Abstract:
OBJECTIVE:The aim was to determine the relationship between the rate of reflow and vulnerability to reperfusion induced arrhythmias. METHODS:Isolated rat hearts, in which left and right coronary arteries were perfused independently, were subjected to transient (10 min) cessation of flow to the left coronary bed. During the subsequent 10 min of reperfusion, flow in the left coronary bed was regulated to create five different reflow profiles (n = 12 per group): (1) immediate restoration of 100% flow which was maintained throughout reperfusion (control); (2) stepwise restoration of flow with 10% flow from 0-1 min, 20% flow from 1-2 min, 40% flow from 2-3 min, 60% flow from 3-4 min, 80% flow from 4-5 min, and 100% flow from 5-10 min; (3) 10% flow from 0-5 min and 100% flow from 5-10 min; (4) 20% flow from 0-5 min and 100% flow from 5-10 min; and (5) 40% flow from 0-5 min and 100% flow from 5-10 min. RESULTS:There were no significant differences between the groups in the incidences of reperfusion induced ventricular tachycardia or fibrillation, which were 100% and 58-92%, respectively. However, the time to onset of reperfusion induced ventricular fibrillation was delayed (p less than 0.05) from 15 (SEM 1) s in group (1) to 191(39), 210(38), and 77(29) s in groups 2, 3, and 4, respectively. No significant delay was observed in group 5. There were no significant differences between the groups in size of ischaemic zone or heart rate. CONCLUSIONS:In crystalloid perfused hearts, restricted reflow delays the time to onset of reperfusion induced ventricular fibrillation but does not reduce the incidence of reperfusion induced ventricular tachycardia or fibrillation.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Ibuki C,Hearse DJ,Avkiran Mdoi
10.1093/cvr/26.4.316subject
Has Abstractpub_date
1992-04-01 00:00:00pages
316-23issue
4eissn
0008-6363issn
1755-3245journal_volume
26pub_type
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pub_type: 杂志文章
doi:10.1016/j.cardiores.2005.09.015
更新日期:2006-01-01 00:00:00
abstract::Labetolol, which blocks both alpha and beta-adrenoceptors, was found to have direct actions on cardiac muscle which could themselves be antiarrhythmic. It depressed the maximum rate of depolarisation, and reduced conduction velocity, in atrial and ventricular muscle and in Purkinje cells, implying restriction of fast ...
journal_title:Cardiovascular research
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doi:10.1093/cvr/16.5.233
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更新日期:2003-01-01 00:00:00
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doi:10.1016/s0008-6363(96)00156-3
更新日期:1996-12-01 00:00:00
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更新日期:2008-05-01 00:00:00
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journal_title:Cardiovascular research
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doi:10.1093/cvr/cvw113
更新日期:2016-09-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/0008-6363(96)00028-4
更新日期:1996-08-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/j.cardiores.2003.09.021
更新日期:2003-12-01 00:00:00
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journal_title:Cardiovascular research
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doi:10.1093/cvr/20.1.36
更新日期:1986-01-01 00:00:00
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更新日期:2020-03-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/20.8.609
更新日期:1986-08-01 00:00:00
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doi:10.1093/cvr/cvm094
更新日期:2008-05-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(98)00068-6
更新日期:1998-09-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1093/cvr/cvp268
更新日期:2010-02-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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doi:10.1093/cvr/16.11.637
更新日期:1982-11-01 00:00:00
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doi:10.1093/cvr/cvp129
更新日期:2009-07-15 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/s0008-6363(98)00110-2
更新日期:1998-07-01 00:00:00
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doi:10.1016/j.cardiores.2004.09.007
更新日期:2005-05-01 00:00:00
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doi:10.1093/cvr/cvz331
更新日期:2021-01-01 00:00:00
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更新日期:2020-11-02 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/23.6.478
更新日期:1989-06-01 00:00:00
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journal_title:Cardiovascular research
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doi:10.1093/cvr/cvs239
更新日期:2012-10-01 00:00:00
abstract::Matricellular proteins are extracellular matrix proteins that modulate cell-matrix interactions and cell function, and do not seem to have a direct structural role. The family includes tenascin-C (TN-C), tenascin-X (TN-X), osteonectin, osteopontin, thrombospondin-1 (TSP1) and thrombospondin-2 (TSP2). Expression of mat...
journal_title:Cardiovascular research
pub_type: 杂志文章,评审
doi:10.1016/j.cardiores.2004.06.006
更新日期:2004-10-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(98)00228-4
更新日期:1999-03-01 00:00:00
abstract::Genetic and environmental factors influence the development of coronary artery disease (CAD). Genetic analyses of families and the population continue to yield important fundamental insights for CAD. For the past four decades, CAD human genetic research focused largely on the study of germline genetic variation in CAD...
journal_title:Cardiovascular research
pub_type: 杂志文章,评审
doi:10.1093/cvr/cvz032
更新日期:2019-04-15 00:00:00
abstract::Known viable allograft canine pulmonary valves were inserted in an isotopic position ensuring normal physiological function and simulating the clinical situation. Valves removed at periods up to eight weeks were assessed for viability using previously established criteria of tissue culture and protein and collagen syn...
journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1093/cvr/11.1.78
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVE:To determine the effect of acute left ventricular dilatation on refractoriness in normal hearts. METHODS:During sustained ventricular fibrillation (VF) in isolated perfused hearts, recording of local activation time yields VF intervals which provide an index of local refractoriness. Simultaneous measurement ...
journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(98)00092-3
更新日期:1998-08-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00