Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves.

abstract：:Changes in left ventricular internal diameter resulting from increasing intrapericardial pressure induced by increasing the pericardial fluid volume were studied in closed chest, anaesthetized dogs. Left ventricular internal diameters were measured by placing an ultrasonic dimension catheter in the left ventricle at t...

journal_title：Cardiovascular research

authors： Pegram BL,Kardon MB,Bishop VS

更新日期：1975-11-01 00:00:00

abstract：:The purpose of this review is to give an integrative view of the effect of stretch on the myocardium from ventricular function changes to cellular and molecular mechanisms. The general approach will be to discuss the cellular and molecular events which can explain the findings obtained in the whole ventricle. Followin...

journal_title：Cardiovascular research

authors： Crozatier B

更新日期：1996-07-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is the most common type of arrhythmia in humans, yet the genetic cause of AF remains elusive. Genome-wide association studies (GWASs) have reported risk variants in four distinct genetic loci, and more recently, a meta-GWAS has further implicated six new loci in AF. However, the functional...

journal_title：Cardiovascular research

authors： Lozano-Velasco E,Hernández-Torres F,Daimi H,Serra SA,Herraiz A,Hove-Madsen L,Aránega A,Franco D

更新日期：2016-01-01 00:00:00

abstract：AIMS:Based on indirect methods, it has been suggested that both L- and T-type Ca(2+) channels mediate signalling in the renal afferent arteriole and that T-type Ca(2+) channels are involved in signalling in the efferent arteriole. However, Ca(2+) currents have never been studied in these two vessels. Our study was init...

journal_title：Cardiovascular research

authors： Smirnov SV,Loutzenhiser K,Loutzenhiser R

更新日期：2013-02-01 00:00:00

abstract：:Effects of sublingual glyceryl trinitrate (GTN) were studied in ten patients without heart failure during diagnostic cardiac catheterisation following angiography. GTN caused substantial reduction in peak left ventricular and aortic pressure (19 mmHg) with lesser reduction in mean aortic pressure (9 mmHg) and no chang...

journal_title：Cardiovascular research

authors： Yaginuma T,Avolio A,O'Rourke M,Nichols W,Morgan JJ,Roy P,Baron D,Branson J,Feneley M

更新日期：1986-02-01 00:00:00

abstract：OBJECTIVE:Previous studies have shown that cardiac protection by ischaemic preconditioning wanes before contractile function recovers; thus stunning is insufficient to cause preconditioning. To test whether reduced contractile effort is necessary for preconditioning induced protection, the effect on myocardial infarct ...

journal_title：Cardiovascular research

authors： Matsuda M,Catena TG,Vander Heide RS,Jennings RB,Reimer KA

更新日期：1993-04-01 00:00:00

abstract：AIMS:Antihypertensive drugs are included in the medical therapy of vascular Ehlers-Danlos syndrome (vEDS). The β-blocker celiprolol has been suggested to prevent arterial damage in vEDS, but the underlying mechanism remains unclear. It is also unknown whether the widely used angiotensin II receptor type 1 antagonist lo...

journal_title：Cardiovascular research

authors： Dubacher N,Münger J,Gorosabel MC,Crabb J,Ksiazek AA,Caspar SM,Bakker ENTP,van Bavel E,Ziegler U,Carrel T,Steinmann B,Zeisberger S,Meienberg J,Matyas G

更新日期：2020-02-01 00:00:00

abstract：:In order to evaluate clinically recorded jugular vein pulses it is necessary to understand the transmission process of the right atrial pressure pulse through the caval veins up to the jugular veins. The transmission speed at distinct points of the venous pressure curve was studied in the superior vena cava of 20 anae...

journal_title：Cardiovascular research

authors： Minten J,Van de Werf F,Aubert AE,Kesteloot H,De Geest H

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVES:Myostatin, a member of the transforming growth factor-beta (TGF-beta) family, plays a key role in skeletal muscle myogenesis by limiting hyperplastic and hypertrophic muscle growth. In cardiac muscle, myostatin has been shown to limit agonist-induced cardiac hypertrophic growth. However, its role in cardiac ...

journal_title：Cardiovascular research

authors： McKoy G,Bicknell KA,Patel K,Brooks G

更新日期：2007-05-01 00:00:00

abstract：:Felodipine (4(2,3-dichlorophenyl)-1,4-dihydro-2, 6-dimethyl-3-ethoxycarbonyl-5-methoxycarbonyl pyridine)), a selective vasodilating anti-hypertensive drug, was used in the treatment of spontaneously hypertensive rats (SHRs) and age-matched Wistar-Kyoto rats (WKYs) from age 6 to 14 weeks, ie during the time of high blo...

journal_title：Cardiovascular research

authors： Nyborg NC,Mulvany MJ

更新日期：1985-09-01 00:00:00

abstract：:The theoretical possibilities and the practical limitations of the Xenon-133 (133Xe) method for the study of regional myocardial perfusion in man are discussed. The techniques for data acqusition and processing developed over the past 5 years are described in detail. Illustrative examples of experimental findings are ...

journal_title：Cardiovascular research

authors： Maseri A,L'abbate A,Michelassi C,Pesola A,Pisani P,Marzilli M,De Nes M,Mancini P

更新日期：1977-07-01 00:00:00

abstract：OBJECTIVES:The A10 cell line was derived from the thoracic aorta of embryonic rat and is a commonly used model of vascular smooth muscle cells (VSMC). Despite its wide use this cell line has not been well characterized. This is especially important in light of recent evidence of phenotypically distinct cell populations...

journal_title：Cardiovascular research

authors： Rao RS,Miano JM,Olson EN,Seidel CL

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:The aim was to clarify the site in the coronary microcirculation that is dilated by an ATP sensitive potassium channel opener, levcromakalim, and to examine whether the magnitude of dilatation is size dependent. METHODS:Coronary arterial microvessels were observed through an intravital microscope equipped wi...

journal_title：Cardiovascular research

authors： Sato K,Kanatsuka H,Sekiguchi N,Akai K,Wang Y,Sugimura A,Kumagai T,Komaru T,Shirato K

更新日期：1994-12-01 00:00:00

abstract：AIMS:Animal studies show that transforming growth factor-β1 (TGF-β1) is an important mediator of atrial fibrosis and atrial fibrillation (AF). This study investigated the role of TGF-β1 in human AF and the mechanism of atrial-selective fibrosis. METHODS AND RESULTS:Atrial specimens from 17 open heart surgery patients ...

journal_title：Cardiovascular research

authors： Rahmutula D,Marcus GM,Wilson EE,Ding CH,Xiao Y,Paquet AC,Barbeau R,Barczak AJ,Erle DJ,Olgin JE

更新日期：2013-09-01 00:00:00

abstract：:The second messenger cyclic guanosine 3'5' monophosphate (cGMP) and its downstream effector protein kinase G (PKG) have been discovered more than 40 years ago. In vessels, PKG1 induces smooth muscle relaxation in response to nitric oxide signalling and thus lowers systemic and pulmonary blood pressure. In platelets, P...

journal_title：Cardiovascular research

authors： Rainer PP,Kass DA

更新日期：2016-07-15 00:00:00

abstract：:Eighty-one consecutive patients representing a wide clinical spectrum were studied to assess the degree of limitation of the atrial extrastimulus technique for measurement of atrioventricular node refractoriness; and, to determine the relationship between conductivity and functional refractoriness of the atrioventricu...

journal_title：Cardiovascular research

authors： Wyse DG

更新日期：1982-08-01 00:00:00

abstract：AIM:Atrial fibrosis, one of the most striking features in the pathology of atrial fibrillation (AF), is promoted by local and systemic inflammation. Electrophilic fatty acid nitroalkenes, endogenously generated by both metabolic and inflammatory reactions, are anti-inflammatory mediators that in synthetic form may be u...

journal_title：Cardiovascular research

authors： Rudolph TK,Ravekes T,Klinke A,Friedrichs K,Mollenhauer M,Pekarova M,Ambrozova G,Martiskova H,Kaur JJ,Matthes B,Schwoerer A,Woodcock SR,Kubala L,Freeman BA,Baldus S,Rudolph V

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:L-arginine exerts anti-atherosclerotic effects in hypercholesterolaemic rabbits via modulating endogenous NO production. We investigated whether L-arginine inhibits thromboxane formation in vivo and platelet aggregation ex vivo in this animal model. METHODS:The urinary excretion rates of 2,3-dinor-6-keto-PG...

journal_title：Cardiovascular research

authors： Bode-Böger SM,Böger RH,Kienke S,Böhme M,Phivthong-ngam L,Tsikas D,Frölich JC

更新日期：1998-03-01 00:00:00

abstract：:Cardiomyocyte death secondary to transient ischaemia occurs mainly during the first minutes of reperfusion in the form of contraction band necrosis. Research on the mechanisms leading to sarcolemmal rupture and necrosis during initial reperfusion identified several promising pharmacological targets directed either to ...

journal_title：Cardiovascular research

authors： Inserte J,Barrabés JA,Hernando V,Garcia-Dorado D

更新日期：2009-07-15 00:00:00

abstract：OBJECTIVE:The aim of this study was to examine the effect of ischaemia on vascular responses to endothelium-dependent and endothelium-independent vasodilators and on vasoconstrictor responses. Furthermore, the ability of preconditioning to prevent ischaemia-induced changes in vascular reactivity was examined in the rat...

journal_title：Cardiovascular research

authors： Loke KE,Woodman OL

更新日期：1996-12-01 00:00:00

abstract：AIMS:Polyunsaturated fatty n-3 acids (PUFAs) have been reported to exhibit antiarrhythmic properties. However, the mechanisms of action remain unclear. We studied the electrophysiological effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on IKs, and on the expression and location of Kv7.1 and KCNE1....

journal_title：Cardiovascular research

authors： Moreno C,de la Cruz A,Oliveras A,Kharche SR,Guizy M,Comes N,Starý T,Ronchi C,Rocchetti M,Baró I,Loussouarn G,Zaza A,Severi S,Felipe A,Valenzuela C

更新日期：2015-02-01 00:00:00

abstract：AIMS:Chronic pressure or volume overload induce concentric vs. eccentric left ventricular (LV) remodelling, respectively. Previous studies suggest that distinct signalling pathways are involved in these responses. NADPH oxidase-4 (Nox4) is a reactive oxygen species-generating enzyme that can limit detrimental cardiac r...

journal_title：Cardiovascular research

authors： Schnelle M,Sawyer I,Anilkumar N,Mohamed BA,Richards DA,Toischer K,Zhang M,Catibog N,Sawyer G,Mongue-Din H,Schröder K,Hasenfuss G,Shah AM

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Sphingosine 1-phosphate is a naturally occurring biologically active lysophospholipid. Recent studies suggested that sphingosine 1-phosphate is released into the blood flow from activated platelets upon stimulation to exert multiple biological phenomenon. The purpose of this study was to assess the effects of...

journal_title：Cardiovascular research

authors： Sugiyama A,Yatomi Y,Ozaki Y,Hashimoto K

更新日期：2000-04-01 00:00:00

abstract：:Myocardial capillary permeability was determined in 20 dogs by applying a new method which resembles the tissue-uptake technique. The method consisted of a bolus injection of 51Cr-EDTA into the left atrium, determination of the average arterial tracer concentration and subsequent assay of myocardial tissue activity 10...

journal_title：Cardiovascular research

authors： Amtorp O,Eliasen P,Abildgaard U,Haunsø S

更新日期：1984-05-01 00:00:00

abstract：OBJECTIVE:To assess the contribution of the Na, K pump current (I(p)) to the action potential duration (APD) and effective refractory period (ERP) in human atrial cells, and to investigate whether I(p) contributes to the changes in APD and ERP associated with chronic atrial fibrillation (AF). METHODS:Action potentials...

journal_title：Cardiovascular research

authors： Workman AJ,Kane KA,Rankin AC

更新日期：2003-09-01 00:00:00

abstract：:Angiotensin II has been implicated as an important factor in cardiac remodeling, particularly in the development of pathological left ventricular hypertrophy. It is generally assumed that angiotensin II is able to alter the phenotype of cardiac myocytes and fibroblasts, and several experiments have suggested that this...

journal_title：Cardiovascular research

authors： Bouzegrhane F,Thibault G

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to investigate the changes in beta-adrenoceptor density (Bmax) and distribution in a model of chronic myocardial infarction in rats, and to relate possible changes to hemodynamic and neurohumoral abnormalities. In addition, we examined the effects of 8 weeks treatment with ibopa...

journal_title：Cardiovascular research

authors： van Veldhuisen DJ,Brodde OE,van Gilst WH,Schulze C,Hegeman H,Anthonio RL,Scholtens E,de Graeff PA,Wesseling H,Lie KI

更新日期：1995-09-01 00:00:00

abstract：AIMS:Adverse cardiovascular events in humans occur with a day/night pattern, presumably related to a daily pattern of behaviours or endogenous circadian rhythms in cardiovascular variables. Healthy humans possess a scale-invariant/fractal structure in heartbeat fluctuations that exhibits an endogenous circadian rhythm ...

journal_title：Cardiovascular research

authors： Hu K,Scheer FA,Buijs RM,Shea SA

更新日期：2008-10-01 00:00:00

abstract：AIMS:TRPM2 is a Ca(2+)-permeable cationic channel of the transient receptor potential (TRP) superfamily that is linked to apoptotic signalling. Its involvement in cardiac pathophysiology is unknown. The aim of this study was to determine whether the pro-apoptotic cytokine tumour necrosis factor-α (TNF-α) induces a TRPM...

journal_title：Cardiovascular research

authors： Roberge S,Roussel J,Andersson DC,Meli AC,Vidal B,Blandel F,Lanner JT,Le Guennec JY,Katz A,Westerblad H,Lacampagne A,Fauconnier J

更新日期：2014-07-01 00:00:00

abstract：AIMS:Apolipoprotein E (apoE) may act as a vasculoprotective factor by promoting plasma lipid clearance and cholesterol efflux. Moreover, apoE accumulates at sites of vascular injury and modulates the effect of growth factors on smooth muscle cells (SMCs). Experimental data suggested that hypothalamic apoE expression is...

journal_title：Cardiovascular research

authors： Schroeter MR,Leifheit-Nestler M,Hubert A,Schumann B,Glückermann R,Eschholz N,Krüger N,Lutz S,Hasenfuss G,Konstantinides S,Schäfer K

更新日期：2013-08-01 00:00:00