Physiological and pathophysiological roles of eicosanoids in the microcirculation.

abstract：OBJECTIVE:Myogenic tone, which has a major role in the regulation of local blood flow, refers to the ability of vascular smooth muscle to adapt its contractility to changes in transmural pressure. Although Rho-kinase is involved in myogenic tone, the pathway involved remains unclear, especially concerning translocation...

journal_title：Cardiovascular research

authors： Dubroca C,Loyer X,Retailleau K,Loirand G,Pacaud P,Feron O,Balligand JL,Lévy BI,Heymes C,Henrion D

更新日期：2007-01-01 00:00:00

abstract：AIMS:The channel function of the cardiac ryanodine receptor (RyR2) is modulated by calmodulin (CaM). However, the involvement of CaM in aberrant Ca(2+) release in diseased hearts remains unclear. Here, we investigated the pathogenic role of defective CaM binding to the RyR2 in the channel dysfunction associated with he...

journal_title：Cardiovascular research

authors： Hino A,Yano M,Kato T,Fukuda M,Suetomi T,Ono M,Murakami W,Susa T,Okuda S,Doi M,Kobayashi S,Yamamoto T,Koseki N,Kyushiki H,Ikemoto N,Matsuzaki M

更新日期：2012-12-01 00:00:00

abstract：AIMS:Our recent work demonstrated that common cardiovascular progenitor cells are characterized and induced by the expression of the transcription factor mesoderm posterior1 (MesP1) in vertebrate embryos and murine embryonic stem cells. As the proliferative potential of stem cell-derived cardiomyocytes is limited, it i...

journal_title：Cardiovascular research

authors： David R,Jarsch VB,Schwarz F,Nathan P,Gegg M,Lickert H,Franz WM

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:The aim was to study (1) the effects of intracoronary saralasin, an angiotensin II receptor antagonist, on ischaemia induced and reperfusion induced regional cardiac noradrenaline release and ventricular arrhythmias; and (2) the implication of angiotensin II in coronary constriction during myocardial ischaemi...

journal_title：Cardiovascular research

authors： Ribuot C,Yamaguchi N,Godin D,Jetté L,Nadeau R

更新日期：1992-10-01 00:00:00

abstract：AIMS:Germ-line mutations in genes encoding components of the RAS/mitogen-activated protein kinase (MAPK) pathway cause developmental disorders called RASopathies. Hypertrophic cardiomyopathy (HCM) is the most common myocardial pathology and a leading cause of death in RASopathy patients. KRAS mutations are found in Noo...

journal_title：Cardiovascular research

authors： Dalin MG,Zou Z,Scharin-Täng M,Safari R,Karlsson C,Bergo MO

更新日期：2014-02-01 00:00:00

abstract：:To improve assessment of ventricular function during cardiac catheterisation there should be available a continuous registration of stroke volume and cardiac output in addition to ventricular pressure. To obtain the desired volumetric quantities a catheter has been developed which measures changes in intraventricular ...

journal_title：Cardiovascular research

authors： Baan J,Jong TT,Kerkhof PL,Moene RJ,van Dijk AD,van der Velde ET,Koops J

更新日期：1981-06-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that prolonged physical exercise induces long-lasting effects on blood pressure and heart rate we studied 17 endurance runners before and after the 1995 Sandia Wilderness Crossing Research Run (46 km of rocky trails, average altitude 2500 m). METHODS:We evaluated the response of the ca...

journal_title：Cardiovascular research

authors： Bernardi L,Passino C,Robergs R,Appenzeller O

更新日期：1997-05-01 00:00:00

abstract：AIMS:A cytosolic calcium (Ca(2+)(i)) increase is an important activation signal for the endothelium. We investigated whether interendothelial spreading of the Ca(2+) signal via gap junctions (GJs) plays a role for the overall Ca(2+)(i) increase in response to vasoactive agonists. METHODS AND RESULTS:In human umbilical...

journal_title：Cardiovascular research

authors： Kameritsch P,Pogoda K,Ritter A,Münzing S,Pohl U

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of the ATP-sensitive potassium (KATP) channel inhibitor sodium 5-hydroxydecanoate (5-HD) on the reduction in myocardial infarct size afforded by ischaemic preconditioning in the sodium pentobarbitone rabbit. METHODS:New Zealand white rabbits were anaesthetised with sodium pentobarbi...

journal_title：Cardiovascular research

authors： Hide EJ,Thiemermann C

更新日期：1996-06-01 00:00:00

abstract：Aims:Metabolic syndrome (MS) is a cluster of cardio-metabolic risk factors associated with atherosclerosis and low-grade inflammation. Using unbiased expression screenings in peripheral blood mononuclear cells, we depict here a novel expression chart of 678 genes and 84 microRNAs (miRNAs) controlling inflammatory, immu...

journal_title：Cardiovascular research

authors： D'Amore S,Härdfeldt J,Cariello M,Graziano G,Copetti M,Di Tullio G,Piglionica M,Scialpi N,Sabbà C,Palasciano G,Vacca M,Moschetta A

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:We recently showed that mitochondrial coupling factor 6 (CF6) is present as a pressor substance and a prostacyclin inhibitor in systemic circulation. However, the regulation mechanism for circulating CF6 is unknown. We investigated the role of tumor necrosis factor-alpha (TNF-alpha) in the generation and rele...

journal_title：Cardiovascular research

authors： Sasaki S,Osanai T,Tomita H,Matsunaga T,Magota K,Okumura K

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:In isolated cardiac preparations of non-failing hearts from different species, including man, there is a positive force-frequency relation which is reversed into a negative relation in preparation from failing hearts. Whether or not such relations between ventricular function and heart rate hold true in the i...

journal_title：Cardiovascular research

authors： Neumann T,Ravens U,Heusch G

更新日期：1998-02-01 00:00:00

abstract：AIMS:Regulated cell death is a main contributor of myocardial ischaemia-reperfusion (IR) injury during acute myocardial infarction. In this context, targeting apoptosis could be a potent therapeutical strategy. In a previous study, we showed that DAXX (death-associated protein) was essential for transducing the FAS-dep...

journal_title：Cardiovascular research

authors： Boisguérin P,Covinhes A,Gallot L,Barrère C,Vincent A,Busson M,Piot C,Nargeot J,Lebleu B,Barrère-Lemaire S

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Calcitonin gene related peptide (CGRP) is a potent vasodilator found in sensory nerve endings in coronary arteries. The effect of intravenous CGRP on myocardial ischaemia, cardiovascular haemodynamics, and epicardial coronary artery stenoses was studied in patients with angina to investigate the possible role...

journal_title：Cardiovascular research

authors： Uren NG,Seydoux C,Davies GJ

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to assess whether the plasma levels of soluble adhesion molecules including E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are elevated in patients with variant angina and whether they are released in the coronary circulation...

journal_title：Cardiovascular research

authors： Miwa K,Igawa A,Inoue H

更新日期：1997-10-01 00:00:00

abstract：:Many observational studies and experimental and animal studies have demonstrated that estrogen therapy (ET) or hormone therapy (HT) significantly reduces the risk of coronary heart disease. Nonetheless, recent randomized controlled trials and the Nurses' Health Study in secondary prevention demonstrate trends toward a...

journal_title：Cardiovascular research

authors： Koh KK,Yoon BK

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVES:This study examined the effects of diet-induced hypercholesterolemia on the extent of postischemic myocyte apoptosis and elucidated the potential mechanisms involved. Furthermore, the effects of rosiglitazone (RSG) on postischemic myocardial apoptosis in HC rabbits were investigated. METHODS:Male New Zealan...

journal_title：Cardiovascular research

authors： Liu HR,Tao L,Gao E,Lopez BL,Christopher TA,Willette RN,Ohlstein EH,Yue TL,Ma XL

更新日期：2004-04-01 00:00:00

abstract：AIMS:Cathepsin-L (CTSL) is a member of the lysozomal cysteine protease family, which participates in remodelling of various tissues. Herein, we sought to examine the potential regulation of CTSL in cardiac remodelling post-infarction. METHODS AND RESULTS:Experimental myocardial infarction (MI) was created in CTSL-defi...

journal_title：Cardiovascular research

authors： Sun M,Chen M,Liu Y,Fukuoka M,Zhou K,Li G,Dawood F,Gramolini A,Liu PP

更新日期：2011-02-01 00:00:00

abstract：AIMS:Hydrogen sulphide (H(2)S) is an endogenously generated gaseous transmitter that has recently been suggested to regulate cardiovascular functions. To date, there is no direct evidence for a potential role of H(2)S in regulating calcium channels in the heart. The present study aims to examine the hypothesis that H(2...

journal_title：Cardiovascular research

authors： Sun YG,Cao YX,Wang WW,Ma SF,Yao T,Zhu YC

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To investigate the possible mechanisms of the antiatherosclerotic effects of the angiotensin-converting enzyme (ACE) inhibitor, fosinopril, in apolipoprotein (apo) E deficient mice. METHODS:Apo E deficient (E0) mice at the age of 8 weeks received either placebo or a high dose (25 mg/kg/d) of fosinopril suppl...

journal_title：Cardiovascular research

authors： Hayek T,Attias J,Coleman R,Brodsky S,Smith J,Breslow JL,Keidar S

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVES:Cardiovascular disease is rare in premenopausal women, but increases after the menopause when hormone replacement therapy reduces coronary events. Vascular smooth muscle cell (SMC) proliferation and migration occur in atherosclerosis, restenosis and venous graft disease. We studied the effects of 17 beta-est...

journal_title：Cardiovascular research

authors： Dai-Do D,Espinosa E,Liu G,Rabelink TJ,Julmy F,Yang Z,Mahler F,Lüscher TF

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:A recent genome-wide association study identified a susceptibility locus for atrial fibrillation at the KCNN3 gene. Since the KCNN3 gene encodes for a small conductance calcium-activated potassium channel, we hypothesized that overexpression of the SK3 channel increases susceptibility to cardiac arrhythmias....

journal_title：Cardiovascular research

authors： Mahida S,Mills RW,Tucker NR,Simonson B,Macri V,Lemoine MD,Das S,Milan DJ,Ellinor PT

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:We determine if action potential duration (APD) shortening and cardioprotection are separable phenomena in ATP-sensitive potassium channel (KATP) openers which protect ischemic myocardium via a glyburide-reversible mechanism. METHODS:We determined the effect of the weakly vasodilating KATP opener, BMS-180448...

journal_title：Cardiovascular research

authors： Grover GJ,D'Alonzo AJ,Hess T,Sleph PG,Darbenzio RB

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVES:Collagen synthesis is one of the major mechanisms of primary atherosclerotic plaque growth and is likely to be similarly important in restenosis. The patterns of collagen gene expression in human restenosis and associations with thrombosis/hemorrhage have not been described. METHODS:Using human coronary art...

journal_title：Cardiovascular research

authors： Rekhter MD,O'Brien E,Shah N,Schwartz SM,Simpson JB,Gordon D

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVE:The aims were: (1) to evaluate whether differences in absolute and cyclic echocardiographic image amplitude exist in different layers (subendocardium and subepicardium) and regions (septal, anterior, lateral, inferior wall) of the canine left ventricle; (2) to assess the dependence of these variables upon loc...

journal_title：Cardiovascular research

authors： Marini C,Ghelardini G,Picano E,Rovai D,Lombardi M,Trivella MG,Distante A,L'Abbate A

更新日期：1993-02-01 00:00:00

abstract：:The response of a simple systolic time interval, the interval between the Q wave and the onset of the aortic blood pressure pulse (the QA interval), to changes in cardiac contractility, cardiac loading, and heart rate was evaluated in anaesthetised open chest dogs. The QA interval was found to be sensitive to increase...

journal_title：Cardiovascular research

authors： Cambridge D,Whiting MV

更新日期：1986-06-01 00:00:00

abstract：OBJECTIVE:Previous investigations have shown the effectiveness of sustained intra- or extravascular administration of vascular endothelial growth factor (VEGF) in chronic myocardial ischemia in improvement of left ventricular function. The present investigations were undertaken in order to evaluate efficacy of a single...

journal_title：Cardiovascular research

authors： Lopez JJ,Laham RJ,Stamler A,Pearlman JD,Bunting S,Kaplan A,Carrozza JP,Sellke FW,Simons M

更新日期：1998-11-01 00:00:00

abstract：:Attempts were made to demonstrate release of vasoactive substances from the heart during coronary occlusion (for 60 min) and reperfusion (for 60 min), and to clarify the pathophysiological significance of them. Vasoactive substances were detected by superfusion of rabbit aortic and dog coronary arterial strips with gr...

journal_title：Cardiovascular research

authors： Tanabe M,Terashita ZI,Fujiwara S,Shimamoto N,Goto N,Nishikawa K,Hirata M

更新日期：1982-02-01 00:00:00

abstract：Aims:To investigate the role of chromobox protein homolog 3 (Cbx3) in vascular smooth muscle cell (VSMC) proliferation, migration, and neointima formation following vascular injury. Methods and results:Overexpression of Cbx3 led to a significant increase in VSMC contractile gene expression and VSMC apoptosis as well a...

journal_title：Cardiovascular research

authors： Zhang C,Chen D,Maguire EM,He S,Chen J,An W,Yang M,Afzal TA,Luong LA,Zhang L,Lei H,Wu Q,Xiao Q

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:In diabetes mellitus several cardiac electrophysiological parameters are known to be affected. In rodent experimental diabetes models changes in these parameters were reported, but no such data are available in other mammalian species including the dog. The present study was designed to analyse the effects of...

journal_title：Cardiovascular research

authors： Lengyel C,Virág L,Bíró T,Jost N,Magyar J,Biliczki P,Kocsis E,Skoumal R,Nánási PP,Tóth M,Kecskeméti V,Papp JG,Varró A

更新日期：2007-02-01 00:00:00