TIMP3 is the primary TIMP to regulate agonist-induced vascular remodelling and hypertension.

abstract：OBJECTIVES:While it is probable that the cerebrovascular spasm which occurs after subarachnoid haemorrhage results from the action of haemoglobin, the mechanism of that process remains unclear. These studies were thus designed to test the hypothesis that the action of oxyhaemoglobin results from the iron-catalyzed form...

journal_title：Cardiovascular research

authors： Vollrath B,Chan P,Findlay M,Cook D

更新日期：1995-10-01 00:00:00

abstract：AIMS:Peripheral chemoreflex sensitivity is potentiated in both clinical and experimental chronic heart failure (CHF). NADPH oxidase-derived superoxide mediates angiotensin II (Ang II)-enhanced carotid body (CB) chemoreceptor sensitivity in CHF rabbits, and tempol, the superoxide dismutase (SOD) mimetic, inhibits this A...

journal_title：Cardiovascular research

authors： Ding Y,Li YL,Zimmerman MC,Davisson RL,Schultz HD

更新日期：2009-03-01 00:00:00

abstract：:Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. The pleiotropic cytokine interferon-gamma (IFN-gamma) is a key pro-inflammatory mediator that is expressed at high levels in atherosclerotic lesions. IFN-gamma regulates the...

journal_title：Cardiovascular research

authors： Harvey EJ,Ramji DP

更新日期：2005-07-01 00:00:00

abstract：:Diabetes is one of the most prevalent chronic conditions that has a high association with death from cardiovascular disease(s). An impaired cardiac function independent of vascular disease suggests the existence of a primary myocardial defect in diabetes mellitus. We and others have documented that myocardial performa...

journal_title：Cardiovascular research

authors： Malhotra A,Sanghi V

更新日期：1997-04-01 00:00:00

abstract：:Attempts were made to demonstrate release of vasoactive substances from the heart during coronary occlusion (for 60 min) and reperfusion (for 60 min), and to clarify the pathophysiological significance of them. Vasoactive substances were detected by superfusion of rabbit aortic and dog coronary arterial strips with gr...

journal_title：Cardiovascular research

authors： Tanabe M,Terashita ZI,Fujiwara S,Shimamoto N,Goto N,Nishikawa K,Hirata M

更新日期：1982-02-01 00:00:00

abstract：AIMS:Doxorubicin (DOX) is widely used in cytostatic treatments, although it may cause cardiovascular dysfunction as a side effect. DOX treatment leads to enhanced free radical production that in turn causes DNA strand breakage culminating in poly(ADP-ribose) polymerase (PARP) activation and mitochondrial and cellular d...

journal_title：Cardiovascular research

authors： Szántó M,Rutkai I,Hegedus C,Czikora Á,Rózsahegyi M,Kiss B,Virág L,Gergely P,Tóth A,Bai P

更新日期：2011-12-01 00:00:00

abstract：AIMS:Chronic heart failure is a complex clinical syndrome with impaired myocardial contractility. In failing cardiomyocytes, decreased signalling efficiency between the L-type Ca(2+) channels (LCCs) in the plasma membrane (including transverse tubules, TTs) and the ryanodine receptors (RyRs) in the sarcoplasmic reticul...

journal_title：Cardiovascular research

authors： Zhang HB,Li RC,Xu M,Xu SM,Lai YS,Wu HD,Xie XJ,Gao W,Ye H,Zhang YY,Meng X,Wang SQ

更新日期：2013-05-01 00:00:00

abstract：:The significance of pre-existing coronary collaterals for preservation of the myocardium during coronary occlusion and reperfusion was studied in anaesthetised open-chest dogs. The extent of myocardial ischaemic damage was assessed by the accumulation of calcium in the central zone of the ischaemic area and the size o...

journal_title：Cardiovascular research

authors： Tanabe M,Fujiwara S,Ohta N,Shimamoto N,Hirata M

更新日期：1980-05-01 00:00:00

abstract：OBJECTIVE:Unidirectional conduction block (UCB) and reentry may occur as a consequence of an abrupt tissue expansion and a related change in the electrical load. The aim of this study was to evaluate critical dimensions of the tissue necessary for establishing UCB in heart cell culture. METHODS:Neonatal rat heart cell...

journal_title：Cardiovascular research

authors： Fast VG,Kléber AG

更新日期：1995-05-01 00:00:00

abstract：:Severe sepsis and septic shock, which are among the most common causes of death in intensive care units worldwide, cause high morbidity, mortality, and social and economic costs. Therefore, developing successful therapies against sepsis is one of the most important challenges in critical care medicine. Death from sept...

journal_title：Cardiovascular research

authors： Cauwels A,Brouckaert P

更新日期：2011-02-15 00:00:00

abstract：:Since the discovery of atrial natriuretic peptide (ANP) more than 20 years ago, numerous studies have focused on the mechanisms regulating ANP secretion. From a physiological standpoint, the most important factor governing ANP secretion is mechanical stretching of the atria, which normally occurs when extracellular fl...

journal_title：Cardiovascular research

authors： Dietz JR

更新日期：2005-10-01 00:00:00

abstract：:Hydrogen sulfide (H2S), as a gaseous signalling molecule, has been found to play important roles in postconditioning (PostC)-induced cardioprotection. Similar to nitric oxide (NO)-mediated protein S-nitrosylation (SNO), recent studies suggest that H2S could regulate protein function through another redox-based post-tr...

journal_title：Cardiovascular research

authors： Sun J,Aponte AM,Menazza S,Gucek M,Steenbergen C,Murphy E

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:The endothelium is a newly recognised target tissue of parathyroid hormone (PTH). It is not clear whether hyperparathyroidism affects endothelial function and whether parathyroidectomy (Ptx) has an influence on arterial vessel wall properties. We studied brachial flow-mediated vasodilation (FMD) and brachial ...

journal_title：Cardiovascular research

authors： Kosch M,Hausberg M,Vormbrock K,Kisters K,Gabriels G,Rahn KH,Barenbrock M

更新日期：2000-09-01 00:00:00

abstract：:Estimation of infarct size from enzyme activities in plasma or serum presupposes known values of circulatory parameters such as the extravascular distribution volume Ve and the permeability constant P for the transport of enzyme between intravascular volume Vi and Ve. In man, parameter values are used that are extrapo...

journal_title：Cardiovascular research

authors： Willems GM,Muijtjens AM,Lambi FH,Hermens WT

更新日期：1979-10-01 00:00:00

abstract：OBJECTIVES:Coronary collateral flow often mitigates the effects of coronary artery obstruction and has a significant impact on the prognosis of patients with coronary artery disease. In the presence of variable degrees of coronary collateral flow, digital radiographic assessment of myocardial blood flow has not been qu...

journal_title：Cardiovascular research

authors： Murata K,Bhargava V,Ricou F,Ono S,Kambayashi M,Oh BH,Peterson KL

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:To study the effect of cardiac contraction on left coronary artery pressure-flow relations at different vascular volumes and to compare these relations in the beating heart with those in the heart arrested in systole and diastole. METHODS:Maximally vasodilated, Tyrode perfused, rabbit hearts (n = 6) with an ...

journal_title：Cardiovascular research

authors： Sipkema P,Takkenberg JJ,Zeeuwe PE,Westerhof N

更新日期：1998-10-01 00:00:00

abstract：Aims:Heart failure (HF) produces left atrial (LA)-selective fibrosis and promotes atrial fibrillation. HF also causes adrenergic activation, which contributes to remodelling via a variety of signalling molecules, including the exchange protein activated by cAMP (Epac). Here, we evaluate the effects of Epac1-signalling ...

journal_title：Cardiovascular research

authors： Surinkaew S,Aflaki M,Takawale A,Chen Y,Qi XY,Gillis MA,Shi YF,Tardif JC,Chattipakorn N,Nattel S

更新日期：2019-01-01 00:00:00

abstract：:The role of the mitochondrial ATP-sensitive potassium channel (mK(ATP)) in ischemic preconditioning and cardioprotection is reviewed. A great deal of accumulated evidence implicatese opening of this channel as an important step in the anti-infarct effect of ischemic preconditioning. Recent studies, however, reveal tha...

journal_title：Cardiovascular research

authors： Oldenburg O,Cohen MV,Yellon DM,Downey JM

更新日期：2002-08-15 00:00:00

abstract：:Although substantial information has accumulated over the past decade, many gaps remain in our understanding of the regulation of contractility and modulation of inotropic responsiveness in the developing heart. There are several important problems facing investigators in the field of developmental cardiology. Respons...

journal_title：Cardiovascular research

authors： Artman M

更新日期：1992-01-01 00:00:00

abstract：AIMS:The molecular mechanisms controlling heart function and rhythmicity are incompletely understood. While it is widely accepted that the type 2 ryanodine receptor (Ryr2) is the major Ca(2+) release channel in excitation-contraction coupling, the role of these channels in setting a consistent beating rate remains cont...

journal_title：Cardiovascular research

authors： Bround MJ,Asghari P,Wambolt RB,Bohunek L,Smits C,Philit M,Kieffer TJ,Lakatta EG,Boheler KR,Moore ED,Allard MF,Johnson JD

更新日期：2012-12-01 00:00:00

abstract：AIMS:To determine the role of gap junctions (GJs) in hypoxic pulmonary vasoconstriction (HPV). METHODS AND RESULTS:Studies were performed in rat isolated intrapulmonary arteries (IPAs) mounted on a myograph and in anaesthetized rats. Hypoxia induced a biphasic HPV response in IPAs preconstricted with prostaglandin F2α...

journal_title：Cardiovascular research

authors： Kizub IV,Strielkov IV,Shaifta Y,Becker S,Prieto-Lloret J,Snetkov VA,Soloviev AI,Aaronson PI,Ward JP

更新日期：2013-08-01 00:00:00

abstract：:Microelectrode recordings of skin nerve sympathetic activity were made in the median nerve supplying the right hand of nine patients with Raynaud's phenomenon and 10 control subjects. With subjects warmed up (finger temperature 33 to 34 degrees C) different manoeuvres were used to evoke strong, single sympathetic burs...

journal_title：Cardiovascular research

authors： Fagius J,Blumberg H

更新日期：1985-05-01 00:00:00

abstract：AIMS:The risk of mortality from the coronavirus disease that emerged in 2019 (COVID-19) is increased by comorbidity from cardiovascular and pulmonary diseases. Air pollution also causes excess mortality from these conditions. Analysis of the first severe acute respiratory syndrome coronavirus (SARS-CoV-1) outcomes in 2...

journal_title：Cardiovascular research

authors： Pozzer A,Dominici F,Haines A,Witt C,Münzel T,Lelieveld J

更新日期：2020-12-01 00:00:00

abstract：:Since the establishment of the inflammatory basis of atherosclerosis, several pro- or anti-inflammatory agents have been examined as potential mediators of the biochemical pathways of lesion formation. Interleukin (IL)-8 was first characterized in 1987. Since then, knowledge regarding its role in leucocyte trafficking...

journal_title：Cardiovascular research

authors： Apostolakis S,Vogiatzi K,Amanatidou V,Spandidos DA

更新日期：2009-12-01 00:00:00

abstract：:Nitric oxide (NO) is a highly reactive, free radical signalling molecule that is constitutively released in cardiomyocytes by both the endothelial and neuronal isoforms of nitric oxide synthase (eNOS and nNOS, respectively). There are increasing data indicating that NO modulates various proteins involved in excitation...

journal_title：Cardiovascular research

authors： Lim G,Venetucci L,Eisner DA,Casadei B

更新日期：2008-01-15 00:00:00

abstract：:Ischemia-reperfusion of the heart and other organs results in the accumulation of unesterified arachidonic acid (AA) via the action of membrane-bound phospholipases, primarily phospholipase A2. AA can be metabolized by the classical cyclooxygenase (COX) and lipoxygenase (LOX) pathways to well-characterized metabolites...

journal_title：Cardiovascular research

authors： Gross GJ,Falck JR,Gross ER,Isbell M,Moore J,Nithipatikom K

更新日期：2005-10-01 00:00:00

abstract：AIMS:The hypoxia-inducible factor-1 (HIF-1) is the master modulator of hypoxic gene expression. The effects of chronically stabilized cardiac HIF-1α and its role in the diseased heart are not precisely known. The aims of this study were as follows: (i) to elucidate consequences of HIF-1α stabilization in the heart; (ii...

journal_title：Cardiovascular research

authors： Hölscher M,Schäfer K,Krull S,Farhat K,Hesse A,Silter M,Lin Y,Pichler BJ,Thistlethwaite P,El-Armouche A,Maier LS,Katschinski DM,Zieseniss A

更新日期：2012-04-01 00:00:00

abstract：AIMS:Baicalin is the major component found in Scutellaria baicalensis root, a widely used herb in traditional Chinese medicine. Although it has been used for thousands of years to treat stroke, the mechanisms of action of S. baicalensis have not been clearly elucidated. In this report, we studied the modulation of angi...

journal_title：Cardiovascular research

authors： Zhang K,Lu J,Mori T,Smith-Powell L,Synold TW,Chen S,Wen W

更新日期：2011-02-01 00:00:00

abstract：AIMS:Cardiac hypertrophy is a risk factor independent of blood pressure; however, the mechanisms that distinguish pathological remodelling due to local cues from pressure overload are unresolved. This study was aimed at discovering a novel gene expression mechanism in heart failure. METHODS AND RESULTS:In angiotensin ...

journal_title：Cardiovascular research

authors： Yue H,Li W,Desnoyer R,Karnik SS

更新日期：2010-01-01 00:00:00

abstract：AIMS:In cardiomyocytes, protein kinase D1 (PKD1) plays a central role in the response to stress signals. From a yeast two-hybrid assay, we have identified Enigma Homolog 1 (ENH1) as a new binding partner of PKD1. Since in neurons, ENH1, associated with protein kinase Cepsilon, was shown to modulate the activity of N-ty...

journal_title：Cardiovascular research

authors： Maturana AD,Wälchli S,Iwata M,Ryser S,Van Lint J,Hoshijima M,Schlegel W,Ikeda Y,Tanizawa K,Kuroda S

更新日期：2008-06-01 00:00:00