Interferon-gamma and atherosclerosis: pro- or anti-atherogenic?

abstract：AIMS:Heparanase, which specifically cleaves carbohydrate chains of heparan sulfate, has been implicated in the pathology of diabetes-associated complications. Using high glucose (HG) to replicate hyperglycaemia observed following diabetes, the present study was designed to determine the mechanism by which HG initiates ...

journal_title：Cardiovascular research

authors： Wang F,Wang Y,Kim MS,Puthanveetil P,Ghosh S,Luciani DS,Johnson JD,Abrahani A,Rodrigues B

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:Despite the frequent use of anti-arrhythmic drugs in the general population, the electrophysiologic effects of these agents have not been elucidated in congestive heart failure (CHF). METHODS:To examine the impact of left ventricular dysfunction on actions of type III anti-arrhythmic drugs, we evaluated the ...

journal_title：Cardiovascular research

authors： Chugh SS,Johnson SB,Packer DL

更新日期：2001-01-01 00:00:00

abstract：AIMS:To describe the overall role of reduced sarcoplasmic reticulum Ca(2+) ATPase (SERCA2) for Ca(2+) wave development. METHODS AND RESULTS:SERCA2 knockout [Serca2(flox/flox) Tg(alphaMHC-MerCreMer); KO] mice allowing inducible cardiomyocyte-specific disruption of the Serca2 gene in adult mice were compared with Serca(...

journal_title：Cardiovascular research

authors： Stokke MK,Hougen K,Sjaastad I,Louch WE,Briston SJ,Enger UH,Andersson KB,Christensen G,Eisner DA,Sejersted OM,Trafford AW

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the effect on the coronary network of the interaction between high arterial blood oxygen tension (PaO2) and stimulation by the alpha adrenergic agonist phenylephrine or by serotonin in an isolated, blood perfused rabbit heart preparation. METHODS:Fresh pig erythrocytes in Krebs-Hen...

journal_title：Cardiovascular research

authors： Mouren S,Vicaut E,Charansonney O,Duvelleroy M

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:Neointimal hyperplasia is a central feature in the pathogenesis of a variety of vascular pathologies. Mitogen-activated protein kinases (MAPK) are involved in the downstream transduction of signals from receptors for many of the molecules known to be instrumental in this process and thus represent a potential...

journal_title：Cardiovascular research

authors： Liu B,Fisher M,Groves P

更新日期：2002-06-01 00:00:00

abstract：:Hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Most previous investigations focused on the role of homocysteine as direct pathogenetic factor for these adverse vascular events. However, the exact pathophysiological mechanism is still unknown. In this review we discuss the hypothesis tha...

journal_title：Cardiovascular research

authors： Riksen NP,Rongen GA,Blom HJ,Russel FG,Boers GH,Smits P

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:Cardiac energetics and performance depend on the expression level of the fast (alpha-) and slow (beta-) myosin heavy chain (MHC) isoform. In ventricular tissue, the beta-MHC isoform predominates, whereas in atrial tissue a variable mixture of alpha- and beta-MHC is found. In several cardiac diseases, the slow...

journal_title：Cardiovascular research

authors： Narolska NA,van Loon RB,Boontje NM,Zaremba R,Penas SE,Russell J,Spiegelenberg SR,Huybregts MA,Visser FC,de Jong JW,van der Velden J,Stienen GJ

更新日期：2005-01-01 00:00:00

abstract：AIMS:Arrhythmias and sudden cardiac death (SCD) occur commonly in patients with heart failure. We found T-box 5 (TBX5) dysregulated in ventricular myocardium from heart failure patients and thus we hypothesized that TBX5 reduction contributes to arrhythmia development in these patients. To understand the underlying mec...

journal_title：Cardiovascular research

authors： Rathjens FS,Blenkle A,Iyer LM,Renger A,Syeda F,Noack C,Jungmann A,Dewenter M,Toischer K,El-Armouche A,Müller OJ,Fabritz L,Zimmermann WH,Zelarayan LC,Zafeiriou MP

更新日期：2020-08-10 00:00:00

abstract：OBJECTIVE:Ischemic preconditioning confers cardioprotection in early and delayed phases. We investigated the delayed window of pharmacological and ischemic preconditioning in human myocardium, and the involvement of mitoKATP, PKC and p38MAPK. METHODS:These studies were carried out using human right atrial tissue in a ...

journal_title：Cardiovascular research

authors： Loubani M,Hassouna A,Galiñanes M

更新日期：2004-02-15 00:00:00

abstract：AIMS:Tungstate reduces blood pressure in experimental animal models of both hypertension and metabolic syndrome, although the underlying mechanisms are not fully understood. Given that the large-conductance voltage- and Ca(2+)-dependent K(+) (BK) channel is a key element in the control of arterial tone, our aim was to ...

journal_title：Cardiovascular research

authors： Fernández-Mariño AI,Porras-González C,González-Rodríguez P,Selent J,Pastor M,Ureña J,Castellano A,Valverde MA,Fernández-Fernández JM

更新日期：2012-07-01 00:00:00

abstract：:The acute haemodynamic effects of taurine were studied in normal and in beta blocker (propranolol) or calcium antagonist (diltiazem) treated rabbits and in rabbits with experimentally produced chronic aortic regurgitation. The administration of taurine (25 mg.kg-1) did not affect heart rate and left ventricular end di...

journal_title：Cardiovascular research

authors： Awata N,Azuma J,Hamaguchi T,Tanaka Y,Ohta H,Takihara K,Harada H,Sawamura A,Kishimoto S

更新日期：1987-04-01 00:00:00

abstract：:Cell communication, an essential component of integrated physiological function in multicellular organisms, is mediated largely through informational molecules, such as hormones and neurotransmitters. After binding to specific receptors, these first messengers activate intracellular signaling cascades and, thereby, tr...

journal_title：Cardiovascular research

authors： Goette A,Lendeckel U,Klein HU

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:There is accumulating evidence that oestrogen replacement therapy protects against the development of coronary atherosclerosis and myocardial infarction in postmenopausal women. The mechanism of this protective effect is uncertain. The aim of this study was to measure the effects of 17 beta-oestradiol on huma...

journal_title：Cardiovascular research

authors： Mügge A,Riedel M,Barton M,Kuhn M,Lichtlen PR

更新日期：1993-11-01 00:00:00

abstract：STUDY OBJECTIVE:The aim of the study was to examine, in a whole heart preparation, the relationship between length changes in cardiac muscle and tension development and length dependent activation. DESIGN:Rat hearts were perfused by the Langendorff technique and isovolumetric pressure changes in the left ventricle, pr...

journal_title：Cardiovascular research

authors： Stefanon I,Vassallo DV,Mill JG

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:To examine if adenosine prevents oxidant-induced mitochondrial dysfunction by producing nitric oxide (NO) in cardiomyocytes. METHODS AND RESULTS:Adenosine significantly enhanced the fluorescence of DAF-FM, a dye specific for NO, implying that adenosine induces synthesis of NO. Adenosine-induced NO production...

journal_title：Cardiovascular research

authors： Xu Z,Park SS,Mueller RA,Bagnell RC,Patterson C,Boysen PG

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:Atrial (ANP) and B-type natriuretics peptides (BNP) via their guanylyl cyclase-A (GC-A) receptor not only regulate arterial blood pressure and volume but also exert local antihypertrophic, antifibrotic and lusitropic effects in the heart. To elucidate whether cardiac hypertrophy/insufficiency and reversal is ...

journal_title：Cardiovascular research

authors： Kuhn M,Voss M,Mitko D,Stypmann J,Schmid C,Kawaguchi N,Grabellus F,Baba HA

更新日期：2004-11-01 00:00:00

abstract：CONDENSED ABSTRACT:We analyzed actomyosin cross-bridge kinetics in human atrial and ventricular muscle strip preparations by using sinusoidal length changes from 0.1 to 60 Hz. The minimum stiffness frequency was higher in atrial than in ventricular human myocardium and lower in failing than in non-failing left ventricu...

journal_title：Cardiovascular research

authors： Ruf T,Schulte-Baukloh H,Lüdemann J,Posival H,Beyersdorf F,Just H,Holubarsch C

更新日期：1998-12-01 00:00:00

abstract：:Inflammation represents the driving feature of many diseases, including atherosclerosis, cancer, autoimmunity and infections. It is now established that metabolic processes shape a proper immune response and within this context the alteration in cellular cholesterol homeostasis has emerged as a culprit of many metabol...

journal_title：Cardiovascular research

authors： Yvan-Charvet L,Bonacina F,Guinamard RR,Norata GD

更新日期：2019-07-01 00:00:00

abstract：:Protein kinase A (PKA) is a central regulator of cardiac performance and morphology. Myocardial PKA activation is induced by a variety of hormones, neurotransmitters and stress signals, most notably catecholamines secreted by the sympathetic nervous system. Catecholamines bind β-adrenergic receptors to stimulate cAMP-...

journal_title：Cardiovascular research

authors： Liu Y,Chen J,Fontes SK,Bautista EN,Cheng Z

更新日期：2021-01-23 00:00:00

abstract：:To provide further evidence that the veratrum alkaloids' mechanical, positive inotropic effect and not their chemical depolarising action predominates in initiating the left ventricular mechanoreceptor (including the Bezold) reflex the effect of intracoronary KCl, a chemical depolarising agent like the veratrum alkalo...

journal_title：Cardiovascular research

authors： Estrin JA,Wahler GM,Booth AM,Swayze CR,Fox IJ

更新日期：1984-08-01 00:00:00

abstract：AIMS:Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine that contributes to pathogenic cardiac remodelling via mechanisms that involve oxidative stress. However, the direct impact of TGF-beta1 on contractile function of ventricular myocytes is incompletely understood. METHODS AND RESULTS:Reacti...

journal_title：Cardiovascular research

authors： Li S,Li X,Zheng H,Xie B,Bidasee KR,Rozanski GJ

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Smooth muscle cell proliferation and migration are the predominant responses to intimal and medial injury after percutaneous transluminal coronary angioplasty. The in vivo inhibitory effect of heparin on these responses is well documented. To test the hypothesis that the antiproliferative effect of heparin in...

journal_title：Cardiovascular research

authors： Hamon M,Bauters C,Wernert N,Courtin P,Delcayre C,Adamantidis M,Lablanche JM,Bertrand ME,Dupuis B,Swynghedauw B

更新日期：1993-07-01 00:00:00

abstract：AIMS:Heart failure is associated with deficient endothelial nitric oxide (NO) production as well as increased oxidative stress and accelerated NO degradation. The aim of this study was to evaluate platelet NO biosynthesis and superoxide anion (O(2)(-)) production in patients with heart failure. METHODS AND RESULTS:In ...

journal_title：Cardiovascular research

authors： Shah A,Passacquale G,Gkaliagkousi E,Ritter J,Ferro A

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to investigate the changes in beta-adrenoceptor density (Bmax) and distribution in a model of chronic myocardial infarction in rats, and to relate possible changes to hemodynamic and neurohumoral abnormalities. In addition, we examined the effects of 8 weeks treatment with ibopa...

journal_title：Cardiovascular research

authors： van Veldhuisen DJ,Brodde OE,van Gilst WH,Schulze C,Hegeman H,Anthonio RL,Scholtens E,de Graeff PA,Wesseling H,Lie KI

更新日期：1995-09-01 00:00:00

abstract：AIMS:Atherogenesis, evolution of plaque, and outcomes following endovascular intervention depend heavily on the unique vascular architecture of each individual. Patient-specific, multiscale models able to correlate changes in microscopic cellular responses with relevant macroscopic flow, and structural conditions may h...

journal_title：Cardiovascular research

authors： Martorell J,Santomá P,Kolandaivelu K,Kolachalama VB,Melgar-Lesmes P,Molins JJ,Garcia L,Edelman ER,Balcells M

更新日期：2014-07-01 00:00:00

abstract：AIMS:Disturbed blood flow at arterial branches and curvatures modulates endothelial function and predisposes the region to endothelial inflammation and subsequent development of atherosclerotic lesions. Activation of the endothelial Toll-like receptors (TLRs), in particular TLR4, contributes to vascular inflammation. T...

journal_title：Cardiovascular research

authors： Qu D,Wang L,Huo M,Song W,Lau CW,Xu J,Xu A,Yao X,Chiu JJ,Tian XY,Huang Y

更新日期：2020-01-01 00:00:00

abstract：Aims:Circular RNA (circRNA) is a newly validated class of single-stranded RNA, ubiquitously expressed in mammalian tissues and possessing key functions including acting as microRNA sponges and as transcriptional regulators by binding to RNA-binding proteins. While independent studies confirm the expression of circRNA i...

journal_title：Cardiovascular research

authors： Tan WL,Lim BT,Anene-Nzelu CG,Ackers-Johnson M,Dashi A,See K,Tiang Z,Lee DP,Chua WW,Luu TD,Li PY,Richards AM,Foo RS

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVES:M cells have been described in many mammalian species. They are thought to be relevant for the genesis of long QT intervals, afterdepolarizations and for dispersion in action potential duration and in repolarization time. Their role in the human heart is subject to debate. METHODS:We simulated action potent...

journal_title：Cardiovascular research

authors： Conrath CE,Wilders R,Coronel R,de Bakker JM,Taggart P,de Groot JR,Opthof T

更新日期：2004-05-01 00:00:00

abstract：:Reperfusion of the heart after a period of ischaemia leads to the opening of a nonspecific pore in the inner mitochondrial membrane, known as the mitochondrial permeability transition pore (MPTP). This transition causes mitochondria to become uncoupled and capable of hydrolysing rather than synthesising ATP. Unrestrai...

journal_title：Cardiovascular research

authors： Halestrap AP,Clarke SJ,Javadov SA

更新日期：2004-02-15 00:00:00

abstract：:The cardioprotective effects of mioflazine, a recently developed cardiovascular drug, were investigated in 41 anaesthetised open chest Beagle dogs subjected to 1 h normothermic global myocardial ischaemia. The severity of the model is evidenced by the finding that only one out of 20 control dogs could be weaned from e...

journal_title：Cardiovascular research

authors： Flameng W,Xhonneux R,Van Belle H,Borgers M,Van de Water A,Wouters L,Wijnants J,Thoné F,Van Daele P,Janssen PA

更新日期：1984-09-01 00:00:00