that distinguish pathological remodelling due to local cues from pressure overload are unresolved. This study was aimed at discovering a novel gene expression mechanism in heart failure. METHODS AND RESULTS:In angiotensin ...

journal_title：Cardiovascular research

authors： Yue H,Li W,Desnoyer R,Karnik SS

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Insulin seems to have vasodilator properties, but it is unclear if insulin in postprandial concentrations is a specific vasodilator of skeletal muscle resistance arterioles only or that various types of vessels are affected. The aim of the present study was to determine the direct effects and the time course ...

journal_title：Cardiovascular research

authors： de Haan CH,van Dielen FM,Houben AJ,de Leeuw PW,Huvers FC,De Mey JG,Wolffenbuttel BH,Schaper NC

更新日期：1997-04-01 00:00:00

abstract：AIMS:Despite the observation that ErbB2 regulates sensitivity of the heart to doxorubicin or ErbB2-targeted cancer therapies, mechanisms that regulate ErbB2 expression and activity have not been studied. Since isoproterenol up-regulates ErbB2 in kidney and salivary glands and β2AR and ErbB2 complex in brain and heart, ...

journal_title：Cardiovascular research

authors： Sysa-Shah P,Tocchetti CG,Gupta M,Rainer PP,Shen X,Kang BH,Belmonte F,Li J,Xu Y,Guo X,Bedja D,Gao WD,Paolocci N,Rath R,Sawyer DB,Naga Prasad SV,Gabrielson K

更新日期：2016-03-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is the most common cardiac arrhythmia, and early-onset lone AF has been linked to mutations in genes encoding ion channels. Mutations in the pore forming subunit KV4.3 leading to an increase in the transient outward potassium current (Ito) have previously been associated with the Brugada S...

journal_title：Cardiovascular research

authors： Olesen MS,Refsgaard L,Holst AG,Larsen AP,Grubb S,Haunsø S,Svendsen JH,Olesen SP,Schmitt N,Calloe K

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVES:Coronary artery often reoccludes after thrombolytic therapy with recombinant tissue-plasminogen activator (rt-PA). This reocclusion is thought to be due to in situ platelet activation mediated by thromboxane (Tx) A2 and thrombin; hence, aspirin and thrombin inhibitors are often used in patients with acute my...

journal_title：Cardiovascular research

authors： Chen LY,Nichols WW,Mattsson C,Teger-Nilson AC,Wallin R,Saldeen TG,Mehta JL

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:The K(+) channel encoded by the human ether-a-go-go-related gene (HERG) is crucial for repolarization in the human heart. In order to investigate the impact of HERG current (I(Kr)) on the incidence of cardiac arrhythmias, we generated a transgenic mouse expressing HERG specifically in the heart. METHODS AND ...

journal_title：Cardiovascular research

authors： Royer A,Demolombe S,El Harchi A,Le Quang K,Piron J,Toumaniantz G,Mazurais D,Bellocq C,Lande G,Terrenoire C,Motoike HK,Chevallier JC,Loussouarn G,Clancy CE,Escande D,Charpentier F

更新日期：2005-01-01 00:00:00

abstract：Aims:β1-adrenergic receptor autoantibodies (β1-AAs) and β2-adrenergic receptor autoantibodies (β2-AAs) are present in patients with heart failure (HF); however, their interrelationship with cardiac structure and function remains unknown. This study explored the effects of the imbalance between β1-AAs and β2-AAs on card...

journal_title：Cardiovascular research

authors： Cao N,Chen H,Bai Y,Yang X,Xu W,Hao W,Zhou Y,Chai J,Wu Y,Wang Z,Yin X,Wang L,Wang W,Liu H,Fu MLX

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:The sequelae of myocardial ischaemia can in principle be alleviated by repeated reperfusion, but the accumulation of adenosine monophosphate (AMP) and the loss of interstitial adenosine may lead to adenylate depletion. Repeated oxidative stress could predispose the heart to reperfusion injury. The aim of this...

journal_title：Cardiovascular research

authors： Høst N,Peuhkurinen K,Haunsø S,Hassinen I

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVE:3-Methylcholanthrene (MC), a polycylic aromatic hydrocarbon, induces atherogenesis in mice fed an atherogenic diet. In this study, we tested the hypothesis that MC would induce DNA adducts in mouse aortic smooth muscle cells (SMCs) and that cytochrome P4501B1 (CYP1B1) plays an important role in the activation...

journal_title：Cardiovascular research

authors： Moorthy B,Miller KP,Jiang W,Ramos KS

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:Apolipoprotein E-deficient mice (apoE(-/-)) on a regular diet become hypercholesterolemic and develop atherosclerosis, but endothelium-dependent relaxation remains undisturbed for up to 6 months. We investigated whether vasomotor dysfunction develops in aged apoE(-/-), whether the defect was systemic (hyperch...

journal_title：Cardiovascular research

authors： Crauwels HM,Van Hove CE,Holvoet P,Herman AG,Bult H

更新日期：2003-07-01 00:00:00

abstract：:Inherited arrhythmias are disorders caused by one or more genetic mutations that increase the risk of arrhythmia, which result in life-long risk of sudden death. These mutations either primarily perturb electrophysiological homeostasis (e.g. long QT syndrome and catecholaminergic polymorphic ventricular tachycardia), ...

journal_title：Cardiovascular research

authors： Bezzerides VJ,Prondzynski M,Carrier L,Pu WT

更新日期：2020-07-15 00:00:00