Abstract:
OBJECTIVE:The aim was to investigate whether intrinsic cardiac neurones can be involved in the genesis of ventricular arrhythmias. METHODS:Nicotinic, muscarinic, beta adrenergic, peptidergic, and amino acidergic agonists, as well as purinergic compounds, were individually administered in microliter quantities adjacent to spontaneously active in situ right atrial neurones in 57 anaesthetised dogs before and after acute decentralisation. RESULTS:Ventricular arrhythmias were induced in one third of the dogs following neurochemical administration. Ventricular arrhythmias are induced much less frequently when intrathoracic extracardiac neurones are modified chemically. Salvos of ventricular premature contractions or ventricular tachycardias were elicited when intrinsic cardiac neurones were modified locally applied nicotine, bethanechol, isoprenaline, angiotensin II, bradykinin, substance P, vasoactive intestinal polypeptide, glutamate, or adenosine. In 60% of those instances in which intrinsic cardiac neuronal activity was modified by a neurochemical, ventricular arrhythmias were elicited. When arrhythmias were induced, activity generated by chemically modified intrinsic cardiac neurones increased from 0.7(SD 0.2) to 2.2(0.4) impulses.s-1 (p < 0.05). Following decentralisation of the intrinsic cardiac nervous system, repeat administration of the same neurochemicals into the same loci elicited ventricular arrhythmias in 42% of those dogs in which ventricular arrhythmias had been elicited previously. Neuronal activity increased [0.8(0.5) to 2.1(0.6) impulses.s-1; p < 0.05] in 86% of these instances. CONCLUSIONS:Intrinsic cardiac neurones can be involved in the genesis of ventricular arrhythmias.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Huang MH,Wolf SG,Armour JAdoi
10.1093/cvr/28.5.636subject
Has Abstractpub_date
1994-05-01 00:00:00pages
636-42issue
5eissn
0008-6363issn
1755-3245pii
0008-6363(94)90166-Xjournal_volume
28pub_type
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journal_title:Cardiovascular research
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更新日期:1997-06-01 00:00:00
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更新日期:2009-05-01 00:00:00
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更新日期:1994-01-01 00:00:00
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更新日期:1976-01-01 00:00:00
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更新日期:1990-09-01 00:00:00
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更新日期:2009-03-01 00:00:00
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更新日期:1987-12-01 00:00:00
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更新日期:2020-07-15 00:00:00