Accumulation of technetium-99m pyrophosphate in experimental infarctions in the rat.

Abstract:

:Cardiac accumulation patterns of pyrophosphate labelled with techetium-99m (TcPyP) in rats one hour to 7 days after coronary artery ligation were studied by light microscopy, myocardial scintigraphy, imaging the isolated heart and by direct measurement of tissue activity. Results suggest that myocardial cells taking up TcPyP are irreversibly damaged and that the disappearance of TcPyP uptake coincides with the removal of necrotic cells by phagocytes.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Lessem J,Polimeni PI,Page E,Resnekov L,Harper PV,Stark V

doi

10.1093/cvr/14.6.352

subject

Has Abstract

pub_date

1980-06-01 00:00:00

pages

352-9

issue

6

eissn

0008-6363

issn

1755-3245

journal_volume

14

pub_type

杂志文章
  • Importance of basal nitric oxide synthesis in regulation of myocardial blood flow.

    abstract:STUDY OBJECTIVE:The aim was to investigate whether basal coronary vascular tone and myocardial perfusion depend upon endothelial nitric oxide (NO) synthesis. DESIGN:Myocardial blood flow and vascular resistance of the left and right ventricles were studied before and after intravenous infusions of either NG-nitro-L-ar...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/25.8.700

    authors: Benyó Z,Kiss G,Szabó C,Csáki C,Kovách AG

    更新日期:1991-08-01 00:00:00

  • Role of microRNAs in the reperfused myocardium towards post-infarct remodelling.

    abstract::Myocardial ischaemia/reperfusion (I/R)-induced remodelling generally includes cell death (necrosis and apoptosis), myocyte hypertrophy, angiogenesis, cardiac fibrosis, and myocardial dysfunction. It is becoming increasingly clear that microRNAs (miRNAs or miRs), a group of highly conserved small (∼18-24 nucleotide) no...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1093/cvr/cvr291

    authors: Zhu H,Fan GC

    更新日期:2012-05-01 00:00:00

  • Transcriptome and proteome mapping in the sheep atria reveal molecular features of atrial fibrillation progression.

    abstract:AIMS:Atrial fibrillation (AF) is a progressive cardiac arrhythmia that increases the risk of hospitalization and adverse cardiovascular events. There is a clear demand for more inclusive and large-scale approaches to understand the molecular drivers responsible for AF, as well as the fundamental mechanisms governing th...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvaa307

    authors: Alvarez-Franco A,Rouco R,Ramirez RJ,Guerrero-Serna G,Tiana M,Cogliati S,Kaur K,Saeed M,Magni R,Enriquez JA,Sanchez-Cabo F,Jalife J,Manzanares M

    更新日期:2020-10-29 00:00:00

  • A model for acute haemodynamic studies in the ascending aorta in pigs.

    abstract::Since data on velocity fields in the ascending aorta downstream of normal aortic valves in pigs have not yet been obtained velocity profiles were visualised using a hot film anemometer needle probe before and after total cardiopulmonary bypass and cold cardioplegic arrest. Furthermore, measurements were made during in...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/22.7.464

    authors: Hasenkam JM,Ostergaard JH,Pedersen EM,Paulsen PK,Nygaard H,Schurizek BA,Johannsen G

    更新日期:1988-07-01 00:00:00

  • Acute haemodynamic effect of taurine on hearts in vivo with normal and depressed myocardial function.

    abstract::The acute haemodynamic effects of taurine were studied in normal and in beta blocker (propranolol) or calcium antagonist (diltiazem) treated rabbits and in rabbits with experimentally produced chronic aortic regurgitation. The administration of taurine (25 mg.kg-1) did not affect heart rate and left ventricular end di...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/21.4.241

    authors: Awata N,Azuma J,Hamaguchi T,Tanaka Y,Ohta H,Takihara K,Harada H,Sawamura A,Kishimoto S

    更新日期:1987-04-01 00:00:00

  • Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection.

    abstract::Reperfusion of the heart after a period of ischaemia leads to the opening of a nonspecific pore in the inner mitochondrial membrane, known as the mitochondrial permeability transition pore (MPTP). This transition causes mitochondria to become uncoupled and capable of hydrolysing rather than synthesising ATP. Unrestrai...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1016/S0008-6363(03)00533-9

    authors: Halestrap AP,Clarke SJ,Javadov SA

    更新日期:2004-02-15 00:00:00

  • Vasopressin-induced coronary constriction at low perfusion pressures.

    abstract::We studied the effects of intracoronary vasopressin on the relationship between pressure and flow in the coronary circulation of anaesthetised swine. In addition to measurements at control levels, diastolic pressure-flow relationships were constructed from steady-state points below a coronary pressure of 50 mmHg, wher...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/19.7.433

    authors: Pantely GA,Ladley HD,Anselone CG,Bristow JD

    更新日期:1985-07-01 00:00:00

  • Amelioration of myocarditis by HVEM-overexpressing dendritic cells through induction of IL-10-producing cells.

    abstract:AIMS:Herpes virus entry mediator (HVEM) is considered to be a molecular 'switch' for immune responses, and a role in immune modification has been reported. The aim of this study was to assess whether HVEM-mediated immune suppression could protect against experimental autoimmune myocarditis (EAM) induced by myosin. MET...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvp219

    authors: Cai G,Wang H,Qin Q,Zhang J,Zhu Z,Liu M,Shen Q

    更新日期:2009-12-01 00:00:00

  • Comparison of the effects of supplementation with whey mineral and potassium on arterial tone in experimental hypertension.

    abstract:OBJECTIVE:The aim of this work was to compare the effects of supplementation of rat chow diet with potassium (K+) and whey mineral concentrate (Whey), a diet rich in milk minerals, on blood pressure and arterial responses in vitro in spontaneously hypertensive rats (SHR). METHODS:Thirty young SHR and twenty Wistar-Kyo...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/s0008-6363(98)00180-1

    authors: Wu X,Tolvanen JP,Hutri-Kähönen N,Kähönen M,Mäkynen H,Korpela R,Ruskoaho H,Karjala K,Pörsti I

    更新日期:1998-11-01 00:00:00

  • Tungstate activates BK channels in a β subunit- and Mg2+-dependent manner: relevance for arterial vasodilatation.

    abstract:AIMS:Tungstate reduces blood pressure in experimental animal models of both hypertension and metabolic syndrome, although the underlying mechanisms are not fully understood. Given that the large-conductance voltage- and Ca(2+)-dependent K(+) (BK) channel is a key element in the control of arterial tone, our aim was to ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvs139

    authors: Fernández-Mariño AI,Porras-González C,González-Rodríguez P,Selent J,Pastor M,Ureña J,Castellano A,Valverde MA,Fernández-Fernández JM

    更新日期:2012-07-01 00:00:00

  • Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells.

    abstract:OBJECTIVE:Vascular endothelial growth factor (VEGF), secreted by vascular cells and a variety of tumour cells, is a potent angiogenic factor. Since nitric oxide (NO) seems to play a key role in the VEGF-induced proliferation of endothelial cells, the aim of the present study was to determine whether VEGF stimulates end...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/s0008-6363(98)00228-4

    authors: Bouloumié A,Schini-Kerth VB,Busse R

    更新日期:1999-03-01 00:00:00

  • Ionic basis of action potential prolongation of hypertrophied cardiac myocytes isolated from hypertensive rats of different ages.

    abstract:OBJECTIVE:The aim was to determine the ionic basis of action potential lengthening associated with cardiac hypertrophy. METHODS:Action potentials and ionic currents of left ventricular myocytes isolated from normal and hypertrophied hearts were recorded with patch pipettes. Since cardiac hypertrophy is a time dependen...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/28.8.1180

    authors: Cerbai E,Barbieri M,Li Q,Mugelli A

    更新日期:1994-08-01 00:00:00

  • Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade.

    abstract:OBJECTIVE:Ischemic postconditioning protects the reperfused heart from infarction, and this protection is dependent on the occupancy of adenosine receptors. We further explored the role of adenosine receptors in this salvage. METHODS:In situ rabbit hearts underwent 30 min of regional ischemia and 3 h of reperfusion, a...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/j.cardiores.2006.02.014

    authors: Philipp S,Yang XM,Cui L,Davis AM,Downey JM,Cohen MV

    更新日期:2006-05-01 00:00:00

  • The effect of cholesteryl ester transfer protein overexpression and inhibition on reverse cholesterol transport.

    abstract:AIMS:Cholesteryl ester transfer protein (CETP) has a well-established role in lipoprotein metabolism, but the effect of its overexpression or inhibition on the efficiency of reverse cholesterol transport (RCT) is unclear. METHODS AND RESULTS:Neither overexpression of CETP nor treatment with CETP inhibitor Torcetrapib ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvm087

    authors: Tchoua U,D'Souza W,Mukhamedova N,Blum D,Niesor E,Mizrahi J,Maugeais C,Sviridov D

    更新日期:2008-03-01 00:00:00

  • Direct and differential effects of stem cell factor on the neovascularization activity of endothelial progenitor cells.

    abstract:AIMS:Previous studies on the role of stem cell factor (SCF) in endothelial progenitor cell (EPC)-mediated neovascularization have focused on the EPC mobilization and homing process. However, the direct effects of SCF on neovascularization activity of EPCs have not been characterized. We sought to determine whether SCF ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvr161

    authors: Kim KL,Meng Y,Kim JY,Baek EJ,Suh W

    更新日期:2011-10-01 00:00:00

  • Demonstration of altered fibroblast contractile activity in hypertensive heart disease.

    abstract:OBJECTIVE:The aim of this study is to investigate the idea that altered fibroblast contractile activity is involved in the pathogenesis of hypertensive heart disease (HHD). METHODS:Cell area and contraction are quantified using the traction force microscopy technique for cardiac fibroblasts isolated from both normoten...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/j.cardiores.2003.09.021

    authors: Marganski WA,De Biase VM,Burgess ML,Dembo M

    更新日期:2003-12-01 00:00:00

  • Intracoronary administration of saralasin: effects on cardiac arrhythmias induced by ischaemia and reperfusion in the anaesthetised dog.

    abstract:OBJECTIVE:The aim was to study (1) the effects of intracoronary saralasin, an angiotensin II receptor antagonist, on ischaemia induced and reperfusion induced regional cardiac noradrenaline release and ventricular arrhythmias; and (2) the implication of angiotensin II in coronary constriction during myocardial ischaemi...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/26.10.968

    authors: Ribuot C,Yamaguchi N,Godin D,Jetté L,Nadeau R

    更新日期:1992-10-01 00:00:00

  • Basilar arterial construction caused by intracisternal NG-nitro-L-arginine in anesthetized monkeys.

    abstract:OBJECTIVES:The present study was designed to determine whether tonic nitric oxide (NO)-mediated vasodilator innervation participates in basilar arterial dilatation in the anesthetized Japanese monkey. METHODS:The basilar arterial diameter was angiographically measured, and NG-nitro-L-arginine (L-NNA), a nitric oxide s...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:

    authors: Okamura T,Ayajiki K,Toda N

    更新日期:1995-11-01 00:00:00

  • Effects of vasoactive drugs upon haemodynamic power and input impedance in normal rats.

    abstract:STUDY OBJECTIVE:The objectives were (a) to describe the effects of vasoactive drugs in normal rats upon cardiovascular function assessed by computing aortic haemodynamic power and input impedance, each separated into their component parts, and (b) to study the relationship between left ventricular pulsatile power outpu...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/25.11.923

    authors: Wright G

    更新日期:1991-11-01 00:00:00

  • Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity.

    abstract:AIMS:n-3 Polyunsaturated fatty acids (PUFAs) are known to protect the cardiovascular system and improve blood pressure control. These important dietary constituents are converted into bioactive metabolites, but their role in regulation of the cardiovascular system is unclear. In particular, the functions of the cytochr...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvq411

    authors: Wang RX,Chai Q,Lu T,Lee HC

    更新日期:2011-05-01 00:00:00

  • Experimental evidence for proarrhythmic mechanisms of antiarrhythmic drugs.

    abstract::The major limitation to antiarrhythmic drug therapy is the risk of arrhythmia promotion, or 'proarrhythmia.' This complication may be lethal, and greatly restricts the value of antiarrhythmic agents, particularly for arrhythmias without an intrinsic mortality risk, such as atrial fibrillation. In order for improved an...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1016/s0008-6363(97)00293-9

    authors: Nattel S

    更新日期:1998-03-01 00:00:00

  • Heme oxygenase-1 inhibition of MAP kinases, calcineurin/NFAT signaling, and hypertrophy in cardiac myocytes.

    abstract:OBJECTIVE:Heme oxygenases (HO) are the rate-limiting enzymes in heme degradation, catalyzing the breakdown of heme to equimolar quantities of biliverdin (BV), carbon monoxide (CO), and ferrous iron. The inducible HO isoform, HO-1, confers protection against ischemia/reperfusion (I/R)-injury in the heart. We hypothesize...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/j.cardiores.2004.04.015

    authors: Tongers J,Fiedler B,König D,Kempf T,Klein G,Heineke J,Kraft T,Gambaryan S,Lohmann SM,Drexler H,Wollert KC

    更新日期:2004-08-15 00:00:00

  • Beta-adrenoceptor function changes with age of subject in myocytes from non-failing human ventricle.

    abstract::The contractile response to beta-adrenoceptor stimulation has been found to be reduced in single myocytes from failing human ventricle. A portion of that reduction was statistically related to the age of the patient. We have developed a method for obtaining viable contracting myocytes from small biopsies of human vent...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:

    authors: Davies CH,Ferrara N,Harding SE

    更新日期:1996-01-01 00:00:00

  • Kir6.2-deficient mice are susceptible to stimulated ANP secretion: K(ATP) channel acts as a negative feedback mechanism?

    abstract:OBJECTIVE:While atrial natriuretic peptide (ANP) has been shown to be released mainly from cardiac muscle cells in response to atrial distension, the regulatory mechanisms of ANP secretion are still not fully understood. We sought to determine whether the ATP-sensitive K+ (K(ATP)) channel modulates the secretion of ANP...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/j.cardiores.2005.03.011

    authors: Saegusa N,Sato T,Saito T,Tamagawa M,Komuro I,Nakaya H

    更新日期:2005-07-01 00:00:00

  • Left ventricular length dependent activation in the isovolumetric rat heart.

    abstract:STUDY OBJECTIVE:The aim of the study was to examine, in a whole heart preparation, the relationship between length changes in cardiac muscle and tension development and length dependent activation. DESIGN:Rat hearts were perfused by the Langendorff technique and isovolumetric pressure changes in the left ventricle, pr...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/24.3.254

    authors: Stefanon I,Vassallo DV,Mill JG

    更新日期:1990-03-01 00:00:00

  • Mechanisms of the pro- and anti-oxidant actions of nitric oxide in atherosclerosis.

    abstract::The association of nitric oxide (NO) with cardiovascular disease has long been recognized and the extensive research on this topic has revealed both pro- and anti-atherosclerotic effects. While these contradictory findings were initially perplexing recent studies offer molecular mechanisms for the integration of these...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1016/s0008-6363(00)00086-9

    authors: Patel RP,Levonen A,Crawford JH,Darley-Usmar VM

    更新日期:2000-08-18 00:00:00

  • Calcineurin regulates NFAT-dependent iNOS expression and protection of cardiomyocytes: co-operation with Src tyrosine kinase.

    abstract:OBJECTIVE:To determine the role of calcineurin and Src tyrosine kinase in the regulation of inducible nitric oxide synthase (iNOS) expression and protection in cardiomyocytes. METHODS:iNOS expression was studied in isolated neonatal rat ventricular myocyte cultures in response to bacterial lipopolysaccharide (LPS) or ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/j.cardiores.2006.05.026

    authors: Obasanjo-Blackshire K,Mesquita R,Jabr RI,Molkentin JD,Hart SL,Marber MS,Xia Y,Heads RJ

    更新日期:2006-09-01 00:00:00

  • Identification and immunolocalisation of annexins V and VI, the major cardiac annexins, in rat heart.

    abstract:OBJECTIVE:The heart contains proteins of the annexin family, a unique group of calcium binding proteins. This study was aimed at identifying the major cardiac annexins and determining their distribution in the rat heart. METHODS:Annexins were isolated by affinity chromatography and purified by ion exchange high pressu...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/27.7.1359

    authors: Doubell AF,Lazure C,Charbonneau C,Thibault G

    更新日期:1993-07-01 00:00:00

  • Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease.

    abstract:AIMS:Coronary arteritis is a life-threatening complication that may arise in the acute stage of Kawasaki disease (KD), the leading cause of systemic vasculitis in childhood. Various microorganisms and molecular pathogens have been reported to cause KD. However, little is known about the key molecules that contribute to...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvz305

    authors: Nakashima Y,Sakai Y,Mizuno Y,Furuno K,Hirono K,Takatsuki S,Suzuki H,Onouchi Y,Kobayashi T,Tanabe K,Hamase K,Miyamoto T,Aoyagi R,Arita M,Yamamura K,Tanaka T,Nishio H,Takada H,Ohga S,Hara T

    更新日期:2021-01-01 00:00:00

  • Axial pressure gradient in the canine superior vena cava.

    abstract::In the superior vena cava of anaesthetised open chest dogs the axial pressure gradient was measured simultaneously with the blood flow velocity under different preload conditions. Both pressure gradient and velocity curves showed distinct systolic and diastolic waves. Peak pressure gradient ranged between 26 and 93 Pa...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/20.12.935

    authors: Minten J,Van de Werf F,Eaubert A,De Geest H

    更新日期:1986-12-01 00:00:00