Acute ischaemic preconditioning and chronic hypoxia independently increase myocardial tolerance to ischaemia.

abstract：OBJECTIVE:Mice with genetic disruption of the guanylyl cyclase-A (GC-A) receptor for atrial natriuretic peptide (ANP), have chronic arterial hypertension and marked cardiac hypertrophy. Intriguingly, despite pronounced remodeling, cardiac contractile functions and cardiomyocyte Ca(2+)-handling are preserved and even en...

journal_title：Cardiovascular research

authors： Yurukova S,Kilić A,Völker K,Leineweber K,Dybkova N,Maier LS,Brodde OE,Kuhn M

更新日期：2007-03-01 00:00:00

abstract：AIMS:Doxorubicin (DOX) is a widely used and effective anti-cancer therapeutic. DOX treatment is associated with both acute and late onset cardiotoxicity, limiting its overall efficacy. Here, the impact of cardiomyocyte cell cycle activation was examined in a juvenile model featuring aspects of acute and late onset DOX ...

journal_title：Cardiovascular research

authors： Zhu W,Reuter S,Field LJ

更新日期：2019-04-15 00:00:00

abstract：:Although fully explored in larger animals, the role of injection site and sample microsphere content on variability of coronary blood flow (CBF) measurement using the microsphere technique remains controversial in rats despite the fact that this species is extensively used in cardiovascular research. We therefore inve...

journal_title：Cardiovascular research

authors： Wicker PA,Healy BP

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVES:Action potential prolongation related to the alteration of several membrane currents is constantly reported in heart failure (HF) but reports about its role in arrhythmogenesis are sparse. Our aim was to determine, by analogy with long QT syndromes, whether prolonged repolarization is associated with increas...

journal_title：Cardiovascular research

authors： Lacroix D,Gluais P,Marquié C,D'Hoinne C,Adamantidis M,Bastide M

更新日期：2002-04-01 00:00:00

abstract：:The effects of hypoxia and subsequent reoxygenation were examined in isolated left ventricular papillary muscles from the rat at 28 degrees C and 33 degrees C. Studies of relaxation were carried out in isometric and physiologically sequenced contractions. In studies of isometric contractions, the following variables w...

journal_title：Cardiovascular research

authors： Nakamura Y,Wiegner AW,Bing OH

更新日期：1986-09-01 00:00:00

abstract：OBJECTIVE:The regulation of pulmonary prostacyclin synthesis is not completely understood. We tested the hypothesis that prostacyclin production is predominantly stimulated by hemodynamic factors, such as increased shear-stress, and is thus increased in rats with chronic hypoxic pulmonary hypertension. METHODS:To this...

journal_title：Cardiovascular research

authors： Blumberg FC,Lorenz C,Wolf K,Sandner P,Riegger GA,Pfeifer M

更新日期：2002-07-01 00:00:00

abstract：:An isolated working rat heart preparation was used to characterise the temperature-dependency of the anti-ischaemic properties of nifedipine. In this study hearts were subjected to pre-ischaemic infusion with the St Thomas' cardioplegic solution with or without added nifedipine (0.075 mumol X litre-1). Hearts were the...

journal_title：Cardiovascular research

authors： Fukunami M,Hearse DJ

更新日期：1985-02-01 00:00:00

abstract：AIMS:TGF-β regulates tissue fibrosis: TGF-β promotes fibrosis, whereas bone morphogenetic protein (BMP)-7 is antifibrotic. To demonstrate that (i) left ventricular (LV) remodelling after pressure overload is associated with disequilibrium in the signalling mediated by these cytokines, and (ii) BMP-7 exerts beneficial e...

journal_title：Cardiovascular research

authors： Merino D,Villar AV,García R,Tramullas M,Ruiz L,Ribas C,Cabezudo S,Nistal JF,Hurlé MA

更新日期：2016-06-01 00:00:00

abstract：:The function of the right ventricle (RV) determines the prognosis of patients with pulmonary hypertension. While much progress has been made in the treatment of pulmonary hypertension, therapies for the RV are less well established. In this review of treatment strategies for the RV, first we focus on ways to reduce wa...

journal_title：Cardiovascular research

authors： Westerhof BE,Saouti N,van der Laarse WJ,Westerhof N,Vonk Noordegraaf A

更新日期：2017-10-01 00:00:00

abstract：:In pulmonary arterial hypertension (PAH), right ventricular (RV) adaptation is essential to overcome the chronic increases in RV pressure overload. Ultimately, RV compensatory mechanisms are not sufficient and patients succumb to RV failure. The processes underlying the transition of RV adaptation to RV failure are no...

journal_title：Cardiovascular research

authors： van der Bruggen CEE,Tedford RJ,Handoko ML,van der Velden J,de Man FS

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:The type 1 fibroblast growth factor receptor (FGFR-1) is the only high affinity receptor for fibroblast growth factor-2 (FGF-2) in the rat myocardium, and is essential for normal growth and development of the heart. Levels of FGFR-1 are developmentally regulated, being high in embryonic cardiac myocytes. Also...

journal_title：Cardiovascular research

authors： Sheikh F,Fandrich RR,Kardami E,Cattini PA

更新日期：1999-06-01 00:00:00

abstract：OBJECTIVE:The restitution mechanism has been the focus of attention as the possible mechanism behind ventricular fibrillation (VF). However, its contribution in chronic ischemic heart has not been established. METHODS:We investigated chronic ischemic dogs with occlusion of left anterior descending artery. Sixty unipol...

journal_title：Cardiovascular research

authors： Yuuki K,Hosoya Y,Kubota I,Yamaki M

更新日期：2004-09-01 00:00:00

abstract：:We studied the effects of intracoronary vasopressin on the relationship between pressure and flow in the coronary circulation of anaesthetised swine. In addition to measurements at control levels, diastolic pressure-flow relationships were constructed from steady-state points below a coronary pressure of 50 mmHg, wher...

journal_title：Cardiovascular research

authors： Pantely GA,Ladley HD,Anselone CG,Bristow JD

更新日期：1985-07-01 00:00:00

abstract：Aims:Circular RNA (circRNA) is a newly validated class of single-stranded RNA, ubiquitously expressed in mammalian tissues and possessing key functions including acting as microRNA sponges and as transcriptional regulators by binding to RNA-binding proteins. While independent studies confirm the expression of circRNA i...

journal_title：Cardiovascular research

authors： Tan WL,Lim BT,Anene-Nzelu CG,Ackers-Johnson M,Dashi A,See K,Tiang Z,Lee DP,Chua WW,Luu TD,Li PY,Richards AM,Foo RS

更新日期：2017-03-01 00:00:00

abstract：:Exaggerated cardiovascular responsiveness is common in young men and may cause non-specific symptoms and poor performance. Conventional autonomic function tests are not clinically useful. We have therefore designed a thermal entrainment method to evaluate sympathetic and parasympathetic cardiovascular function in subj...

journal_title：Cardiovascular research

authors： Lindqvist A,Parviainen P,Kolari P,Tuominen J,Välimäki I,Antila K,Laitinen LA

更新日期：1989-03-01 00:00:00

abstract：Aims:MicroRNAs (miRNAs) have been implicated in the pathogenesis of pulmonary hypertension (PH), a multifactorial and progressive condition associated with an increased afterload of the right ventricle leading to heart failure and death. The main aim of this study was to correlate the levels of miR-424(322) with the se...

journal_title：Cardiovascular research

authors： Baptista R,Marques C,Catarino S,Enguita FJ,Costa MC,Matafome P,Zuzarte M,Castro G,Reis A,Monteiro P,Pêgo M,Pereira P,Girão H

更新日期：2018-01-01 00:00:00

abstract：AIMS:It is well established that leukotrienes (LTs), products of the 5-lipoxygenase (5-LO) pathway, participate in inflammatory tissue reactions and immune responses. In the present study, the impact of the 5-LO pathway on vasculogenesis of mouse embryonic stem (ES) cells was investigated. METHODS AND RESULTS:Immunohi...

journal_title：Cardiovascular research

authors： Finkensieper A,Kieser S,Bekhite MM,Richter M,Mueller JP,Graebner R,Figulla HR,Sauer H,Wartenberg M

更新日期：2010-04-01 00:00:00

abstract：:In the heart, Ca(2+) influx via Ca(V)1.2 L-type calcium channels (LTCCs) is a multi-functional signal that triggers muscle contraction, controls action potential duration, and regulates gene expression. The use of LTCC Ca(2+) as a multi-dimensional signalling molecule in the heart is complicated by several aspects of ...

journal_title：Cardiovascular research

authors： Shaw RM,Colecraft HM

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:Important physiological and pathophysiological conditions are associated with changes in secretion and synthesis of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP). The aim of this study was to examine the effects of mechanical stretch and endothelin-1 on ANF and BNP secretion and gene exp...

journal_title：Cardiovascular research

authors： Bruneau BG,de Bold AJ

更新日期：1994-10-01 00:00:00

abstract：:This review attempts to define the early events that lead to lesions of human atherosclerosis based on careful morphological studies in human autopsy specimens. In contrast to most small laboratory animals, diffuse intimal thickening (DIT) is present in human arteries before atherosclerosis develops, particularly in t...

journal_title：Cardiovascular research

authors： Nakashima Y,Wight TN,Sueishi K

更新日期：2008-07-01 00:00:00

abstract：AIMS:To describe the overall role of reduced sarcoplasmic reticulum Ca(2+) ATPase (SERCA2) for Ca(2+) wave development. METHODS AND RESULTS:SERCA2 knockout [Serca2(flox/flox) Tg(alphaMHC-MerCreMer); KO] mice allowing inducible cardiomyocyte-specific disruption of the Serca2 gene in adult mice were compared with Serca(...

journal_title：Cardiovascular research

authors： Stokke MK,Hougen K,Sjaastad I,Louch WE,Briston SJ,Enger UH,Andersson KB,Christensen G,Eisner DA,Sejersted OM,Trafford AW

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:The aim was to determine the relationship between the rate of reflow and vulnerability to reperfusion induced arrhythmias. METHODS:Isolated rat hearts, in which left and right coronary arteries were perfused independently, were subjected to transient (10 min) cessation of flow to the left coronary bed. Durin...

journal_title：Cardiovascular research

authors： Ibuki C,Hearse DJ,Avkiran M

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:Air bubbles entering the coronary artery may have harmful effects on cardiac function. From the physical point of view it is the relatively high surface tension of the blood-air interface which causes bubbles to trap in small vessels. The aim of the present study was to reduce depression of myocardial functio...

journal_title：Cardiovascular research

authors： van Blankenstein JH,Slager CJ,Soei LK,Boersma H,Stijnen T,Schuurbiers JC,Krams R,Lachmann B,Verdouw PD

更新日期：1997-06-01 00:00:00

abstract：:The effect of lidocaine on the effective refractory period of the right ventricle (EVRP) was measured in 10 patients using the extra stimulus technique of progressive introduction of premature stimuli until a response could not be elicited. In four patients lidocaine produced a significant decrease in the EVRP, in a f...

journal_title：Cardiovascular research

authors： Olsson SB,Harper R,Rydén L,Hilmy WA

更新日期：1975-09-01 00:00:00

abstract：OBJECTIVE:Cardiac parasympathetic nerve activity is reduced in most cardiovascular disease states, and this may contribute to enhanced cardiac sympathetic responsiveness. Disruption of inhibitory G-proteins (Gi) ablates the cholinergic pathway and increases cardiac endothelial nitric oxide (NO) synthase (eNOS) expressi...

journal_title：Cardiovascular research

authors： Danson EJ,Zhang YH,Sears CE,Edwards AR,Casadei B,Paterson DJ

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:Cholinergic vasodilation has been thought to play little if any role in the regulation of blood pressure in humans. Autonomic denervation potentiates the vasoconstriction evoked by nitric oxide synthase inhibition in humans, but the mechanism is unclear. We hypothesized that this may be related to loss of neu...

journal_title：Cardiovascular research

authors： Lepori M,Sartori C,Duplain H,Nicod P,Scherrer U

更新日期：2001-09-01 00:00:00

abstract：STUDY OBJECTIVE:The aim of the study was to determine whether the deleterious effects of anaesthesia on cardiac muscle function were due to disturbance of protein synthesis. Comparative investigations were made on anaerobic and aerobic skeletal muscles, and plasma insulin and growth hormone levels were also measured to...

journal_title：Cardiovascular research

authors： Siddiq T,Richardson PJ,Hashim IA,Preedy VR

更新日期：1991-04-01 00:00:00

abstract：:Currently, a high carbohydrate/low fat diet is recommended for patients with hypertension; however, the potentially important role that the composition of dietary fat and carbohydrate plays in hypertension and the development of pathological left ventricular hypertrophy (LVH) has not been well characterized. Recent st...

journal_title：Cardiovascular research

authors： Sharma N,Okere IC,Duda MK,Chess DJ,O'Shea KM,Stanley WC

更新日期：2007-01-15 00:00:00

abstract：OBJECTIVE:To investigate the possible mechanisms of the antiatherosclerotic effects of the angiotensin-converting enzyme (ACE) inhibitor, fosinopril, in apolipoprotein (apo) E deficient mice. METHODS:Apo E deficient (E0) mice at the age of 8 weeks received either placebo or a high dose (25 mg/kg/d) of fosinopril suppl...

journal_title：Cardiovascular research

authors： Hayek T,Attias J,Coleman R,Brodsky S,Smith J,Breslow JL,Keidar S

更新日期：1999-12-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to determine whether depressed myocardial contractility is responsible for the decline in stroke volume that occurs with cardiac tamponade. DESIGN:Left ventricular contractile performance was assessed before and after beta adrenergic blockade using the end systolic pressure-volume relation,...

journal_title：Cardiovascular research

authors： Johnston WE,Vinten-Johansen J,Klopfenstein HS,Santamore WP,Little WC

更新日期：1990-08-01 00:00:00