Cardiac-enriched LIM domain protein fhl2 is required to generate I(Ks) in a heterologous system.

abstract：OBJECTIVE:Activin-like kinase receptor 1 (ALK1) is a transforming growth factor (TGF)-beta type I receptor expressed in vascular mesenchyme, yet its function in vascular mesenchymal cells (VMC) is unclear. We examined ALK1 expression in human coronary atherosclerotic lesions and bovine and human VMC undergoing cellular...

journal_title：Cardiovascular research

authors： Yao Y,Zebboudj AF,Torres A,Shao E,Boström K

更新日期：2007-05-01 00:00:00

abstract：:Hyponatremia is a frequent electrolyte disorder. It is often found in congestive cardiac failure, liver cirrhosis, plasma volume contraction and in SiADH. In these disorders hyponatremia is caused by nonosmotic vasopressin and sustained fluid intake. This provides a rationale for V2 vasopressin receptor antagonists in...

journal_title：Cardiovascular research

authors： Palm C,Reimann D,Gross P

更新日期：2001-08-15 00:00:00

abstract：:In order to evaluate clinically recorded jugular vein pulses it is necessary to understand the transmission process of the right atrial pressure pulse through the caval veins up to the jugular veins. The transmission speed at distinct points of the venous pressure curve was studied in the superior vena cava of 20 anae...

journal_title：Cardiovascular research

authors： Minten J,Van de Werf F,Aubert AE,Kesteloot H,De Geest H

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:The functional status of heart failure (HF) is conventionally evaluated by peak exercise oxygen consumption (VO2 max). Dobutamine echocardiography can be used to evaluate myocardial reserve. The aim of this study was to estimate the functional status of chronic HF in patients with dilated cardiomyopathy, by ...

journal_title：Cardiovascular research

authors： Paraskevaidis IA,Tsiapras DP,Adamopoulos S,Kremastinos DT

更新日期：1999-07-01 00:00:00

abstract：:Electrophysiologic remodeling is a process whereby heart disease alters the electrophysiologic properties of cardiac tissue. These alterations, in turn, can cause or exacerbate disease-related arrhythmias. Ion channels are the fundamental molecular units underlying cardiac electrophysiology, and it therefore follows t...

journal_title：Cardiovascular research

authors： Roden DM,Kupershmidt S

更新日期：1999-05-01 00:00:00

abstract：:Cell communication, an essential component of integrated physiological function in multicellular organisms, is mediated largely through informational molecules, such as hormones and neurotransmitters. After binding to specific receptors, these first messengers activate intracellular signaling cascades and, thereby, tr...

journal_title：Cardiovascular research

authors： Goette A,Lendeckel U,Klein HU

更新日期：2002-05-01 00:00:00

abstract：AIMS:Chronic pressure or volume overload induce concentric vs. eccentric left ventricular (LV) remodelling, respectively. Previous studies suggest that distinct signalling pathways are involved in these responses. NADPH oxidase-4 (Nox4) is a reactive oxygen species-generating enzyme that can limit detrimental cardiac r...

journal_title：Cardiovascular research

authors： Schnelle M,Sawyer I,Anilkumar N,Mohamed BA,Richards DA,Toischer K,Zhang M,Catibog N,Sawyer G,Mongue-Din H,Schröder K,Hasenfuss G,Shah AM

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Left ventricular assist devices (LVAD) have been used to 'bridge' patients with end-stage heart failure to transplantation. Although several reports have suggested that the native ventricular function recovers after long-term LVAD support, a process called 'reverse remodeling', the underlying biological mecha...

journal_title：Cardiovascular research

authors： Grabellus F,Levkau B,Sokoll A,Welp H,Schmid C,Deng MC,Takeda A,Breithardt G,Baba HA

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:The aim was to clarify the site in the coronary microcirculation that is dilated by an ATP sensitive potassium channel opener, levcromakalim, and to examine whether the magnitude of dilatation is size dependent. METHODS:Coronary arterial microvessels were observed through an intravital microscope equipped wi...

journal_title：Cardiovascular research

authors： Sato K,Kanatsuka H,Sekiguchi N,Akai K,Wang Y,Sugimura A,Kumagai T,Komaru T,Shirato K

更新日期：1994-12-01 00:00:00

abstract：:The effects of repeated (10 X), brief Ca2+-free perfusions (20 to 120 s) on myocardial contractility, coronary flow and release of cellular constituents of isolated rat heart were investigated. Ten successive Ca2+-deprivations of 20 or 40 s had no irreversible influences on cardiac performance. Ca2+-deprivations, howe...

journal_title：Cardiovascular research

authors： Koomen JM,Noordhoek J,Zimmerman AN

更新日期：1983-08-01 00:00:00

abstract：OBJECTIVE:The aims of the study were (1) to elucidate the effects of raised oxygen tension on the response of the ductus arteriosus to a range of vasodilators; and (2) to establish the effect, if any, of cyclo-oxygenase inhibition on the interaction between oxygen and prostaglandin (PG)E2. METHODS:Rings of ductus arte...

journal_title：Cardiovascular research

authors： Smith GC,McGrath JC

更新日期：1993-12-01 00:00:00

abstract：AIMS:Nonsense mutations in the SCN5A gene result in truncated, non-functional derivatives of the cardiac Na+ channel and thus cause arrhythmias. Studies of other genes suggest that pathogenic phenotypes of nonsense mutations may be alleviated by enhancing readthrough, which enables ribosomes to ignore premature termina...

journal_title：Cardiovascular research

authors： Teng S,Gao L,Paajanen V,Pu J,Fan Z

更新日期：2009-08-01 00:00:00

abstract：AIMS:SR-B1 is a cholesterol transporter that exerts anti-atherogenic properties in liver and peripheral tissues in mice. Bone marrow (BM) transfer studies suggested an atheroprotective role in cells of haematopoietic origin. Here, we addressed the specific contribution of SR-B1 in the monocyte/macrophage. METHODS AND ...

journal_title：Cardiovascular research

authors： Galle-Treger L,Moreau M,Ballaire R,Poupel L,Huby T,Sasso E,Troise F,Poti F,Lesnik P,Le Goff W,Gautier EL,Huby T

更新日期：2020-03-01 00:00:00

abstract：AIMS:Aortic adaptive immunity plays a role in atherosclerosis; however, the precise mechanisms leading to T-cell activation in the arterial wall remain poorly understood. METHODS AND RESULTS:Here, we have identified naïve T cells in the aorta of wild-type and T-cell receptor transgenic mice and we demonstrate that naï...

journal_title：Cardiovascular research

authors： MacRitchie N,Grassia G,Noonan J,Cole JE,Hughes CE,Schroeder J,Benson RA,Cochain C,Zernecke A,Guzik TJ,Garside P,Monaco C,Maffia P

更新日期：2020-02-01 00:00:00

abstract：AIMS:The regulation of vascular diameter by vasoconstrictors and vasodilators requires that vascular smooth muscle cells (VSMCs) be physically coupled to extracellular matrix (ECM) and neighbouring cells in order for a vessel to mechanically function and transfer force. The hypothesis was tested that integrin-mediated ...

journal_title：Cardiovascular research

authors： Hong Z,Sun Z,Li Z,Mesquitta WT,Trzeciakowski JP,Meininger GA

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVES:The concept of lethal reperfusion injury in ischemic myocardium has been the subject of controversy. Adenosine administered during reperfusion has been reported to limit lethal reperfusion injury in several studies. On the contrary, it has been reported that cardioprotection may not be achieved with adenosin...

journal_title：Cardiovascular research

authors： Vander Heide RS,Reimer KA

更新日期：1996-05-01 00:00:00

abstract：:The theory related to the loss of R waves and appearance of Q waves in acute myocardial infarction is discussed. A method of praecordial mapping of RS ratio changes and the appearance of Q waves that occur in acute myocardial infarction is described. The serial changes in these electrocardiographic signs in 17 patient...

journal_title：Cardiovascular research

authors： Selwyn AP,Shillingford JP

更新日期：1977-03-01 00:00:00

abstract：AIMS:Following a large myocardial infarction (MI), remaining viable muscle often undergoes pathological remodelling and progresses towards chronic heart failure. Mitochondria may also be affected by this process and, due to their functional importance, likely contribute to the progression of the disease. Aerobic interv...

journal_title：Cardiovascular research

authors： Kraljevic J,Marinovic J,Pravdic D,Zubin P,Dujic Z,Wisloff U,Ljubkovic M

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:Our aim was to determine in desmin homozygous mutant mice the viscoelastic properties, the mechanical strength and the structure of the carotid artery. METHODS:To assess the viscoelastic properties of large arteries, we have performed an in vivo analysis of the diameter-, and distensibility-pressure curves o...

journal_title：Cardiovascular research

authors： Lacolley P,Challande P,Boumaza S,Cohuet G,Laurent S,Boutouyrie P,Grimaud JA,Paulin D,Lamazière JM,Li Z

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:Dexamethasone-eluting stents are currently under evaluation to prevent post-angioplasty restenosis. The efficacy and safety of dexamethasone as an anti-restenotic agent is still unclear. We assess the effect of perivascular delivery of dexamethasone on vascular pathology in a mouse model of restenosis. METHO...

journal_title：Cardiovascular research

authors： Pires NM,Schepers A,van der Hoeven BL,de Vries MR,Boesten LS,Jukema JW,Quax PH

更新日期：2005-12-01 00:00:00

abstract：:Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in multiple human tissues and regulate different cellular functions...

journal_title：Cardiovascular research

authors： Perrucci GL,Gowran A,Zanobini M,Capogrossi MC,Pompilio G,Nigro P

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:The contribution of vascular changes to the development of heart failure is largely unknown. In the present study, we evaluated endothelial and vascular contractile function in the rat hindlimb vascular bed after myocardial infarction (MI), including the modulatory role of basal nitric oxide (NO) production ...

journal_title：Cardiovascular research

authors： Ceiler DL,Nelissen-Vrancken M,De Mey JG,Smits JF

更新日期：1999-08-15 00:00:00

abstract：Aims:Heart failure (HF) produces left atrial (LA)-selective fibrosis and promotes atrial fibrillation. HF also causes adrenergic activation, which contributes to remodelling via a variety of signalling molecules, including the exchange protein activated by cAMP (Epac). Here, we evaluate the effects of Epac1-signalling ...

journal_title：Cardiovascular research

authors： Surinkaew S,Aflaki M,Takawale A,Chen Y,Qi XY,Gillis MA,Shi YF,Tardif JC,Chattipakorn N,Nattel S

更新日期：2019-01-01 00:00:00

abstract：:Labetolol, which blocks both alpha and beta-adrenoceptors, was found to have direct actions on cardiac muscle which could themselves be antiarrhythmic. It depressed the maximum rate of depolarisation, and reduced conduction velocity, in atrial and ventricular muscle and in Purkinje cells, implying restriction of fast ...

journal_title：Cardiovascular research

authors： Vaughn Williams EM,Millar JS,Campbell TJ

更新日期：1982-05-01 00:00:00

abstract：:Inherited arrhythmias are disorders caused by one or more genetic mutations that increase the risk of arrhythmia, which result in life-long risk of sudden death. These mutations either primarily perturb electrophysiological homeostasis (e.g. long QT syndrome and catecholaminergic polymorphic ventricular tachycardia), ...

journal_title：Cardiovascular research

authors： Bezzerides VJ,Prondzynski M,Carrier L,Pu WT

更新日期：2020-07-15 00:00:00

abstract：OBJECTIVE:We have attempted to demonstrate the induction of inducible nitric oxide synthase in human vascular tissue and define the capacity of different cytokines to induce this enzyme. METHODS:Segments of human arteries were stimulated with lipopolysaccharide (10 micrograms/ml), interleukin-1 beta (5 U/ml), tumor ne...

journal_title：Cardiovascular research

authors： Chester AH,Borland JA,Buttery LD,Mitchell JA,Cunningham DA,Hafizi S,Hoare GS,Springall DR,Polak JM,Yacoub MH

更新日期：1998-06-01 00:00:00

abstract：:The major limitation to antiarrhythmic drug therapy is the risk of arrhythmia promotion, or 'proarrhythmia.' This complication may be lethal, and greatly restricts the value of antiarrhythmic agents, particularly for arrhythmias without an intrinsic mortality risk, such as atrial fibrillation. In order for improved an...

journal_title：Cardiovascular research

authors： Nattel S

更新日期：1998-03-01 00:00:00

abstract：AIMS:Disturbed blood flow at arterial branches and curvatures modulates endothelial function and predisposes the region to endothelial inflammation and subsequent development of atherosclerotic lesions. Activation of the endothelial Toll-like receptors (TLRs), in particular TLR4, contributes to vascular inflammation. T...

journal_title：Cardiovascular research

authors： Qu D,Wang L,Huo M,Song W,Lau CW,Xu J,Xu A,Yao X,Chiu JJ,Tian XY,Huang Y

更新日期：2020-01-01 00:00:00

abstract：:Cardiac hypertrophy was induced in rabbits at atmospheric pressure by exposing them to hypoxia equivalent to an altitude of 6000 m for 280 to 350 h. Intracellular action potentials were recorded from Purkinje cells, and from atrial and papillary muscles, contractions of which were also measured. Hearts from normoxic l...

journal_title：Cardiovascular research

authors： Dukes ID,Vaughan Williams EM

更新日期：1984-10-01 00:00:00

abstract：OBJECTIVE:The heart contains proteins of the annexin family, a unique group of calcium binding proteins. This study was aimed at identifying the major cardiac annexins and determining their distribution in the rat heart. METHODS:Annexins were isolated by affinity chromatography and purified by ion exchange high pressu...

journal_title：Cardiovascular research

authors： Doubell AF,Lazure C,Charbonneau C,Thibault G

更新日期：1993-07-01 00:00:00