Creatine kinase isoenzymes: their separation and quantitation.

abstract：OBJECTIVE:Co-expression of the KvLQT1 and minK potassium channel subunits is required to recapitulate I(Ks), the slow component of the cardiac delayed rectifier current, and mutations in either gene cause the congenital Long QT syndrome. It is becoming increasingly well-recognized that multiprotein channel complexes co...

journal_title：Cardiovascular research

authors： Kupershmidt S,Yang IC,Sutherland M,Wells KS,Yang T,Yang P,Balser JR,Roden DM

更新日期：2002-10-01 00:00:00

abstract：:The potent anaphylatoxin C3a was measured in the peripheral blood of eleven patients receiving radiocontrast agents whilst undergoing coronary angiography. In seven patients C3a levels were raised during this procedure and in three of these the anaphylatoxin was increased between four and tenfold. In four patients C3a...

journal_title：Cardiovascular research

authors： Westaby S,Dawson P,Turner MW,Pridie RB

更新日期：1985-02-01 00:00:00

abstract：AIMS:Macrophage-related oxidative stress plays an important role in the inflammatory process in atherosclerosis. Recently, dextromethorphan (DXM), a common cough-suppressing ingredient with a high safety profile, was found to inhibit the activation of microglia, the resident macrophage in the nervous system. We investi...

journal_title：Cardiovascular research

authors： Liu SL,Li YH,Shi GY,Tang SH,Jiang SJ,Huang CW,Liu PY,Hong JS,Wu HL

更新日期：2009-04-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to determine whether depressed myocardial contractility is responsible for the decline in stroke volume that occurs with cardiac tamponade. DESIGN:Left ventricular contractile performance was assessed before and after beta adrenergic blockade using the end systolic pressure-volume relation,...

journal_title：Cardiovascular research

authors： Johnston WE,Vinten-Johansen J,Klopfenstein HS,Santamore WP,Little WC

更新日期：1990-08-01 00:00:00

abstract：:Segments of the canine ascending aorta, upper descending thoracic aorta, and middle descending thoracic aorta were instrumented with ultrasonic dimension gauges and a cathetertip manometer simultaneously to measure changes in segment diameter, length, and intravascular pressure. Volume distensibility (EV) was calculat...

journal_title：Cardiovascular research

authors： Gentile BJ,Gross DR,Chuong CJ,Hwang NH

更新日期：1988-06-01 00:00:00

abstract：AIMS:The channel function of the cardiac ryanodine receptor (RyR2) is modulated by calmodulin (CaM). However, the involvement of CaM in aberrant Ca(2+) release in diseased hearts remains unclear. Here, we investigated the pathogenic role of defective CaM binding to the RyR2 in the channel dysfunction associated with he...

journal_title：Cardiovascular research

authors： Hino A,Yano M,Kato T,Fukuda M,Suetomi T,Ono M,Murakami W,Susa T,Okuda S,Doi M,Kobayashi S,Yamamoto T,Koseki N,Kyushiki H,Ikemoto N,Matsuzaki M

更新日期：2012-12-01 00:00:00

abstract：:To examine how end systole differs from end ejection and also whether the slope of the end systolic pressure-volume relation can be approximated to that of the end ejection pressure-volume relation, nine isolated, perfused, paced canine hearts ejecting into a hydraulic loading system that simulated the aortic input im...

journal_title：Cardiovascular research

authors： Nishioka O,Maruyama Y,Ashikawa K,Isoyama S,Satoh S,Suzuki H,Watanabe J,Watanabe H,Shimizu Y,Ino-Oka E

更新日期：1987-02-01 00:00:00

abstract：OBJECTIVE:We determine if action potential duration (APD) shortening and cardioprotection are separable phenomena in ATP-sensitive potassium channel (KATP) openers which protect ischemic myocardium via a glyburide-reversible mechanism. METHODS:We determined the effect of the weakly vasodilating KATP opener, BMS-180448...

journal_title：Cardiovascular research

authors： Grover GJ,D'Alonzo AJ,Hess T,Sleph PG,Darbenzio RB

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:Pigment epithelial-derived factor (PEDF) is a potent anti-angiogenic factor whose effects are partially mediated through the induction of endothelial cell apoptosis. The pathway mediating endothelial cell apoptosis has not been fully established. Here we investigated the participation of peroxisome proliferat...

journal_title：Cardiovascular research

authors： Ho TC,Chen SL,Yang YC,Liao CL,Cheng HC,Tsao YP

更新日期：2007-11-01 00:00:00

abstract：AIMS:ATP sensitive K(+) channels (K(ATP)) sense adenine nucleotide concentrations and thus couple the metabolic state of the cell to membrane potential. The hetero-octameric complex of a sulphonylurea receptor (SUR2B) and an inwardly rectifying K(+) channel (Kir6.1) and the corresponding native channel in smooth muscle...

journal_title：Cardiovascular research

authors： Farzaneh T,Tinker A

更新日期：2008-09-01 00:00:00

abstract：:By measuring the coronary sinus blood flow using the thermodilution technique the influence of "thermodilution catheter" withdrawal from the great cardiac vein to the ostium of the coronary sinus was investigated in 41 patients. In addition, the influence of normal and forced respiration on coronary sinus blood flow w...

journal_title：Cardiovascular research

authors： Bagger JP

更新日期：1985-01-01 00:00:00

abstract：:The effects of increasing oxygen tension from fetal to neonatal levels and of incubation in the cyclo-oxygenase inhibitor, indomethacin, on the response of isolated rings of neonatal rabbit ductus arteriosus and aorta to noradrenaline were studied in vitro. Increasing oxygen tension did not affect the sensitivity, as ...

journal_title：Cardiovascular research

authors： Smith GC,McGrath JC

更新日期：1988-12-01 00:00:00

abstract：OBJECTIVES:L-arginine exerts anti-atherosclerotic effects in hypercholesterolaemic rabbits via modulating endogenous NO production. We investigated whether L-arginine inhibits thromboxane formation in vivo and platelet aggregation ex vivo in this animal model. METHODS:The urinary excretion rates of 2,3-dinor-6-keto-PG...

journal_title：Cardiovascular research

authors： Bode-Böger SM,Böger RH,Kienke S,Böhme M,Phivthong-ngam L,Tsikas D,Frölich JC

更新日期：1998-03-01 00:00:00

abstract：:Myocardial capillary permeability was determined in 20 dogs by applying a new method which resembles the tissue-uptake technique. The method consisted of a bolus injection of 51Cr-EDTA into the left atrium, determination of the average arterial tracer concentration and subsequent assay of myocardial tissue activity 10...

journal_title：Cardiovascular research

authors： Amtorp O,Eliasen P,Abildgaard U,Haunsø S

更新日期：1984-05-01 00:00:00

abstract：OBJECTIVE:To determine the role of calcineurin and Src tyrosine kinase in the regulation of inducible nitric oxide synthase (iNOS) expression and protection in cardiomyocytes. METHODS:iNOS expression was studied in isolated neonatal rat ventricular myocyte cultures in response to bacterial lipopolysaccharide (LPS) or ...

journal_title：Cardiovascular research

authors： Obasanjo-Blackshire K,Mesquita R,Jabr RI,Molkentin JD,Hart SL,Marber MS,Xia Y,Heads RJ

更新日期：2006-09-01 00:00:00

abstract：AIMS:Despite their ability to cause septic shock and myocardial dysfunction, components of Gram-negative bacterial cell walls, like lipopolysaccharide, have been shown in numerous studies to induce myocardial protection during ischaemia-reperfusion injury. Muramyl dipeptide (MDP) is another such component recognized by...

journal_title：Cardiovascular research

authors： Sicard P,Jacquet S,Kobayashi KS,Flavell RA,Marber MS

更新日期：2009-07-15 00:00:00

abstract：OBJECTIVE:The endothelium is a newly recognised target tissue of parathyroid hormone (PTH). It is not clear whether hyperparathyroidism affects endothelial function and whether parathyroidectomy (Ptx) has an influence on arterial vessel wall properties. We studied brachial flow-mediated vasodilation (FMD) and brachial ...

journal_title：Cardiovascular research

authors： Kosch M,Hausberg M,Vormbrock K,Kisters K,Gabriels G,Rahn KH,Barenbrock M

更新日期：2000-09-01 00:00:00

abstract：:To improve assessment of ventricular function during cardiac catheterisation there should be available a continuous registration of stroke volume and cardiac output in addition to ventricular pressure. To obtain the desired volumetric quantities a catheter has been developed which measures changes in intraventricular ...

journal_title：Cardiovascular research

authors： Baan J,Jong TT,Kerkhof PL,Moene RJ,van Dijk AD,van der Velde ET,Koops J

更新日期：1981-06-01 00:00:00

abstract：:Ischemic preconditioning is a powerful biologic phenomenon that activates innate cell survival programs to protect the heart from ischemic injury. The preponderance of research into classical ischemic preconditioning has focused on signaling pathways orchestrating cardioprotection. Conceptually classified into trigger...

journal_title：Cardiovascular research

authors： Minners J,McLeod CJ,Sack MN

更新日期：2003-07-01 00:00:00

abstract：AIMS:The angiotensin II type 1 receptor (AT1R) through the activation of immune cells plays a key role in arterial inward remodelling and reduced blood flow in cardiovascular disorders. On the other side, flow (shear stress)-mediated outward remodelling (FMR), involved in collateral arteries growth in ischaemic disease...

journal_title：Cardiovascular research

authors： Caillon A,Grenier C,Grimaud L,Vessieres E,Guihot AL,Blanchard S,Lelievre E,Chabbert M,Foucher ED,Jeannin P,Beauvillain C,Abraham P,Loufrani L,Delneste Y,Henrion D

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:The aim was to determine if isolated rabbit cardiomyocytes could be preconditioned. METHODS:Cardiomyocytes isolated from rabbit hearts were subjected to 15 min oxygenated preincubation, with and without substrate, prior to concentration into an ischaemic slurry, with or without glucose present. The effects o...

journal_title：Cardiovascular research

authors： Armstrong S,Downey JM,Ganote CE

更新日期：1994-01-01 00:00:00

abstract：:Ventricular function curves relating stroke work and left ventricular end-diastolic pressure were generated in awake dogs during increases in preload produced by infusion of fluid and during increases in afterload produced by administration of phenylephrine. The ventricular function curves produced by preloading were ...

journal_title：Cardiovascular research

authors： Rosenfeldt FL,Cobb FR,Bache RJ,Sabiston DC Jr

更新日期：1979-07-01 00:00:00

abstract：:An isolated working rat heart preparation was used to characterise the temperature-dependency of the anti-ischaemic properties of nifedipine. In this study hearts were subjected to pre-ischaemic infusion with the St Thomas' cardioplegic solution with or without added nifedipine (0.075 mumol X litre-1). Hearts were the...

journal_title：Cardiovascular research

authors： Fukunami M,Hearse DJ

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVES:To elucidate the effect of selective endothelin ET(A)- and mixed ET(A/B)-receptor antagonists on endothelial vasomotor dysfunction in rats with heart failure after myocardial infarction (MI). METHODS:Vasoreactivity and superoxide anion formation were determined in aortic rings from Wistar rats 12 weeks afte...

journal_title：Cardiovascular research

authors： Bauersachs J,Fraccarollo D,Galuppo P,Widder J,Ertl G

更新日期：2000-07-01 00:00:00

abstract：AIMS:Disturbed blood flow at arterial branches and curvatures modulates endothelial function and predisposes the region to endothelial inflammation and subsequent development of atherosclerotic lesions. Activation of the endothelial Toll-like receptors (TLRs), in particular TLR4, contributes to vascular inflammation. T...

journal_title：Cardiovascular research

authors： Qu D,Wang L,Huo M,Song W,Lau CW,Xu J,Xu A,Yao X,Chiu JJ,Tian XY,Huang Y

更新日期：2020-01-01 00:00:00

abstract：AIMS:Heart failure is associated with deficient endothelial nitric oxide (NO) production as well as increased oxidative stress and accelerated NO degradation. The aim of this study was to evaluate platelet NO biosynthesis and superoxide anion (O(2)(-)) production in patients with heart failure. METHODS AND RESULTS:In ...

journal_title：Cardiovascular research

authors： Shah A,Passacquale G,Gkaliagkousi E,Ritter J,Ferro A

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Unidirectional conduction block (UCB) and reentry may occur as a consequence of an abrupt tissue expansion and a related change in the electrical load. The aim of this study was to evaluate critical dimensions of the tissue necessary for establishing UCB in heart cell culture. METHODS:Neonatal rat heart cell...

journal_title：Cardiovascular research

authors： Fast VG,Kléber AG

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:NG,NG-dimethylarginine (asymmetric dimethylarginine, ADMA) is an important endogenous substance with potent inhibitory actions on nitric oxide (NO) synthesis. The present study was designed to determine circulating ADMA levels and endothelium-dependent, NO mediated vasodilation in a rat model of congestive he...

journal_title：Cardiovascular research

authors： Feng Q,Lu X,Fortin AJ,Pettersson A,Hedner T,Kline RL,Arnold JM

更新日期：1998-03-01 00:00:00

abstract：AIMS:G-protein-coupled receptors (GPCRs) modulate vascular tone, at least in part, via matrix metalloproteinase (MMP) transactivation of the epidermal growth factor receptor (EGFR). We previously have identified novel signalling pathways downstream of the EGFR suggestive of mitogen-activated protein kinase and mitochon...

journal_title：Cardiovascular research

authors： Nagareddy PR,Chow FL,Hao L,Wang X,Nishimura T,MacLeod KM,McNeill JH,Fernandez-Patron C

更新日期：2009-12-01 00:00:00

abstract：:Pulsatile haemodynamics associated with graded degrees of experimentally produced stenosis were studied in the canine femoral artery. Invasively determined pulsatile blood flow and noninvasively determined blood velocity with Doppler ultrasound were measured an average of 1.3 and 2.3 cm proximal to the stenosis, respe...

journal_title：Cardiovascular research

authors： Farrar DJ,Green HD,Peterson DW

更新日期：1979-01-01 00:00:00