Abstract:
:Blood vessels are permanently exposed to stretch and shear stress due to blood pressure and blood flow. Significant variations in the mechanical environment, of physiological or pathophysiological nature, occur in vivo. These trigger acute changes in vessel diameter that tend to restore basal levels of tensile and shear stress. However, when altered mechanical conditions persist, they lead to compensatory phenotypical modulation of the endothelial and vascular smooth muscle cells, producing structural and functional modifications of the arterial wall. Such vascular remodelling is a fundamental basis of normal vessel growth and adaptation. However, when the vascular environment changes, due to humoral, metabolic or surgical alterations, for example, mechanical factors may actually exacerbate the underlying conditions and contribute significantly to disease progression. Several studies have demonstrated that reactive oxygen species are induced in the vascular response to changes in shear stress or stretch. It appears that the balance between oxidant and antioxidant generation, which is directly determined by the nature of the mechanical stimulus, can greatly influence the process of vascular remodelling, contributing to both transient and more prolonged adaptations.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Lehoux Sdoi
10.1016/j.cardiores.2006.05.008subject
Has Abstractpub_date
2006-07-15 00:00:00pages
269-79issue
2eissn
0008-6363issn
1755-3245pii
S0008-6363(06)00191-Xjournal_volume
71pub_type
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journal_title:Cardiovascular research
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更新日期:2013-02-01 00:00:00
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doi:10.1016/j.cardiores.2005.04.034
更新日期:2005-09-01 00:00:00
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更新日期:1996-05-01 00:00:00
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journal_title:Cardiovascular research
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更新日期:2020-07-15 00:00:00
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更新日期:2012-08-01 00:00:00
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更新日期:2002-03-01 00:00:00
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更新日期:2013-08-01 00:00:00
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更新日期:2002-08-01 00:00:00
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更新日期:2002-11-01 00:00:00
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更新日期:2011-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/cvr/cvr250
更新日期:2011-12-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/0008-6363(95)00216-2
更新日期:1996-02-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章,评审
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更新日期:2004-10-01 00:00:00
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更新日期:2015-02-01 00:00:00
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更新日期:2002-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1998-07-01 00:00:00
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更新日期:2013-01-01 00:00:00
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doi:10.1093/cvr/28.9.1326
更新日期:1994-09-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:10.1016/s0008-6363(99)00397-1
更新日期:2000-03-01 00:00:00
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journal_title:Cardiovascular research
pub_type: 杂志文章
doi:
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doi:10.1093/cvr/cvt074
更新日期:2013-09-01 00:00:00
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更新日期:1997-06-01 00:00:00
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