Animal models of human cardiovascular disease, heart failure and hypertrophy.

abstract：OBJECTIVE:Matrix metalloproteinase-9 (MMP-9) activity is up regulated in the heart subjected to ischemic insult. Whether increased MMP-9 activity contributes to acute myocardial injury after ischemia-reperfusion remains unknown. To investigate the role of MMP-9 in myocardial infarction, we utilized a MMP-9 knockout mou...

journal_title：Cardiovascular research

authors： Romanic AM,Harrison SM,Bao W,Burns-Kurtis CL,Pickering S,Gu J,Grau E,Mao J,Sathe GM,Ohlstein EH,Yue TL

更新日期：2002-06-01 00:00:00

abstract：:When the vagus nerves are stimulated with one burst of pulses per minute, but each burst is placed at a different time in the cardiac cycle, a "vagal effect curve" can be derived which displays the changes in cardiac cycle length (CCL) as a function of the elapsed time from the stimulus. This curve consists of a prima...

journal_title：Cardiovascular research

authors： Wallick DW,Valencic F,Fratianne RB,Levy MN

更新日期：1984-02-01 00:00:00

abstract：AIMS:Human influenza A virus (hIAV) infection is associated with important cardiovascular complications, although cardiac infection pathophysiology is poorly understood. We aimed to study the ability of hIAV of different pathogenicity to infect the mouse heart, and establish the relationship between the infective capac...

journal_title：Cardiovascular research

authors： Filgueiras-Rama D,Vasilijevic J,Jalife J,Noujaim SF,Alfonso JM,Nicolas-Avila JA,Gutierrez C,Zamarreño N,Hidalgo A,Bernabé A,Cop CP,Ponce-Balbuena D,Guerrero-Serna G,Calle D,Desco M,Ruiz-Cabello J,Nieto A,Falcon A

更新日期：2020-04-28 00:00:00

abstract：STUDY OBJECTIVE:The aim was to investigate the arrhythmogenic properties of several sympathomimetic amines and their antagonism by adrenergic blocking drugs. DESIGN:Arrhythmia was induced by the investigated drugs, injected intravenously: adrenaline (ADR); noradrenaline (NA); phenylephrine (PE); isoprenaline (IP); ter...

journal_title：Cardiovascular research

authors： Oppenheimer E,Akavia E,Shavit S,Korczyn AD

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that mild hypothermia potentiates the cardioprotection afforded by ischaemic preconditioning so that infarct size limitation can be obtained after coronary artery occlusion (CAO) durations which exceed the cardioprotective range (> 90 min) of either hypothermia or ischaemic precondition...

journal_title：Cardiovascular research

authors： van den Doel MA,Gho BC,Duval SY,Schoemaker RG,Duncker DJ,Verdouw PD

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:We have attempted to demonstrate the induction of inducible nitric oxide synthase in human vascular tissue and define the capacity of different cytokines to induce this enzyme. METHODS:Segments of human arteries were stimulated with lipopolysaccharide (10 micrograms/ml), interleukin-1 beta (5 U/ml), tumor ne...

journal_title：Cardiovascular research

authors： Chester AH,Borland JA,Buttery LD,Mitchell JA,Cunningham DA,Hafizi S,Hoare GS,Springall DR,Polak JM,Yacoub MH

更新日期：1998-06-01 00:00:00

abstract：AIMS:The hypoxia-inducible factor-1 (HIF-1) is the master modulator of hypoxic gene expression. The effects of chronically stabilized cardiac HIF-1α and its role in the diseased heart are not precisely known. The aims of this study were as follows: (i) to elucidate consequences of HIF-1α stabilization in the heart; (ii...

journal_title：Cardiovascular research

authors： Hölscher M,Schäfer K,Krull S,Farhat K,Hesse A,Silter M,Lin Y,Pichler BJ,Thistlethwaite P,El-Armouche A,Maier LS,Katschinski DM,Zieseniss A

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:To determine the effect of Na(+)-H+ exchange blockade on ischemic rigor contracture and reperfusion-induced hypercontracture. METHODS:Thirty-six pigs were submitted to 55 min of coronary occlusion and 5 h reperfusion. Myocardial segment length analysis with ultrasonic microcrystals was used to detect ischemi...

journal_title：Cardiovascular research

authors： Garcia-Dorado D,González MA,Barrabés JA,Ruiz-Meana M,Solares J,Lidon RM,Blanco J,Puigfel Y,Piper HM,Soler-Soler J

更新日期：1997-07-01 00:00:00

abstract：:Experimental studies have provided evidence that the autonomic nervous activity is modulated by oestrogen. Such modulation at central and peripheral levels tends to suppress sympathetic but elevate parasympathetic tone to the cardiovascular system. Thus, available data support the view that cardiovascular protection b...

journal_title：Cardiovascular research

authors： Du XJ,Riemersma RA,Dart AM

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVES:5-Hydroxytryptamine (5-HT) has a wide range of vascular effects mediated via specific receptors and it has been suggested to be a mediator in ischemic heart disease. The aim of the present study was to localise the 5-HT receptors within the vessel wall. METHODS:Epicardial coronary arteries obtained from pat...

journal_title：Cardiovascular research

authors： Dahm PL,Bodelsson M,Törnebrandt K,Muddle JR,Sykes RM,Yacoub M,Dashwood MR

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVES:To characterize the 'anti-ischemic' effects of adenosine metabolism inhibition in ischemic-reperfused myocardium. METHODS:Perfused C57/B16 mouse hearts were subjected to 20 min ischemia 40 min reperfusion in the absence or presence of adenosine deaminase inhibition (50 microM erythro-2-(2-hydroxy-3-nonyl)ad...

journal_title：Cardiovascular research

authors： Peart J,Matherne GP,Cerniway RJ,Headrick JP

更新日期：2001-10-01 00:00:00

abstract：:It has long been known that gap junctions are required for the propagation of electrical impulse in the heart. A good deal later, the connexins (Cxs), which are probably exclusive components of the junctional channels that constitute the gap junctions, were identified. More recently, the in vivo functions of cardiac C...

journal_title：Cardiovascular research

authors： Gros D,Dupays L,Alcoléa S,Meysen S,Miquerol L,Théveniau-Ruissy M

更新日期：2004-05-01 00:00:00

abstract：AIMS:Sleep disturbances exhibit a strong social patterning, and inadequate sleep has been associated with adverse health outcomes, including cardiovascular disorders (CVD). However, the contribution of sleep to socioeconomic inequalities in CVD is unclear. This study pools data from eight European cohorts to investigat...

journal_title：Cardiovascular research

authors： Petrovic D,Haba-Rubio J,de Mestral Vargas C,Kelly-Irving M,Vineis P,Kivimäki M,Nyberg S,Gandini M,Bochud M,Vollenweider P,d'Errico A,Barros H,Fraga S,Goldberg M,Zins M,Steptoe A,Delpierre C,Heinzer R,Carmeli C,Chade

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:The aim of the presented method was the characterization of different complex heart rate dynamics in conscious rabbits as well as during general anaesthesia and vagal blockade. This was done by non-linear prediction of original measured and special surrogate data in the phase space. METHOD:The development of...

journal_title：Cardiovascular research

authors： Hoyer D,Schmidt K,Zwiener U,Bauer R

更新日期：1996-03-01 00:00:00

abstract：:Exogenous angiotensin II causes noradrenaline supersensitivity in rat mesenteric vasculature preparations. The noradrenaline supersensitivity of tissues from renal/salt hypertensive rats, with low plasma renin activity, is not caused by endogenous angiotensin II since it was unaffected by Sar1 Ileu8 angiotensin II. Di...

journal_title：Cardiovascular research

authors： Collis MG,Alps BJ

更新日期：1976-03-01 00:00:00

abstract：OBJECTIVE:Previous studies have shown that cardiac protection by ischaemic preconditioning wanes before contractile function recovers; thus stunning is insufficient to cause preconditioning. To test whether reduced contractile effort is necessary for preconditioning induced protection, the effect on myocardial infarct ...

journal_title：Cardiovascular research

authors： Matsuda M,Catena TG,Vander Heide RS,Jennings RB,Reimer KA

更新日期：1993-04-01 00:00:00

abstract：:An isolated working rat heart preparation was used to characterise the temperature-dependency of the anti-ischaemic properties of nifedipine. In this study hearts were subjected to pre-ischaemic infusion with the St Thomas' cardioplegic solution with or without added nifedipine (0.075 mumol X litre-1). Hearts were the...

journal_title：Cardiovascular research

authors： Fukunami M,Hearse DJ

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:To investigate the cellular mechanisms underlying global and regional LV dysfunction in the post-infarct (MI) remodeled rat hearts. METHODS:LV remodeling and function were quantified by echocardiography, morphometry, in vivo hemodynamics, and isolated perfused heart studies in 6 weeks post-MI and sham-operat...

journal_title：Cardiovascular research

authors： Gupta S,Prahash AJ,Anand IS

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:Angiotensin II (ANG II) has recently been reported to increase inotropy in adult rabbit myocytes by a mechanism of alkalinization and consequent increased myofilament sensitivity to calcium. Accordingly, we tested the hypothesis that ANG II would have a greater inotropic effect during ischemic conditions than...

journal_title：Cardiovascular research

authors： Libonati JR,Eberli FR,Sesselberg HW,Apstein CS

更新日期：1997-01-01 00:00:00

abstract：:Microvascular barrier dysfunction is implicated in the initiation and progression of inflammation, posttraumatic complications, sepsis, ischaemia-reperfusion injury, atherosclerosis, and diabetes. Under physiological conditions, a precise equilibrium between endothelial cell-cell adhesion and actin-myosin-based centri...

journal_title：Cardiovascular research

authors： Shen Q,Rigor RR,Pivetti CD,Wu MH,Yuan SY

更新日期：2010-07-15 00:00:00

abstract：OBJECTIVE:The mechanism of spontaneous myogenic tone was investigated in isolated arteriolar segments. METHODS:Arterioles were isolated from rat cremaster muscle. Segments were endothelium-denuded and mounted in a pressure myograph at 75 mmHg. Under this condition, segments spontaneously constricted from a passive dia...

journal_title：Cardiovascular research

authors： Bakker EN,Kerkhof CJ,Sipkema P

更新日期：1999-01-01 00:00:00

abstract：AIMS:Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for the treatment of ischaemic heart or limb disease. Despite promising results in preclinical and clinical trials, the exact mechanism of action remains unknown. Toll-like receptor 3, which is part of the innate...

journal_title：Cardiovascular research

authors： Holfeld J,Tepeköylü C,Reissig C,Lobenwein D,Scheller B,Kirchmair E,Kozaryn R,Albrecht-Schgoer K,Krapf C,Zins K,Urbschat A,Zacharowski K,Grimm M,Kirchmair R,Paulus P

更新日期：2016-02-01 00:00:00

abstract：:Cardiovascular complications in the course of human immunodeficiency virus (HIV) infection are multifactorial and may be caused by the virus itself or by the related opportunistic infections and neoplasms. Highly active antiretroviral therapy (HAART) has prolonged many patients' lives, but many cardiac sequelae of HIV...

journal_title：Cardiovascular research

authors： Barbaro G

更新日期：2003-10-15 00:00:00

abstract：AIMS:Adverse cardiovascular events in humans occur with a day/night pattern, presumably related to a daily pattern of behaviours or endogenous circadian rhythms in cardiovascular variables. Healthy humans possess a scale-invariant/fractal structure in heartbeat fluctuations that exhibits an endogenous circadian rhythm ...

journal_title：Cardiovascular research

authors： Hu K,Scheer FA,Buijs RM,Shea SA

更新日期：2008-10-01 00:00:00

abstract：:The effects of both gradual and abrupt coronary occlusion on regional wall function (sonomicrometry) and left ventricular relaxation were studied in the intact dog heart. The ischaemic dysfunction observed in the two interventions as assessed by pressure-length loops showed considerably different patterns. The regiona...

journal_title：Cardiovascular research

authors： Doyle RL,Foëx P,Ryder WA,Jones LA

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:Alkalinizing agents reverse cardiotoxicity of a variety of sodium channel blockers, including tricyclic antidepressants, but their mechanisms of action are poorly understood. PURPOSE:To establish the mechanisms by which alkalinization diminishes the sodium channel blocking action of imipramine. METHODS:The...

journal_title：Cardiovascular research

authors： Bou-Abboud E,Nattel S

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVES:Anthracyclines cause apoptotic death in many cell types through activation of the ceramide pathway. We tested the hypothesis that doxorubicin induces cardiac myocyte apoptosis through ceramide generation. METHODS:Adult rat ventricular myocytes were grown in the presence of 10% fetal calf serum, and exposed ...

journal_title：Cardiovascular research

authors： Delpy E,Hatem SN,Andrieu N,de Vaumas C,Henaff M,Rücker-Martin C,Jaffrézou JP,Laurent G,Levade T,Mercadier JJ

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:It has been shown that cGMP content is reduced in post-ischemic myocardium, and that stimulation of cGMP synthesis prevents cardiomyocyte hypercontracture and cell death in vitro. This study was aimed at determining whether administration of the natriuretic peptide urodilatin (URO) at the time of reperfusion ...

journal_title：Cardiovascular research

authors： Padilla F,Garcia-Dorado D,Agulló L,Barrabés JA,Inserte J,Escalona N,Meyer M,Mirabet M,Pina P,Soler-Soler J

更新日期：2001-08-15 00:00:00

abstract：AIMS:AMP-activated protein kinase (AMPK) is thought to be a central player in regulating myocardial metabolism and its activation has been shown to inhibit cardiac hypertrophy. Recently, mice with muscle-specific deletion of AMPK β1/β2 subunits (AMPKβ1β2-deficient mice, β1β2M-KO) have been generated and possess <10% of...

journal_title：Cardiovascular research

authors： Sung MM,Zordoky BN,Bujak AL,Lally JS,Fung D,Young ME,Horman S,Miller EJ,Light PE,Kemp BE,Steinberg GR,Dyck JR

更新日期：2015-07-15 00:00:00

abstract：:The effects on an acute myocardial infarction of equipotent hypotensive doses of nitroglycerin and dipyridamole were studied using the thermographic technique in open-chest dogs. Nitroglycerin did not reduce the cool ischaemic area in any of the nine dogs studied. In six of the dogs, in which the ischaemic region coul...

journal_title：Cardiovascular research

authors： Malm A,Arborelius M Jr,Lilja B,Gil RL,Bornmyr S

更新日期：1979-05-01 00:00:00