Angiotensin II, adhesion, and cardiac fibrosis.

Abstract:

:Angiotensin II (AII) plays a critical role in cardiac remodeling. This peptide promotes cardiac myocyte hypertrophy and cardiac fibroblast interstitial fibrotic changes associated with left ventricular hypertrophy, post myocardial infarction remodeling and congestive heart failure. AII mediates cardiac myocyte hypertrophy directly via induction of immediate early genes through a MAP kinase dependent pathway. In addition, it mediates cardiac hypertrophy indirectly by stimulating release of norepinephrine from cardiac nerve endings and endothelin from endothelial cells. AII also has multiple effects on cardiac fibroblasts: it induces cardiac fibroblast proliferation, synthesis and secretion of adhesion molecules and extracellular matrix proteins, and expression of integrin adhesion receptors. In addition it stimulates cardiac fibroblasts to adhere more vigorously to defined matrixes. This review will discuss the molecular pathways that have been implicated in these AII induced effects in the cardiac fibroblast.

journal_name

Cardiovasc Res

journal_title

Cardiovascular research

authors

Schnee JM,Hsueh WA

doi

10.1016/s0008-6363(00)00044-4

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

264-8

issue

2

eissn

0008-6363

issn

1755-3245

pii

S0008-6363(00)00044-4

journal_volume

46

pub_type

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