Strategies for directing the differentiation of stem cells into the cardiomyogenic lineage in vitro.

abstract：OBJECTIVE:Current guidelines are controversial regarding exercise intensity in cardiovascular prevention and rehabilitation. Although high-intensity training induces larger increases in fitness and maximal oxygen uptake (VO(2max)), moderate intensity is often recommended as equally effective. Controlled preclinical stu...

journal_title：Cardiovascular research

authors： Kemi OJ,Haram PM,Loennechen JP,Osnes JB,Skomedal T,Wisløff U,Ellingsen Ø

更新日期：2005-07-01 00:00:00

abstract：:By measuring the coronary sinus blood flow using the thermodilution technique the influence of "thermodilution catheter" withdrawal from the great cardiac vein to the ostium of the coronary sinus was investigated in 41 patients. In addition, the influence of normal and forced respiration on coronary sinus blood flow w...

journal_title：Cardiovascular research

authors： Bagger JP

更新日期：1985-01-01 00:00:00

abstract：AIMS:Diabetes is a major risk factor for cardiovascular diseases. Circulating endothelial microparticles (EMP) are increased in diabetic patients, but their potential contribution in atherogenesis is unclear. We sought to determine the role of EMP derived under high glucose conditions in the development of atherosclero...

journal_title：Cardiovascular research

authors： Jansen F,Yang X,Franklin BS,Hoelscher M,Schmitz T,Bedorf J,Nickenig G,Werner N

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:Inhibitors of poly (ADP-ribose) synthetase (PARS) activity reduce the infarct size caused by regional myocardial ischaemia and reperfusion in the rabbit and rat in vivo. The mechanism of action of these inhibitors is unclear. Here we investigate the effects of the PARS inhibitor 3-aminobenzamide (3-AB) on inf...

journal_title：Cardiovascular research

authors： Bowes J,McDonald MC,Piper J,Thiemermann C

更新日期：1999-01-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to determine if prostaglandin like activity might be involved in changes due to exercise training in the coronary flow responses to hypoxia. DESIGN:The coronary flow response to hypoxia was measured under constant perfusion pressure in isolated perfused hearts from 12 endurance exercise tra...

journal_title：Cardiovascular research

authors： Baur TS,Brodowicz GR,Lamb DR

更新日期：1990-09-01 00:00:00

abstract：STUDY OBJECTIVE:Afterload reduction is known to reduce regurgitant flow in patients with aortic regurgitation. Both arterial compliance and total peripheral resistance are determinants of afterload. The aim of this study was to evaluate the influence of arterial compliance and total peripheral resistance on the regurgi...

journal_title：Cardiovascular research

authors： Slørdahl SA,Piene H

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVE:Chlamydia pneumoniae infection has been associated with atherosclerosis, although the mechanisms by which C. pneumoniae contribute to atherogenesis remain unclear. Altered production of nitric oxide, a known bactericidal and anti-inflammatory agent, represents one possible mechanistic link. To examine this is...

journal_title：Cardiovascular research

authors： Chesebro BB,Blessing E,Kuo CC,Rosenfeld ME,Puolakkainen M,Campbell LA

更新日期：2003-10-15 00:00:00

abstract：OBJECTIVE:To determine the effect of Na(+)-H+ exchange blockade on ischemic rigor contracture and reperfusion-induced hypercontracture. METHODS:Thirty-six pigs were submitted to 55 min of coronary occlusion and 5 h reperfusion. Myocardial segment length analysis with ultrasonic microcrystals was used to detect ischemi...

journal_title：Cardiovascular research

authors： Garcia-Dorado D,González MA,Barrabés JA,Ruiz-Meana M,Solares J,Lidon RM,Blanco J,Puigfel Y,Piper HM,Soler-Soler J

更新日期：1997-07-01 00:00:00

abstract：AIMS:Current mechanisms driving cardiac pacemaker function have focused on ion channel and gap junction channel function, which are essential for action potential generation and propagation between pacemaker cells. However, pacemaker cells also harbour desmosomes that structurally anchor pacemaker cells to each other i...

journal_title：Cardiovascular research

authors： Mezzano V,Liang Y,Wright AT,Lyon RC,Pfeiffer E,Song MY,Gu Y,Dalton ND,Scheinman M,Peterson KL,Evans SM,Fowler S,Cerrone M,McCulloch AD,Sheikh F

更新日期：2016-08-01 00:00:00

abstract：:The theory related to the loss of R waves and appearance of Q waves in acute myocardial infarction is discussed. A method of praecordial mapping of RS ratio changes and the appearance of Q waves that occur in acute myocardial infarction is described. The serial changes in these electrocardiographic signs in 17 patient...

journal_title：Cardiovascular research

authors： Selwyn AP,Shillingford JP

更新日期：1977-03-01 00:00:00

abstract：AIMS:To describe the overall role of reduced sarcoplasmic reticulum Ca(2+) ATPase (SERCA2) for Ca(2+) wave development. METHODS AND RESULTS:SERCA2 knockout [Serca2(flox/flox) Tg(alphaMHC-MerCreMer); KO] mice allowing inducible cardiomyocyte-specific disruption of the Serca2 gene in adult mice were compared with Serca(...

journal_title：Cardiovascular research

authors： Stokke MK,Hougen K,Sjaastad I,Louch WE,Briston SJ,Enger UH,Andersson KB,Christensen G,Eisner DA,Sejersted OM,Trafford AW

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:This study examined the effects of diet-induced hypercholesterolemia on the extent of postischemic myocyte apoptosis and elucidated the potential mechanisms involved. Furthermore, the effects of rosiglitazone (RSG) on postischemic myocardial apoptosis in HC rabbits were investigated. METHODS:Male New Zealan...

journal_title：Cardiovascular research

authors： Liu HR,Tao L,Gao E,Lopez BL,Christopher TA,Willette RN,Ohlstein EH,Yue TL,Ma XL

更新日期：2004-04-01 00:00:00

abstract：:The rate of QT adaptation to abrupt changes in pacing rate was studied in seven patients with newly diagnosed complete heart block with a ventricular escape rate of less than 40 beats.min-1. Their median age was 70 (range 36-84) years, and none was taking any cardioactive medication known to affect the QT interval. Fr...

journal_title：Cardiovascular research

authors： Lau CP,Freedman AR,Fleming S,Malik M,Camm AJ,Ward DE

更新日期：1988-01-01 00:00:00

abstract：:The effects of repeated (10 X), brief Ca2+-free perfusions (20 to 120 s) on myocardial contractility, coronary flow and release of cellular constituents of isolated rat heart were investigated. Ten successive Ca2+-deprivations of 20 or 40 s had no irreversible influences on cardiac performance. Ca2+-deprivations, howe...

journal_title：Cardiovascular research

authors： Koomen JM,Noordhoek J,Zimmerman AN

更新日期：1983-08-01 00:00:00

abstract：OBJECTIVES:Saphenous vein graft failures, resulting from thrombosis and the abnormal proliferation, migration and apoptosis of vascular smooth muscle cells (VSMC) are major limitations of coronary artery bypass surgery. We investigated whether surgical trauma of human saphenous vein induces the early response gene c-fo...

journal_title：Cardiovascular research

authors： Galea J,Armstrong J,Francis SE,Cooper G,Crossman DC,Holt CM

更新日期：1999-11-01 00:00:00

abstract：AIMS:Our previous studies demonstrated that inflammation contributes to atherosclerosis through disruption of the low density lipoprotein receptor (LDLr) pathway. However, this effect is overridden by rapamycin, which is an inhibitor of mammalian target of rapamycin (mTOR). This study investigated the role of the mTOR ...

journal_title：Cardiovascular research

authors： Ma KL,Liu J,Wang CX,Ni J,Zhang Y,Wu Y,Lv LL,Ruan XZ,Liu BC

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:A circadian rhythm of blood pressure has been demonstrated both in subjects who are physically active during the day and in those confined to bed. The study of the circadian rhythm of arterial flow and peripheral resistance, on the other hand, is limited to pioneer experiments. This paper is aimed at demonstr...

journal_title：Cardiovascular research

authors： Casiglia E,Pizziol A,Piacentini F,Biasin R,Onesto C,Tikhonoff V,Prati R,Palatini P,Pessina AC

更新日期：1999-01-01 00:00:00

abstract：AIMS:Animal studies show that transforming growth factor-β1 (TGF-β1) is an important mediator of atrial fibrosis and atrial fibrillation (AF). This study investigated the role of TGF-β1 in human AF and the mechanism of atrial-selective fibrosis. METHODS AND RESULTS:Atrial specimens from 17 open heart surgery patients ...

journal_title：Cardiovascular research

authors： Rahmutula D,Marcus GM,Wilson EE,Ding CH,Xiao Y,Paquet AC,Barbeau R,Barczak AJ,Erle DJ,Olgin JE

更新日期：2013-09-01 00:00:00

abstract：:There is evidence that catecholamines may promote the development of cardiac hypertrophy in hypertension. To test the hypothesis that adrenaline directly determines left ventricular mass, normotensive Wistar rats were made adrenaline-deficient by adrenalectomy and hypertensive by administration of glucocorticoid. Bloo...

journal_title：Cardiovascular research

authors： Burris JF,Waeber B,Brunner HR

更新日期：1985-12-01 00:00:00

abstract：:The effect of catheterisation on the rabbit aortic wall is investigated employing a technique identical to that used for continuous monitoring of blood pressure in humans. The catheters were introduced into the aorta through the right femoral artery of the rabbit using the Seldinger technique, except that the catheter...

journal_title：Cardiovascular research

authors： Madsen JK,Garbarsch C,Nielsen PE

更新日期：1979-09-01 00:00:00

abstract：OBJECTIVES:Thrombin induces endothelial barrier failure by activating the contractile machinery of endothelial cells. Contractile activation is due to an increase in myosin light chain (MLC) phosphorylation. Here, it was investigated whether stimulation of endothelial cells with ATP can interrupt this thrombin-induced ...

journal_title：Cardiovascular research

authors： Gündüz D,Hirche F,Härtel FV,Rodewald CW,Schäfer M,Pfitzer G,Piper HM,Noll T

更新日期：2003-08-01 00:00:00

abstract：UNLABELLED:Recent investigations have established the feasibility of using exogenously delivered angiogenic growth factors to increase collateral artery development in animal models of myocardial and hindlimb ischemia. OBJECTIVE:Our aim was to evaluate the ability of a stabilized form of acidic fibroblast growth facto...

journal_title：Cardiovascular research

authors： Hershey JC,Corcoran HA,Baskin EP,Gilberto DB,Mao X,Thomas KA,Cook JJ

更新日期：2003-10-01 00:00:00

abstract：AIMS:Our recent work demonstrated that common cardiovascular progenitor cells are characterized and induced by the expression of the transcription factor mesoderm posterior1 (MesP1) in vertebrate embryos and murine embryonic stem cells. As the proliferative potential of stem cell-derived cardiomyocytes is limited, it i...

journal_title：Cardiovascular research

authors： David R,Jarsch VB,Schwarz F,Nathan P,Gegg M,Lickert H,Franz WM

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Mice with genetic disruption of the guanylyl cyclase-A (GC-A) receptor for atrial natriuretic peptide (ANP), have chronic arterial hypertension and marked cardiac hypertrophy. Intriguingly, despite pronounced remodeling, cardiac contractile functions and cardiomyocyte Ca(2+)-handling are preserved and even en...

journal_title：Cardiovascular research

authors： Yurukova S,Kilić A,Völker K,Leineweber K,Dybkova N,Maier LS,Brodde OE,Kuhn M

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:Some neuropeptides have direct cardiac effects and also modulate the cardiac effects of catecholamines. Vasopressin is an abundantly available neuropeptide having well known interactions with catecholamines in vascular smooth muscle. The aim of this study was to determine the direct and modulatory effects of ...

journal_title：Cardiovascular research

authors： Sun LS,Sawyer WH,Steinberg SF,Rosen MR

更新日期：1993-09-01 00:00:00

abstract：:The second messenger cyclic guanosine 3'5' monophosphate (cGMP) and its downstream effector protein kinase G (PKG) have been discovered more than 40 years ago. In vessels, PKG1 induces smooth muscle relaxation in response to nitric oxide signalling and thus lowers systemic and pulmonary blood pressure. In platelets, P...

journal_title：Cardiovascular research

authors： Rainer PP,Kass DA

更新日期：2016-07-15 00:00:00

abstract：:Platelet-dependent thrombus formation is a key event in the pathogenesis of acute myocardial infarction (AMI). Platelets mediate both thrombotic occlusion of the entire epicardial coronary artery and also accumulate in the microcirculation resulting in impairment of microcirculation and provoking myocardial ischemia d...

journal_title：Cardiovascular research

authors： Gawaz M

更新日期：2004-02-15 00:00:00

abstract：:The cardiac SR Ca(2+)-ATPase (SERCA2a) regulates intracellular Ca(2+)-handling and thus, plays a crucial role in initiating cardiac contraction and relaxation. SERCA2a may be modulated through its accessory phosphoprotein phospholamban or by direct phosphorylation through Ca(2+)/calmodulin dependent protein kinase II ...

journal_title：Cardiovascular research

authors： Frank KF,Bölck B,Erdmann E,Schwinger RH

更新日期：2003-01-01 00:00:00

abstract：:Hyponatremia is a frequent electrolyte disorder. It is often found in congestive cardiac failure, liver cirrhosis, plasma volume contraction and in SiADH. In these disorders hyponatremia is caused by nonosmotic vasopressin and sustained fluid intake. This provides a rationale for V2 vasopressin receptor antagonists in...

journal_title：Cardiovascular research

authors： Palm C,Reimann D,Gross P

更新日期：2001-08-15 00:00:00

abstract：OBJECTIVE:Increased pulse pressure has been observed in aging subjects, but the impact on the structure and reactivity of small arteries has been scarcely evaluated. METHODS:This study presents the modifications of vascular structure and function observed in female rats of 5, 18 and 32 months of age, and their relatio...

journal_title：Cardiovascular research

authors： Moreau P,d'Uscio LV,Lüscher TF

更新日期：1998-01-01 00:00:00