Rate of reflow and reperfusion induced arrhythmias: studies with dual coronary perfusion.

Abstract:

OBJECTIVE:The aim was to determine the relationship between the rate of reflow and vulnerability to reperfusion induced arrhythmias. METHODS:Isolated rat hearts, in which left and right coronary arteries were perfused independently, were subjected to transient (10 min) cessation of flow to the left coronary bed. During the subsequent 10 min of reperfusion, flow in the left coronary bed was regulated to create five different reflow profiles (n = 12 per group): (1) immediate restoration of 100% flow which was maintained throughout reperfusion (control); (2) stepwise restoration of flow with 10% flow from 0-1 min, 20% flow from 1-2 min, 40% flow from 2-3 min, 60% flow from 3-4 min, 80% flow from 4-5 min, and 100% flow from 5-10 min; (3) 10% flow from 0-5 min and 100% flow from 5-10 min; (4) 20% flow from 0-5 min and 100% flow from 5-10 min; and (5) 40% flow from 0-5 min and 100% flow from 5-10 min. RESULTS:There were no significant differences between the groups in the incidences of reperfusion induced ventricular tachycardia or fibrillation, which were 100% and 58-92%, respectively. However, the time to onset of reperfusion induced ventricular fibrillation was delayed (p less than 0.05) from 15 (SEM 1) s in group (1) to 191(39), 210(38), and 77(29) s in groups 2, 3, and 4, respectively. No significant delay was observed in group 5. There were no significant differences between the groups in size of ischaemic zone or heart rate. CONCLUSIONS:In crystalloid perfused hearts, restricted reflow delays the time to onset of reperfusion induced ventricular fibrillation but does not reduce the incidence of reperfusion induced ventricular tachycardia or fibrillation.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Ibuki C,Hearse DJ,Avkiran M

doi

10.1093/cvr/26.4.316

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

316-23

issue

4

eissn

0008-6363

issn

1755-3245

journal_volume

26

pub_type

杂志文章
  • Resistin is secreted from macrophages in atheromas and promotes atherosclerosis.

    abstract:OBJECTIVE:Resistin belongs to a family of cysteine-rich secreted polypeptides that are mainly produced by monocytes/macrophages in humans. Recently, high concentrations of resistin were shown to induce vascular endothelial dysfunction and vascular smooth muscle cell proliferation. We examined if resistin was secreted f...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/j.cardiores.2005.09.015

    authors: Jung HS,Park KH,Cho YM,Chung SS,Cho HJ,Cho SY,Kim SJ,Kim SY,Lee HK,Park KS

    更新日期:2006-01-01 00:00:00

  • Electrophysiological effects of labetolol on rabbit atrial, ventricular and Purkinje cells, in normoxia and hypoxia.

    abstract::Labetolol, which blocks both alpha and beta-adrenoceptors, was found to have direct actions on cardiac muscle which could themselves be antiarrhythmic. It depressed the maximum rate of depolarisation, and reduced conduction velocity, in atrial and ventricular muscle and in Purkinje cells, implying restriction of fast ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/16.5.233

    authors: Vaughn Williams EM,Millar JS,Campbell TJ

    更新日期:1982-05-01 00:00:00

  • Sarcoplasmic reticulum Ca2+-ATPase modulates cardiac contraction and relaxation.

    abstract::The cardiac SR Ca(2+)-ATPase (SERCA2a) regulates intracellular Ca(2+)-handling and thus, plays a crucial role in initiating cardiac contraction and relaxation. SERCA2a may be modulated through its accessory phosphoprotein phospholamban or by direct phosphorylation through Ca(2+)/calmodulin dependent protein kinase II ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1016/s0008-6363(02)00694-6

    authors: Frank KF,Bölck B,Erdmann E,Schwinger RH

    更新日期:2003-01-01 00:00:00

  • Cardiac beta-adrenoreceptor activation and ventricular fibrillation under normal and ischemic conditions.

    abstract:OBJECTIVES:To investigate the role of ventricular and atrial beta-adrenoceptor activation by isoprenaline in the genesis of rhythm disorders and risk of fibrillation in the healthy or ischaemic heart. METHODS:The study was performed in anaesthetized, open-chest pigs. Electrical fibrillation threshold (EFT) of the vent...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/s0008-6363(96)00156-3

    authors: Bui-Xuan B,Aupetit JF,Freysz M,Loufoua J,Faucon G,Timour Q

    更新日期:1996-12-01 00:00:00

  • Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead.

    abstract::Sprouting angiogenesis is an invasive process that involves proteolytic activities required for the degradation of the endothelial basement membrane, cell migration with removal of obstructing matrix proteins, and generation of space in the matrix to allow endothelial cells to form a proper lumen. In the last decade i...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1093/cvr/cvm102

    authors: van Hinsbergh VW,Koolwijk P

    更新日期:2008-05-01 00:00:00

  • Induced NCX1 overexpression attenuates pressure overload-induced pathological cardiac remodelling.

    abstract:AIMS:Although increased Na(+)/Ca(2+) exchanger 1 (NCX1) expression is observed during heart failure (HF), the pathological role of NCX1 during the progression of HF remains unclear. We examined alterations of NCX1 expression and activity in hearts after transverse aortic constriction (TAC) surgery and explored whether ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvw113

    authors: Ujihara Y,Iwasaki K,Takatsu S,Hashimoto K,Naruse K,Mohri S,Katanosaka Y

    更新日期:2016-09-01 00:00:00

  • Myocardial infarct size is smaller in dogs with pacing-induced heart failure.

    abstract:OBJECTIVE:Determine if ischemic tolerance is reduced in the setting of experimental heart failure (HF). METHODS:Dogs were paced for 3 weeks at 240 BPM to induce heart failure which was confirmed with hemodynamic and echocardiographic measurements. The pacemaker was turned off 30 min prior to the ischemia study. Normal...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/0008-6363(96)00028-4

    authors: Hoskins DE,Ignasiak DP,Saganek LJ,Gallagher KP,Peterson JT

    更新日期:1996-08-01 00:00:00

  • Demonstration of altered fibroblast contractile activity in hypertensive heart disease.

    abstract:OBJECTIVE:The aim of this study is to investigate the idea that altered fibroblast contractile activity is involved in the pathogenesis of hypertensive heart disease (HHD). METHODS:Cell area and contraction are quantified using the traction force microscopy technique for cardiac fibroblasts isolated from both normoten...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/j.cardiores.2003.09.021

    authors: Marganski WA,De Biase VM,Burgess ML,Dembo M

    更新日期:2003-12-01 00:00:00

  • Distribution of fibrinogen and albumin in normal, ischaemic, and necrotic myocardium during the evolution of myocardial infarction: an immunohistochemical study.

    abstract::The role of mediators of inflammation in the pathogenesis and evolution of myocardial infarction has attracted increased interest as interventions which inhibit the inflammatory response after coronary artery occlusion have been shown to decrease infarct size. The distribution of fibrinogen and albumin in ischaemia my...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/20.1.36

    authors: Fishbein MC,Kulber D,Stancl M,Edwalds G

    更新日期:1986-01-01 00:00:00

  • Targeted invalidation of SR-B1 in macrophages reduces macrophage apoptosis and accelerates atherosclerosis.

    abstract:AIMS:SR-B1 is a cholesterol transporter that exerts anti-atherogenic properties in liver and peripheral tissues in mice. Bone marrow (BM) transfer studies suggested an atheroprotective role in cells of haematopoietic origin. Here, we addressed the specific contribution of SR-B1 in the monocyte/macrophage. METHODS AND ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvz138

    authors: Galle-Treger L,Moreau M,Ballaire R,Poupel L,Huby T,Sasso E,Troise F,Poti F,Lesnik P,Le Goff W,Gautier EL,Huby T

    更新日期:2020-03-01 00:00:00

  • Contractile properties of papillary muscle from young cardiomyopathic hamsters: effects of isoprenaline.

    abstract::Papillary muscles isolated from the left ventricle of 17-20 day old Syrian hamsters with genetic cardiomyopathy (BIO 14.6 strain) were examined for their mechanophysiological response to the beta adrenoceptor agonist isoprenaline. The indices of isometric twitch for both myopathic and aged matched normal (BIO RB strai...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/20.8.609

    authors: Rossner KL,Coudrai PR

    更新日期:1986-08-01 00:00:00

  • VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis.

    abstract:AIMS:Vascular endothelial growth factor-C (VEGF-C) has been shown to stimulate both angiogenesis and lymphangiogenesis in some but not all models where VEGF-C is over-expressed. Our aim was to investigate the interaction between lymphangiogenesis and angiogenesis in adult tissues regulated by VEGF-C and identify eviden...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvm094

    authors: Benest AV,Harper SJ,Herttuala SY,Alitalo K,Bates DO

    更新日期:2008-05-01 00:00:00

  • Acute effects of an endothelin-1 receptor antagonist bosentan at different stages of heart failure in conscious dogs.

    abstract:OBJECTIVE:Inhibition by endothelin antagonist is a potential therapy in heart failure. However, the effect of endothelin inhibition during the development of heart failure has not been evaluated. The goal of our study was to examine the acute hemodynamic effects of the mixed endothelin receptor antagonist bosentan in t...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/s0008-6363(98)00068-6

    authors: Choussat R,Hittinger L,Barbe F,Maistre G,Carayon A,Crozatier B,Su J

    更新日期:1998-09-01 00:00:00

  • Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix.

    abstract::Matrix metalloproteinase (MMP)-2 belongs to a family of zinc-dependent proteases which are best known for their ability to proteolyse extracellular matrix proteins throughout the body, including the cardiovascular system. Increased MMP-2 activity has been demonstrated in myocardial ischaemia and reperfusion injury and...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1093/cvr/cvp268

    authors: Kandasamy AD,Chow AK,Ali MA,Schulz R

    更新日期:2010-02-01 00:00:00

  • Angiotensin converting enzyme and kininase-II-like activities in cultured valvular interstitial cells of the rat heart.

    abstract:OBJECTIVE:The function of angiotensin converting enzyme (ACE) at cell sites of high collagen turnover, such as heart valves, is uncertain. The aim of this study was to assess ACE and kininase-II-like activities and collagen turnover in cultured valvular interstitial cells of the adult rat heart. METHODS:The valvular i...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:

    authors: Katwa LC,Ratajska A,Cleutjens JP,Sun Y,Zhou G,Lee SJ,Weber KT

    更新日期:1995-01-01 00:00:00

  • Separation of the oscillatory current from other currents in cardiac Purkinje fibres.

    abstract::An oscillatory current (Ios) can be recorded after depolarising clamps of a given amplitude and duration. To determine whether Ios depends on other currents activated during the clamp, the Ios was investigated in the absence and in the presence of 4-aminopyridine (4-AP) and cesium (Cs). The following results were obta...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/16.11.637

    authors: Mugelli A

    更新日期:1982-11-01 00:00:00

  • Protective ischaemia in patients: preconditioning and postconditioning.

    abstract::Infarct size can be limited by reducing the determinants of infarct size or increasing collateral blood flow by treatment initiated before the ischaemic event. Reperfusion is the definitive treatment for permanently reducing infarct size and restoring some degree of contractile function to the affected myocardium. Inn...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1093/cvr/cvp129

    authors: Granfeldt A,Lefer DJ,Vinten-Johansen J

    更新日期:2009-07-15 00:00:00

  • Animal models of human cardiovascular disease, heart failure and hypertrophy.

    abstract::The progress made in our understanding of the pathophysiology and treatment of congestive heart failure (CHF) would not have been possible without a number of animal models of heart failure and hypertrophy, each one having unique advantages as well as disadvantages. The species and interventions used to create CHF dep...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1016/s0008-6363(98)00110-2

    authors: Hasenfuss G

    更新日期:1998-07-01 00:00:00

  • Aging, telomeres, and atherosclerosis.

    abstract::Although the level and pace of population aging display high geographical variability, virtually all countries have been experiencing growth in their elderly population, particularly in developed nations. Because aging is a major risk factor for atherosclerosis and associated disease, it is of up most importance to un...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1016/j.cardiores.2004.09.007

    authors: Edo MD,Andrés V

    更新日期:2005-05-01 00:00:00

  • Tubulin polymerization modifies cardiac sodium channel expression and gating.

    abstract:AIMS:Treatment with the anticancer drug taxol (TXL), which polymerizes the cytoskeleton protein tubulin, may evoke cardiac arrhythmias based on reduced human cardiac sodium channel (Na(v)1.5) function. Therefore, we investigated whether enhanced tubulin polymerization by TXL affects Na(v)1.5 function and expression and...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvp352

    authors: Casini S,Tan HL,Demirayak I,Remme CA,Amin AS,Scicluna BP,Chatyan H,Ruijter JM,Bezzina CR,van Ginneken AC,Veldkamp MW

    更新日期:2010-03-01 00:00:00

  • NADPH oxidase-4 promotes eccentric cardiac hypertrophy in response to volume overload.

    abstract:AIMS:Chronic pressure or volume overload induce concentric vs. eccentric left ventricular (LV) remodelling, respectively. Previous studies suggest that distinct signalling pathways are involved in these responses. NADPH oxidase-4 (Nox4) is a reactive oxygen species-generating enzyme that can limit detrimental cardiac r...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvz331

    authors: Schnelle M,Sawyer I,Anilkumar N,Mohamed BA,Richards DA,Toischer K,Zhang M,Catibog N,Sawyer G,Mongue-Din H,Schröder K,Hasenfuss G,Shah AM

    更新日期:2021-01-01 00:00:00

  • Updated Perspectives On Vascular Cell Specification And Pluripotent Stem Cell-Derived Vascular Organoids For Studying Vasculopathies.

    abstract::Vasculopathy is a pathological process occurring in the blood vessel wall, which could affect the haemostasis and physiological functions of all the vital tissues/organs and is one of the main underlying causes for a variety of human diseases including cardiovascular diseases. Current pharmacological interventions aim...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvaa313

    authors: Liu C,Niu K,Xiao Q

    更新日期:2020-11-02 00:00:00

  • Endocardial injury and the pathogenesis of mural thrombosis in the left ventricle.

    abstract::To define the interactions between blood and endocardium damaged by lactic acid, the left ventricles of 48 isolated continuously perfused and beating hearts were exposed for 0-4 hours to Krebs Henseleit buffer (KHB) with or without 33 mumol.ml-1 of lactic acid (pH 6.4). After excising its apex, the left ventricle was ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/23.6.478

    authors: Carter G,Gavin JB

    更新日期:1989-06-01 00:00:00

  • Coordination of fibronectin adhesion with contraction and relaxation in microvascular smooth muscle.

    abstract:AIMS:The regulation of vascular diameter by vasoconstrictors and vasodilators requires that vascular smooth muscle cells (VSMCs) be physically coupled to extracellular matrix (ECM) and neighbouring cells in order for a vessel to mechanically function and transfer force. The hypothesis was tested that integrin-mediated ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/cvs239

    authors: Hong Z,Sun Z,Li Z,Mesquitta WT,Trzeciakowski JP,Meininger GA

    更新日期:2012-10-01 00:00:00

  • Matricellular proteins in the heart: possible role during stress and remodeling.

    abstract::Matricellular proteins are extracellular matrix proteins that modulate cell-matrix interactions and cell function, and do not seem to have a direct structural role. The family includes tenascin-C (TN-C), tenascin-X (TN-X), osteonectin, osteopontin, thrombospondin-1 (TSP1) and thrombospondin-2 (TSP2). Expression of mat...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1016/j.cardiores.2004.06.006

    authors: Schellings MW,Pinto YM,Heymans S

    更新日期:2004-10-01 00:00:00

  • Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells.

    abstract:OBJECTIVE:Vascular endothelial growth factor (VEGF), secreted by vascular cells and a variety of tumour cells, is a potent angiogenic factor. Since nitric oxide (NO) seems to play a key role in the VEGF-induced proliferation of endothelial cells, the aim of the present study was to determine whether VEGF stimulates end...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/s0008-6363(98)00228-4

    authors: Bouloumié A,Schini-Kerth VB,Busse R

    更新日期:1999-03-01 00:00:00

  • Completing the genetic spectrum influencing coronary artery disease: from germline to somatic variation.

    abstract::Genetic and environmental factors influence the development of coronary artery disease (CAD). Genetic analyses of families and the population continue to yield important fundamental insights for CAD. For the past four decades, CAD human genetic research focused largely on the study of germline genetic variation in CAD...

    journal_title:Cardiovascular research

    pub_type: 杂志文章,评审

    doi:10.1093/cvr/cvz032

    authors: Patel AP,Natarajan P

    更新日期:2019-04-15 00:00:00

  • Post implantation viability in canine allograft heart valves.

    abstract::Known viable allograft canine pulmonary valves were inserted in an isotopic position ensuring normal physiological function and simulating the clinical situation. Valves removed at periods up to eight weeks were assessed for viability using previously established criteria of tissue culture and protein and collagen syn...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1093/cvr/11.1.78

    authors: Wheatley DJ,McGregor CG

    更新日期:1977-01-01 00:00:00

  • Effect of sustained stretch on dispersion of ventricular fibrillation intervals in normal rabbit hearts.

    abstract:OBJECTIVE:To determine the effect of acute left ventricular dilatation on refractoriness in normal hearts. METHODS:During sustained ventricular fibrillation (VF) in isolated perfused hearts, recording of local activation time yields VF intervals which provide an index of local refractoriness. Simultaneous measurement ...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:10.1016/s0008-6363(98)00092-3

    authors: Burton FL,Cobbe SM

    更新日期:1998-08-01 00:00:00

  • Mediators of perivascular inflammation in the left ventricle of renovascular hypertensive rats.

    abstract:OBJECTIVE:Inflammatory cells invade the fibrotic myocardium of spontaneously hypertensive rats at the same sites as where fibroblasts are produced. The role of these inflammatory cells in myocardial fibrogenesis was studied in the present work. METHODS:The production and distribution of proteins that may be implicated...

    journal_title:Cardiovascular research

    pub_type: 杂志文章

    doi:

    authors: Nicoletti A,Mandet C,Challah M,Bariéty J,Michel JB

    更新日期:1996-04-01 00:00:00