Peptidyl-prolyl isomerases: a full cast of critical actors in cardiovascular diseases.

abstract：BACKGROUND:Plasma low density lipoproteins (LDL) play a key role in the pathogenesis of atherosclerosis. LDL modify gene expression in vascular cells leading to disturbances in the functional state of the vessel wall. METHODS:Expression levels of C-4 sterol methyl oxidase gene (ERG25), sterol regulatory element bindin...

journal_title：Cardiovascular research

authors： Rodriguez C,Raposo B,Martínez-González J,Llorente-Cortés V,Vilahur G,Badimon L

更新日期：2003-04-01 00:00:00

abstract：AIMS:Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is caused by mutations in the cardiac ryanodine receptor (RyR2) that lead to disrupted Ca(2+) handling in cardiomyocytes and ventricular tachycardia. The aim of this study was to test whether exercise training could reduce the propensity for arrh...

journal_title：Cardiovascular research

authors： Manotheepan R,Danielsen TK,Sadredini M,Anderson ME,Carlson CR,Lehnart SE,Sjaastad I,Stokke MK

更新日期：2016-08-01 00:00:00

abstract：:Functional studies in extrarenal non-epithelial cells such as smooth muscle cells and easily accessible human lymphocytes have demonstrated that aldosterone not only produces classical genomic effects, but also rapid non-genomic effects on transmembrane electrolyte movements. These involve the activation of the Na+/H+...

journal_title：Cardiovascular research

authors： Wehling M

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:The mechanism of defibrillation is controversial. Reentry appearing immediately after the shock has been shown to be responsible for defibrillation failure in some studies while other studies have demonstrated that a rapid train of focal activations with the first focus appearing >50 ms after the shock is re...

journal_title：Cardiovascular research

authors： Chattipakorn N,Banville I,Gray RA,Ideker RE

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Sepsis-stimulated nitric oxide (NO) production impairs arteriolar responsiveness in skeletal muscle. Using wild type (WT), eNOS(-/-), iNOS(-/-) and nNOS(-/-) mice, we aimed to determine the key nitric oxide synthase (NOS) isoenzyme(s) responsible for the arteriolar hyporesponsiveness to acetylcholine (ACh) in...

journal_title：Cardiovascular research

authors： Lidington D,Li F,Tyml K

更新日期：2007-04-01 00:00:00

abstract：STUDY OBJECTIVE:Incidence of spontaneous cardiac arrhythmias and inducibility of ventricular arrhythmias in the cardiomyopathic hamster, BIO 14.6 strain, were examined. DESIGN:A 3 min electrocardiogram (ECG) was recorded weekly to 50 weeks of age. Programmed ventricular stimulation was then performed with single and d...

journal_title：Cardiovascular research

authors： Hano O,Mitsuoka T,Matsumoto Y,Ahmed R,Hirata M,Hirata T,Mori M,Yano K,Hashiba K

更新日期：1991-01-01 00:00:00

abstract：AIMS:The presence and potential function of transient receptor potential melastatin 7 (TRPM7), a Ca2+-permeable non-selective cation channel of the TRP channel superfamily in human vascular endothelial cells, were examined. METHODS AND RESULTS:Whole-cell patch-clamp recordings showed outward-rectifying currents in hum...

journal_title：Cardiovascular research

authors： Inoue K,Xiong ZG

更新日期：2009-08-01 00:00:00

abstract：:In acute myocardial infarction (MI), reactive oxygen species (ROS) are generated in the ischaemic myocardium especially after reperfusion. ROS directly injure the cell membrane and cause cell death. However, ROS also stimulate signal transduction to elaborate inflammatory cytokines, e.g. tumour necrosis factor-alpha (...

journal_title：Cardiovascular research

authors： Hori M,Nishida K

更新日期：2009-02-15 00:00:00

abstract：:Therapeutic neovascularization for cardiovascular ischemia is a promising avenue in spite of disappointing early clinical trial results. The concept of three different mechanisms of neovascularization has served to define potential therapeutic targets such as vascular remodeling and stem cell recruitment, but it is an...

journal_title：Cardiovascular research

authors： Cao Y,Hong A,Schulten H,Post MJ

更新日期：2005-02-15 00:00:00

abstract：AIMS:The channel function of the cardiac ryanodine receptor (RyR2) is modulated by calmodulin (CaM). However, the involvement of CaM in aberrant Ca(2+) release in diseased hearts remains unclear. Here, we investigated the pathogenic role of defective CaM binding to the RyR2 in the channel dysfunction associated with he...

journal_title：Cardiovascular research

authors： Hino A,Yano M,Kato T,Fukuda M,Suetomi T,Ono M,Murakami W,Susa T,Okuda S,Doi M,Kobayashi S,Yamamoto T,Koseki N,Kyushiki H,Ikemoto N,Matsuzaki M

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to investigate the relationship between acute decreases in right ventricular volume during Valsalva strain (with resultant changes in autonomic neural tone) and measures of local endocardial repolarization time independent of heart rate and autonomic neural tone. METHODS:Patie...

journal_title：Cardiovascular research

authors： Nanthakumar K,Dorian P,Paquette M,Hutchison S,Andrews J,Newman D

更新日期：2000-01-14 00:00:00

abstract：:Blood vessels are permanently exposed to stretch and shear stress due to blood pressure and blood flow. Significant variations in the mechanical environment, of physiological or pathophysiological nature, occur in vivo. These trigger acute changes in vessel diameter that tend to restore basal levels of tensile and she...

journal_title：Cardiovascular research

authors： Lehoux S

更新日期：2006-07-15 00:00:00

abstract：:Chemokines, originally discovered as mediators of directional migration of immune cells to sites of inflammation and injury, have a function beyond their role in leukocyte chemotaxis. Indeed, they participate in organ development, angiogenesis, tumourigenesis and, more importantly, in the immune response. The chemokin...

journal_title：Cardiovascular research

authors： Balestrieri ML,Balestrieri A,Mancini FP,Napoli C

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:Myocardial adaptation has been reported to result from mild but chronic ischaemia in the hearts of patients with coronary artery disease. The aim of this study was to test the hypothesis that the responses of the chronically hypoxic myocardium to an episode of severe ischaemia, or the effects of acute ischaem...

journal_title：Cardiovascular research

authors： Tajima M,Katayose D,Bessho M,Isoyama S

更新日期：1994-03-01 00:00:00

abstract：:Coronary microvascular dysfunction (CMD) is commonly present in patients with metabolic derangements and is increasingly recognized as an important contributor to myocardial ischaemia, both in the presence and absence of epicardial coronary atherosclerosis. The latter condition is termed 'ischaemia and no obstructive ...

journal_title：Cardiovascular research

authors： Sorop O,van de Wouw J,Chandler S,Ohanyan V,Tune JD,Chilian WM,Merkus D,Bender SB,Duncker DJ

更新日期：2020-03-01 00:00:00

abstract：:The second messenger cyclic guanosine 3'5' monophosphate (cGMP) and its downstream effector protein kinase G (PKG) have been discovered more than 40 years ago. In vessels, PKG1 induces smooth muscle relaxation in response to nitric oxide signalling and thus lowers systemic and pulmonary blood pressure. In platelets, P...

journal_title：Cardiovascular research

authors： Rainer PP,Kass DA

更新日期：2016-07-15 00:00:00

abstract：STUDY OBJECTIVE:The aim was to evaluate the protective effect of verapamil during myocardial ischaemia and reperfusion. DESIGN:In vivo phosphorus-31 (31P) magnetic resonance spectroscopy was performed on rats pretreated with verapamil (mg.kg-1 intraperitoneal) and controls during a 45 min left coronary artery occlusio...

journal_title：Cardiovascular research

authors： Wolfe CL,Donnelly TJ,Sievers R,Parmley WW

更新日期：1991-02-01 00:00:00

abstract：OBJECTIVE:R 75,231, a potent and specific nucleoside transport inhibitor, largely prevents cardiac damage and death in catecholamine challenged rabbits. The major biochemical effect of nucleoside transport inhibition in ischaemic and reperfused myocardium is a prolonged accumulation of adenosine. The cardioprotection b...

journal_title：Cardiovascular research

authors： Van Belle H,Ver Donck K,Verheyen W

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Clinical trials suggest that sotalol and dofetilide are much more effective in preventing atrial fibrillation (AF) than in terminating it. This study evaluated potential mechanisms of discordant sotalol and dofetilide effects on AF termination vs. prevention. METHODS:We applied 240-electrode epicardial mapp...

journal_title：Cardiovascular research

authors： Derakhchan K,Villemaire C,Talajic M,Nattel S

更新日期：2001-04-01 00:00:00

abstract：:If the posterior hypothalamus contributes to elevate blood pressure in hypertension by increasing sympathetic vasomotor activity, then lesions of the posterior hypothalamus should lower blood pressure more in hypertensive than in normotensive rats. To test this hypothesis without complications caused by anaesthesia, a...

journal_title：Cardiovascular research

authors： Buñag R,Eferakeya A

更新日期：1976-11-01 00:00:00

abstract：AIMS:Increased proinflammatory cytokines after myocardial infarction augment the progression of heart failure (HF) and are of prognostic significance. Recently, we demonstrated that increased proinflammatory cytokines in the brains of HF rats increased paraventricular nucleus (PVN) superoxide and down-regulated neurona...

journal_title：Cardiovascular research

authors： Kang YM,He RL,Yang LM,Qin DN,Guggilam A,Elks C,Yan N,Guo Z,Francis J

更新日期：2009-09-01 00:00:00

abstract：AIMS:Following a large myocardial infarction (MI), remaining viable muscle often undergoes pathological remodelling and progresses towards chronic heart failure. Mitochondria may also be affected by this process and, due to their functional importance, likely contribute to the progression of the disease. Aerobic interv...

journal_title：Cardiovascular research

authors： Kraljevic J,Marinovic J,Pravdic D,Zubin P,Dujic Z,Wisloff U,Ljubkovic M

更新日期：2013-07-01 00:00:00

abstract：STUDY OBJECTIVE:The aim of the study was to test an intermittent ECG synchronised suction device which was added to a coronary vein retroinfusion system (selective suction and retroinfusion = SSR) in order to transport oxygenated fluid more efficiently into ischaemic myocardium. DESIGN:The suction period preceding the...

journal_title：Cardiovascular research

authors： Boekstegers P,Diebold J,Weiss C

更新日期：1990-06-01 00:00:00

abstract：OBJECTIVE:The acute administration of growth hormone (GH) or insulin-like growth factor-1 (IGF-1) improves cardiac performance, possibly contributing to the beneficial effects of GH therapy on heart failure (HF). GH can induce the production of IGF-1 and thus the actions of GH may be mediated through its IGF-1 inductio...

journal_title：Cardiovascular research

authors： Kinugawa S,Tsutsui H,Ide T,Nakamura R,Arimura K,Egashira K,Takeshita A

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:Transient atrial fibrillation is sometimes observed following adenosine administration and adenosine is known to shorten atrial action potential duration and refractory period. This study was designed to characterise the dose-response relationship of adenosine on these variables relative to arrhythmia inducti...

journal_title：Cardiovascular research

authors： Kabell G,Buchanan LV,Gibson JK,Belardinelli L

更新日期：1994-09-01 00:00:00

abstract：Aims:Atherosclerosis is an inflammatory disease wherein cholesterol-loaded macrophages play a major role. MicroRNAs and microparticles propagate inflammatory pathways and are involved in cardiovascular disease. We aimed to screen and validate circulating microRNAs correlated with atherosclerosis development in humans, ...

journal_title：Cardiovascular research

authors： Ceolotto G,Giannella A,Albiero M,Kuppusamy M,Radu C,Simioni P,Garlaschelli K,Baragetti A,Catapano AL,Iori E,Fadini GP,Avogaro A,Vigili de Kreutzenberg S

更新日期：2017-11-01 00:00:00

abstract：:Acute occlusions of the proximal left circumflex coronary arteriovenous pedicle were performed in open chest anaesthetised dogs. Twenty eight dogs were randomly allocated to receive acebutolol (3 mg X kg-1 twice daily) or placebo given blindly by mouth for five days; a control group of 14 dogs without any pretreatment...

journal_title：Cardiovascular research

authors： Puddu PE,Jouve R,Langlet F,Guillen JC,Fornaris M,Torresani J,Reale A

更新日期：1986-10-01 00:00:00

abstract：:Postextrasystolic potentiation was studied by means of a catheter-tip manometer in patients with and without cardiomyopathy. The results imply that the enhancement of the left ventricular contraction is increased in patients with cardiomyopathy. ...

journal_title：Cardiovascular research

authors： Kvasnicka J,Liander B,Broman H,Varnauskas E

更新日期：1975-05-01 00:00:00

abstract：OBJECTIVE:The aim was to estimate the relative contributions of the various intracellular and sarcolemmal systems to the relaxation of the systolic calcium transient. METHODS:The experiments were performed on isolated rat ventricular myocytes. The cells were loaded with the fluorescent indicator indo-1 in order to mea...

journal_title：Cardiovascular research

authors： Negretti N,O'Neill SC,Eisner DA

更新日期：1993-10-01 00:00:00

abstract：AIMS:Atherosclerotic vascular disease has an inflammatory pathogenesis. Heme from intraplaque hemorrhage may drive a protective and pro-resolving macrophage M2-like phenotype, Mhem, via AMPK and ATF1. The anti-diabetic drug metformin may also activate AMPK-dependent signalling. HYPOTHESIS:Metformin systematically indu...

journal_title：Cardiovascular research

authors： Seneviratne A,Cave L,Hyde G,Moestrup SK,Carling D,Mason JC,Haskard DO,Boyle JJ

更新日期：2020-07-15 00:00:00