Ca2+-free perfusion of isolated rat heart: early irreversible changes and discrepancy between functional impairments and release of cellular constituents.

abstract：OBJECTIVE:We investigated the efficacy of nicaraven in reducing myocardial as well as coronary endothelial preservation-reperfusion (P/R) injury. METHODS:In experiment I, isolated rat hearts were mounted on a Langendorff (L) apparatus to estimate the baseline cardiac function. Group 1, 8- and 12-h storage in histidine...

journal_title：Cardiovascular research

authors： Alam MS,Ku K,Hashimoto M,Nosaka S,Saitoh Y,Yamauchi M,Masumura S,Nakayama K,Tamura K

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:The aim was to evaluate in a minipig model of acute myocardial infarction the cardioprotection provided by the beta adrenoceptor blocking and vasodilating activities present in carvedilol; comparison was made to the pure beta adrenoceptor antagonist, propranolol. METHODS:Experiments were performed in 25 Yuca...

journal_title：Cardiovascular research

authors： Bril A,Slivjak M,DiMartino MJ,Feuerstein GZ,Linee P,Poyser RH,Ruffolo RR Jr,Smith EF 3rd

更新日期：1992-05-01 00:00:00

abstract：:Segments of the canine ascending aorta, upper descending thoracic aorta, and middle descending thoracic aorta were instrumented with ultrasonic dimension gauges and a cathetertip manometer simultaneously to measure changes in segment diameter, length, and intravascular pressure. Volume distensibility (EV) was calculat...

journal_title：Cardiovascular research

authors： Gentile BJ,Gross DR,Chuong CJ,Hwang NH

更新日期：1988-06-01 00:00:00

abstract：OBJECTIVES:Coronary microvascular endothelial cells (CMVEs) can modulate the contractile performance of the adjacent myocardium by the release of agents such as nitric oxide (NO). Most previous studies using CMVEs have been done in situ, in the intact organ. We set out to study possible differences in NO synthase (NOS)...

journal_title：Cardiovascular research

authors： Lang D,Bell JP,Bayraktutan U,Small GR,Shah AM,Lewis MJ

更新日期：1999-06-01 00:00:00

abstract：OBJECTIVE:We have attempted to demonstrate the induction of inducible nitric oxide synthase in human vascular tissue and define the capacity of different cytokines to induce this enzyme. METHODS:Segments of human arteries were stimulated with lipopolysaccharide (10 micrograms/ml), interleukin-1 beta (5 U/ml), tumor ne...

journal_title：Cardiovascular research

authors： Chester AH,Borland JA,Buttery LD,Mitchell JA,Cunningham DA,Hafizi S,Hoare GS,Springall DR,Polak JM,Yacoub MH

更新日期：1998-06-01 00:00:00

abstract：AIMS:Despite the observation that ErbB2 regulates sensitivity of the heart to doxorubicin or ErbB2-targeted cancer therapies, mechanisms that regulate ErbB2 expression and activity have not been studied. Since isoproterenol up-regulates ErbB2 in kidney and salivary glands and β2AR and ErbB2 complex in brain and heart, ...

journal_title：Cardiovascular research

authors： Sysa-Shah P,Tocchetti CG,Gupta M,Rainer PP,Shen X,Kang BH,Belmonte F,Li J,Xu Y,Guo X,Bedja D,Gao WD,Paolocci N,Rath R,Sawyer DB,Naga Prasad SV,Gabrielson K

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:The aim was to study the contractility of the conduit coronary artery to vasoactive agents in developing and established volume overload cardiac hypertrophy and to compare it with structural alterations in the artery. METHODS:Aortic valve insufficiency in rabbits was used to produce a volume overloaded heart...

journal_title：Cardiovascular research

authors： Gerová M,Holécyová A,Kristek F,Fízel' A,Fízel'ová A

更新日期：1993-11-01 00:00:00

abstract：AIMS:Although increased Na(+)/Ca(2+) exchanger 1 (NCX1) expression is observed during heart failure (HF), the pathological role of NCX1 during the progression of HF remains unclear. We examined alterations of NCX1 expression and activity in hearts after transverse aortic constriction (TAC) surgery and explored whether ...

journal_title：Cardiovascular research

authors： Ujihara Y,Iwasaki K,Takatsu S,Hashimoto K,Naruse K,Mohri S,Katanosaka Y

更新日期：2016-09-01 00:00:00

abstract：:A mathematical formulation of the blood flow behaviour through a capillaron model is described. The formulation is applied to the analysis of post-occlusion (reactive) hyperaemia and autoregulation. ...

journal_title：Cardiovascular research

authors： Murao H,Rodbard S

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVE:The aims were: (1) to evaluate whether differences in absolute and cyclic echocardiographic image amplitude exist in different layers (subendocardium and subepicardium) and regions (septal, anterior, lateral, inferior wall) of the canine left ventricle; (2) to assess the dependence of these variables upon loc...

journal_title：Cardiovascular research

authors： Marini C,Ghelardini G,Picano E,Rovai D,Lombardi M,Trivella MG,Distante A,L'Abbate A

更新日期：1993-02-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to determine if prostaglandin like activity might be involved in changes due to exercise training in the coronary flow responses to hypoxia. DESIGN:The coronary flow response to hypoxia was measured under constant perfusion pressure in isolated perfused hearts from 12 endurance exercise tra...

journal_title：Cardiovascular research

authors： Baur TS,Brodowicz GR,Lamb DR

更新日期：1990-09-01 00:00:00

abstract：:Congenital coronary artery anomalies are of major significance in clinical cardiology and cardiac surgery due to their association with myocardial ischaemia and sudden death. Such anomalies are detectable by imaging modalities and, according to various definitions, their prevalence ranges from 0.21 to 5.79%. This cons...

journal_title：Cardiovascular research

authors： Pérez-Pomares JM,de la Pompa JL,Franco D,Henderson D,Ho SY,Houyel L,Kelly RG,Sedmera D,Sheppard M,Sperling S,Thiene G,van den Hoff M,Basso C

更新日期：2016-02-01 00:00:00

abstract：AIMS:Ischaemic preconditioning (IPC) protects the heart against prolonged lethal ischaemia through a signalling cascade involving Akt, glycogen synthase kinase-3β (GSK-3β), and mitochondrial ATP-sensitive potassium channels (mitoK(ATP)). We previously demonstrated the involvement of the Wnt pathway in IPC in vivo via G...

journal_title：Cardiovascular research

authors： Vigneron F,Dos Santos P,Lemoine S,Bonnet M,Tariosse L,Couffinhal T,Duplaà C,Jaspard-Vinassa B

更新日期：2011-04-01 00:00:00

abstract：:The cardiospecificity of the MB isoenzyme of creatine kinase, EC 2.7.3.2, (CK) with its associated diagnostic and research value has resulted in the development of a number of procedures for the separation and quantitation of the three isoenzymes of CK. In our experience methods involving cellulose acetate electrophor...

journal_title：Cardiovascular research

authors： Ogunro EA,Hearse DJ,Shillingford JP

更新日期：1977-03-01 00:00:00

abstract：:Impairment of contractile function and extent of release of several intracellular marker enzymes and DNA were studied in isolated perfused rat hearts after low-flow (0.16 ml . min-1) ischaemia followed by 2 h of reperfusion and after anoxia followed by 2 h of reoxygenation. After varying periods of ischaemia or anoxia...

journal_title：Cardiovascular research

authors： van der Laarse A,Altona JC,Zoet AC,Oemrawsingh P,van Dijkman PR

更新日期：1984-12-01 00:00:00

abstract：OBJECTIVES:To elucidate the effect of selective endothelin ET(A)- and mixed ET(A/B)-receptor antagonists on endothelial vasomotor dysfunction in rats with heart failure after myocardial infarction (MI). METHODS:Vasoreactivity and superoxide anion formation were determined in aortic rings from Wistar rats 12 weeks afte...

journal_title：Cardiovascular research

authors： Bauersachs J,Fraccarollo D,Galuppo P,Widder J,Ertl G

更新日期：2000-07-01 00:00:00

abstract：:This review focuses on the genomic response following a preconditioning stimulus. Initial studies demonstrated that classical ischemic preconditioning mediated by cyclic episodes of short durations of reversible ischemia and reperfusion could result in the reprogramming of gene expression. Some of these genes are tran...

journal_title：Cardiovascular research

authors： Das DK,Maulik N

更新日期：2006-05-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to investigate the arrhythmogenic properties of several sympathomimetic amines and their antagonism by adrenergic blocking drugs. DESIGN:Arrhythmia was induced by the investigated drugs, injected intravenously: adrenaline (ADR); noradrenaline (NA); phenylephrine (PE); isoprenaline (IP); ter...

journal_title：Cardiovascular research

authors： Oppenheimer E,Akavia E,Shavit S,Korczyn AD

更新日期：1990-09-01 00:00:00

abstract：AIMS:Notch signalling is essential for blood vessel formation. During angiogenesis, the Notch ligand DLL4 on the leading tip cell activates Notch receptors on the adjacent stalk cells. DLL4-Notch signalling is impaired by the Notch ligand JAG1 in endothelial cells. The Delta/Serrate/Lag2 (DSL) domain of the Notch ligan...

journal_title：Cardiovascular research

authors： Klose R,Berger C,Moll I,Adam MG,Schwarz F,Mohr K,Augustin HG,Fischer A

更新日期：2015-07-01 00:00:00

abstract：:The role of mediators of inflammation in the pathogenesis and evolution of myocardial infarction has attracted increased interest as interventions which inhibit the inflammatory response after coronary artery occlusion have been shown to decrease infarct size. The distribution of fibrinogen and albumin in ischaemia my...

journal_title：Cardiovascular research

authors： Fishbein MC,Kulber D,Stancl M,Edwalds G

更新日期：1986-01-01 00:00:00

abstract：:The QT interval, a global index of ventricular repolarization, varies among individuals and is influenced by diverse physiologic and pathophysiologic stimuli such as gender, age, heart rate, electrolyte concentrations, concomitant cardiac disease, and other diseases such as diabetes. Many drugs produce a small but rep...

journal_title：Cardiovascular research

authors： Roden DM

更新日期：2019-04-15 00:00:00

abstract：AIMS:A blood pressure-independent metabolic shift toward a catabolic state upon high sodium (Na+) diet, ultimately favouring body fluid preservation, has recently been described in pre-clinical controlled settings. We sought to investigate the real-life impact of high Na+ intake on measures of renal Na+/water handling ...

journal_title：Cardiovascular research

authors： Rossitto G,Maiolino G,Lerco S,Ceolotto G,Blackburn G,Mary S,Antonelli G,Berton C,Bisogni V,Cesari M,Seccia TM,Lenzini L,Pinato A,Montezano A,Touyz RM,Petrie MC,Daly R,Welsh P,Plebani M,Rossi GP,Delles C

更新日期：2020-07-16 00:00:00

abstract：OBJECTIVES:Coronary collateral flow often mitigates the effects of coronary artery obstruction and has a significant impact on the prognosis of patients with coronary artery disease. In the presence of variable degrees of coronary collateral flow, digital radiographic assessment of myocardial blood flow has not been qu...

journal_title：Cardiovascular research

authors： Murata K,Bhargava V,Ricou F,Ono S,Kambayashi M,Oh BH,Peterson KL

更新日期：1997-02-01 00:00:00

abstract：:The last decade has seen a dramatic increase in the understanding of the molecular basis of arrhythmias. Much of this new information has been driven by genetic studies that focused on rare, monogenic arrhythmia syndromes that were accompanied or followed by cellular electrophysiological or biochemical studies. The ma...

journal_title：Cardiovascular research

authors： Kääb S,Schulze-Bahr E

更新日期：2005-08-15 00:00:00

abstract：AIMS:Doxorubicin (DOX) is widely used in cytostatic treatments, although it may cause cardiovascular dysfunction as a side effect. DOX treatment leads to enhanced free radical production that in turn causes DNA strand breakage culminating in poly(ADP-ribose) polymerase (PARP) activation and mitochondrial and cellular d...

journal_title：Cardiovascular research

authors： Szántó M,Rutkai I,Hegedus C,Czikora Á,Rózsahegyi M,Kiss B,Virág L,Gergely P,Tóth A,Bai P

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:After-depolarization associated arrhythmias are frequently observed in heart failure and associated with spontaneous calcium release from sarcoplasmic reticulum (SR), calcium after-transients. We hypothesize that disturbed SR calcium handling underlies calcium after-transients in heart failure (HF). METHODS:...

journal_title：Cardiovascular research

authors： Baartscheer A,Schumacher CA,Belterman CN,Coronel R,Fiolet JW

更新日期：2003-04-01 00:00:00

abstract：:The effect of circulation time on plasma high density lipoprotein cholesterol concentrations was investigated in 20 male Wistar rats injected with alcohol, stressed with lighting, or fed a high fat diet. Circulation time was measured during anaesthesia with a computerised dichromatic earpiece densitometer. Indocyanine...

journal_title：Cardiovascular research

authors： Ishizuka T

更新日期：1988-05-01 00:00:00

abstract：OBJECTIVE:The aim was to estimate the relative contributions of the various intracellular and sarcolemmal systems to the relaxation of the systolic calcium transient. METHODS:The experiments were performed on isolated rat ventricular myocytes. The cells were loaded with the fluorescent indicator indo-1 in order to mea...

journal_title：Cardiovascular research

authors： Negretti N,O'Neill SC,Eisner DA

更新日期：1993-10-01 00:00:00

abstract：AIMS:Our recent work demonstrated that common cardiovascular progenitor cells are characterized and induced by the expression of the transcription factor mesoderm posterior1 (MesP1) in vertebrate embryos and murine embryonic stem cells. As the proliferative potential of stem cell-derived cardiomyocytes is limited, it i...

journal_title：Cardiovascular research

authors： David R,Jarsch VB,Schwarz F,Nathan P,Gegg M,Lickert H,Franz WM

更新日期：2011-10-01 00:00:00

abstract：:Coronary microvascular dysfunction (CMD) is commonly present in patients with metabolic derangements and is increasingly recognized as an important contributor to myocardial ischaemia, both in the presence and absence of epicardial coronary atherosclerosis. The latter condition is termed 'ischaemia and no obstructive ...

journal_title：Cardiovascular research

authors： Sorop O,van de Wouw J,Chandler S,Ohanyan V,Tune JD,Chilian WM,Merkus D,Bender SB,Duncker DJ

更新日期：2020-03-01 00:00:00