Left ventricular length dependent activation in the isovolumetric rat heart.


STUDY OBJECTIVE:The aim of the study was to examine, in a whole heart preparation, the relationship between length changes in cardiac muscle and tension development and length dependent activation. DESIGN:Rat hearts were perfused by the Langendorff technique and isovolumetric pressure changes in the left ventricle, produced by increasing diastolic pressures (0, 5, 10, 15, 20, 25 mm Hg), were studied at different calcium concentrations (0.5, 1.25, 2.5, 3.75 mmol.litre-1). EXPERIMENTAL MATERIALS:20 whole heart preparations were obtained from albino rats of either sex, weight 180-240 g (females) and 220-330 g (males). MEASUREMENTS AND MAIN RESULTS:In a comparison of ventricular diastolic upsilon systolic pressure curves, normalised with respect to maximum isovolumetric systolic pressure, there was a separation and an upward displacement of the curves with increments in calcium concentration in the perfusate. CONCLUSIONS:The results show, as in isolated preparations, that there is length dependent activation in the whole rat heart.


Cardiovasc Res


Cardiovascular research


Stefanon I,Vassallo DV,Mill JG




Has Abstract


1990-03-01 00:00:00












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    abstract:AIMS:Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is caused by mutations in the cardiac ryanodine receptor (RyR2) that lead to disrupted Ca(2+) handling in cardiomyocytes and ventricular tachycardia. The aim of this study was to test whether exercise training could reduce the propensity for arrh...

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    abstract::Activation of sphingosine kinase/sphingosine-1-phosphate (SK/S1P)-mediated signalling has been recognized as critical for cardioprotection in response to acute ischaemia/reperfusion injury. Incubation of S1P with cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischaemia or ...

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    pub_type: 杂志文章


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    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Brown LA,Nunez DJ,Brookes CI,Wilkins MR

    更新日期:1995-06-01 00:00:00

  • Hypercapnic acidosis and dimethyl amiloride reduce reperfusion induced cell death in ischaemic ventricular myocardium.

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    pub_type: 杂志文章


    authors: Kaplan SH,Yang H,Gilliam DE,Shen J,Lemasters JJ,Cascio WE

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    journal_title:Cardiovascular research

    pub_type: 杂志文章


    authors: Avontuur JA,Bruining HA,Ince C

    更新日期:1997-08-01 00:00:00