L-type calcium channel targeting and local signalling in cardiac myocytes.

abstract：AIMS:The TRPV1, transient receptor potential vanilloid type 1, agonist capsaicin is considered to be beneficial for cardiovascular health because it dilates coronary arteries through an endothelial-dependent mechanism and may slow atheroma progression. However, recent reports indicate that high doses of capsaicin may c...

journal_title：Cardiovascular research

authors： Hiett SC,Owen MK,Li W,Chen X,Riley A,Noblet J,Flores S,Sturek M,Tune JD,Obukhov AG

更新日期：2014-09-01 00:00:00

abstract：AIMS:Sphingosine-1-phosphate (S1P), a key regulator of vascular homeostasis and angiogenesis, promotes endothelial cell migration via stimulation of phosphoinositide 3-kinase (PI3K). The aim of this study was to identify the role of PI3Kbeta and gamma isoforms and their downstream effector pathways in mediating endothe...

journal_title：Cardiovascular research

authors： Heller R,Chang Q,Ehrlich G,Hsieh SN,Schoenwaelder SM,Kuhlencordt PJ,Preissner KT,Hirsch E,Wetzker R

更新日期：2008-10-01 00:00:00

abstract：:Postextrasystolic potentiation was studied by means of a catheter-tip manometer in patients with and without cardiomyopathy. The results imply that the enhancement of the left ventricular contraction is increased in patients with cardiomyopathy. ...

journal_title：Cardiovascular research

authors： Kvasnicka J,Liander B,Broman H,Varnauskas E

更新日期：1975-05-01 00:00:00

abstract：OBJECTIVE:The aim was to determine if either heparin or N-acetylheparin could reduce the extent of myocardial injury resulting from 90 min of coronary artery occlusion and 6 h of reperfusion in the anaesthetised dog. METHODS:Heparin or N-acetylheparin was given in three repeated intravenous doses of 2 mg.kg-1. Drug or...

journal_title：Cardiovascular research

authors： Black SC,Gralinski MR,Friedrichs GS,Kilgore KS,Driscoll EM,Lucchesi BR

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:In human heart failure beta-adrenergic-mediated protein kinase A (PKA) activity is down-regulated, while protein kinase C (PKC) activity is up-regulated. PKC-mediated myofilament protein phosphorylation might be detrimental for contractile function in cardiomyopathy. This study was designed to reveal the effe...

journal_title：Cardiovascular research

authors： van der Velden J,Narolska NA,Lamberts RR,Boontje NM,Borbély A,Zaremba R,Bronzwaer JG,Papp Z,Jaquet K,Paulus WJ,Stienen GJ

更新日期：2006-03-01 00:00:00

abstract：AIMS:Exercise started early after myocardial infarction (MI) improves in vivo cardiac function and myofilament responsiveness to Ca(2+). We investigated whether this represents partial or complete reversal of cellular remodelling. METHODS AND RESULTS:Mice with MI following left coronary ligation were given free access...

journal_title：Cardiovascular research

authors： Bito V,de Waard MC,Biesmans L,Lenaerts I,Ozdemir S,van Deel E,Abdel-Mottaleb Y,Driesen R,Holemans P,Duncker DJ,Sipido KR

更新日期：2010-04-01 00:00:00

abstract：:Cardiomyocyte death secondary to transient ischaemia occurs mainly during the first minutes of reperfusion in the form of contraction band necrosis. Research on the mechanisms leading to sarcolemmal rupture and necrosis during initial reperfusion identified several promising pharmacological targets directed either to ...

journal_title：Cardiovascular research

authors： Inserte J,Barrabés JA,Hernando V,Garcia-Dorado D

更新日期：2009-07-15 00:00:00

abstract：:The role of the mitochondrial ATP-sensitive potassium channel (mK(ATP)) in ischemic preconditioning and cardioprotection is reviewed. A great deal of accumulated evidence implicatese opening of this channel as an important step in the anti-infarct effect of ischemic preconditioning. Recent studies, however, reveal tha...

journal_title：Cardiovascular research

authors： Oldenburg O,Cohen MV,Yellon DM,Downey JM

更新日期：2002-08-15 00:00:00

abstract：BACKGROUND:During reperfusion of ischaemic myocardium, Na+/H+ exchange promotes recovery from acidosis resulting in an accumulation of intracellular Na+. This leads to calcium overload via Na+/Ca2+ exchange and might result in cell necrosis contributing to reperfusion injury. METHODS AND RESULTS:We assessed whether HO...

journal_title：Cardiovascular research

authors： Rohmann S,Weygandt H,Minck KO

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:This study aimed to examine the effects of adenovirus-mediated expression of p35, a baculovirus gene, on apoptosis induced by hypoxia/reoxygenation (H/R) in cardiomyocytes. METHODS:Neonatal rat cardiomyocytes were infected with recombinant adenoviral vectors expressing p35 (Ad2/CMVp35) or no transgene (Ad2/C...

journal_title：Cardiovascular research

authors： Date T,Belanger AJ,Mochizuki S,Sullivan JA,Liu LX,Scaria A,Cheng SH,Gregory RJ,Jiang C

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to investigate the idea that altered fibroblast contractile activity is involved in the pathogenesis of hypertensive heart disease (HHD). METHODS:Cell area and contraction are quantified using the traction force microscopy technique for cardiac fibroblasts isolated from both normoten...

journal_title：Cardiovascular research

authors： Marganski WA,De Biase VM,Burgess ML,Dembo M

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVES:Conduction of vasoconstrictor and vasodilator responses in the microcirculation involves electrical coupling through gap junction channels among cells of the vascular wall. The present study determined whether reported differences in the properties of conduction along the arterioles of the epithelial hamster...

journal_title：Cardiovascular research

authors： Sandow SL,Looft-Wilson R,Doran B,Grayson TH,Segal SS,Hill CE

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:Smooth muscle cell proliferation and migration are the predominant responses to intimal and medial injury after percutaneous transluminal coronary angioplasty. The in vivo inhibitory effect of heparin on these responses is well documented. To test the hypothesis that the antiproliferative effect of heparin in...

journal_title：Cardiovascular research

authors： Hamon M,Bauters C,Wernert N,Courtin P,Delcayre C,Adamantidis M,Lablanche JM,Bertrand ME,Dupuis B,Swynghedauw B

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:Calcitonin gene related peptide (CGRP) is a potent vasodilator found in sensory nerve endings in coronary arteries. The effect of intravenous CGRP on myocardial ischaemia, cardiovascular haemodynamics, and epicardial coronary artery stenoses was studied in patients with angina to investigate the possible role...

journal_title：Cardiovascular research

authors： Uren NG,Seydoux C,Davies GJ

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVE:In isolated cardiac preparations of non-failing hearts from different species, including man, there is a positive force-frequency relation which is reversed into a negative relation in preparation from failing hearts. Whether or not such relations between ventricular function and heart rate hold true in the i...

journal_title：Cardiovascular research

authors： Neumann T,Ravens U,Heusch G

更新日期：1998-02-01 00:00:00

abstract：AIMS:Cardiovascular research requires complex and functionally intact experimental models. Due to major differences in the cellular and subcellular composition of the myocardium between species, the use of human heart tissue is highly desirable. To enhance the experimental use of the human myocardium, we established me...

journal_title：Cardiovascular research

authors： Brandenburger M,Wenzel J,Bogdan R,Richardt D,Nguemo F,Reppel M,Hescheler J,Terlau H,Dendorfer A

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:The contribution of vascular changes to the development of heart failure is largely unknown. In the present study, we evaluated endothelial and vascular contractile function in the rat hindlimb vascular bed after myocardial infarction (MI), including the modulatory role of basal nitric oxide (NO) production ...

journal_title：Cardiovascular research

authors： Ceiler DL,Nelissen-Vrancken M,De Mey JG,Smits JF

更新日期：1999-08-15 00:00:00

abstract：OBJECTIVES:Prior studies have shown that the performance of the left ventricle on any one beat is influenced by the mechanical events of the previous beat, a phenomenon called "previous-beat contraction history". This previous-beat contraction history, which appears to be an interplay between the mechanical events of o...

journal_title：Cardiovascular research

authors： Slinker BK,Tobias AH

更新日期：1996-07-01 00:00:00

abstract：AIMS:We have previously characterized a cGMP-dependent Ca(2+)-activated Cl(-) current in vascular smooth muscle cells (SMCs) and have shown its dependence on bestrophin-3 expression. We hypothesize that this current is important for synchronization of SMCs in the vascular wall. In the present study, we aimed to test th...

journal_title：Cardiovascular research

authors： Broegger T,Jacobsen JC,Secher Dam V,Boedtkjer DM,Kold-Petersen H,Pedersen FS,Aalkjaer C,Matchkov VV

更新日期：2011-09-01 00:00:00

abstract：:Hydrogen sulfide (H2S), as a gaseous signalling molecule, has been found to play important roles in postconditioning (PostC)-induced cardioprotection. Similar to nitric oxide (NO)-mediated protein S-nitrosylation (SNO), recent studies suggest that H2S could regulate protein function through another redox-based post-tr...

journal_title：Cardiovascular research

authors： Sun J,Aponte AM,Menazza S,Gucek M,Steenbergen C,Murphy E

更新日期：2016-05-01 00:00:00

abstract：AIMS:Both mitochondria and nitric oxide (NO*) contribute to cardioprotection by ischaemic preconditioning (IPC). IPC causes mild uncoupling of mitochondria via uncoupling proteins (UCPs) and the adenine nucleotide translocase (ANT), and mild uncoupling per se is cardioprotective. Although electrophilic lipids are known...

journal_title：Cardiovascular research

authors： Nadtochiy SM,Baker PR,Freeman BA,Brookes PS

更新日期：2009-05-01 00:00:00

abstract：:A recently developed highly sensitive radioimmunoassay method for detecting plasma kinin was used to re-evaluate the results of previous studies, in which plasma kinin had been measured with a bioassay method. To clarify the mechanism of plasma kinin release in global myocardial ischaemia the left main coronary artery...

journal_title：Cardiovascular research

authors： Matsuki T,Shoji T,Yoshida S,Kudoh Y,Motoe M,Inoue M,Nakata T,Hosoda S,Shimamoto K,Yellon D

更新日期：1987-06-01 00:00:00

abstract：AIMS:In cardiomyocytes, protein kinase D1 (PKD1) plays a central role in the response to stress signals. From a yeast two-hybrid assay, we have identified Enigma Homolog 1 (ENH1) as a new binding partner of PKD1. Since in neurons, ENH1, associated with protein kinase Cepsilon, was shown to modulate the activity of N-ty...

journal_title：Cardiovascular research

authors： Maturana AD,Wälchli S,Iwata M,Ryser S,Van Lint J,Hoshijima M,Schlegel W,Ikeda Y,Tanizawa K,Kuroda S

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:Co-expression of the KvLQT1 and minK potassium channel subunits is required to recapitulate I(Ks), the slow component of the cardiac delayed rectifier current, and mutations in either gene cause the congenital Long QT syndrome. It is becoming increasingly well-recognized that multiprotein channel complexes co...

journal_title：Cardiovascular research

authors： Kupershmidt S,Yang IC,Sutherland M,Wells KS,Yang T,Yang P,Balser JR,Roden DM

更新日期：2002-10-01 00:00:00

abstract：:Having an apparently healthy, thriving infant fail to reach his/her first birthday is profoundly tragic. This tragedy is compounded when the infant's death is unexpected and unexplained, signed out as sudden infant death syndrome (SIDS). Despite impressive success and welcome reductions in these tragic deaths due in l...

journal_title：Cardiovascular research

authors： Tester DJ,Ackerman MJ

更新日期：2005-08-15 00:00:00

abstract：:The QT interval, a global index of ventricular repolarization, varies among individuals and is influenced by diverse physiologic and pathophysiologic stimuli such as gender, age, heart rate, electrolyte concentrations, concomitant cardiac disease, and other diseases such as diabetes. Many drugs produce a small but rep...

journal_title：Cardiovascular research

authors： Roden DM

更新日期：2019-04-15 00:00:00

abstract：AIMS:Current mechanisms driving cardiac pacemaker function have focused on ion channel and gap junction channel function, which are essential for action potential generation and propagation between pacemaker cells. However, pacemaker cells also harbour desmosomes that structurally anchor pacemaker cells to each other i...

journal_title：Cardiovascular research

authors： Mezzano V,Liang Y,Wright AT,Lyon RC,Pfeiffer E,Song MY,Gu Y,Dalton ND,Scheinman M,Peterson KL,Evans SM,Fowler S,Cerrone M,McCulloch AD,Sheikh F

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:The mechanosensitive nonselective cation channel (NSC(MS)) and endothelin-1 (ET-1) play critical roles in the regulation of vascular tone. This study was undertaken to investigate the effect of ET-1 on NSC(MS) and on the myogenic response of arteries. METHODS:Cell-attached patch-clamp techniques were applied...

journal_title：Cardiovascular research

authors： Lee HA,Baek EB,Park KS,Jung HJ,Kim JI,Kim SJ,Earm YE

更新日期：2007-11-01 00:00:00

abstract：:Functional studies in extrarenal non-epithelial cells such as smooth muscle cells and easily accessible human lymphocytes have demonstrated that aldosterone not only produces classical genomic effects, but also rapid non-genomic effects on transmembrane electrolyte movements. These involve the activation of the Na+/H+...

journal_title：Cardiovascular research

authors： Wehling M

更新日期：1995-02-01 00:00:00

abstract：:End-diastolic current thresholds have been measured in 12 open-chested dogs with epicardial disc electrodes ranging in radius from 0.01 to 9.0 mm. The current threshold for cathodal 1 ms impulses proved to be independent of electrode size for radii smaller than 0.2 mm and proportional to the radius to the power 1.5 fo...

journal_title：Cardiovascular research

authors： Lindemans FW,Denier Van der Gon JJ

更新日期：1978-08-01 00:00:00