MicroRNAs and atrial fibrillation: new fundamentals.

abstract：AIMS:Brugada syndrome (BrS) is an autosomal-inherited cardiac arrhythmia characterized by an ST-segment elevation in the right precordial leads of the electrocardiogram and an increased risk of syncope and sudden death. SCN5A, encoding the cardiac sodium channel Na(v)1.5, is the main gene involved in BrS. Despite the f...

journal_title：Cardiovascular research

authors： Clatot J,Ziyadeh-Isleem A,Maugenre S,Denjoy I,Liu H,Dilanian G,Hatem SN,Deschênes I,Coulombe A,Guicheney P,Neyroud N

更新日期：2012-10-01 00:00:00

abstract：:Impairment of contractile function and extent of release of several intracellular marker enzymes and DNA were studied in isolated perfused rat hearts after low-flow (0.16 ml . min-1) ischaemia followed by 2 h of reperfusion and after anoxia followed by 2 h of reoxygenation. After varying periods of ischaemia or anoxia...

journal_title：Cardiovascular research

authors： van der Laarse A,Altona JC,Zoet AC,Oemrawsingh P,van Dijkman PR

更新日期：1984-12-01 00:00:00

abstract：:Most studies on stem cell transplantation therapy on myocardially infarcted animal models and phase-I human clinical trials have focused on the use of undifferentiated stem cells. There is a strong possibility that some degree of cardiomyogenic differentiation of stem cells in vitro prior to transplantation would resu...

journal_title：Cardiovascular research

authors： Heng BC,Haider HKh,Sim EK,Cao T,Ng SC

更新日期：2004-04-01 00:00:00

abstract：AIMS:Percutaneous implantation has already been used clinically and is a great option for treating young patients. The use of autologous tissue-engineered valved stents might solve the problem of degeneration and limited durability of biological heart valves. METHODS AND RESULTS:Porcine pulmonary heart valves and smal...

journal_title：Cardiovascular research

authors： Metzner A,Stock UA,Iino K,Fischer G,Huemme T,Boldt J,Braesen JH,Bein B,Renner J,Cremer J,Lutter G

更新日期：2010-12-01 00:00:00

abstract：:Vasculopathy is a pathological process occurring in the blood vessel wall, which could affect the haemostasis and physiological functions of all the vital tissues/organs and is one of the main underlying causes for a variety of human diseases including cardiovascular diseases. Current pharmacological interventions aim...

journal_title：Cardiovascular research

authors： Liu C,Niu K,Xiao Q

更新日期：2020-11-02 00:00:00

abstract：OBJECTIVE:The aim was to investigate whether infusion of either atrial natriuretic factor (ANF, 800 ng.h-1.rat-1) or a specific inhibitory of neutral endopeptidase 24.11 (NEI, UK 73,967, 5.4 mg.kg-1.d-1) can influence the reversal of the pulmonary vascular remodelling produced by exposure to hypoxia. METHODS:Male Wist...

journal_title：Cardiovascular research

authors： Zhao L,Hughes JM,Winter RJ

更新日期：1994-04-01 00:00:00

abstract：AIMS:Alteration of connexin43 (Cx43)-mediated intercellular communication is known to promote susceptibility to ventricular tachyarrhythmias. However, the precise mechanism of the altered Cx43 responsible for arrhythmogenesis remains unclear. We sought to understand changes in impulse propagation of ventricular myocyte...

journal_title：Cardiovascular research

authors： Nakagami T,Tanaka H,Dai P,Lin SF,Tanabe T,Mani H,Fujiwara K,Matsubara H,Takamatsu T

更新日期：2008-07-01 00:00:00

abstract：:The effect of axial rotation on flow through and pressure gradient across saphenous vein segments was studied using 15 cadaver long saphenous veins. A significant reduction in flow occurred at a mean rotation of 25 degrees/cm and a significant increase in head loss across the segments occurred at a mean rotation of 23...

journal_title：Cardiovascular research

authors： Gordon A,Williams J,Buxton B

更新日期：1975-07-01 00:00:00

abstract：OBJECTIVE:The mechanism of spontaneous myogenic tone was investigated in isolated arteriolar segments. METHODS:Arterioles were isolated from rat cremaster muscle. Segments were endothelium-denuded and mounted in a pressure myograph at 75 mmHg. Under this condition, segments spontaneously constricted from a passive dia...

journal_title：Cardiovascular research

authors： Bakker EN,Kerkhof CJ,Sipkema P

更新日期：1999-01-01 00:00:00

abstract：:The most critical determinant of prognosis in patients with acute myocardial infarction (MI) is infarct magnitude, which can be established within several hours of an attack. The importance of the subsequent healing process is not negligible, however. In fact, much experimental and clinical evidence suggests that late...

journal_title：Cardiovascular research

authors： Takemura G,Nakagawa M,Kanamori H,Minatoguchi S,Fujiwara H

更新日期：2009-07-15 00:00:00

abstract：STUDY OBJECTIVE:The aim was to study the interactions between pulmonary capillary wedge pressure (an estimate of left atrial pressure), left atrial dimension, and atrial natriuretic factor during evolving heart failure. DESIGN:Sequential simultaneous measurements of haemodynamic variables, left atrial dimension, and p...

journal_title：Cardiovascular research

authors： Moe GW,Angus C,Howard RJ,De Bold AJ,Armstrong PW

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVE:Gap junction channels provide for direct electrical coupling between cells, and play an important role in homeostasis and electrical coupling. One of the proteins that form gap junctions, Connexin40 (Cx40), shows restricted expression in the body, and is found in blood vessels and in the atrium and conduction...

journal_title：Cardiovascular research

authors： van Rijen HV,van Veen TA,Hermans MM,Jongsma HJ

更新日期：2000-03-01 00:00:00

abstract：AIMS:Hyperhomocysteinaemia is an independent risk factor for atherosclerotic vascular disease and is associated with vascular endothelial dysfunction. Homocysteine modulates cellular methylation reactions. P66shc is a protein that promotes oxidative stress whose expression is governed by promoter methylation. We asked ...

journal_title：Cardiovascular research

authors： Kim CS,Kim YR,Naqvi A,Kumar S,Hoffman TA,Jung SB,Kumar A,Jeon BH,McNamara DM,Irani K

更新日期：2011-12-01 00:00:00

abstract：:Although researchers in radiation and cancer biology have known about the existence of free radicals and their potential role in pathobiology for several decades, cardiac biologists only began to take notice of these noxious species in the 1970s. Exponential growth of free radical research occurred after the discovery...

journal_title：Cardiovascular research

authors： Singal PK,Khaper N,Palace V,Kumar D

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:The aim was to test the hypothesis that nitric oxide (or a related compound) contributes to the coronary vasodilatation during physiological increases of myocardial O2 consumption that occur with exercise. METHODS:Active hyperaemia associated with graded treadmill exercise and coronary reactive hyperaemia we...

journal_title：Cardiovascular research

authors： Altman JD,Kinn J,Duncker DJ,Bache RJ

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVES:Diastolic dysfunction that determines symptoms and prognosis in patients with systolic dysfunction causes heart failure even in the absence of systolic dysfunction. Our recent studies have suggested that myocardial stiffening is likely to play a crucial role in triggering deleterious cardiac disorder. This s...

journal_title：Cardiovascular research

authors： Yamamoto K,Masuyama T,Sakata Y,Nishikawa N,Mano T,Yoshida J,Miwa T,Sugawara M,Yamaguchi Y,Ookawara T,Suzuki K,Hori M

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:We investigated the efficacy of nicaraven in reducing myocardial as well as coronary endothelial preservation-reperfusion (P/R) injury. METHODS:In experiment I, isolated rat hearts were mounted on a Langendorff (L) apparatus to estimate the baseline cardiac function. Group 1, 8- and 12-h storage in histidine...

journal_title：Cardiovascular research

authors： Alam MS,Ku K,Hashimoto M,Nosaka S,Saitoh Y,Yamauchi M,Masumura S,Nakayama K,Tamura K

更新日期：1997-03-01 00:00:00

abstract：:Known viable allograft canine pulmonary valves were inserted in an isotopic position ensuring normal physiological function and simulating the clinical situation. Valves removed at periods up to eight weeks were assessed for viability using previously established criteria of tissue culture and protein and collagen syn...

journal_title：Cardiovascular research

authors： Wheatley DJ,McGregor CG

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVE:Experimental and clinical studies have shown that administration of insulin during reperfusion is cardioprotective, but the underlying mechanisms are still unknown. In this study, we investigated in isolated rat cardiomyocytes subjected to hypoxia and reoxygenation whether administration of insulin during reo...

journal_title：Cardiovascular research

authors： Abdallah Y,Gkatzoflia A,Gligorievski D,Kasseckert S,Euler G,Schlüter KD,Schäfer M,Piper HM,Schäfer C

更新日期：2006-05-01 00:00:00

abstract：:A new type of pneumonia caused by a novel coronavirus SARS-CoV-2 outbreaks recently in China and spreads into many other countries. This disease, named as COVID-19, is similar to patients infected by SARS-CoV and MERS-CoV, and nearly 20% of patients developed severe condition. Cardiac injury is a prevalent complicatio...

journal_title：Cardiovascular research

authors： Chen L,Li X,Chen M,Feng Y,Xiong C

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:Pigment epithelial-derived factor (PEDF) is a potent anti-angiogenic factor whose effects are partially mediated through the induction of endothelial cell apoptosis. The pathway mediating endothelial cell apoptosis has not been fully established. Here we investigated the participation of peroxisome proliferat...

journal_title：Cardiovascular research

authors： Ho TC,Chen SL,Yang YC,Liao CL,Cheng HC,Tsao YP

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:The sequelae of myocardial ischaemia can in principle be alleviated by repeated reperfusion, but the accumulation of adenosine monophosphate (AMP) and the loss of interstitial adenosine may lead to adenylate depletion. Repeated oxidative stress could predispose the heart to reperfusion injury. The aim of this...

journal_title：Cardiovascular research

authors： Høst N,Peuhkurinen K,Haunsø S,Hassinen I

更新日期：1992-05-01 00:00:00

abstract：:Papillary muscles isolated from the left ventricle of 17-20 day old Syrian hamsters with genetic cardiomyopathy (BIO 14.6 strain) were examined for their mechanophysiological response to the beta adrenoceptor agonist isoprenaline. The indices of isometric twitch for both myopathic and aged matched normal (BIO RB strai...

journal_title：Cardiovascular research

authors： Rossner KL,Coudrai PR

更新日期：1986-08-01 00:00:00

abstract：OBJECTIVE:The aim of the presented method was the characterization of different complex heart rate dynamics in conscious rabbits as well as during general anaesthesia and vagal blockade. This was done by non-linear prediction of original measured and special surrogate data in the phase space. METHOD:The development of...

journal_title：Cardiovascular research

authors： Hoyer D,Schmidt K,Zwiener U,Bauer R

更新日期：1996-03-01 00:00:00

abstract：AIMS:Hydrogen sulphide (H(2)S) is an endogenously generated gaseous transmitter that has recently been suggested to regulate cardiovascular functions. To date, there is no direct evidence for a potential role of H(2)S in regulating calcium channels in the heart. The present study aims to examine the hypothesis that H(2...

journal_title：Cardiovascular research

authors： Sun YG,Cao YX,Wang WW,Ma SF,Yao T,Zhu YC

更新日期：2008-09-01 00:00:00

abstract：AIMS:The mesenchymal cushions lining the early embryonic heart undergo complex remodelling to form the membranous ventricular septum as well as the atrioventricular and semilunar valves in later life. Disruption of this process underlies the most common congenital heart defects. Here, we identified a novel role for Sli...

journal_title：Cardiovascular research

authors： Mommersteeg MT,Yeh ML,Parnavelas JG,Andrews WD

更新日期：2015-04-01 00:00:00

abstract：:Attempts were made to demonstrate release of vasoactive substances from the heart during coronary occlusion (for 60 min) and reperfusion (for 60 min), and to clarify the pathophysiological significance of them. Vasoactive substances were detected by superfusion of rabbit aortic and dog coronary arterial strips with gr...

journal_title：Cardiovascular research

authors： Tanabe M,Terashita ZI,Fujiwara S,Shimamoto N,Goto N,Nishikawa K,Hirata M

更新日期：1982-02-01 00:00:00

abstract：:Elevated sympathetic activity changes renal function and accelerates the development of hypertension. Principles of sympatho-renal interactions in chronic hypertension are reviewed. Alterations in the ontogeny of the sympathetic nervous system and the kidney, inherited abnormalities in sensory receptor function and ex...

journal_title：Cardiovascular research

authors： Grisk O,Rettig R

更新日期：2004-02-01 00:00:00

abstract：AIMS:KCNQ1 (alias KvLQT1 or Kv7.1) and KCNE1 (alias IsK or minK) co-assemble to form the voltage-activated K(+) channel responsible for I(Ks)-a major repolarizing current in the human heart-and their dysfunction promotes cardiac arrhythmias. The channel is a component of larger macromolecular complexes containing known...

journal_title：Cardiovascular research

authors： Nicolas CS,Park KH,El Harchi A,Camonis J,Kass RS,Escande D,Mérot J,Loussouarn G,Le Bouffant F,Baró I

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:The contribution of vascular changes to the development of heart failure is largely unknown. In the present study, we evaluated endothelial and vascular contractile function in the rat hindlimb vascular bed after myocardial infarction (MI), including the modulatory role of basal nitric oxide (NO) production ...

journal_title：Cardiovascular research

authors： Ceiler DL,Nelissen-Vrancken M,De Mey JG,Smits JF

更新日期：1999-08-15 00:00:00