Abstract:
OBJECTIVE:The aims were: (1) to evaluate whether differences in absolute and cyclic echocardiographic image amplitude exist in different layers (subendocardium and subepicardium) and regions (septal, anterior, lateral, inferior wall) of the canine left ventricle; (2) to assess the dependence of these variables upon local variations of coronary blood flow. METHODS:In six anaesthetised open chest dogs the circumflex coronary artery was cannulated and perfused by a roller pump with blood from their own femoral artery. Maximum coronary vasodilatation was obtained by continuous adenosine infusion. The absolute values and the transmural distribution of coronary blood flow were measured by radionuclide labelled microspheres. Echo images were obtained in short axis view by a commercially available electronic sector scanner with a 5.0 MHz transducer directly placed on the epicardial surface of the right ventricle, and digitised off-line into a matrix of 256 x 256 pixels with 25% grey level per pixel. The average grey level was calculated for each region of interest. RESULTS:In 32 different conditions, circumflex flow ranged from 0.80 to 12.89 ml.min-1.g-1 and the endocardial/epicardial ratio of flow from 0.53 to 1.73. In the circumflex region (subjected to flow changes) segmental amplitude varied from 76(SD 20) (end diastole) to 56(18) (end systole), p < 0.001. In all regions, a consistent cyclic variation was found, ranging from 9(14) to 28(16)%. For all levels of flow, subendocardial and subepicardial regions showed similar values of both absolute amplitude and cyclic variation. No significant relationship was found between transmural distribution of blood flow and either segmental amplitude (r = 0.26) or cyclic variation (r = 0.04). CONCLUSIONS:(1) a consistent cyclic grey level variation is present in all regions of the canine left ventricle, but subendocardial and subepicardial layers show similar values of both absolute amplitude and cyclic variation; (2) in the absence of severe underperfusion and echocardiographically detectable dyssynergy, absolute amplitude and cyclic variation are totally unrelated to changes in coronary blood flow.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Marini C,Ghelardini G,Picano E,Rovai D,Lombardi M,Trivella MG,Distante A,L'Abbate Adoi
10.1093/cvr/27.2.279subject
Has Abstractpub_date
1993-02-01 00:00:00pages
279-83issue
2eissn
0008-6363issn
1755-3245journal_volume
27pub_type
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doi:10.1093/cvr/24.12.1013
更新日期:1990-12-01 00:00:00
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doi:10.1016/s0008-6363(97)00246-0
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journal_title:Cardiovascular research
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1093/cvr/28.12.1780
更新日期:1994-12-01 00:00:00
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更新日期:2006-05-01 00:00:00
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更新日期:2005-02-15 00:00:00
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journal_title:Cardiovascular research
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doi:10.1093/cvr/13.5.297
更新日期:1979-05-01 00:00:00
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更新日期:2014-10-01 00:00:00
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更新日期:2013-02-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(97)00081-3
更新日期:1997-06-01 00:00:00
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doi:10.1016/s0008-6363(00)00261-3
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/15.6.328
更新日期:1981-06-01 00:00:00
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更新日期:2012-07-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.cardiores.2003.09.017
更新日期:2003-12-01 00:00:00
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更新日期:2007-12-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/24.7.560
更新日期:1990-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0008-6363(00)00107-3
更新日期:2000-08-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/j.cardiores.2005.05.009
更新日期:2005-08-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/27.5.801
更新日期:1993-05-01 00:00:00
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更新日期:2007-01-15 00:00:00
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更新日期:2005-10-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/23.12.1015
更新日期:1989-12-01 00:00:00
abstract::Cholesterol is an essential component of both the peripheral nervous system and central nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes and oligodendrocytes and is almost completely isolated from other pools of cholesterol in the body, but a small fraction can be taken up from t...
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更新日期:2014-08-01 00:00:00